公开(公告)号：US09302116B2

公开(公告)日：2016-04-05

申请号：US12764184

申请日：2010-04-21

Applicant: Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian N. Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Harold Walder ,  Zak Fathi ,  Jennifer A. Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

Inventor： Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian N. Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Harold Walder ,  Zak Fathi ,  Jennifer A. Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

IPC: A61N5/06 ,  A61K49/00 ,  A61L2/08 ,  A61N1/40 ,  A61N5/02

CPC classification number: A61N5/062 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/055 ,  A61B5/4848 ,  A61B6/481 ,  A61K41/0042 ,  A61K41/0052 ,  A61K41/0061 ,  A61K49/0039 ,  A61L2/0047 ,  A61L2/08 ,  A61L2202/21 ,  A61L2202/22 ,  A61M5/007 ,  A61N1/406 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/0624 ,  A61N5/10 ,  A61N2005/063 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  A61N2005/1098

Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

Abstract translation: 用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病 或胞外结构。 所述方法可以以非侵入性方式在原位进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并向受试者施加引发能量，从而产生 直接或通过调制剂对目标结构的影响或改变。 纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。 所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在一种或多种等离子体激活剂活性剂的存在下进行，从而产生对其的作用或改变 目标结构。 包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

公开(公告)号：US20110021970A1

公开(公告)日：2011-01-27

申请号：US12764184

申请日：2010-04-21

Applicant: Tuan VO-DINH ,  Jonathan P. SCAFFIDI ,  Venkata Gopal Reddy CHADA ,  Benoit LAULY ,  Yan ZHANG ,  Molly K. GREGAS ,  Ian N. STANTON ,  Joshua T. STECHER ,  Michael J. THERIEN ,  Frederic A. BOURKE, JR. ,  Harold WALDER ,  Zak FATHI ,  Jennifer A. AYRES ,  Zhenyuan ZHANG ,  Joseph H. SIMMONS ,  Stephen John NORTON

Inventor： Tuan VO-DINH ,  Jonathan P. SCAFFIDI ,  Venkata Gopal Reddy CHADA ,  Benoit LAULY ,  Yan ZHANG ,  Molly K. GREGAS ,  Ian N. STANTON ,  Joshua T. STECHER ,  Michael J. THERIEN ,  Frederic A. BOURKE, JR. ,  Harold WALDER ,  Zak FATHI ,  Jennifer A. AYRES ,  Zhenyuan ZHANG ,  Joseph H. SIMMONS ,  Stephen John NORTON

IPC: A61M37/00 ,  G02F1/01 ,  A61K35/12 ,  A61K39/00 ,  A61K9/16 ,  B82Y5/00

CPC classification number: A61N5/062 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/055 ,  A61B5/4848 ,  A61B6/481 ,  A61K41/0042 ,  A61K41/0052 ,  A61K41/0061 ,  A61K49/0039 ,  A61L2/0047 ,  A61L2/08 ,  A61L2202/21 ,  A61L2202/22 ,  A61M5/007 ,  A61N1/406 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/0624 ,  A61N5/10 ,  A61N2005/063 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  A61N2005/1098

Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

Abstract translation: 用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病 或胞外结构。 所述方法可以以非侵入性方式在原位进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并向受试者施加引发能量，从而产生 直接或通过调制剂对目标结构的影响或改变。 纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。 所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在一种或多种等离子体激活剂活性剂的存在下进行，从而产生对其的作用或改变 目标结构。 包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

公开(公告)号：US20100261263A1

公开(公告)日：2010-10-14

申请号：US12725108

申请日：2010-03-16

Applicant: Tuan VO-DINH ,  Jonathan P. SCAFFIDI ,  Venkata Gopal Reddy CHADA ,  Benoit LAULY ,  Yan ZHANG ,  Molly K. GREGAS ,  Ian N. STANTON ,  Joshua T. STECHER ,  Michael J. THERIEN ,  Frederic A. BOURKE, JR. ,  Zak FATHI ,  Jennifer A. AYRES ,  Zhenyuan ZHANG ,  Joseph H. SIMMONS ,  Stephen John Norton

Inventor： Tuan VO-DINH ,  Jonathan P. SCAFFIDI ,  Venkata Gopal Reddy CHADA ,  Benoit LAULY ,  Yan ZHANG ,  Molly K. GREGAS ,  Ian N. STANTON ,  Joshua T. STECHER ,  Michael J. THERIEN ,  Frederic A. BOURKE, JR. ,  Zak FATHI ,  Jennifer A. AYRES ,  Zhenyuan ZHANG ,  Joseph H. SIMMONS ,  Stephen John Norton

IPC: B32B5/16 ,  B01J19/08 ,  B01J19/12 ,  G01N30/96 ,  B01J19/00 ,  C12M1/34 ,  C08F2/46 ,  F21V9/16 ,  A61L2/08 ,  G21K1/00 ,  G01N21/63 ,  A61N5/06

CPC classification number: F21K2/00 ,  A61L2/08 ,  A61L2202/22 ,  A61N5/062 ,  B82Y20/00 ,  B82Y30/00 ,  G01N21/63 ,  G02B5/003 ,  G02F2/02 ,  Y10T428/25 ,  Y10T428/256

Abstract: A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength λ1 of radiation, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1 and 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength λ1 or the second wavelength λ2, or with both λ1 and λ2. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength λ2, generates the photostimulated reaction.

