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81.
公开(公告)号:US20060205773A1
公开(公告)日:2006-09-14
申请号:US11375692
申请日:2006-03-14
IPC分类号: A61K31/4706 , A61K31/4412 , A61K31/428 , A61K31/165 , C07D277/62 , C07D215/38
CPC分类号: C07C233/65 , A61K31/165 , A61K31/428 , A61K31/4412 , A61K31/4706 , C07C233/75 , C07C2601/02 , C07C2602/10 , C07D213/75 , C07D215/38 , C07D277/62 , C07D319/18
摘要: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
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82.
公开(公告)号:US20060194801A1
公开(公告)日:2006-08-31
申请号:US11362451
申请日:2006-02-24
申请人: Michael Kelly , John Kincaid , Matthew Duncton , Kiran Sahasrabudhe , Satyanarayana Janagani , Ravindra Upasani , Guoxian Wu , Yunfeng Fang , Zhi-Liang Wei
发明人: Michael Kelly , John Kincaid , Matthew Duncton , Kiran Sahasrabudhe , Satyanarayana Janagani , Ravindra Upasani , Guoxian Wu , Yunfeng Fang , Zhi-Liang Wei
IPC分类号: A61K31/538 , A61K31/4709 , C07D405/14 , C07D413/02
CPC分类号: C07D263/58 , C07C233/65 , C07C2603/18 , C07D209/12 , C07D209/48 , C07D209/88 , C07D215/38 , C07D217/02 , C07D231/56 , C07D235/06 , C07D235/08 , C07D235/12 , C07D265/36 , C07D277/64 , C07D317/66 , C07D319/18 , C07D471/04 , C07D491/04
摘要: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
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公开(公告)号:US20060168100A1
公开(公告)日:2006-07-27
申请号:US11036080
申请日:2005-01-13
申请人: Michael Kelly , Bruce Calvert
发明人: Michael Kelly , Bruce Calvert
IPC分类号: G06F15/16 , G06F15/173
CPC分类号: G06F17/30569 , H04Q3/0045 , H04Q3/54533
摘要: A computing device embodiment includes a processor, memory coupled to the processor, and computer executable instructions executable by the processor. Computer executable instructions are provided to the memory and executable by the processor to access a first provider's communications computing device, having a user's information thereon, through a data lookup utility used by the first carrier. The computer executable instructions can also retrieve the user's information from the first provider's communications computing device and transfer the retrieved information to a second provider's communications computing device.
摘要翻译: 计算设备实施例包括处理器,耦合到处理器的存储器以及可由处理器执行的计算机可执行指令。 计算机可执行指令被提供给存储器并且可由处理器执行,以通过第一运营商使用的数据查找工具访问第一提供商的通信计算设备,其上具有用户的信息。 计算机可执行指令还可以从第一提供商的通信计算设备检索用户的信息,并将检索到的信息传送到第二提供商的通信计算设备。
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公开(公告)号:US20060030618A1
公开(公告)日:2006-02-09
申请号:US11100272
申请日:2005-04-05
申请人: Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
发明人: Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
IPC分类号: A61K31/353 , C07D319/08
CPC分类号: C07D471/04 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
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公开(公告)号:US20050277779A1
公开(公告)日:2005-12-15
申请号:US11150607
申请日:2002-06-12
申请人: Michael Kelly , Raymond Anderson , Todd Barsby
发明人: Michael Kelly , Raymond Anderson , Todd Barsby
IPC分类号: C07C235/28 , C07C235/46
CPC分类号: C07C235/28
摘要: Antibiotic polyketide compounds are provided having the formula wherein: R1 and R2 are the same or different and are independently H or R; R is a structural fragment having a saturated or unsaturated linear, branched, or cyclic, skeleton containing one to ten carbon atoms in which the carbon atoms may be optionally substituted with a substituent selected from the group consisting of: —OH; ═O; —OR5; —O2CR5, —SH; —SR5; —SOCR5; —NH2; —NH5; —NH(R5)2; —NHCOR5; NRCOR5; —I; —Br; —Cl; —F; —CN; —CO2H; —CO2R5; —CH0; —COR5; —CONH2; —CONHR5; —CON(R5)2; —COSH; —COSR5; —N02; —S03H; —SOR5; and —SO2R5, wherein R5 is a linear, branched or cyclic, one to ten carbon saturated or unsaturated alkyl group; R3 and R4 are different and are independently selected from the groups consisting of OH, wherein Z1 and Z are linear or branched saturated or unsaturated, one to en carbon fragments optionally substituted with Y; Ar is a monocyclic, bicyclic or tricyclic, fully or partially aromatic system containing five or six membered carbocyclic or, oxygen, nitrogen or sulphur containing heterocyclic rings, optionally substituted with R or Y; Y is selected from the group consisting of: H; ═O, —OH; —OR; —02CR; —SH; —SR; —SOCR; —NH2; —NHR; —NH(R)2; —NHCOR; NRCOR; —I; —Br; —Cl; —F; —CN— —CO2H; —CO2R; —CHO; —COR; —CONH2; —CONHR: —CON(R)2; —COSH; —COSR; —N02; —SO3H; —SOR; —SO2R; and, —O— (epoxide); W is H or R; with the provisos that when W is H, R2 is not H; when R2 is CH3, W is not n-propyl; and, one of R3 and R4 is (a) or (b) and another of R3 and R4 is OH.
