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    MASS SPECTROMETER, USE THEREOF, AND METHOD FOR THE MASS SPECTROMETRIC EXAMINATION OF A GAS MIXTURE
    61.
    发明申请
    MASS SPECTROMETER, USE THEREOF, AND METHOD FOR THE MASS SPECTROMETRIC EXAMINATION OF A GAS MIXTURE 审中-公开
    质谱仪，其使用方法和气体混合物质谱检测方法

    公开(公告)号：US20160111269A1

    公开(公告)日：2016-04-21

    申请号：US14967699

    申请日：2015-12-14

    申请人： Carl Zeiss Microscopy GmbH ,  Carl Zeiss SMT GmbH

    发明人： Gennady Fedosenko ,  Michel Aliman ,  Hin Yiu Anthony Chung ,  Albrecht Ranck ,  Leonid Gorkhover

    IPC分类号： H01J49/04 ,  H01J49/14 ,  H01J49/00

    CPC分类号： H01J49/04 ,  H01J49/0027 ,  H01J49/105 ,  H01J49/14 ,  H01J49/145 ,  H01J49/147

    摘要： The disclosure relates to a mass spectrometer for mass spectrometric examination of gas mixtures, including: an ionization device and an ion trap for storage and mass spectrometric examination of the gas mixture. In one aspect of the disclosure, the ionization device is embodied for supplying ions and/or metastable particles of an ionization gas and/or for supplying electrons to the ion trap for ionizing the gas mixture to be examined and the mass spectrometer is embodied to determine the number of ions and/or metastable particles of the ionization gas present in the ion trap and/or the number of ions of a residual gas present in the ion trap prior to examining the gas mixture. The disclosure also relates to the use of such a mass spectrometer and a method for mass spectrometric examination of a gas mixture.

    摘要翻译： 本公开涉及用于气体混合物质谱检测的质谱仪，包括：用于气体混合物的存储和质谱检查的离子阱和离子阱。 在本公开的一个方面，电离装置被实施用于提供电离气体的离子和/或亚稳颗粒和/或用于向离子阱提供电子以电离待检查的气体混合物，并且体现质谱仪以确定 存在于离子阱中的离子和/或亚稳颗粒的数量和/或在检查气体混合物之前存在于离子阱中的残留气体的离子数。 本公开还涉及使用这种质谱仪和气体混合物的质谱检测方法。

    Mass spectrometer
    62.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US09316625B2

    公开(公告)日：2016-04-19

    申请号：US14429025

    申请日：2012-09-20

    申请人： SHIMADZU CORPORATION

    发明人： Shinjiro Fujita

    IPC分类号： H01J49/00 ,  G01N30/72 ,  H01J49/02 ,  H01J49/04 ,  H01J49/10

    CPC分类号： G01N30/7233 ,  H01J49/0027 ,  H01J49/025 ,  H01J49/0431 ,  H01J49/10

    摘要： Every time a target sample is injected from an injector (12) of an LC unit (1) and a mass spectrometry for a target component in the sample is performed, a CD voltage applied to a conversion dynode of an ion detector (29) is switched. For each of the multiple CD-voltage levels, a data collector (32) collects noise data during a period of time where no component is present and intensity data of an ion originating from the target component, while the SN ratio calculator (33) calculates an SN ratio. After the actual measurement is completed, an optimum CD voltage determiner (34) compares the SN ratios calculated for each CD voltage, finds the CD voltage which gives the highest SN ratio, and stores this voltage in an optimum CD voltage memory (42) as an optimum CD voltage for the analysis conditions at that point in time and for the m/z of the analysis target. According to this method, even when the flow rate of the mobile phase is particularly high or when a hard-to-vaporize mobile phase is used, the CD voltage is appropriately set and a detection signal is obtained with high SN ratios.

    摘要翻译： 每当从LC单元（1）的注射器（12）注入目标样品并执行样品中的目标组分的质谱时，施加到离子检测器（29）的转换倍增极的CD电压为 切换 对于多个CD电压电平中的每一个，数据采集器（32）在SN比计算器（33）计算出的时间段内收集噪声数据，该时间段内不存在任何分量和源自目标分量的离子的强度数据 一个SN比。 在实际测量完成后，最佳CD电压确定器（34）比较为每个CD电压计算的SN比，找出给出最高SN比的CD电压，并将该电压存储在最佳CD电压存储器（42）中作为 在该时间点和分析目标的m / z处的分析条件的最佳CD电压。 根据该方法，即使流动相的流量特别高，或者当使用难以汽化的流动相时，也适当设定CD电压，并以高SN比获得检测信号。

    Apparatus and method for determining the amounts of two or more substances present in a liquid
    65.
    发明授权
    Apparatus and method for determining the amounts of two or more substances present in a liquid 有权
    用于确定存在于液体中的两种或更多种物质的量的装置和方法

