公开(公告)号：US20160220842A1

公开(公告)日：2016-08-04

申请号：US15095276

申请日：2016-04-11

Applicant: DePuy Synthes Products, Inc.

Inventor： Richard Toselli ,  Thomas M DiMauro ,  Michael Fisher

IPC: A61N5/06

CPC classification number: A61N5/0622 ,  A61N5/0601 ,  A61N2005/0612 ,  A61N2005/063 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/0663 ,  A61N2005/067

Abstract: Endoscopic delivery of Red/NIR light to the Substantia Nigra to treat Parkinson's Disease in order to raise the energy levels in the substantia nigra.

Abstract translation: 将红/ NIR光内窥镜递送给黑质黑质以治疗帕金森病，以提高黑质中的能量水平。

公开(公告)号：US09403030B2

公开(公告)日：2016-08-02

申请号：US14005561

申请日：2012-03-25

Applicant: Uri Oron ,  Hana Tuby ,  Dan Frenkel ,  Dorit Farfara

Inventor： Uri Oron ,  Hana Tuby ,  Dan Frenkel ,  Dorit Farfara

IPC: A61N5/06 ,  A61N5/00 ,  A61N5/067

CPC classification number: A61N5/0618 ,  A61N5/0601 ,  A61N5/0603 ,  A61N2005/005 ,  A61N2005/0612 ,  A61N2005/063 ,  A61N2005/0645 ,  A61N2005/0651 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067

Abstract: Methods and systems are provided for delivering visible or infrared biostimulatory energy to bone marrow to subjects having or developing Alzheimer's disease. The radiation is delivered to sites remote from the brain at a dose sufficient to cause stimulated mesenchymal stem cells to appear in the brain and degrade β-amyloid. The energy may be coherent light and can be administered transcutaneously, subcutaneously, or via an intramedullary probe.

Abstract translation: 提供的方法和系统用于将可见或红外生物刺激能量递送至具有或发展阿尔茨海默病的受试者的骨髓。 辐射以足以引起刺激的间充质干细胞出现在脑中并降低β-淀粉样蛋白的剂量被输送到远离脑的部位。 能量可以是相干光，并且可以经皮，皮下或经髓内探针施用。

公开(公告)号：US20160192988A1

公开(公告)日：2016-07-07

申请号：US14798106

申请日：2015-07-13

Applicant: K-LASER, LLC

Inventor： Richard Albright

IPC: A61B18/22 ,  A61B18/20 ,  A61N5/06

CPC classification number: A61B18/203 ,  A61B18/22 ,  A61B2018/00047 ,  A61B2018/00178 ,  A61B2018/00642 ,  A61B2018/00654 ,  A61B2018/00785 ,  A61B2018/1226 ,  A61B2018/2075 ,  A61B2018/2266 ,  A61N5/0616 ,  A61N5/0624 ,  A61N2005/063 ,  A61N2005/0644 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/0663 ,  A61N2005/0665 ,  A61N2005/067

Abstract: Provided is a modular multiple laser source system to produce and deliver laser light for laser therapy and/or surgery, the system including a plurality of laser sources of same or different wavelengths, a focusing lens to focus laser light from the plurality of laser sources to a common output, a casing to enclose the laser sources and focusing lens, an output portion provided to the casing to transmit the laser light from one or more of the plurality of laser sources delivered to the common output, and a communication interface provided to the casing to provide electrical communication between components of the system and a controller, wherein the plurality of laser sources are configured to supply the laser light in different wavelengths and/or combinations of wavelengths according to desired medical procedures.

Abstract translation: 提供了一种用于激光治疗和/或手术的生产和传送激光的模块化多激光源系统，该系统包括多个相同或不同波长的激光源，聚焦透镜将来自多个激光源的激光聚焦到 公共输出端，用于封装激光源和聚焦透镜的壳体，设置到壳体的输出部分，用于传送来自传送到公共输出端的多个激光源中的一个或多个的激光;以及通信接口， 以提供所述系统的组件与控制器之间的电通信，其中所述多个激光源被配置为根据期望的医疗程序提供不同波长和/或波长组合的激光。

公开(公告)号：US20160175612A1

公开(公告)日：2016-06-23

申请号：US14578969

申请日：2014-12-22

Applicant: FOTONA D.D.

Inventor： Marko Kazic ,  Matjaz Lukac

IPC: A61N5/06 ,  A61B18/20

CPC classification number: A61N5/0624 ,  A61B18/203 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2018/2065 ,  A61N2005/063 ,  A61N2005/0635 ,  A61N2005/0659 ,  A61N2005/067

Abstract: A method for treating a fungal infection in an infected nail is disclosed. An embodiment includes placing an optical delivery system designed to deliver a laser beam with light having strongly water-absorbed wavelengths to the infected nail. The diseased nail is irradiated with the laser beam, and the fluence and a duration of the laser irradiation received by the nail are adjusted such that by laser energy absorption in a surface portion of the nail a superficial heating of the nail and heat diffusion from said heated surface portion into the infected nail bed are achieved. The bottom of the nail plate in this embodiment is heated to a treatment temperature needed to inactivate the infecting organism.

