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公开(公告)号：US08734345B2
公开(公告)日：2014-05-27
申请号：US13195287
申请日：2011-08-01
申请人： Manish Deshpande , Terri A. Kapur
发明人： Manish Deshpande , Terri A. Kapur
IPC分类号： A61B5/00
CPC分类号： A61B5/145 , A61B5/6852 , A61B10/04 , A61B2010/045 , A61B2562/028
摘要： A real time tissue sampling and analysis system includes a catheter including an elongated body defining at least one internal lumen, a sampling device positionable within the at least one internal lumen of the catheter for collecting a tissue sample, and a biochip disposed within the at least one internal lumen. The biochip includes a substrate for receiving the tissue sample, a marker for interacting with the tissue sample, and a sensor for identifying a characteristic of the tissue sample and transmitting data about the tissue sample to a processing unit for analysis.
摘要翻译： 实时组织采样和分析系统包括导管，其包括限定至少一个内腔的细长主体，可定位在导管的至少一个内腔内用于收集组织样本的采样装置，以及设置在至少一个内部腔内的生物芯片 一个内腔。 生物芯片包括用于接收组织样本的基底，用于与组织样本相互作用的标记，以及用于识别组织样本的特征并将关于组织样本的数据传送到处理单元进行分析的传感器。
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公开(公告)号：US20120078146A1
公开(公告)日：2012-03-29
申请号：US12893679
申请日：2010-09-29
申请人： Manish Deshpande
发明人： Manish Deshpande
IPC分类号： A61H7/00
CPC分类号： A61H9/0007 , A61F13/06 , A61F13/085 , A61H9/0078 , A61H2201/1638 , A61H2201/1642 , A61H2201/5064 , A61H2201/5069 , A61H2201/5084 , A61H2205/06 , A61H2205/106 , A61H2205/108 , A61H2209/00
摘要： A compression garment apparatus including a compression garment and a pressurizer. The pressurizer intermittently pressurizes a therapeutic bladder on the compression garment and maintains a baseline pressure in the therapeutic bladder to maintain the therapeutic bladder in position with respect to a target compression zone on a body part on which the garment is worn. The baseline pressure is adjusted in response to sensed physical characteristics.
摘要翻译： 一种压缩服装设备，包括压缩衣服和加压器。 加压器对压缩衣服上的治疗膀胱间歇地加压，并且在治疗膀胱中保持基线压力，以使治疗膀胱相对于穿着衣服的身体部位上的目标压缩区域保持在适当位置。 响应于感测的物理特性来调整基线压力。
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73.发明申请MICROFLUIDIC SYSTEM INCLUDING A BUBBLE VALVE FOR REGULATING FLUID FLOW THROUGH A MICROCHANNEL 有权包括用于通过微通道调节流体流量的气泡的微流体系统公开(公告)号：US20120015442A1
公开(公告)日：2012-01-19
申请号：US13245331
申请日：2011-09-26
IPC分类号： G01N33/50
CPC分类号： B01L3/502738 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2300/089 , B01L2400/0415 , B01L2400/06 , B01L2400/0688 , B01L2400/082 , B07C5/34 , F16K99/0001 , F16K99/0017 , F16K99/0019 , F16K99/0034 , F16K99/0036 , F16K99/004 , F16K99/0046 , F16K99/0048 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G01N2015/149 , Y10T29/49405 , Y10T137/0318 , Y10T137/0396 , Y10T137/0497 , Y10T137/2076 , Y10T137/2082 , Y10T137/2191 , Y10T137/2196 , Y10T137/2202 , Y10T137/2207 , Y10T137/2213 , Y10T137/2224 , Y10T436/143333 , Y10T436/25375
摘要： A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.
摘要翻译： 微流体系统包括用于调节通过微通道的流体流动的气泡阀。 气泡阀包括与微通道内部接合的流体弯液面和用于将膜偏转到微通道内部以调节流体流动的致动器。 当在膜上产生足够的压力时，致动器在微通道中的液体中产生气泡。
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公开(公告)号：US20120006727A1
公开(公告)日：2012-01-12
申请号：US13158960
申请日：2011-06-13
CPC分类号： B03B5/00 , B01L3/5027 , B07C5/34 , F15C5/00 , F16K99/0001 , F16K99/0028 , F16K99/0046 , F16K99/0048 , F16K99/0061 , F16K2099/0084 , G01N15/14 , G01N2015/149 , Y10S209/906 , Y10S209/932
摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.
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公开(公告)号：US07963399B2
公开(公告)日：2011-06-21
申请号：US12537802
申请日：2009-08-07
IPC分类号： B07C5/00
CPC分类号： B03B5/00 , B01L3/5027 , B07C5/34 , F15C5/00 , F16K99/0001 , F16K99/0028 , F16K99/0046 , F16K99/0048 , F16K99/0061 , F16K2099/0084 , G01N15/14 , G01N2015/149 , Y10S209/906 , Y10S209/932
摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.
