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    IMPLANTABLE DEVICE FOR RETAINING LIVE CELLS AND PROVIDING NUTRIENTS THERETO
    85.
    发明申请
    IMPLANTABLE DEVICE FOR RETAINING LIVE CELLS AND PROVIDING NUTRIENTS THERETO 审中-公开

    公开(公告)号：US20170086963A1

    公开(公告)日：2017-03-30

    申请号：US15274229

    申请日：2016-09-23

    申请人： California Institute of Technology ,  City of Hope

    发明人： Yu-Chong Tai ,  Dongyang Kang ,  Hirotake Komatsu ,  Henry K. Lin ,  Yoko Mullen

    IPC分类号： A61F2/02

    CPC分类号： A61F2/022 ,  A61F2240/004 ,  C12M21/00

    摘要： An implantable medical device, a method of manufacturing, and a method of use are described. The implantable medical device includes an absorption bag connected by a cannula to a discharge bag. The implantable medical device also includes a reservoir external to the discharge bag and attached to a surface of the discharge bag. At least a portion of the absorption bag and at least a portion of a bottom surface of the reservoir are permeable to a predefined class of small molecules, such as molecular oxygen. The reservoir can retain live cells that rely on the small molecules for survival and growth. Based on concentration of the small molecules, the small molecules permeate into the absorption bag and are transported to the discharge bag for permeation into the reservoir, thereby providing a supply of the small molecules to the live cells.

    ULTRATHIN PARYLENE-C SEMIPERMEABLE MEMBRANES FOR BIOMEDICAL APPLICATIONS
    90.
    发明申请
    ULTRATHIN PARYLENE-C SEMIPERMEABLE MEMBRANES FOR BIOMEDICAL APPLICATIONS 审中-公开
    ULTRATHIN PARYLENE-C可生物医学应用的可切割膜

    公开(公告)号：US20150147810A1

    公开(公告)日：2015-05-28

    申请号：US14498918

    申请日：2014-09-26

    申请人： California Institute of Technology ,  University of Southern California

    发明人： Yu-Chong Tai ,  Bo Lu ,  Mark Humayun

    IPC分类号： C12N5/00

    CPC分类号： A61L27/16 ,  A61L27/50 ,  A61L27/56 ,  A61L2430/16 ,  B01D71/44 ,  B01D2325/06 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2535/10 ,  C12N2539/00

    摘要： Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there.

    摘要翻译： 公开了具有较厚区域散布的具有光滑前侧和超薄区域（例如，0.01μm至5μm厚）的薄聚对二甲苯C膜。 与光滑的前侧相比，膜的背面可能是粗糙的。 膜可以在体外用于在实验室或体内生长细胞的单层，作为外科手术植入的生长层，例如替代眼睛中的Bruch膜。 聚对二甲苯的薄区域是半渗透性的，以允许血清中的蛋白质通过，并且厚区域给予外科医生处理的机械支持。 光滑的前侧允许单层细胞生长，粗糙的背面有助于防止细胞附着在那里。