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1112 条记录 (耗时 0.048 秒)

    CARNOSINE HYALURONIC ACID MIXTURES AND THEIR USE
    81.
    发明申请
    CARNOSINE HYALURONIC ACID MIXTURES AND THEIR USE 审中-公开
    CARNOSINE HYALURONIC酸混合物及其用途

    公开(公告)号：US20140303116A1

    公开(公告)日：2014-10-09

    申请号：US13991833

    申请日：2011-12-06

    申请人： Gianfranco De Paoli Ambrosi

    发明人： Gianfranco De Paoli Ambrosi

    IPC分类号： C08B37/08

    CPC分类号： C08B37/0072 ,  A61K8/4946 ,  A61K8/735 ,  A61K31/198 ,  A61K31/4172 ,  A61K31/728 ,  A61K2800/91 ,  A61Q7/00 ,  A61Q19/08 ,  A61K2300/00

    摘要： A novel compound is disclosed, said compound comprising hyaluronic acid, optionally cross-linked, or an oligomer, optionally cross-linked, dimer or monomer thereof, which is salified or at least partially salified with carnosine, wherein the carnosine is in the form of an L- or D-enantiomer or a racemate; a process for producing this compound, its cosmetic and therapeutic use as well as pharmaceutical and cosmetic compositions containing the same are also disclosed.

    摘要翻译： 公开了一种新型化合物，所述化合物包含任选交联的透明质酸，任选交联的寡聚体，或其任选交联的二聚体或其单体，其与谷氨酸成盐或至少部分成盐，其中肌肽为 L-对映异构体或外消旋体; 还公开了制备该化合物的方法，其化妆品和治疗用途以及含有该化合物的药物和化妆品组合物。

    Polysaccharide derivative and hydrogel thereof
    84.
    发明授权
    Polysaccharide derivative and hydrogel thereof 失效
    多糖衍生物及其水凝胶

    公开(公告)号：US08748409B2

    公开(公告)日：2014-06-10

    申请号：US13263929

    申请日：2010-04-19

    申请人： Hiroaki Kaneko ,  Masaya Ito

    发明人： Hiroaki Kaneko ,  Masaya Ito

    IPC分类号： A61K31/70 ,  C07H5/04

    CPC分类号： A61L27/52 ,  A61K9/0024 ,  A61K47/36 ,  A61L27/20 ,  A61L31/042 ,  A61L31/145 ,  C08B37/0072 ,  C08J3/075 ,  C08J2305/08 ,  C08L5/08

    摘要： Disclosed are a polysaccharide derivative obtained by substituting some of the carboxyl groups of a carboxy polysaccharide with —NH—X—CO—Y—Z; and a hydrogel thereof. Here, X is a C1-10 hydrocarbon group, Y is a polyalkylene oxide having oxygen atoms at both ends, and Z is a C1-24 hydrocarbon group or —CO—R2, with R2 being a C1-23 hydrocarbon group. The hydrogel has excellent viscoelasticity and can be injected into a predetermined location with an injection device such as a syringe, and thus can be advantageously used as a medical gel or an adhesion barrier.

    摘要翻译： 公开了通过用-NH-X-CO-Y-Z取代羧基多糖的一些羧基得到的多糖衍生物; 及其水凝胶。 这里，X是C 1-10烃基，Y是在两端具有氧原子的聚环氧烷烃，Z是C1-24烃基或-CO-R2，R2是C1-23烃基。 水凝胶具有优异的粘弹性，并且可以通过诸如注射器的注射装置注射到预定位置，因此可以有利地用作医用凝胶或粘合屏障。

    PROCESS FOR PRODUCING WATER-SOLUBLE HYALURONIC ACID MODIFICATION
    86.
    发明申请
    PROCESS FOR PRODUCING WATER-SOLUBLE HYALURONIC ACID MODIFICATION 有权
    生产水溶性羟丙酸改性方法