    公开(公告)号：US09285317B2

    公开(公告)日：2016-03-15

    申请号：US14272645

    申请日：2012-11-05

    申请人： ADVANCED SENSORS LIMITED

    发明人： Khalid Thabeth ,  Stephen Taylor

    IPC分类号： G01J1/58 ,  G01N21/00 ,  G01N21/64 ,  H01J49/26 ,  H01J49/00

    CPC分类号： G01N21/645 ,  G01N21/64 ,  G01N2201/06113 ,  H01J49/0009 ,  H01J49/0027 ,  H01J49/26

    摘要： An apparatus for determining the total amount of two or more substances in a liquid, at least one of said substances comprising a fluorescent substance, said apparatus comprising: a mass spectrometer device; a fluorometer device; and a processing means; wherein said mass spectrometer device is adapted to obtain a periodic measurement of the total amount of said two or more substances in the liquid, said fluorometer device being adapted to detect the fluorescent response of said at least one fluorescent substance in said liquid to an excitation signal, said processing means being programmed to determine a calibration factor by comparing a measurement obtained by the fluorometer device with said periodic measurement of the total amount of said two or more substances present obtained by the mass spectrometer device, the processing means subsequently using said calibration factor to determine measurements representative of the total amount of both fluorescent and non-fluorescent substances present in the liquid based upon the fluorescent response detected by the fluorometer device.

    摘要翻译： 一种用于确定液体中两种或多种物质的总量的装置，所述物质中的至少一种包括荧光物质，所述装置包括：质谱仪装置; 荧光计装置; 和处理装置; 其中所述质谱仪装置适于获得液体中所述两种或多种物质的总量的周期性测量，所述荧光计装置适于将所述液体中所述至少一种荧光物质的荧光响应检测为激发信号 所述处理装置被编程以通过将由所述荧光计装置获得的测量值与由所述质谱仪装置获得的所述两种或多种物质的总量的所述周期性测量进行比较来确定校准因子，所述处理装置随后使用所述校准因子 基于由荧光计装置检测到的荧光响应来确定代表存在于液体中的荧光和非荧光物质的总量的测量值。

    ION MODIFICATION
    68.
    发明申请
    ION MODIFICATION 有权
    离子改性

    公开(公告)号：US20160054263A1

    公开(公告)日：2016-02-25

    申请号：US14776938

    申请日：2014-03-12

    申请人： David SHARP ,  Jonathan ATKINSON

    发明人： David Sharp ,  Jonathan Atkinson

    IPC分类号： G01N27/62 ,  H01J49/00 ,  H01J49/40

    CPC分类号： G01N27/622 ,  H01J49/0027 ,  H01J49/40

    摘要： An ion mobility spectrometry method comprising determining whether a sample comprises ions having a first characteristic, and in the event that it is determined that the sample comprises ions having the first characteristic, applying thermal energy together with a radio frequency, RF, electric field to parent ions so as to obtain daughter ions having a second characteristic for inferring at least one identity for the parent ions based on the first characteristic and the second characteristic.

    摘要翻译： 一种离子迁移谱分析方法，包括确定样品是否包含具有第一特征的离子，并且在确定样品包含具有第一特征的离子的情况下，将热能与射频RF RF电场一起施加到母体 离子，以获得具有第二特性的子离子，用于基于第一特征和第二特征推断母体离子的至少一个同一性。

    TRIFLUOROBORATE MASS SPECTROMETRIC TAGS
    69.
    发明申请
    TRIFLUOROBORATE MASS SPECTROMETRIC TAGS 审中-公开
    三倍体质谱标签

    公开(公告)号：US20160052942A1

    公开(公告)日：2016-02-25

    申请号：US14779805

    申请日：2014-03-26

    申请人： CELLMOSAIC INC.

    发明人： Yumei Huang

    IPC分类号： C07F5/02 ,  H01J49/00 ,  C08G65/34

    CPC分类号： C07F5/02 ,  C07F5/025 ,  C08G65/34 ,  C08G65/48 ,  C08G2650/04 ,  C08G2650/48 ,  G01N27/62 ,  H01J49/0027 ,  H01J49/02

    摘要： The invention provides compositions and methods for mass spectrometric (MS), organic synthesis, and applications of organo-trifluoroborate, for example, as mass tags for use in negative ion mode. When subject to MS fragmentation, organo-trifluoroborates preferentially undergo neutral losses of hydrogen fluoride (HF) or boron trifluoride (BF3) molecules, transferring the negative charge to the rest of the molecule. Such a fragmentation pattern is used to detect and quantitate analytes of interest after derivatization with organo-trifluoroborates.

    摘要翻译： 本发明提供用于质谱（MS），有机合成和有机三氟硼酸盐的应用的组合物和方法，例如用作负离子模式的质量标签。 当经过MS断裂时，有机 - 三氟硼酸盐优先发生氟化氢（HF）或三氟化硼（BF 3）分子的中性损失，将负电荷转移到分子的其余部分。 这种分裂模式用于在有机三氟硼酸衍生化后检测和定量感兴趣的分析物。