公开(公告)号：US09486470B2

公开(公告)日：2016-11-08

申请号：US14832417

申请日：2015-08-21

申请人： University of South Florida

发明人： Jin Q. Cheng ,  Said M. Sebti

IPC分类号： A61K31/70 ,  A61K31/7052 ,  A61K31/7064 ,  A61K31/7076 ,  A61K31/282 ,  A61K31/555 ,  A61K31/706 ,  A61K39/395 ,  C12Q1/48 ,  A61K9/00 ,  A61K33/24 ,  G01N33/574

CPC分类号： A61K31/7064 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/282 ,  A61K31/555 ,  A61K31/706 ,  A61K31/7076 ,  A61K33/24 ,  A61K39/39558 ,  C12Q1/485 ,  G01N33/57496 ,  G01N2333/91205

摘要： This application encompasses combination therapies including triciribine and related compounds and one or more platinum compounds and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.

公开(公告)号：US09473831B2

公开(公告)日：2016-10-18

申请号：US14523526

申请日：2014-10-24

申请人： MASTINC.

发明人： Brian Von Herzen ,  Steven Van Fleet

IPC分类号： H04Q9/00

CPC分类号： G01N33/30 ,  B01D35/143 ,  B01D2201/54 ,  F01M11/10 ,  F16N29/00 ,  F16N2250/00 ,  F16N2270/50 ,  G01M15/042 ,  G01M15/048 ,  G01M15/05 ,  G01M15/09 ,  G01N21/95 ,  G01N27/02 ,  G01N27/74 ,  G01N29/02 ,  G01N33/2888 ,  G06F17/10 ,  H04Q9/00

摘要： This invention encompasses embodiments for multi-modal integrated simultaneous measurement of various aspects of fluids contained in circulating systems such as automotive reciprocating engines and vehicle transmissions. These circulating systems perform constant internal lubrication, and heat and contaminant removal to protect the internal moving parts from the inherent friction and damage in normal operation. Most commonly this is achieved with fluids based on hydrocarbon and/or related synthetics, which, over time, can lose their protective properties, and vary in their performance or breakdown/decay due to internal and external events. Several components within the lubricant fluid can be measured and can provide insight into the efficacy of the system to perform its designed mission. Described herein is a real-time, simultaneous, integrated, multi-modal sensor system for early warning notification that can be further enhanced using specifically designed nanoparticles that can be introduced into the system, engineered to specifically bind with the contaminants and/or undergo an irreversible state change upon certain experienced conditions to both increase the detectability as well as provide for a framework to improve filter performance.

公开(公告)号：US09457040B2

公开(公告)日：2016-10-04

申请号：US14832400

申请日：2015-08-21

申请人： University of South Florida

发明人： Jin Q. Cheng

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K31/7064 ,  C07H19/23 ,  A61K31/7042 ,  A61K31/7052 ,  G01N33/574

CPC分类号： A61K31/7064 ,  A61K9/0019 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  C07H19/23 ,  G01N33/57407 ,  G01N2333/912

摘要： The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat esophogeal adenocarcinoma by one or a combination of (i) administering triciribine only to patients which according to a diagnostic test described below, exhibit enhanced sensitivity to the drug; (ii) use of a described dosage level that minimizes the toxicity of the drug but yet still exhibits efficacy; or (iii) use of a described dosage regimen that minimizes the toxicity of the drug.

摘要翻译： 发明人已经确定，与现有技术和经验相反，如何成功地使用三苯呋嗪来治疗卵巢癌，其中一种或其组合（i）仅对根据下述诊断试验的患者给予三苯呋嗪，表现出对 药物; （ii）使用使药物的毒性最小化但仍显示功效的所述剂量水平; 或（iii）使用最小化药物的毒性的所述剂量方案。

公开(公告)号：US09429567B2

公开(公告)日：2016-08-30

申请号：US14127422

申请日：2012-06-22

申请人： Toshihiro Nakajima

发明人： Toshihiro Nakajima

IPC分类号： C12Q1/68 ,  G01N33/50

CPC分类号： G01N33/5044 ,  C12Q1/6883 ,  C12Q2600/136 ,  G01N33/5008 ,  G01N2333/9015

摘要： The present invention relates to a method for screening substances having weight-regulating action.

摘要翻译： 本发明涉及一种筛选具有体重调节作用的物质的方法。

公开(公告)号：US09406834B2

公开(公告)日：2016-08-02

申请号：US14269152

申请日：2014-05-04

申请人： HITACHI CHEMICAL COMPANY, LTD.

