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425 条记录 (耗时 0.019 秒)

    Imidazolidinone prostaglandins, compositions and use
    65.
    发明授权
    Imidazolidinone prostaglandins, compositions and use 失效
    咪唑啉酮前列腺素，成分及用途

    公开(公告)号：US4496577A

    公开(公告)日：1985-01-29

    申请号：US539197

    申请日：1983-10-05

    申请人： Joseph M. Muchowski ,  Angel Guzman

    发明人： Joseph M. Muchowski ,  Angel Guzman

    IPC分类号： C07D233/22 ,  A61K31/415 ,  A61P7/02 ,  C07D233/32 ,  C07D233/34 ,  C07D309/12 ,  C07D333/00 ,  C07D405/06 ,  C07D409/06 ,  C07D233/02

    CPC分类号： C07C247/00 ,  C07D233/32 ,  C07D309/12

    摘要： This invention relates to novel imidazolidinone prostaglandin compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sup.1 and R.sup.2 are independently hydrogen or alkyl of 1 to 4 carbons; R.sup.3 is hydrogen or methyl; and R4 is --(CH.sub.2).sub.n CH.sub.3 wherein n is 3-7, cycloalkyl of 5-7 carbons, a substituent of the formula ##STR2## wherein R.sup.5 is hydrogen, alkyl of 1 to 4 carbons, alkoxy of 1 to 4 carbons, halo or trifluoromethyl. These compounds are inhibitors of blood platelet aggregation.

    摘要翻译： 本发明涉及式（I）的新型咪唑啉酮前列腺素化合物及其药学上可接受的盐，其中R 1和R 2独立地是氢或1至4个碳的烷基; R3是氢或甲基; 并且R 4是 - （CH 2）n CH 3，其中n是3-7，5-7个碳的环烷基，式的取代基，其中R5是氢，1至4个碳的烷基，1个烷氧基， 至4个碳，卤素或三氟甲基。 这些化合物是血小板聚集的抑制剂。

    Insensitive polynitramine compound
    66.
    发明授权
    Insensitive polynitramine compound 失效
    不敏感的多硝胺化合物

    公开(公告)号：US4485237A

    公开(公告)日：1984-11-27

    申请号：US473300

    申请日：1983-03-08

    申请人： Rodney L. Willer

    发明人： Rodney L. Willer

    IPC分类号： C07D233/02 ,  C07D239/04 ,  C07D243/04 ,  C07D487/10

    CPC分类号： C07D487/10 ,  C07D233/02 ,  C07D239/04 ,  C07D243/04

    摘要： The energetic compound 2,4,8,10-tetranitro-2,4,8,10-tetraazaspiro [5.5]undecane(TNSU) is disclosed. A general method of making 1,3-dinitroso-1,3-diazacycloalkanes in a one pot synthesis by the condensation of the diamine and formaldehyde, followed by conversion to the nitroso compound with nitrous acid. The general method also provides for the production of the tetranitroso precusor of TNSU.

    摘要翻译： 公开了能量化合物2,4,8,10-四硝基-2,4,8,10-四氮杂螺[5.5]十一烷（TNSU）。 通过二胺和甲醛缩合制备1,3-二硝基-1,3-二氮杂环烷烃的一般方法，然后用亚硝酸转化成亚硝基化合物。 一般方法还提供了TNSU的四硝基四氢呋喃的制备。

    Cycloaminals and a process for their preparation
    68.
    发明授权
    Cycloaminals and a process for their preparation 失效
    环状物及其制备方法

