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177 条记录 (耗时 0.092 秒)

    Antigenic fragment of human T-lymphotropic virus
    73.
    发明申请
    Antigenic fragment of human T-lymphotropic virus 有权
    人类T淋巴细胞病毒的抗原片段

    公开(公告)号：US20040116662A1

    公开(公告)日：2004-06-17

    申请号：US10423156

    申请日：2003-04-25

    发明人： Hsin-Yu Lin ,  Ching-Long Hwong

    IPC分类号： C07K014/16

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/35 ,  C12N2740/14022 ,  C12Q1/702

    摘要： Antigenic fragments of human T-lymphotropic virus (HTLV), their fusion proteins with glutathione S-tranferase (GST) or thioredoxin (Thio), and a process for producing the fusion proteins thereof. The antigenic fragment of HTLV comprises the amino acid sequence of SEQ ID Nos: 3 or 4.

    摘要翻译： 人类T淋巴细胞病毒（HTLV）的抗原性片段及其与谷胱甘肽S-转移酶（GST）或硫氧还蛋白（Thio）的融合蛋白，以及其融合蛋白的制备方法。 HTLV的抗原性片段包含SEQ ID No：3或4的氨基酸序列。

    Discrimination between antibodies against HTLV-I, HTLV-II or related retroviruses, new peptides, detection of antibodies and immunoassay kits
    77.
    发明授权
    Discrimination between antibodies against HTLV-I, HTLV-II or related retroviruses, new peptides, detection of antibodies and immunoassay kits 失效
    针对HTLV-1，HTLV-II或相关逆转录病毒的抗体，新肽，抗体检测和免疫测定试剂盒

    公开(公告)号：US06242174B1

    公开(公告)日：2001-06-05

    申请号：US07752639

    申请日：1991-10-07

    申请人： Jonas Blomberg ,  Rüdiger Pipkorn

    发明人： Jonas Blomberg ,  Rüdiger Pipkorn

    IPC分类号： C12Q170

    CPC分类号： C07K14/005 ,  C12N2740/14022 ,  G01N33/56988 ,  Y10S435/974 ,  Y10S435/975 ,  Y10S530/826

    摘要： A method of discriminating between specific antibodies in samples of sera or other body fluids from humans or other primates containing antibodies arising from infection with HTLV-I, containing antibodies arising from infection with HTLV-II or containing antibodies arising from infection with related retroviruses, is described. In said method, the sample to be analyzed is subjected to at least four immunoassays, each using a different diagnostic antigen selected from four defined groups of peptides. Additionally, an immunoassay kit adapted for said method of discrimination, new peptides and a method of detecting antibodies with said peptides, are described.

    摘要翻译： 鉴别来自人或其他灵长类动物的血清或其他体液样品中特异性抗体的特征抗体，其含有由HTLV-I感染引起的抗体，其含有由HTLV-II感染引起的抗体或含有由相关逆转录病毒感染引起的抗体的抗体。 描述。 在所述方法中，待分析的样品经受至少四种免疫测定，每种免疫测定使用选自四个限定的肽组的不同诊断抗原。另外，适用于所述鉴别方法的免疫测定试剂盒，新肽和检测方法 描述了具有所述肽的抗体。

    Peptide derived from human immunodeficiency virus type 1 (HIV-1), isolate Ant70, containing an immunodominant epitope and it's use in immunodiagnostic assays
    78.
    发明授权
    Peptide derived from human immunodeficiency virus type 1 (HIV-1), isolate Ant70, containing an immunodominant epitope and it's use in immunodiagnostic assays 失效
    衍生自人类免疫缺陷病毒1型（HIV-1）的肽，分离的Ant70，含有免疫优势表位，并且其用于免疫诊断测定

    公开(公告)号：US06210903B1

    公开(公告)日：2001-04-03

    申请号：US09112206

    申请日：1998-07-09

    申请人： Robert De Leys

    发明人： Robert De Leys

    IPC分类号： G01N3353

    CPC分类号： C07K1/13 ,  C07K14/005 ,  C07K2319/00 ,  C12N2740/14022 ,  C12N2740/16122 ,  C12N2770/24222 ,  G01N33/531 ,  G01N33/56983 ,  G01N33/56988 ,  G01N33/6878 ,  G01N2333/18

    摘要： This invention is directed toward a peptide corresponding to an immunologically important viral epitope. Specifically, the peptide corresponds to an immunodominant epitope identified in the gp120 region of the human immunodeficiency virus type 1 (HIV-1), strain Ant70. This peptide has the following amino acid sequence: NH2-Gln-Ile-Asp-Ile-Gln-Glu-Met-Arg-Ile-Gly-Pro-Met-Ala-Trp-Tyr-Ser-Met-Gly-Ile-Gly-Gly-CO2H. The invention also relates to the use of this peptide, particularly when biotinylated in the form of complexes of streptavidin-biotinylated peptides or of avidin-biotinylated peptides, for the in vitro determination of HIV-1-specific antibodies.

    摘要翻译： 本发明涉及对应于免疫重要的病毒表位的肽。 具体地，该肽对应于在人类免疫缺陷病毒1型（HIV-1），菌株Ant70的gp120区域中鉴定的免疫显性表位。 该肽具有以下氨基酸序列：NH2-Gln-Ile-Asp-Ile-Gln-Glu-Met-Arg-Ile-Gly-Pro-Met-Ala-Trp-Tyr-Ser-Met-Gly-Ile-Gly -Gly-CO2H。 本发明还涉及该肽的用途，特别是当以链霉抗生物素蛋白 - 生物素化肽或抗生物素蛋白 - 生物素化肽的复合物的形式生物素化时，用于体外测定HIV-1特异性抗体。

    Mutant Rev transdominant repressors of HIV replication
    79.
    发明授权
    Mutant Rev transdominant repressors of HIV replication 失效
    突变型转录反义寡核苷酸HIV复制

    公开(公告)号：US6162898A

    公开(公告)日：2000-12-19

    申请号：US138069

    申请日：1998-08-21

    申请人： Bryan R. Cullen

    发明人： Bryan R. Cullen

    IPC分类号： A61K38/00 ,  C07K14/15 ,  C07K14/16 ,  C07K16/10 ,  C12N15/49 ,  G03C7/30 ,  G03C7/36 ,  C07K14/00

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C07K16/1036 ,  C12N2740/10022 ,  C12N2740/10043 ,  C12N2740/14022 ,  C12N2740/14043 ,  C12N2740/16322 ,  G03C7/3013 ,  G03C7/36

    摘要： Transdominant repressors of viral gene phenotypic expression derived from the rev gene product of HIV-1 or the rex gene product of HTLV-1 and corresponding mutated genes, having the capability of repressing the Rev function in HIV-1 and/or the Rex function in HTLV-I and HTLV-II. And in some cases both the Rev and the Rex function and are, active in more than one viral species. Such transdominant viral mutants are useful as anti-viral agents to, for example of these transdominant inhibitors may be used in such therapeutic approaches as intracellular immunization in order to protect cells against the deleterious effects of viral, e.g. HIV-1, infection.

    摘要翻译： 衍生自HIV-1的rev基因产物或HTLV-1的rex基因产物和相应的突变基因的具有抑制HIV-1中Rev功能和/或Rex功能的能力的病毒基因表型表达的显性阻遏物 HTLV-I和HTLV-II。 在某些情况下，Rev和Rex的功能都是活跃在一种以上的病毒物种中。 这样的显性病毒突变体可用作抗病毒剂，例如这些跨主导抑制剂可用于诸如细胞内免疫的治疗方法中，以保护细胞免受病毒的有害影响，例如， HIV-1，感染。