Abstract translation: 一种用于能量上转换和/或下转换的系统和用于在介质中产生光刺激反应的系统。 这些系统包括1）在暴露于辐射的第一波长λ1时配置的纳米颗粒，以产生具有比第一波长λ1更高的能量的辐射的第二波长λ2，和2）相对于纳米颗粒设置的金属结构。 金属结构的物理特性被设定为金属结构中的表面等离子体共振在以与第一波长λ1或第二波长λ2或与λ1和λ2两者提供光谱重叠的频率谐振的值。 用于在培养基中产生光刺激反应的系统包括设置在接近纳米颗粒的培养基中的受体，其在第二波长λ2激活时产生光刺激反应。

公开(公告)号：US20090148348A1

公开(公告)日：2009-06-11

申请号：US11719531

申请日：2006-08-10

Applicant: Kenneth I. Pettigrew ,  Pang-Jen Craig Kung ,  Joshua T. Stecher ,  Gregory Fenton Smith ,  Hugh C. Crenshaw

Inventor： Kenneth I. Pettigrew ,  Pang-Jen Craig Kung ,  Joshua T. Stecher ,  Gregory Fenton Smith ,  Hugh C. Crenshaw

IPC: B01L3/00 ,  B05D3/00

CPC classification number: C08J7/12 ,  B01L3/00 ,  B01L3/5027 ,  C08J7/126

Abstract: A method of treating a plastic surface with fluorine gas to decrease adsorption of hydrophobic solute molecules to the surface is provided. The method can include treating a surface with a first gas comprising fluorine gas and a second gas comprising oxygen gas, water vapor, or both oxygen gas and water vapor. Plastics treated using the method provide useful drug discovery and biochemical tools for the testing, handling, and storage of solutions containing low concentrations of hydrophobic solutes. Microfluidic devices containing treated plastic interior surfaces and methods of using such devices to make concentration-dependent measurements are also described.

Abstract translation: 提供了一种用氟气处理塑料表面以减少疏水性溶质分子对表面的吸附的方法。 该方法可以包括用包含氟气的第一气体和包含氧气，水蒸气或氧气和水蒸气的第二气体处理表面。 使用该方法处理的塑料为含有低浓度疏水性溶质的溶液的测试，处理和储存提供了有用的药物发现和生化工具。 还描述了包含经处理的塑料内表面的微流体装置和使用这些装置进行浓度依赖测量的方法。

公开(公告)号：US09023249B2

公开(公告)日：2015-05-05

申请号：US13102277

申请日：2011-05-06

Applicant: Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, Jr. ,  Ian Stanton ,  Jennifer Ayres ,  Joshua T. Stecher ,  Michael Therien ,  Eric Toone ,  Dave Gooden ,  Mark Dewhirst ,  Joseph A. Herbert ,  Diane Fels ,  Katherine S. Hansen

Inventor： Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, Jr. ,  Ian Stanton ,  Jennifer Ayres ,  Joshua T. Stecher ,  Michael Therien ,  Eric Toone ,  Dave Gooden ,  Mark Dewhirst ,  Joseph A. Herbert ,  Diane Fels ,  Katherine S. Hansen

IPC: C09J4/00 ,  B41J2/175

CPC classification number: H01L24/83 ,  A61B17/0057 ,  A61L24/06 ,  B32B3/266 ,  B32B7/14 ,  B32B9/04 ,  B32B37/1284 ,  B32B37/18 ,  B32B38/0008 ,  B32B2037/1253 ,  B32B2457/00 ,  B32B2457/08 ,  B32B2457/14 ,  B41J2/17559 ,  C08K3/00 ,  C09J4/00 ,  C09J9/02 ,  C09J11/04 ,  C09J11/06 ,  C09J133/08 ,  C09K11/02 ,  C09K11/7769 ,  C09K11/777 ,  H01L23/5226 ,  H01L24/32 ,  H01L25/0657 ,  H01L25/50 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/73204 ,  H01L2224/73253 ,  H01L2224/73265 ,  H01L2224/83192 ,  H01L2224/83855 ,  H01L2224/92125 ,  H01L2225/06524 ,  H01L2225/06589 ,  H01L2924/07811 ,  H01L2924/1461 ,  H01L2924/15311 ,  Y10T428/2852 ,  H01L2924/00014 ,  H01L2924/00