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公开(公告)号:US06974758B2
公开(公告)日:2005-12-13
申请号:US10673962
申请日:2003-09-29
申请人: Michael Kelly , Oliver Ambacher , Martin Stutzmann , Martin Brandt , Roman Dimitrov , Robert Handschuh
发明人: Michael Kelly , Oliver Ambacher , Martin Stutzmann , Martin Brandt , Roman Dimitrov , Robert Handschuh
CPC分类号: H01L21/6835 , H01L21/78 , H01L24/81 , H01L2221/68331 , H01L2221/68363 , H01L2224/81801 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01033 , H01L2924/01049 , H01L2924/0106 , H01L2924/01082 , H01L2924/10329 , H01L2924/12041 , H01L2924/12042 , H01L2924/00
摘要: A method of separating two layers of material from one another in such a way that the two separated layers of material are essentially fully preserved. An interface between the two layers of material at which the layers of material are to be separated, or a region in the vicinity of the interface, is exposed to electromagnetic radiation through one of the two layers of material. The electromagnetic radiation is absorbed at the interface or in the region in the vicinity of the interface and the absorbed radiation energy induces a decomposition of material at the interface.
摘要翻译: 将两层材料彼此分开的方法,使得两层分离的材料层基本上完全保留。 要分离材料层的两层材料之间的界面或界面附近的区域通过两层材料之一暴露于电磁辐射。 电磁辐射在界面处或界面附近的区域被吸收,并且吸收的辐射能量在界面处引起材料的分解。
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公开(公告)号:US20050272931A1
公开(公告)日:2005-12-08
申请号:US11099978
申请日:2005-04-05
申请人: Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
发明人: Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
IPC分类号: C07D249/18 , A61K31/17 , A61K31/18 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/37 , A61K31/381 , A61K31/4025 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/444 , A61K31/453 , A61K31/47 , A61K31/4704 , A61K31/4709 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/498 , A61K31/505 , A61K31/517 , A61K31/5375 , A61K31/538 , A61P1/00 , A61P1/04 , A61P1/12 , A61P3/10 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/00 , A61P13/10 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/00 , A61P25/06 , A61P27/02 , A61P29/00 , A61P31/12 , A61P37/08 , A61P43/00 , C07C233/11 , C07C233/15 , C07C233/33 , C07C233/44 , C07C311/13 , C07C311/16 , C07C317/40 , C07C323/35 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/32 , C07D215/38 , C07D215/40 , C07D215/42 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D235/08 , C07D235/26 , C07D237/20 , C07D239/42 , C07D239/88 , C07D239/90 , C07D241/20 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D311/16 , C07D319/18 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D215/16
CPC分类号: C07D471/04 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
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公开(公告)号:US20050224954A1
公开(公告)日:2005-10-13
申请号:US10820484
申请日:2004-04-08
申请人: Michael Kelly
发明人: Michael Kelly
IPC分类号: H01L21/48 , H01L21/60 , H01L23/34 , H01L23/367
CPC分类号: H01L23/367 , H01L23/3675 , H01L24/48 , H01L24/81 , H01L2224/48091 , H01L2224/81801 , H01L2224/82 , H01L2224/85 , H01L2224/86 , H01L2924/00014 , H01L2924/01079 , H01L2924/09701 , H01L2924/14 , H01L2924/15311 , H01L2924/00 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要: Integrated circuit systems with thermal dissipation enhancement features are described. In one aspect, an integrated circuit system includes a die incorporating an integrated circuit. The die has a top side and a bottom side. The top side supports an electrical signal communication metallization and a top side thermal dissipation metallization. The bottom side supports a bottom side thermal dissipation metallization.
