Filler for Optical Isomer Separation
    82.
    发明申请
    Filler for Optical Isomer Separation 有权
    光学异构体分离填料

    公开(公告)号:US20090105440A1

    公开(公告)日:2009-04-23

    申请号:US12227150

    申请日:2007-05-02

    Abstract: Disclosed is a filler for optical isomer separation which: allows a polymer compound derivative to be immobilized on the surface of a carrier at a high ratio; and is excellent in optical separation ability. The filler is characterized in that the filler is obtained by modifying part of hydroxy or amino groups of a polymer compound having the hydroxy or amino groups with molecules of a compound represented by the following general formula (I): A-X—Si(Y)nR3-n, and is carried by a carrier through chemical bonding.

    Abstract translation: 公开了一种光学异构体分离用填料,其可以使高分子化合物衍生物以高比例固定在载体的表面上; 光学分离能力优异。 填料的特征在于,通过用下列通式(I)表示的化合物的分子改性具有羟基或氨基的高分子化合物的羟基或氨基的一部分来修饰填料:AX-Si(Y)nR3 -n,并通过化学键合由载体承载。

    Method for separation of enantiomeric isomers by simulated moving bed chromatography
    89.
    发明授权
    Method for separation of enantiomeric isomers by simulated moving bed chromatography 失效
    通过模拟移动床层析分离对映体异构体的方法

    公开(公告)号:US07306734B2

    公开(公告)日:2007-12-11

    申请号:US10943436

    申请日:2004-09-17

    Abstract: The present invention provides a method having a high productivity for preparative separation by simulated moving bed chromatography. That is, in a filler for enantiomeric isomer separation by simulated moving bed chromatography, which has a porous carrier carrying a polysaccharide derivative thereon and has a TS coefficient in a range of 0.55 to 1.20, the TS coefficient being defined by the below-shown formula (I), and obtained by using an enantiomeric isomer separation column for simulated moving bed chromatography in which the filler is filled in a column tube by a slurry filling method: TS coefficient=[Vc−[t(TS)−t(blank)]×FR]/[t(TS)−t(blank)]×FR,  (I) wherein Vc (cm3): a column volume; FR (ml/min.): a flow velocity; t(TS) (min.): an elution time for tetrakis(trimethylsilyl)silane (=TS); and t(blank) (min.): an elution time for TS in the state where the column is not connected.

    Abstract translation: 本发明提供了一种通过模拟移动床色谱法制备分离的高生产率的方法。 也就是说,在通过模拟移动床层析法的对映体异构体分离的填料中,其具有在其上载有多糖衍生物的多孔载体并且TS系数在0.55至1.20的范围内,TS系数由下表所示的式 (I),并通过使用用于模拟移动床层析的对映体异构体分离柱,其中通过浆料填充方法将填料填充在柱管中获得:<?在线公式描述=“在线配方”末端 =“lead”?> TS系数= [Vc- [t(TS)-t(空白)] xFR] / [t(TS)-t(空白)] xFR,(I) =“直线公式”end =“tail”?>其中Vc(cm 3):柱体积; FR(ml / min):流速; t(TS)(分钟):四(三甲基甲硅烷基)硅烷(= TS)的洗脱时间; 和t(空白)(分钟):在未连接色谱柱的状态下TS的洗脱时间。

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