摘要翻译： 用于分选移动通过毛细管尺寸的封闭通道系统的颗粒的方法和装置包括气泡阀，用于选择性地产生压力脉冲以将具有预定特征的颗粒与颗粒流分离。 颗粒分选系统还可以包括用于吸收压力脉冲的缓冲器。 颗粒分选系统可以包括多个紧密耦合的分类模块，其被组合以进一步提高排序率。 颗粒分选系统可以包括用于串行排列颗粒流的多级分选装置，以便降低误差率。
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公开(公告)号：US07870964B2
公开(公告)日：2011-01-18
申请号：US12276930
申请日：2008-11-24
申请人： John R. Gilbert , Manish Deshpande
发明人： John R. Gilbert , Manish Deshpande
CPC分类号： C30B7/00 , B01L3/06 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L2200/027 , B01L2200/028 , B01L2200/146 , B01L2300/041 , B01L2300/047 , B01L2300/0681 , B01L2400/0481 , B01L2400/0655 , B01L2400/0666 , C30B29/58 , F04B43/02 , F04B43/043 , Y10T137/0324 , Y10T436/2575
摘要： A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system. An infusion pump for delivering a fluid from a fluid source may be integrated in a microfluidic chip using a capping module having pumping components formed therein.
摘要翻译： 用于在微流体系统中整合微流体组分的系统和方法使得微流体系统能够执行选定的微流体功能。 封盖模块包括用于执行微流控功能的微流体元件。 封盖模块堆叠在具有微流管道的微流体衬底上，以将微流控功能结合到系统中。 用于从流体源输送流体的输液泵可以使用其中形成有泵送部件的封盖模块集成在微流体芯片中。
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公开(公告)号：US07157274B2
公开(公告)日：2007-01-02
申请号：US10664587
申请日：2003-09-16
IPC分类号： C12N5/00
CPC分类号： G01N15/1456 , B01L3/5027 , B07C5/34 , G01N2015/1477 , G01N2015/149 , G01N2015/1497 , Y10S209/906 , Y10S209/932
摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.
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公开(公告)号：US09109993B2
公开(公告)日：2015-08-18
申请号：US12821790
申请日：2010-06-23
摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.
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公开(公告)号：US08870769B2
公开(公告)日：2014-10-28
申请号：US13113175
申请日：2011-05-23
申请人： Manish Deshpande
发明人： Manish Deshpande
CPC分类号： A61B5/1427 , A61B5/14528 , A61B5/15003 , A61B5/150229 , A61B5/150755 , A61B5/150992 , A61B5/155 , A61B5/157 , A61B5/6852 , A61B5/6866 , A61B2560/0443 , A61B2562/0295 , A61M1/3609 , A61M2230/20 , A61M2230/30
摘要： An inter dialytic monitoring device is disclosed which monitors in vivo preselected parameters of blood content during an inter dialytic period to monitor patient health. The monitoring device is configured to extend through and releasably engage a catheter which has been placed within a patient to monitor a patient's blood. A sensor is provided to detect the presence of selected analytes and to identify when preselected parameters have been reached.
摘要翻译： 公开了一种透析前监测装置，其在体内透析期间监测血液内容物的预选参数以监测患者健康。 监测装置构造成延伸通过并可释放地接合已经放置在患者体内以便监测患者血液的导管。 提供了一个传感器来检测选定分析物的存在并识别何时达到了预先选择的参数。
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公开(公告)号：US08636682B2
公开(公告)日：2014-01-28
申请号：US13248658
申请日：2011-09-29
申请人： Manish Deshpande
发明人： Manish Deshpande
CPC分类号： A61M25/0075 , A61M1/285 , A61M1/3653 , A61M1/3659 , A61M1/3661 , A61M25/003 , A61M25/007 , A61M25/0074 , A61M25/008 , A61M2025/0031 , A61M2025/0037 , A61M2025/0073 , A61M2202/0413
摘要： A catheter includes an elongated tubular body including a first wall and second wall defining first and second lumens, respectively. Each wall extends to a distal end and defines a distal opening. The first and second walls may each include one or more side openings disposed proximal of the distal end. The first and second lumens are separated by a septum. The septum includes a septum extension extending distally from the septum. The septum extension is adapted to articulate relative to the septum in response to fluid flow into and out of the distal openings of the first and second lumens. The septum extension is dimensioned to partially obstruct fluid flow into the catheter through one of the distal openings upon the articulation of the septum extension.
摘要翻译： 导管包括细长的管状体，其包括分别限定第一和第二腔的第一壁和第二壁。 每个壁延伸到远端并限定远端开口。 第一和第二壁可以各自包括设置在远端附近的一个或多个侧开口。 第一和第二内腔由隔膜隔开。 隔膜包括从隔膜向远侧延伸的隔膜延伸部。 隔膜延伸部适于响应于进入和离开第一和第二内腔的远端开口的流体流动而相对于隔膜铰接。 隔膜延伸部的尺寸被设计成在隔膜延伸部的铰接时通过其中一个远端开口部分地阻碍流体进入导管。
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