摘要翻译: 描述了具有散热增强特征的集成电路系统。 在一个方面,集成电路系统包括结合有集成电路的管芯。 模具具有顶侧和底侧。 顶侧支持电信号通信金属化和顶侧散热金属化。 底侧支撑底侧散热金属化。
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公开(公告)号:US20050165892A1
公开(公告)日:2005-07-28
申请号:US10667984
申请日:2004-01-08
申请人: Michael Kelly
发明人: Michael Kelly
IPC分类号: G06F15/16 , G06F15/173 , G06Q10/00 , H04L12/58
CPC分类号: H04L51/12 , G06Q10/107
摘要: A process to reduce the total amount of spam being sent as opposed to processes to manage spam sent and received. A company is formed to establish and maintain a database of email addresses. E-mail address owners that wish to avoid spam may apply to be added to the database and become clients. When a client receives spam, they may notify the company. The company may notify a selected list of clients of the spam event. These notified clients may advise the spammer of the company, the database, and its client's desires. When the spammer has received sufficient notification, the spammer will remove the client list from their list of addresses.
摘要翻译: 一个减少发送垃圾邮件总量的过程,而不是管理发送和接收垃圾邮件的过程。 公司成立以建立和维护电子邮件地址数据库。 希望避免垃圾邮件的电子邮件地址所有者可能会被添加到数据库中并成为客户端。 当客户收到垃圾邮件时,他们可能会通知公司。 公司可能会通知客户的垃圾邮件事件列表。 这些通知的客户可能会建议公司的垃圾邮件发送者,数据库及其客户的需求。 当垃圾邮件发送者收到足够的通知后,垃圾邮件发送者将从其地址列表中删除客户端列表。
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公开(公告)号:US20050059038A1
公开(公告)日:2005-03-17
申请号:US10806758
申请日:2004-03-22
申请人: Steven Adams , Daniel Flynn , Michael Kelly , Gergely Makara , Keith Mason , Ciamac Moallemi , Huw Nash , Edward Wintner , Zhongli Zheng
发明人: Steven Adams , Daniel Flynn , Michael Kelly , Gergely Makara , Keith Mason , Ciamac Moallemi , Huw Nash , Edward Wintner , Zhongli Zheng
IPC分类号: C12N20060101 , C12N9/00 , C12N9/12 , C12N15/09 , C12Q1/37 , C12Q1/48 , C12Q1/68 , G01N30/72 , G01N33/00 , G01N33/53 , G01N33/68
CPC分类号: C12Q1/485 , C12N9/12 , G01N30/72 , G01N33/6845 , G01N2500/04 , B01D15/34
摘要: A general system for screening targets (e.g., biomolecules) is described. The screening can be used to discover compounds that bind to a naturally occurring low activity or inactive state of a target and act as inhibitors of the target function as seen in subsequent biological assays.
摘要翻译: 描述了用于筛选靶标的一般系统(例如,生物分子)。 筛选可以用于发现结合靶的天然存在的低活性或非活性状态的化合物,并且作为靶功能的抑制剂,如随后的生物测定中所见。
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