发明人： Akihiro Orita ,  Masato Yoshida ,  Takeshi Nojiri ,  Yoichi Machii ,  Mitsunori Iwamuro ,  Shuichiro Adachi ,  Tetsuya Sato ,  Toru Tanaka

IPC分类号： H01L35/24 ,  H01L31/18 ,  C08K3/22 ,  C08K5/05 ,  H01L23/29 ,  H01L23/31 ,  H01L31/0216 ,  H01L31/068 ,  C09D127/18 ,  H01L21/02 ,  H01L21/306 ,  C08J5/24 ,  C08K3/28 ,  C08K3/34 ,  B82Y10/00 ,  H01L51/00 ,  H01L51/05 ,  H01L51/50

CPC分类号： H01L31/1868 ,  B82Y10/00 ,  C08J5/24 ,  C08J2363/00 ,  C08J2425/08 ,  C08J2433/24 ,  C08K3/22 ,  C08K3/28 ,  C08K3/34 ,  C08K5/05 ,  C09D127/18 ,  H01L21/02118 ,  H01L21/02282 ,  H01L21/30604 ,  H01L23/293 ,  H01L23/3171 ,  H01L31/02168 ,  H01L31/068 ,  H01L31/1804 ,  H01L51/0036 ,  H01L51/0541 ,  H01L51/0545 ,  H01L51/5012 ,  H01L2924/0002 ,  Y02E10/547 ,  Y02P70/521 ,  H01L2924/00

摘要： The invention provides a material for forming a passivation film for a semiconductor substrate. The material includes a polymer compound having an anionic group or a cationic group.

摘要翻译： 本发明提供一种用于形成用于半导体衬底的钝化膜的材料。 该材料包括具有阴离子基团或阳离子基团的高分子化合物。

公开(公告)号：US09293610B2

公开(公告)日：2016-03-22

申请号：US13808526

申请日：2011-07-04

申请人： Hiroshi Yamaguchi ,  Mitsuo Umezawa ,  Makoto Yanagisawa ,  Masaki Yaginuma ,  Satoshi Maeda

发明人： Hiroshi Yamaguchi ,  Mitsuo Umezawa ,  Makoto Yanagisawa ,  Masaki Yaginuma ,  Satoshi Maeda

IPC分类号： H01L31/048 ,  C09J133/04 ,  C09D133/04 ,  C09D175/04 ,  C09J7/02 ,  H01L31/0216 ,  C08G18/62 ,  C08G18/80 ,  C08G18/81 ,  C09J175/16

CPC分类号： H01L31/02167 ,  C08G18/6229 ,  C08G18/6237 ,  C08G18/807 ,  C08G18/8116 ,  C09D133/04 ,  C09D175/04 ,  C09J7/20 ,  C09J133/04 ,  C09J175/16 ,  H01L31/048 ,  H01L31/0481 ,  H01L31/049 ,  Y02E10/50 ,  Y10T428/2887

摘要： To overcome a problem in related art and to provide an easy-adhesive having an excellent adhesive property and an excellent adhesive durability for a solar cell rear surface protection sheet, a solar cell rear surface protection sheet, and a solar cell module formed by using the solar cell rear surface protection sheet. An easy-adhesive for a solar cell rear surface protection sheet according to the present invention exhibits a specific glass transition temperature, a specific number average molecular weight, and a specific hydroxyl value. Further, the easy-adhesive for a solar cell rear surface protection sheet contains a (meth)acrylic-based copolymer (A) that contains a carbon-carbon double bond in a side chain at a specific rate, and a polyisocyanate compound (B) at a specific rate.

摘要翻译： 为了克服现有技术中的问题并且提供一种对于太阳能电池背面保护片，太阳能电池背面保护片和太阳能电池组件具有优异的粘合性和优异的粘合耐久性的易粘合剂，并且通过使用 太阳能电池背面保护板。 根据本发明的用于太阳能电池背面保护片的易粘合剂显示出特定的玻璃化转变温度，特定的数均分子量和特定的羟值。 此外，太阳能电池背面保护片的易粘合剂含有在侧链中以特定比例含有碳 - 碳双键的（甲基）丙烯酸系共聚物（A）和多异氰酸酯化合物（B） 以特定的速率。

公开(公告)号：US09293265B1

公开(公告)日：2016-03-22

申请号：US14565052

申请日：2014-12-09

申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Jeung Ku Kang ,  Gede Widia Pratama Adhyaksa ,  Dong Ki Lee ,  Il Woo Ock

IPC分类号： H01G9/20

CPC分类号： H01G9/2004 ,  H01G9/2022 ,  H01G9/2031 ,  H01G9/2059 ,  H01L51/0093 ,  Y02E10/542 ,  Y02E10/549

摘要： Disclosed is a technique for fabricating a bio-photovoltaic cell which includes coupling graminoids extracted from natural grasses to a semiconductor electron acceptor, on which plasmonic silver nanoparticles are aligned, by using an organic ligand material. More particularly, disclosed is a technique for fabricating a new renewable energy generation device useable for fabrication of high efficiency bio-photovoltaic cells by improving a photo-electron generation rate of graminoids through a surface plasmon effect of silver nanoparticles and increasing an effective photo-electron amount transferred to the electron acceptor due to optimized bonding between a photo sensitizer and an electron acceptor.