    公开(公告)号：US20140011991A1

    公开(公告)日：2014-01-09

    申请号：US13947716

    申请日：2013-07-22

    申请人： Chugai Seiyaku Kabushiki Kaisha

    发明人： Kenji YASUGI ,  Teruo NAKAMURA ,  Tsuyoshi SHIMOBOJI ,  Mika SATO

    IPC分类号： C08B37/08

    CPC分类号： C08B37/0072 ,  A61K47/61 ,  C08J3/075 ,  C08J3/122 ,  C08L5/08

    摘要： The present invention provides a water-soluble modified HA practically used as a drug carrier and a production method thereof. The present invention provides: a water-soluble modified hyaluronic acid, the residence time in blood of which is elongated to a practical level, which is produced by introducing a substituent into the carboxy group of the glucuronic acid of hyaluronic acid or a derivative thereof, via an amide bond, at a lower limit of an introduction ratio of 5 mole % or more, using a BOP condensing agent in an aprotic polar solvent; and a production method thereof. Moreover, by cross-linking the modified hyaluronic acid, the present invention provides a hyaluronic acid gel capable of extremely long drug sustained-release even at the same cross-linking functional group introduction ratio as that of the conventionally known gel.

    摘要翻译： 本发明提供实际上用作药物载体的水溶性改性HA及其制备方法。 本发明提供：通过将透明质酸的葡糖醛酸或其衍生物的羧基引入取代基而产生的水溶性改性透明质酸，其在血液中的停留时间延长到实用水平， 通过酰胺键，在引发比为5摩尔％以上的下限，使用BOP缩合剂在非质子传递极性溶剂中; 及其制造方法。 此外，通过交联改性透明质酸，本发明提供即使以与常规已知凝胶相同的交联官能团引入比例，能够极长的药物持续释放的透明质酸凝胶。

    METHOD FOR MAKING A POLYSACCHARIDE DIALDEHYDE HAVING HIGH PURITY
    88.
    发明申请
    METHOD FOR MAKING A POLYSACCHARIDE DIALDEHYDE HAVING HIGH PURITY 审中-公开
    制备具有高纯度的多糖二盐酸盐的方法

    公开(公告)号：US20130274225A1

    公开(公告)日：2013-10-17

    申请号：US13811474

    申请日：2011-07-19

    申请人： Douglas J. Adelman

    发明人： Douglas J. Adelman

    IPC分类号： C08B37/02

    CPC分类号： C08B37/0021 ,  A61K9/70 ,  A61L15/58 ,  C08B11/20 ,  C08B15/02 ,  C08B31/18 ,  C08B37/00 ,  C08B37/0057 ,  C08B37/0069 ,  C08B37/0072

    摘要： A method for making polysaccharide dialdehydes is disclosed, which uses a combination of precipitation and separation steps to purify the polysaccharide dialdehyde formed by oxidation of a polysaccharide with periodate. The method is simple, rapid, and provides a polysaccharide dialdehyde having very low levels of iodine-containing species and a low ash content. The polysaccharide dialdehyde is particularly suitable for preparing hydrogel adhesives for medical applications.

    摘要翻译： 公开了一种制备多糖二醛的方法，其使用沉淀和分离步骤的组合来纯化由多糖与高碘酸盐氧化形成的多糖二醛。 该方法简单，快速，提供了含有非常低含量碘含量和低灰分含量的多糖二醛。 多糖二醛特别适用于制备用于医疗应用的水凝胶粘合剂。

    Outer layer having entanglement of hydrophobic polymer host and hydrophilic polymer guest
    90.
    发明授权
    Outer layer having entanglement of hydrophobic polymer host and hydrophilic polymer guest 有权

    公开(公告)号：US08524886B2

    公开(公告)日：2013-09-03

    申请号：US12705753

    申请日：2010-02-15

    申请人： Susan P. James ,  Min Zhang ,  Guy Beauregard

    发明人： Susan P. James ,  Min Zhang ,  Guy Beauregard

    IPC分类号： C07H5/04 ,  C07H1/00

    CPC分类号： C08J9/42 ,  B05D5/00 ,  B29C67/24 ,  C08B37/00 ,  C08B37/0072 ,  C08L5/08 ,  C08L101/00 ,  Y10T428/249953 ,  Y10T428/31504 ,  Y10T428/31855 ,  Y10T428/31971 ,  C08L2666/02 ,  C08L2666/26

    摘要： An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. The intermingling of the guest and host includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer.