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18 条记录 (耗时 0.016 秒)

    Devices and methods for on-line whole blood treatment
    1.
    发明授权
    Devices and methods for on-line whole blood treatment 有权

    公开(公告)号：US10744258B1

    公开(公告)日：2020-08-18

    申请号：US15913729

    申请日：2018-03-06

    申请人： Qualigen Inc.

    发明人： Michael Poirier

    IPC分类号： A61M5/00 ,  A61M5/165 ,  B01D15/38 ,  B01D15/18 ,  B01D15/20 ,  A61M27/00

    摘要： A whole blood treatment device includes a first conduit, a second conduit, and a rotating or reciprocating element having a channel. The first and second conduits are fluidly coupled to the rotating or reciprocating element such that the channel is fluidly continuous with the first conduit when the channel is fluidly discontinuous with the second conduit, and such that the channel is fluidly discontinuous with the first conduit when the channel is fluidly continuous with the second conduit. The first conduit is configured to receive whole blood, and the second conduit is configured to receive a regeneration fluid. The channel comprises a surface that is modified with an affinity agent at a concentration effective to allow removal of a target compound from whole blood.

    WHOLE BLOOD TREATMENT DEVICE AND METHODS OF REMOVING TARGET AGENTS FROM WHOLE BLOOD
    2.
    发明申请
    WHOLE BLOOD TREATMENT DEVICE AND METHODS OF REMOVING TARGET AGENTS FROM WHOLE BLOOD 有权

    公开(公告)号：US20220143291A1

    公开(公告)日：2022-05-12

    申请号：US17434107

    申请日：2020-02-26

    申请人： Qualigen Inc.

    发明人： Michael Poirier

    IPC分类号： A61M1/36 ,  A61P39/06

    摘要： A whole blood treatment device includes a cartridge configured to receive whole blood, having a wall defining an interior volume, an inlet, and an outlet, a support structure having a surface, inside of the cartridge, and an affinity agent, attached to the surface of the support structure. The affinity agent is effective to bind to a target agent that is desirable for removal from a patient. The target agent is selected from the group consisting of: inhibitory checkpoint molecules, inflammatory factors, cancerous cells, autoantibodies, opioids and heavy metals. A method of removing a target agent from whole blood of a patient in a whole blood treatment device comprising pumping whole blood into a cartridge, containing a support structure having a surface, with a plurality of affinity agents on the support structure, to contact the whole blood with the affinity agents; binding the target agent with the affinity agents; and removing the whole blood having a reduced amount of the target agent from the cartridge. The target agent is selected from the group consisting of: inhibitory checkpoint molecules, inflammatory factors, cancerous cells, autoantibodies, opioids and heavy metals.

    Methods and apparatus for separation of biological fluids
    5.
    发明申请
    Methods and apparatus for separation of biological fluids 有权
    用于分离生物液体的方法和装置

    公开(公告)号：US20020052008A1

    公开(公告)日：2002-05-02

    申请号：US09949314

    申请日：2001-09-07

    申请人： Qualigen, Inc.

    发明人： Vijay Mahant ,  Byron Doneen

    IPC分类号： G01N033/53

    CPC分类号： G01N1/34 ,  G01N33/491 ,  G01N2001/4016 ,  Y10T436/25375 ,  Y10T436/255

    摘要： A method of separating a cell-containing sample into a substantially cell-depleted portion, and a cell-containing portion comprising at least one of a stem cell, a lymphocyte, and a leukocyte comprises a step in which the sample is received in a vessel with at least one flexible wall. In another step, an additive and particles are added to the sample, wherein the additive substantially binds to the at least one of the stem cell, lymphocyte, and leukocyte, and the particles and wherein the particles substantially bind to the at least one of the stem cell, lymphocyte, and leukocyte, and the additive, thereby producing a cell-containing network. In a further step, the network is separated from the substantially cell-depleted portion by applying a magnetic force.

    摘要翻译： 将含有细胞的样品分离成基本上细胞贫乏的部分的方法和包含干细胞，淋巴细胞和白细胞中的至少一种的含细胞部分包括将样品容纳在容器中的步骤 至少有一个柔性墙。 在另一步骤中，向样品中加入添加剂和颗粒，其中所述添加剂基本上结合至干细胞，淋巴细胞和白细胞中的至少一种，以及所述颗粒，并且其中所述颗粒基本上结合至所述至少一种 干细胞，淋巴细胞和白细胞，以及添加剂，从而产生含细胞的网络。 在另一步骤中，通过施加磁力将网络与基本上细胞耗尽的部分分离。

    System and method of using multi-chambered receptacles
    10.
    发明授权
    System and method of using multi-chambered receptacles 有权

    公开(公告)号：US10688458B2

    公开(公告)日：2020-06-23

    申请号：US15485330

    申请日：2017-04-12

    申请人： GEN-PROBE INCORPORATED ,  QUALIGEN, INC.

    发明人： Scott S. Breidenthal ,  Richard S. Lee ,  Norman C. Nelson ,  Matthew J. Scott ,  Jason A. Taylor

    IPC分类号： B01L3/00 ,  B01F11/00 ,  B01F13/00 ,  B01L7/00 ,  G01N21/64 ,  B01F15/00 ,  G01N21/01 ,  C12Q1/6844 ,  G01N35/00 ,  C12N15/10 ,  B01F3/12 ,  C12Q1/6806

    摘要： A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.