公开(公告)号：US20160161465A1

公开(公告)日：2016-06-09

申请号：US15041589

申请日：2016-02-11

Applicant: Axion BioSystems, Inc.

Inventor： Isaac Perry Clements ,  Amanda Jervis Preyer ,  Swaminathan Rajaraman ,  Daniel Christopher Millard ,  James David Ross

IPC: G01N33/483 ,  G01N21/01

CPC classification number: G01N33/4836 ,  B01L3/50853 ,  B01L2300/046 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/01 ,  G01N21/75 ,  G01N2021/015 ,  G01N2021/0346 ,  G01N2201/0446 ,  G01N2201/062

Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.

公开(公告)号：US09322784B2

公开(公告)日：2016-04-26

申请号：US13227761

申请日：2011-09-08

Applicant: Josef Grassl ,  Gerald Probst ,  Markus Schürf

Inventor： Josef Grassl ,  Gerald Probst ,  Markus Schürf

IPC: C12Q1/02 ,  C12M1/34 ,  G01N21/00 ,  G01N21/17 ,  G01N21/64 ,  C12M1/04 ,  G01N21/25 ,  G01N33/50 ,  G01N35/02 ,  B01L9/00 ,  G01J3/12 ,  G01N35/00

CPC classification number: G01N35/028 ,  B01L9/52 ,  C12M1/04 ,  C12M41/14 ,  C12M41/16 ,  C12Q1/02 ,  G01J3/12 ,  G01N21/253 ,  G01N21/6452 ,  G01N33/5005 ,  G01N2035/00356 ,  G01N2201/023 ,  G01N2201/0231 ,  G01N2201/0238 ,  G01N2201/0446 ,  G01N2201/06113

Abstract: A microplate reader and method has at least one measuring device and a holding device for accommodating at least one microplate and for positioning samples-containing wells of microplates in relation to the measuring device. The at least one measuring device is used for detecting light emitted by samples in wells of a microplate and/or which is influenced by samples transilluminated by light in the wells. The microplate reader has a control unit for controlling the composition of a gas atmosphere surrounding the wells containing the samples. A respective use is characterized particularly in that living cells are measured in a controlled gas atmosphere, wherein the living cells are chosen from microaerophilic, optionally anaerobic and obligatorily anaerobic microorganisms as well as fungi and eukaryotic cells.

Abstract translation: 微板读数器和方法具有至少一个测量装置和保持装置，用于容纳至少一个微孔板并且用于相对于测量装置定位含有微孔板的样品孔。 所述至少一个测量装置用于检测由微孔板的孔中的样品发射的光和/或受孔中由光透射的样品的影响。 微板读数器具有控制单元，用于控制包含样品的孔周围的气体气氛的组成。 各自的用途的特征在于，在受控气体气氛中测量活细胞，其中活细胞选自微需氧，任选的厌氧和强制性厌氧微生物以及真菌和真核细胞。

公开(公告)号：US20160025637A1

公开(公告)日：2016-01-28

申请号：US14877411

申请日：2015-10-07

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Kurt J. Halverson ,  Raymond J. Kenney ,  Olester Benson, JR. ,  Raymond P. Johnston ,  Guoping Mao ,  Patrick R. Fleming ,  George Van Dyke Tiers ,  Naiyong Jing

IPC: G01N21/75 ,  G01N21/64 ,  G01N21/55 ,  G01N21/31

CPC classification number: G01N21/75 ,  B01L3/50853 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0851 ,  B01L2300/0887 ,  B29C35/0888 ,  B29C59/046 ,  B29C59/08 ,  B29C59/10 ,  B29C59/14 ,  B29C59/16 ,  B29C2035/0827 ,  B29C2059/023 ,  G01N21/03 ,  G01N21/253 ,  G01N21/31 ,  G01N21/55 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/0346 ,  G01N2201/0446 ,  G01N2201/064 ,  G01N2201/08

Abstract: The disclosure provides microstructured articles and methods useful for detecting an analyte in a sample. The articles include microwell arrays. The articles can be used with an optical system component in methods to detect or characterize an analyte.

Abstract translation: 本公开提供了用于检测样品中的分析物的微结构化制品和方法。 文章包括微孔阵列。 在用于检测或表征分析物的方法中，物品可以与光学系统组件一起使用。

公开(公告)号：US20160025633A1

公开(公告)日：2016-01-28

申请号：US14775255

申请日：2014-03-14

Applicant: BIOGEN MA INC.

Inventor： Justin Moretto ,  Brandon Berry ,  Alex Doane

IPC: G01N21/65

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2201/0446 ,  G01N2201/06113

Abstract: In one aspect, the disclosure provides a method of defining a Raman signature of a culture component, the method comprising: obtaining a Raman spectrum of a culture component in a non-interfering or minimally-interfering solution, identifying peaks in the Raman spectrum that are associated with the culture component, obtaining a Raman spectrum of a culture medium comprising the culture component, and, removing peaks of the culture component in the Raman spectrum of the culture medium that are distorted compared to the peaks identified in the Raman spectrum of the culture component in a non-interfering or minimally-interfering solution.

