公开(公告)号：US09730987B2

公开(公告)日：2017-08-15

申请号：US14632863

申请日：2015-02-26

Applicant: MERIAL INC.

Inventor： Noel Joseph Francois Detraz ,  Guillaume Rigaut

IPC: A61K39/00 ,  A61K47/26 ,  A61K9/00 ,  A61K9/107 ,  A61K45/06 ,  A61K47/06 ,  C12N7/00 ,  A61K39/39 ,  A61K39/02 ,  A61K39/12 ,  A61K39/135 ,  A61K39/125

CPC classification number: A61K39/00 ,  A61K9/0019 ,  A61K9/107 ,  A61K39/0241 ,  A61K39/12 ,  A61K39/125 ,  A61K39/135 ,  A61K39/39 ,  A61K45/06 ,  A61K47/06 ,  A61K47/26 ,  A61K2039/52 ,  A61K2039/525 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/55577 ,  C12N7/00 ,  C12N2750/00022 ,  C12N2750/00034 ,  C12N2750/10034 ,  C12N2770/32022 ,  C12N2770/32134

Abstract: The present invention provides for a novel oil-in-water (O/W) emulsion, with increased stability in the presence of bacterial or viral suspensions, especially those concentrated and non-purified (crude extracts) or minimally purified. The emulsion of the present invention can act as vehicle for the delivery of a pharmaceutical composition comprising at least one immunogen and, in particular, an immunogen selected from the group consisting of an inactivated pathogen, an attenuated pathogen, a subunit, a recombinant expression vector, and a plasmid or combinations thereof.

公开(公告)号：US20170224756A1

公开(公告)日：2017-08-10

申请号：US15423280

申请日：2017-02-02

Applicant: MERIAL INC.

Inventor： Alphons Rutten ,  Caroline Pommellet ,  Pierre Chicoteau

IPC: A61K36/87 ,  A61K9/00 ,  A61K47/02 ,  A23K20/10 ,  A61K39/215 ,  A61K39/12 ,  C12N7/00 ,  A23K20/20 ,  A61K33/04 ,  A61K47/12

CPC classification number: A61K36/87 ,  A23K10/37 ,  A23K20/10 ,  A23K20/20 ,  A23K20/22 ,  A23K20/30 ,  A23K50/30 ,  A23K50/60 ,  A23K50/75 ,  A61K9/0007 ,  A61K9/0095 ,  A61K33/04 ,  A61K39/12 ,  A61K39/215 ,  A61K47/02 ,  A61K47/12 ,  A61K2039/542 ,  A61K2039/544 ,  A61K2039/545 ,  A61K2039/552 ,  C12N7/00 ,  C12N2720/10034 ,  C12N2770/20034 ,  Y02P60/877 ,  A61K2300/00

Abstract: The present invention encompasses an effervescent Grape extract plus selenium composition which improves stress response. The invention also encompasses methods of improving stress response, such as stress response to vaccination or weaning, by administration of the composition. The invention also encompasses methods of producing meat with improved quality by raising an animal on a diet supplemented with an effervescent Grape extract plus selenium composition.

公开(公告)号：US09695129B2

公开(公告)日：2017-07-04

申请号：US15148168

申请日：2016-05-06

Applicant: MERIAL INC.

Inventor： Charles Q Meng

IPC: C07D235/28 ,  C07D235/10 ,  C07D235/08 ,  C07D405/10 ,  C07D409/10 ,  A61K45/06 ,  A61K31/4184 ,  A61K31/277 ,  C07D235/18 ,  C07D405/04 ,  C07D409/04

CPC classification number: C07D235/28 ,  A61K31/277 ,  A61K31/4184 ,  A61K45/06 ,  C07D235/08 ,  C07D235/10 ,  C07D235/18 ,  C07D405/04 ,  C07D405/10 ,  C07D409/04 ,  C07D409/10

Abstract: The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one benzimidazole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.

公开(公告)号：US09675682B2

公开(公告)日：2017-06-13

申请号：US14991003

申请日：2016-01-08

Applicant: MERIAL INC.

Inventor： Russell F. Bey ,  Paulraj Kirubakaran Lawrence ,  Randy R. Simonson

IPC: A61K39/02 ,  A61K49/00 ,  A61K39/00 ,  A61K39/102 ,  C07K14/285 ,  C12N1/36

CPC classification number: A61K39/102 ,  A61K2039/522 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/285 ,  C12N1/36

Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.

公开(公告)号：US20170087230A1

公开(公告)日：2017-03-30

申请号：US15311093

申请日：2015-05-13

Applicant: MERIAL INC. ,  VITAMFERO S.A ,  L'UNIVERSITE DE BOURGOGNE ,  L'Institut National Superieur des Sciences Agronomiques de L'Alimentation et de L'Environmen

Inventor： Noel Yves Henri Jean Genin ,  Jean-Christophe Audonnet ,  Didier Roy ,  Edouard Seche ,  Patrick Gervais ,  Samira Khaldi-Plassart ,  Romain Useo ,  Joelle DeConinck

IPC: A61K39/002 ,  A61K9/19 ,  A01N1/02

CPC classification number: A61K39/002 ,  A01N1/02 ,  A01N1/0221 ,  A01N1/0278 ,  A01N1/0284 ,  A61K9/0019 ,  A61K9/19 ,  A61K2039/522 ,  Y02A50/41 ,  Y02A50/412

Abstract: The present invention relates generally to the fields of immunology and vaccine technology. More specifically, the present invention relates to methods for freeze-drying biological preparations, including peptides, antigens, antibodies, and especially, cells. Importantly, the disclosed methods preserve the viability, infectivity and immunogenicity of cells from the Apicomplexa phylum, the Sarcocystidae family, and in particular, cells from the Toxoplasma genus.