摘要翻译： 公开了一种用于制造生物光伏电池的技术，其包括通过使用有机配体材料将从天然草提取的graminids与其上等离子体银纳米粒子对准的半导体电子受体耦合。 更具体地，公开了一种用于制造可用于制造高效率生物光伏电池的新的可再生能源发生装置的技术，其通过银纳米颗粒的表面等离子体效应改善葛氨酸的光电子产生速率并增加有效的光电子 由于光敏剂和电子受体之间的优化结合，转移到电子受体的量。

公开(公告)号：US09249178B2

公开(公告)日：2016-02-02

申请号：US14385050

申请日：2013-03-15

申请人： UNIVERSITÄT BERN

发明人： Christian Leumann ,  Branislav Dugovic ,  Jory Liétard

IPC分类号： C07H21/02 ,  C07H21/04 ,  C07H21/00 ,  C07H19/16 ,  C07H19/04 ,  C07H19/02 ,  C07H19/06

CPC分类号： C07F9/65517 ,  C07H19/02 ,  C07H19/04 ,  C07H19/06 ,  C07H19/16 ,  C07H21/00 ,  C12N15/113 ,  C12N2310/11

摘要： The present invention provides novel tricyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound is expected to enhance one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions. In certain embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.

摘要翻译： 本发明提供由其制备的新型三环核苷和寡聚化合物。 预期将一种或多种三环核苷掺入低聚化合物可增强寡聚化合物的一种或多种性质。 这种低聚化合物也可以包括在双链组合物中。 在某些实施方案中，预期本文提供的寡聚化合物与靶RNA的一部分杂交，导致靶RNA的正常功能丧失。

公开(公告)号：US09220692B2

公开(公告)日：2015-12-29

申请号：US13101929

申请日：2011-05-05

申请人： Charles E. DiLiberti ,  Anu Mahashabde

发明人： Charles E. DiLiberti ,  Anu Mahashabde

IPC分类号： A61F6/06 ,  A61K31/00 ,  A61K31/137 ,  A61K31/465 ,  A61K31/515 ,  A61K31/522 ,  A61K31/551 ,  A61M31/00 ,  A61M37/00

CPC分类号： A61K31/00 ,  A61K31/137 ,  A61K31/465 ,  A61K31/515 ,  A61K31/522 ,  A61K31/551 ,  A61M31/002 ,  A61M37/00

摘要： The present invention is directed to methods of reducing symptoms associated with an abrupt reduction in an endogenous or exogenous chemical in subjects, the methods comprising: (a) administering to the subject a single dosage form comprising an active agent, wherein the release rate of the active agent from the single dosage form tapers throughout the administration; and (b) removing the single dosage form from the subjects after the release rate of the active agent is at or below a terminal symptom threshold level.

摘要翻译： 本发明涉及减少与受试者内源或外源化学物质突然减少有关的症状的方法，所述方法包括：（a）向受试者施用包含活性剂的单一剂型，其中， 单剂量活性剂在整个给药过程中逐渐变细; 和（b）在活性剂的释放速率处于或低于终末症状阈值水平之前，从受试者中除去单一剂型。

公开(公告)号：US09150912B2

公开(公告)日：2015-10-06

申请号：US14115785

申请日：2012-05-04

申请人： Daniel Müller ,  Francesca Di Pasquale

发明人： Daniel Müller ,  Francesca Di Pasquale

IPC分类号： C07H17/00 ,  C07H21/02 ,  C07H21/04 ,  C07H19/04 ,  C12Q1/68 ,  B01L3/00 ,  C07H21/00

CPC分类号： C12Q1/6853 ,  C07H21/00 ,  C12Q1/6813 ,  C12Q1/686 ,  C12Q1/6876 ,  C12Q2525/197 ,  C12Q2563/107 ,  C12Q2525/125 ,  C12Q2565/125 ,  C12Q2565/629

摘要： The present application discloses a labeled nucleotide comprising a label attached via a linker, wherein said labeled nucleotide has the formula wherein R1 is a residue with a negative net charge, preferably selected from the group consisting of a phosphate group, and a sulphate group; wherein R2, R3 and R4 are independently selected from the group consisting of H2, OH2, and O; wherein “n” is an integer between 0 and 16; wherein “a” is an integer between 1 and 10; wherein SP is absent or a spacer; wherein X is said label; and wherein Y is a nucleotide or nucleoside. Furthermore, oligonucleotides comprising a labeled nucleotide according to the present invention and the use as a primer in amplification based methods is disclosed herein.

摘要翻译： 本申请公开了一种标记的核苷酸，其包含通过连接体连接的标记，其中所述标记的核苷酸具有下式：其中R1是具有负净电荷的残基，优选选自磷酸酯基和硫酸酯基; 其中R2，R3和R4独立地选自H 2，OH 2和O; 其中“n”为0至16之间的整数; 其中“a”为1至10之间的整数; 其中SP不存在或间隔物; 其中X是所述标签; 并且其中Y是核苷酸或核苷。 此外，本文公开了包含根据本发明的标记的核苷酸的寡核苷酸和基于扩增的方法作为引物的用途。