Abstract translation: 一方面，本公开提供了一种限定培养组分的拉曼特征的方法，所述方法包括：获得非干扰或最小干扰溶液中培养组分的拉曼光谱，鉴定拉曼光谱中的峰，其为 与培养组分相关，获得包含培养组分的培养基的拉曼光谱，并且除去与在培养物的拉曼光谱中鉴定的峰相比变形的培养基的拉曼光谱中的培养成分的峰 在非干扰或最小干扰的解决方案中的组件。

公开(公告)号：US20150233815A1

公开(公告)日：2015-08-20

申请号：US14697012

申请日：2015-04-27

Applicant: TECAN TRADING AG

Inventor： Friedrich Menges ,  Harald Gebetsroither ,  Gyoergy Wenczel

IPC: G01N21/03 ,  G01N21/76 ,  G01N21/64

CPC classification number: G01N21/0303 ,  G01N21/6428 ,  G01N21/76 ,  G01N35/028 ,  G01N35/04 ,  G01N2021/036 ,  G01N2035/00287 ,  G01N2035/0405 ,  G01N2201/022 ,  G01N2201/0446 ,  Y10S436/807

Abstract: Microplate reader has a housing, at least one optical measuring/detection device, a microplate support, a moving unit and an integrated lid holding apparatus. The lid holding apparatus moves the microplate in one respective, at least approximately vertical direction for moving the microplate lid away from the microplate. The lid holding apparatus is arranged inside the housing as a magnetic lifter and comprises a non-array arrangement of at least one permanent magnet, or at least three electro magnets, or at least one switchable permanent magnet. Each microplate lid to be moved away from the microplate comprises magnetizable material with a physical area. A projected area of the at least one permanent magnet, electro magnet, or switchable permanent magnet is smaller than the physical area of the magnetizable material of the microplate lid.

Abstract translation: 酶标板读取器具有壳体，至少一个光学测量/检测装置，微孔板支架，移动单元和一体式盖保持装置。 盖保持装置使微板在一个相应的至少大致垂直的方向上移动，以使微板盖远离微板。 盖保持装置作为磁性提升器布置在壳体内部，并且包括至少一个永磁体或至少三个电磁体或至少一个可切换永磁体的非阵列布置。 每个微板盖要移动离开微板包括具有物理区域的可磁化材料。 所述至少一个永磁体，电磁体或可切换永磁体的投影面积小于微板盖板的可磁化材料的物理面积。

公开(公告)号：US20150204786A1

公开(公告)日：2015-07-23

申请号：US14674267

申请日：2015-03-31

Applicant: SONY CORPORATION

Inventor： AYUMU TAGUCHI

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N21/6454 ,  G01N21/6486 ,  G01N2021/6471 ,  G01N2021/6482 ,  G01N2201/0446 ,  G01N2201/061

Abstract: An emission intensity measuring device includes a light receiving unit that is disposed opposed to a biochip having a plurality of compartments in which a sample is housed, and includes a plurality of light receiving elements that are arranged, and a determining section that determines a weighting rate of each of the light receiving elements based on a noise characteristic of the light receiving element, acquired in advance. The emission intensity measuring device further includes a multiplying section that multiplies the output of each of the light receiving elements by the weighting rate to calculate a weighted output of each of the light receiving elements, and an adding section that adds the weighted outputs of the light receiving elements opposed to a respective one of the compartments.

Abstract translation: 一种发光强度测量装置，包括：光接收单元，其与具有容纳有样品的多个隔室的生物芯片相对设置，并且包括布置的多个光接收元件;以及确定部，其确定加权率 基于预先获取的光接收元件的噪声特性的每个光接收元件。 发光强度测量装置还包括：乘法部分，用于将每个光接收元件的输出乘以加权速率，以计算每个光接收元件的加权输出;以及相加部分，其将光的加权输出相加 接收元件与相应的一个隔室相对。

公开(公告)号：US20150119298A1

公开(公告)日：2015-04-30

申请号：US14500399

申请日：2014-09-29

Applicant: Fluidigm Corporation

Inventor： Gang Sun ,  Greg Harris ,  Andy May ,  Kyle Self ,  Kevin Farrell ,  Paul Wyatt

IPC: G01N35/00

CPC classification number: G01N35/00029 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/06 ,  B01L2300/0654 ,  B01L2300/0829 ,  C12Q1/686 ,  G01N15/1475 ,  G01N21/6428 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/1065 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00752 ,  G01N2035/0091 ,  G01N2035/1034 ,  G01N2201/025 ,  G01N2201/0446 ,  Y10S901/01 ,  Y10T436/11

Abstract: A system for performing one or more microfluidic processes includes an integrated fluidic device comprising a plurality of well regions and a plurality of control valves and a workflow manager. The system also includes a transfer robot adapted to transfer the integrated fluidic device between a plurality of stations in response to a series of instructions from the workflow manager and a first station comprising a dispensing robot adapted to dispense at least one of a plurality of sample solutions and at least one of a plurality of reagents into the integrated fluidic device. The system further includes a second station comprising a fluidic controller unit and a third station comprising an inspection station.