公开(公告)号：US20170081372A1

公开(公告)日：2017-03-23

申请号：US15017486

申请日：2016-02-05

Applicant: MERIAL INC.

Inventor： Laurent Bernard Fischer ,  Nicolas Pierre Yves Carboulec ,  Fabien Lux

IPC: C07K14/44 ,  C12N9/50 ,  A61K39/008 ,  C12N9/10

CPC classification number: C07K14/245 ,  A23L3/0155 ,  A61K39/008 ,  A61K39/0225 ,  A61K39/0241 ,  A61K39/099 ,  A61K2039/552 ,  A61L2/0011 ,  C07K14/44 ,  C07K2319/00 ,  C07K2319/35 ,  C07K2319/40 ,  C12N5/0031 ,  C12N9/1007 ,  C12N9/50 ,  C12N9/52 ,  C12P21/02 ,  C12Y201/01041 ,  C12Y304/22

Abstract: The present invention encompasses vaccines or compositions comprising the chimeric KSAC protein that possesses immunogenic and protective properties, and methods of use including administering to an animal the antigenic KSAC protein thereof to protect animals. The invention also encompasses methods for making and producing the soluble, disaggregated, refolded or active proteins from inclusion bodies produced from prokaryotes or eukaryotes.

公开(公告)号：US09555098B2

公开(公告)日：2017-01-31

申请号：US14427197

申请日：2013-09-10

Applicant: Merial, Inc.

Inventor： Francois Xavier Le Gros

IPC: A61K39/23 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/23 ,  A61K2039/5254 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N2750/14122 ,  C12N2750/14134 ,  C12N2750/14322 ,  C12N2750/14334

Abstract: This disclosure provides an attenuated palmiped parvovirus that affords heterologous protection for both Muscovy duck parvovirus and goose parvovirus (i.e., Derzsy's Disease). The disclosure further provides compositions comprising the same, and methods of production and use thereof.

Abstract translation: 本公开提供了减毒的掌状细小病毒，其对俄罗斯鸭细小病毒和鹅细小病毒（即Derzsy氏病）提供异源保护。 本公开进一步提供包含该组合物的组合物，及其制备方法和用途。

公开(公告)号：US20170020849A1

公开(公告)日：2017-01-26

申请号：US15286133

申请日：2016-10-05

Applicant: MERIAL, INC.

Inventor： Mark D. Soll ,  Joseph K. Rosentel, JR. ,  Monica Tejwani-Motwani ,  Carol Belansky

IPC: A61K31/42 ,  A61K31/44 ,  A61K31/4402 ,  A61K9/00 ,  A61K45/06 ,  A61K31/4745 ,  A61K31/7048 ,  A61K47/22 ,  A61K31/231 ,  A61K47/08

CPC classification number: A61K31/42 ,  A01N43/40 ,  A01N43/80 ,  A01N49/00 ,  A61K9/0017 ,  A61K9/06 ,  A61K31/215 ,  A61K31/22 ,  A61K31/231 ,  A61K31/366 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4745 ,  A61K31/7048 ,  A61K38/15 ,  A61K45/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K2300/00

Abstract: This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

Abstract translation: 本发明涉及用于对抗动物体内外寄生虫和内寄生虫的局部组合物，其包含至少一种异恶唑啉活性剂和药学上可接受的载体，任选地与一种或多种另外的活性剂组合。 本发明还提供了用于消除，控制和预防动物中的寄生虫感染和侵染的改进方法，包括将本发明的组合物施用于有需要的动物。

公开(公告)号：US20170020848A1

公开(公告)日：2017-01-26

申请号：US15092491

申请日：2016-04-06

Applicant: MERIAL INC.

Inventor： Susan Mancini Cady ,  Peter Cheifetz ,  Izabela Galeska ,  Loic Le Hir de Fallois

IPC: A61K31/42 ,  A61K9/00

CPC classification number: A61K31/42 ,  A61K9/00 ,  A61K9/0019 ,  A61K31/422 ,  A61K47/10 ,  A61K47/22 ,  A61K2300/00

Abstract: This invention relates to extended release injectable formulations for combating parasites in animals, comprising at least one isoxazoline active agent, a pharmaceutically acceptable polymer, and a solvent. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the extended release injectable formulations of the invention to the animal in need thereof.

Abstract translation: 本发明涉及用于对抗动物寄生虫的延长释放可注射制剂，其包含至少一种异恶唑啉活性剂，药学上可接受的聚合物和溶剂。 本发明还提供了用于消除，控制和预防动物中的寄生虫感染和侵染的改进方法，包括向有需要的动物施用本发明的延长释放可注射制剂。

公开(公告)号：US20160374342A1

公开(公告)日：2016-12-29

申请号：US14757414

申请日：2014-06-23

Applicant: MERIAL, INC.

Inventor： Pascal Bindschädler ,  Wolfgang Von Deyn ,  Karsten Körber ,  Deborah L. Culbertson ,  Koshi Gunjima ,  Franz Josef Braun

IPC: A01N47/34 ,  A01N43/80 ,  C07D275/02

CPC classification number: A01N47/34 ,  A01N43/80 ,  A01N47/30 ,  C07D275/02

Abstract: The present invention relates to naphthyl- or isoquinolinyl-substituted isothiazoline compounds of formula I wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

Abstract translation: 其中变量如权利要求和描述中所定义。 这些化合物可用于对抗或控制无脊椎害虫，特别是节肢动物害虫和线虫。 本发明还涉及通过使用这些化合物和植物繁殖材料以及包含所述化合物的农业和兽用组合物来控制无脊椎害虫的方法。