Abstract: A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

Abstract translation: 可聚合组合物包括至少一种单体，当暴露于光时能够引发单体聚合的光引发剂和当暴露于辐射（通常为X射线）时能产生光的荧光体）。 该材料特别适用于在外部光源不能接合接合点的情况下在环境温度下结合部件。 相关方法包括：将可聚合粘合剂组合物，包括光引发剂和能量转换材料（例如下变换磷光体）与要结合的至少两种组分接触以形成组件; 并且能够将第一波长的辐射照射到组件上，该辐射能够转换（由荧光体进行下变频）到能够激活光引发剂的第二波长，以制备诸如喷墨墨盒，晶片到晶片组件，半导体， 集成电路等。

公开(公告)号：US20120089180A1

公开(公告)日：2012-04-12

申请号：US13102277

申请日：2011-05-06

Applicant: Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, JR. ,  Ian Stanton ,  Jennifer Ayres ,  Joshua T. Stecher ,  Michael Therien ,  Eric Toone ,  Dave Gooden ,  Mark Dewhirst ,  Joseph A. Herbert ,  Diane Fels ,  Katherine S. Hansen

Inventor： Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, JR. ,  Ian Stanton ,  Jennifer Ayres ,  Joshua T. Stecher ,  Michael Therien ,  Eric Toone ,  Dave Gooden ,  Mark Dewhirst ,  Joseph A. Herbert ,  Diane Fels ,  Katherine S. Hansen

IPC: A61B17/03 ,  G03F7/038 ,  C09D163/10 ,  H01B1/12 ,  C09D167/07 ,  G21K5/00 ,  B41J2/175 ,  H01L23/28 ,  B32B37/12 ,  B32B38/14 ,  B32B7/12 ,  C09D7/12 ,  C09D4/02 ,  B82Y30/00

CPC classification number: H01L24/83 ,  A61B17/0057 ,  A61L24/06 ,  B32B3/266 ,  B32B7/14 ,  B32B9/04 ,  B32B37/1284 ,  B32B37/18 ,  B32B38/0008 ,  B32B2037/1253 ,  B32B2457/00 ,  B32B2457/08 ,  B32B2457/14 ,  B41J2/17559 ,  C08K3/00 ,  C09J4/00 ,  C09J9/02 ,  C09J11/04 ,  C09J11/06 ,  C09J133/08 ,  C09K11/02 ,  C09K11/7769 ,  C09K11/777 ,  H01L23/5226 ,  H01L24/32 ,  H01L25/0657 ,  H01L25/50 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/73204 ,  H01L2224/73253 ,  H01L2224/73265 ,  H01L2224/83192 ,  H01L2224/83855 ,  H01L2224/92125 ,  H01L2225/06524 ,  H01L2225/06589 ,  H01L2924/07811 ,  H01L2924/1461 ,  H01L2924/15311 ,  Y10T428/2852 ,  H01L2924/00014 ,  H01L2924/00

Abstract: A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

Abstract translation: 可聚合组合物包括至少一种单体，当暴露于光时能够引发单体聚合的光引发剂和当暴露于辐射（通常为X射线）时能产生光的荧光体）。 该材料特别适用于在外部光源不能接合接合点的情况下在环境温度下结合部件。 相关方法包括：将可聚合粘合剂组合物，包括光引发剂和能量转换材料（例如下变换磷光体）与要结合的至少两种组分接触以形成组件; 并且能够将第一波长的辐射照射到组件上，该辐射能够转换（由荧光体进行下变频）到能够激活光引发剂的第二波长，以制备诸如喷墨墨盒，晶片到晶片组件，半导体， 集成电路等。

公开(公告)号：US08389958B2

公开(公告)日：2013-03-05

申请号：US12725108

申请日：2010-03-16

Applicant: Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian Nicholas Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Zak Fathi ,  Jennifer Ann Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

Inventor： Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian Nicholas Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Zak Fathi ,  Jennifer Ann Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

IPC: G01J1/58

CPC classification number: F21K2/00 ,  A61L2/08 ,  A61L2202/22 ,  A61N5/062 ,  B82Y20/00 ,  B82Y30/00 ,  G01N21/63 ,  G02B5/003 ,  G02F2/02 ,  Y10T428/25 ,  Y10T428/256

Abstract: A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength λ1 of radiation, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1 and 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength λ1 or the second wavelength λ2, or with both λ1 and λ2. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength λ2, generates the photostimulated reaction.

Abstract translation: 一种用于能量上转换和/或下转换的系统和用于在介质中产生光刺激反应的系统。 这些系统包括1）在暴露于辐射的第一波长λ1时配置的纳米颗粒，以产生具有比第一波长λ1更高的能量的辐射的第二波长λ2，和2）相对于纳米颗粒设置的金属结构。 金属结构的物理特性被设定为金属结构中的表面等离子体共振在以与第一波长λ1或第二波长λ2或与λ1和λ2两者提供光谱重叠的频率谐振的值。 用于在培养基中产生光刺激反应的系统包括设置在接近纳米颗粒的培养基中的受体，其在第二波长λ2激活时产生光刺激反应。