Abstract translation: 公开了一种治疗感染指甲中真菌感染的方法。 一个实施例包括放置光学传送系统，该光学传送系统被设计成将具有强吸水波长的光的激光束传送到受感染的指甲。 用激光束照射患病钉，并且调整由指甲接受的激光照射的注量和持续时间，使得通过在指甲的表面部分中的激光能量吸收，指甲的表面加热和来自所述指甲的热扩散 加热表面部分进入感染的甲床。 在该实施方案中，将甲板的底部加热至灭活感染生物体所需的处理温度。

公开(公告)号：US20160166846A1

公开(公告)日：2016-06-16

申请号：US14908043

申请日：2014-07-28

Applicant: Hiun Suk CHAE

Inventor： Hiun Suk CHAE

IPC: A61N5/06

CPC classification number: A61N5/062 ,  A61N5/0603 ,  A61N2005/0609 ,  A61N2005/063

Abstract: There is provided a therapeutic apparatus for photodynamic therapy that includes a hollow tube inserted into a living body; an unfolding part that is coupled to one end of the tube and is unfolded; a light irradiation part that is disposed in the unfolding part to irradiate light; and an operating part that is coupled to the other end of the tube to unfold the unfolding part, wherein the light irradiation part irradiates light when the unfolding part is unfolded.The therapeutic apparatus for photodynamic therapy according to the present disclosure allows irradiation of light by unfolding tissues of the curved portion in the living body, using an unfolding part capable of being unfolded depending on the user's selection and the light irradiation part coupled to the unfolding part, there is an effect of allowing the use of the photodynamic therapy even in a portion that cannot be conventionally treated using the photodynamic therapy.

Abstract translation: 提供了一种用于光动力疗法的治疗装置，其包括插入生物体中的中空管; 一个展开部分，其连接到管的一端并被展开; 光照射部，其设置在展开部中以照射光; 以及操作部，其连接到所述管的另一端以展开所述展开部，其中，当所述展开部展开时，所述光照射部照射光。 根据本发明的用于光动力学治疗的治疗装置允许通过使生物体中弯曲部分的组织展开，使用能够根据使用者的选择展开的展开部分和耦合到展开部分的光照射部分来照射光 即使在使用光动力疗法不能进行常规治疗的部分中也存在能够使用光动力学治疗的效果。

公开(公告)号：US20160157706A1

公开(公告)日：2016-06-09

申请号：US14905374

申请日：2014-07-16

Applicant: FONDAZIONE ISTITUTO ITALLANO DI TECNOLGGIA ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Ferruccio PISANELLO ,  Luigi MARTIRADONNA ,  Leonardo SILEO ,  Ian Anton OLDENBURG ,  Marco PISANELLO ,  Bernardo Luis SABATINI ,  John Abraham ASSAD ,  Massimo DE VITTORIO

IPC: A61B1/07 ,  A61B18/22 ,  A61N5/06 ,  G02B6/26 ,  G02B6/14

CPC classification number: A61B1/07 ,  A61B5/0084 ,  A61B2018/2255 ,  A61B2018/2261 ,  A61B2562/0233 ,  A61N5/062 ,  A61N5/0622 ,  A61N2005/063 ,  G02B6/14 ,  G02B6/262

Abstract: A multi-point light-delivering device, comprising a waveguide carrying light along a longitudinal axis and including multiple optical windows, through which the carried light is out-coupled from the waveguide. The waveguide comprises a tapered region along which the optical windows are distributed, wherein each optical window out-couples a specific subset of propagating modes of the carried light to which the optical window is matched.

Abstract translation: 一种多点光输送装置，包括沿着纵向轴线携带光并包括多个光学窗口的波导，所携带的光从所述波导输出耦合。 波导包括光学窗口分布在其上的锥形区域，其中每个光学窗口将耦合光学窗口匹配的被携带的光的传播模式的特定子集输出。

公开(公告)号：US09359449B2

公开(公告)日：2016-06-07

申请号：US13623612

申请日：2012-09-20

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Karl Deisseroth ,  Feng Zhang ,  Viviana Gradinaru

IPC: A61K48/00 ,  C12N15/62 ,  C12N15/63 ,  C12N15/864 ,  C12N15/869 ,  A61N5/06 ,  C07K19/00 ,  A01K67/027 ,  C07K14/00

CPC classification number: C07K14/405 ,  A01K67/0271 ,  A01K67/0275 ,  A01K2207/05 ,  A01K2227/105 ,  A01K2267/0393 ,  A61K38/00 ,  A61K48/00 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0626 ,  A61N2005/063 ,  A61N2005/0651 ,  A61N2005/0663 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K19/00 ,  C07K2319/01 ,  C12N15/86 ,  C12N2750/14143 ,  C12N2799/025

Abstract: The invention provides polynucleotides and methods for expressing light-activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The invention also provides animal cells and non-human animals comprising cells expressing the light-activated proteins.