Abstract translation: 用于执行一个或多个微流程过程的系统包括包括多个井区域和多个控制阀以及工作流程管理器的集成流体设备。 该系统还包括传送机器人，其适于响应于来自工作流程管理器的一系列指令而在多个站之间传送集成流体设备，第一站包括分配机器人，其适于分配多个样品溶液中的至少一个样品溶液 和多个试剂中的至少一种进入集成流体装置。 该系统还包括第二站，其包括流体控制器单元和包括检查站的第三站。

公开(公告)号：US20140343860A1

公开(公告)日：2014-11-20

申请号：US14133199

申请日：2013-12-18

Applicant: NEXUS DX, INC.

Inventor： Richard EGAN ,  Graham LIDGARD ,  David BOOKER

IPC: G01N21/01 ,  G01N21/84 ,  G01N33/487

CPC classification number: G01N21/01 ,  G01N21/84 ,  G01N21/8483 ,  G01N33/487 ,  G01N2201/0446 ,  G01N2201/126 ,  G16H10/40 ,  Y02A90/26

Abstract: A diagnostic assay system including a test device and a scanning device are described. In one implementation, the scanning device includes a source of electromagnetic radiation, an optics assembly, a detector, and a microprocessor disposed within a chassis. The test device and scanning device may be configured to be movable relative to each other during operation of the scanning device.

Abstract translation: 描述了包括测试装置和扫描装置的诊断测定系统。 在一个实施方式中，扫描装置包括电磁辐射源，光学组件，检测器和布置在底盘内的微处理器。 测试装置和扫描装置可以被配置为在扫描装置的操作期间可相对于彼此移动。

公开(公告)号：US08236504B2

公开(公告)日：2012-08-07

申请号：US12827521

申请日：2010-06-30

Applicant: Igor Kordunsky ,  Jeffrey A. Goldman ,  Michael J. Finney

Inventor： Igor Kordunsky ,  Jeffrey A. Goldman ,  Michael J. Finney

IPC: C12Q1/68 ,  C12P19/34

CPC classification number: C12Q1/686 ,  B01L7/52 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1822 ,  G01N21/276 ,  G01N21/6452 ,  G01N2201/0446

Abstract: A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module is removable from the support structure to allow easy replacement.

Abstract translation: 提供了用于分析位于热循环仪中的多个孔中的样品的荧光检测装置和使用方法。 在一个实施例中，该装置包括可附接到热循环仪的支撑结构和可移动地安装在支撑结构上的检测模块。 检测模块包括一个或多个通道，每个通道具有设置在检测模块内的激发光发生器和发射光检测器。 当支撑结构附接到热循环仪并且检测模块安装在支撑结构上时，检测模块可移动以便定位成与多个井中的不同井的光通信。 检测模块可从支撑结构移除，以方便更换。

公开(公告)号：US20120196775A1

公开(公告)日：2012-08-02

申请号：US13326021

申请日：2011-12-14

Applicant: Ayumu Taguchi

Inventor： Ayumu Taguchi

IPC: C40B60/12

CPC classification number: G01N21/6452 ,  G01N21/6454 ,  G01N21/6486 ,  G01N2021/6471 ,  G01N2021/6482 ,  G01N2201/0446 ,  G01N2201/061

Abstract: An emission intensity measuring device includes a light receiving unit that is disposed opposed to a biochip having a plurality of compartments in which a sample is housed, and includes a plurality of light receiving elements that are arranged, and a determining section that determines a weighting rate of each of the light receiving elements based on a noise characteristic of the light receiving element, acquired in advance. The emission intensity measuring device further includes a multiplying section that multiplies the output of each of the light receiving elements by the weighting rate to calculate a weighted output of each of the light receiving elements, and an adding section that adds the weighted outputs of the light receiving elements opposed to a respective one of the compartments.

Abstract translation: 一种发光强度测量装置，包括：光接收单元，其与具有容纳有样品的多个隔室的生物芯片相对设置，并且包括布置的多个光接收元件;以及确定部，其确定加权率 基于预先获取的光接收元件的噪声特性的每个光接收元件。 发光强度测量装置还包括：乘法部分，用于将每个光接收元件的输出乘以加权速率，以计算每个光接收元件的加权输出;以及相加部分，其将光的加权输出相加 接收元件与相应的一个隔室相对。