    公开(公告)号：US4404379A

    公开(公告)日：1983-09-13

    申请号：US935439

    申请日：1978-08-21

    申请人： Manfred Hajek ,  Kuno Wagner ,  Walter Uerdingen ,  Wolfgang Wellner

    发明人： Manfred Hajek ,  Kuno Wagner ,  Walter Uerdingen ,  Wolfgang Wellner

    IPC分类号： C07D233/02 ,  C07D239/04 ,  C08G18/80

    CPC分类号： C07D239/04 ,  C07D233/02 ,  C08G18/808

    摘要： The present invention is concerned with a new class of compounds prepared by reacting cyclic aminals of the formula ##STR1## with polyisocyanates of the formula R.sub.5 (NCO).sub.m+n to yield ##STR2## and with this process for obtaining said compounds, as well as the use of such compounds in polyurethane chemistry. If such compounds are free of isocyanates (n=0) they are useful as latent cross-linkers or hardeners activatable by heat or moisture. If such compounds carry free isocyanate groups (n=1 or 2) there are useful as synthetic resin precursors. In the above formulaem represents an integer of from 1 to 3, andn represents 0, 1 or 2, and the sum of m+n is 2 or 3,R.sub.1 represents an aliphatic hydrocarbon group which is optionally cyano-substituted and which has from 1 to 6 carbon atoms, a cycloaliphatic hydrocarbon group having from 5-10 carbon atoms or an araliphatic hydrocarbon group having from 7-10 carbon atoms;R.sub.2 represents a divalent aliphatic hydrocarbon group having from 2 to 6 carbon atoms, at least two carbon atoms being situated between the two nitrogen atoms;R.sub.3 and R.sub.4 are identical or different and represent hydrogen, aliphatic hydrocarbon groups having from 1 to 18 carbon atoms, cycloaliphatic hydrocarbon groups having from 5 to 10 carbon atoms or aromatic hydrocarbon groups having from 6 to 10 carbon atoms, or the two groups R.sub.3 and R.sub.4 together with the carbon atom of the heterocyclic ring may also form a 5-membered or 6-membered cycloaliphatic ring; andR.sub.5 represents an (m+n)-valent group such as that which can be obtained by the removal of m+n isocyanate groups from an (m+n)-valent polyisocyanate.

    摘要翻译： 本发明涉及通过使式“IMAGE”的环状胺与式R 5（NCO）m + n的多异氰酸酯反应得到新一类化合物，得到所述化合物的方法 作为这种化合物在聚氨酯化学中的应用。 如果这些化合物不含异氰酸酯（n = 0），它们可用作潜热的交联剂或通过热或湿气活化的硬化剂。 如果这些化合物带有游离异氰酸酯基团（n = 1或2），则可用作合成树脂前体。 在上式中，m表示1〜3的整数，n表示0,1或2，m + n的和为2或3，R1表示任意氰基取代的脂肪族烃基， 1至6个碳原子，具有5-10个碳原子的脂环族烃基或具有7-10个碳原子的芳脂族烃基; R2表示具有2至6个碳原子的二价脂族烃基，至少两个碳原子位于两个氮原子之间; R3和R4相同或不同，表示氢，具有1至18个碳原子的脂族烃基，具有5至10个碳原子的脂环族烃基或具有6至10个碳原子的芳族烃基，或两个基团R3和 R4与杂环的碳原子一起也可以形成5元或6元脂环族环; 并且R 5表示可以通过从（m + n）价多异氰酸酯除去m + n个异氰酸酯基团而得到的（m + n）价基团。

    Piperazine compounds
    70.
    发明授权
    Piperazine compounds 失效
    哌嗪化合物

    公开(公告)号：US4122178A

    公开(公告)日：1978-10-24

    申请号：US692395

    申请日：1976-06-03

    申请人： Gen Hasegawa ,  Takanori Oe ,  Chiaki Kitami

    发明人： Gen Hasegawa ,  Takanori Oe ,  Chiaki Kitami

    IPC分类号： C07D295/08 ,  A61K31/495 ,  A61P25/04 ,  C07D213/38 ,  C07D233/02 ,  C07D239/42 ,  C07D295/084 ,  C07D295/10 ,  C07D333/20 ,  C07D401/06 ,  C07D295/04

    CPC分类号： C07D295/092 ,  C07C317/00

    摘要： Piperazine compounds useful as analgesics, and having the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or CF.sub.3 ; R.sup.3 is hydrogen, hydroxyl, an optionally substituted phenyl (e.g. phenyl, halo-phenyl, C.sub.1-4 alkyl-phenyl, C.sub.1-4 alkoxy-phenyl or CF.sub.3 -phenyl), pyridyl, 2-thienyl or 2-pyrimidinyl; m is 2 or 3; and n is 0, 1 or 2, and pharmaceutically acceptable acid addition salts thereof are disclosed.

    摘要翻译： 可用作止痛剂的哌嗪化合物，具有下式：其中R 1和R 2各自为氢，卤素，C 1-4烷基，C 1-4烷氧基或CF 3; R 3是氢，羟基，任选取代的苯基（例如苯基，卤代 - 苯基，C 1-4烷基 - 苯基，C 1-4烷氧基 - 苯基或CF 3 - 苯基），吡啶基，2-噻吩基或2-嘧啶基; m为2或3; 和n为0,1或2，并且其药学上可接受的酸加成盐被公开。