公开(公告)号：US20160147002A1

公开(公告)日：2016-05-26

申请号：US14555437

申请日：2014-11-26

Applicant: LightMed Dental Technology Corp.

Inventor： Yuan-Peng HUANG ,  Jyh-Rou SZE ,  Hsien-Nan KUO

IPC: F21V8/00 ,  A61N5/06

CPC classification number: G02B6/0008 ,  A61B18/20 ,  A61B18/203 ,  A61B2018/00452 ,  A61B2018/00601 ,  A61B2018/204 ,  A61N5/0603 ,  A61N2005/0606 ,  A61N2005/063 ,  A61N2005/067 ,  G02B6/0006

Abstract: This invention relates to a light field-modulable optical needle assembly including a coherent light source, a light conduction member and a light modulation member. The light conduction member includes a light incident face that is proximate to the coherent light source, a light exiting face that is opposite to the light incident face and distal from the coherent light source, and a surrounding face that peripherally extends from the light incident face to the light exiting face to be connected therebetween. The light modulation member is disposed proximate to one of the light incident face, the light exiting face and the surrounding face of the light conduction member and is formed with a microstructure. The light emitted from the light field-modulable optical needle assembly has a light output power distribution adjustable by the microstructure of the light modulation member.

Abstract translation: 本发明涉及一种包括相干光源，导光部件和光调制部件的光场可调光学针组件。 导光构件包括靠近相干光源的光入射面，与光入射面相对且远离相干光源的光出射面，以及从光入射面外周延伸的周围面 到要连接的光出射面。 光调制部件靠近导光部件的光入射面，光出射面和周围面中的一个设置，并且形成有微结构。 从光场可调光学针组件发射的光具有可由光调制构件的微结构调节的光输出功率分布。

公开(公告)号：US20160144149A1

公开(公告)日：2016-05-26

申请号：US15012034

申请日：2016-02-01

Applicant: Johnson & Johnson Vision Care, Inc.

Inventor： Randall B. PUGH ,  William C. Neeley ,  Robertson Towart ,  Mario J. Peeters ,  Wilhelmus Drinkenburg ,  Aleksandar Miletic

IPC: A61M21/00 ,  A61N5/06

CPC classification number: A61M21/00 ,  A61M21/02 ,  A61M2021/0044 ,  A61N5/0601 ,  A61N5/0618 ,  A61N2005/063 ,  A61N2005/0648 ,  A61N2005/0651 ,  A61N2005/0663 ,  G02C7/04 ,  G02C11/04

Abstract: The present invention provides for eyeglasses used together with contact lenses to deliver light therapy to the wearer. The eyeglass lenses or frames feature an embedded light source in logical and electrical communication with power, sensors, processors, and other components contained within the eyeglasses. The eyeglass lenses or frames project light into complimentary contact lenses which refract, diffract or reflect light into the wearer's eyes.

Abstract translation: 本发明提供与隐形眼镜一起使用的眼镜，以将光疗法递送给佩戴者。 眼镜镜片或镜架具有与电源，传感器，处理器和包含在眼镜内的其他部件逻辑和电气通信的嵌入式光源。 眼镜镜片或镜架将光线投射到互补的隐形眼镜中，将眼睛折射，衍射或反射到佩戴者的眼睛。

公开(公告)号：US09302116B2

公开(公告)日：2016-04-05

申请号：US12764184

申请日：2010-04-21

Applicant: Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian N. Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Harold Walder ,  Zak Fathi ,  Jennifer A. Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

Inventor： Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian N. Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Harold Walder ,  Zak Fathi ,  Jennifer A. Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

IPC: A61N5/06 ,  A61K49/00 ,  A61L2/08 ,  A61N1/40 ,  A61N5/02

CPC classification number: A61N5/062 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/055 ,  A61B5/4848 ,  A61B6/481 ,  A61K41/0042 ,  A61K41/0052 ,  A61K41/0061 ,  A61K49/0039 ,  A61L2/0047 ,  A61L2/08 ,  A61L2202/21 ,  A61L2202/22 ,  A61M5/007 ,  A61N1/406 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/0624 ,  A61N5/10 ,  A61N2005/063 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  A61N2005/1098

Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

Abstract translation: 用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病 或胞外结构。 所述方法可以以非侵入性方式在原位进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并向受试者施加引发能量，从而产生 直接或通过调制剂对目标结构的影响或改变。 纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。 所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在一种或多种等离子体激活剂活性剂的存在下进行，从而产生对其的作用或改变 目标结构。 包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。