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公开(公告)号：US20240361213A1
公开(公告)日：2024-10-31
申请号：US18766072
申请日：2024-07-08
发明人： Sheelah Ching CHANGHO , Michael Allen GURNEY , Grishma KHANAL , Laurel Anne Katharine MCKEE , John Douglas PALTING , Woody Yuh-Fan PERNG
CPC分类号： G01N1/31 , G01N2001/302
摘要： A method of depigmenting melanin-pigmented samples is provided. The sample is incubated in the presence of a hydrogen peroxide-based solution at a temperature less than 65° C. for up to 180 minutes. Times, temperatures, and concentrations of hydrogen peroxide that appropriately balance extent of depigmentation with maintenance of cellular morphology and sample retention are also disclosed.
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公开(公告)号：US20240347177A1
公开(公告)日：2024-10-17
申请号：US18752731
申请日：2024-06-24
IPC分类号： G16H30/40 , G06F3/0482 , G06F3/04845 , G16H30/20
CPC分类号： G16H30/40 , G06F3/0482 , G06F3/04845 , G16H30/20 , G06F2203/04803 , G06F2203/04806
摘要： A method, system, and computer program product for an image visualization system (120) that includes a contextually adaptive digital pathology interface. At least one image of a biological sample stained for the presence of one or more biomarkers is obtained (300). The image is displayed on a display screen at a first zoom level (310), in which a first subset of user selectable elements is contemporaneously displayed (320). As a result of user input, the image being is displayed at a second zoom level (330), in which a second subset of user selectable elements are contemporaneously displayed with the image (340). The one or more elements within the second subset of user selectable elements are disabled or hidden at the first zoom level, or one or more elements within the first subset of user selectable elements are disabled or hidden at the second zoom level.
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公开(公告)号：US20240304006A1
公开(公告)日：2024-09-12
申请号：US18668118
申请日：2024-05-17
IPC分类号： G06V20/69
CPC分类号： G06V20/69
摘要： The present disclosure provides for image processing systems and methods for analyzing digital images of biological samples stained for the presence of protein and/or nucleic acid biomarkers and detecting and quantifying signals corresponding to one or more biomarkers. The present disclosure also provides systems and methods for the clinical interpretation of dual ISH slides where the cells to score are selected (e.g. by using one or more cell detection and identification algorithms. By detecting, identifying, and selecting cells for assessment, it is believed that subjectivity is reduced or eliminated. The systems and methods also allow for an increased number of cells to be considered for scoring as compared with manual dot counting methods, thereby increasing detection sensitivity, ultimately enabling improved patient care and treatment.
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公开(公告)号：US20240272043A1
公开(公告)日：2024-08-15
申请号：US18582749
申请日：2024-02-21
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , G01N2001/302
摘要： Presented herein are methods of improving the consistency of staining with a counterstain. In some embodiments, the method makes use of an automated specimen processing apparatus or other staining device. In some embodiments, the staining methods are applied manually. In some embodiments, the counterstain includes eosin.
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公开(公告)号：US20240210288A1
公开(公告)日：2024-06-27
申请号：US18599067
申请日：2024-03-07
发明人： Nelson Alexander , Aoune Barhoumi , Melinda Day , Lisa Gallegos , Katherine Leith , Samantha Rajkovich , Esteban Roberts , Stacey Stanislaw , Eric Walk
IPC分类号： G01N1/28 , A01N1/02 , G01N1/30 , G01N1/36 , G01N33/483
CPC分类号： G01N1/286 , A01N1/0226 , A01N1/0278 , G01N1/30 , G01N1/36 , G01N33/4833 , G01N2001/2866 , G01N2001/368
摘要： The disclosure generally relates to the preparation of representative samples from clinical samples, e.g., tumors (whole or in part), lymph nodes, metastases, cysts, polyps, or a combination or portion thereof, using mechanical and/or biochemical dissociation methods to homogenize intact samples or large portions thereof. The resulting homogenate provides the ability to obtain a correct representative sample despite spatial heterogeneity within the sample, increasing detection likelihood of low prevalence subclones, and is suitable for use in various diagnostic assays as well as the production of therapeutics, especially “personalized” anti-tumor vaccines or immune cell based therapies.
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公开(公告)号：US11971387B2
公开(公告)日：2024-04-30
申请号：US17228743
申请日：2021-04-13
发明人： Daniel Bauer , Michael Otter , Benjamin Stevens
CPC分类号： G01N29/024 , G01N29/07 , G01N29/4418 , G01N1/30 , G01N2291/012 , G01N2291/02475
摘要： The subject disclosure presents systems and computer-implemented methods for determining an acoustic time-of-flight (TOF) of sound waves through a sample material with greater accuracy and in a more repeatable fashion, by invoking one or more of an envelope generation for an error function, fitting a non-linear curve to an ultrasound frequency sweep, or performing a clustered piece-wise linear regression on individual linear parts of the ultrasonic frequency sweep. The systems and methods are useful for, among other things, monitoring diffusion of fluids through porous materials, such as tissue samples.
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公开(公告)号：US11971333B2
公开(公告)日：2024-04-30
申请号：US16828802
申请日：2020-03-24
发明人： Nils B. Adey , Dale B. Emery , Leonid Fomin , Rene M. Guerrero , Emmanuel Naouri , Robert J. Parry , Peter Romanowich
CPC分类号： G01N1/06 , G01N1/04 , G01N1/286 , G05B15/02 , G01N2001/061 , G01N2001/383 , G01N33/4833
摘要： A system, an instrument, a computer-implemented method, and a clinical workflow for mesodissection of biological specimens on tissue slides by incorporating annotations. An image of an annotated reference slide is acquired and transposed onto a plurality of serial samples on the tissue slides along with the corresponding annotations and metadata. The serial samples are milled based on the annotations, and the milled tissue is automatically collected along with a milling buffer solution inside milling tips, and then dispensed in designated collection vials. The instrument automates the filling of aqueous buffer inside the milling tips and the monitoring of the buffer solution and the sequential filling of the milling tips. The workflow provides an integrated interface that performs tissue annotation, alignment, dissection, tracking, and reporting on a single screen. The degree of precision, ease of use and repeatability will improve PCR and NGS test results, ultimately providing timely patient results.
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公开(公告)号：US20240135532A1
公开(公告)日：2024-04-25
申请号：US18389714
申请日：2023-12-19
发明人： Srinivas Chukka , Ting Chen
CPC分类号： G06T7/0012 , G06T7/90 , G06V20/698 , G06T2207/10024 , G06T2207/10056 , G06T2207/30024 , G06T2207/30204
摘要： Systems and methods described herein relate, among other things, to unmixing more than three stains, while preserving the biological constraints of the biomarkers. Unlimited numbers of markers may be unmixed from a limited-channel image, such as an RGB image, without adding any mathematical complicity to the model. Known co-localization information of different biomarkers within the same tissue section enables defining fixed upper bounds for the number of stains at one pixel. A group sparsity model may be leveraged to explicitly model the fractions of stain contributions from the co-localized biomarkers into one group to yield a least squares solution within the group. A sparse solution may be obtained among the groups to ensure that only a small number of groups with a total number of stains being less than the upper bound are activated.
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公开(公告)号：US11959931B2
公开(公告)日：2024-04-16
申请号：US17326760
申请日：2021-05-21
发明人： Aaron Ewoniuk , Dylan Miller , Kevin Talucci
IPC分类号： G01N35/10 , B01L3/02 , G01F15/075 , G01F22/00 , G01N1/31 , G01N15/14 , G01N35/00 , G01N15/10
CPC分类号： G01N35/1016 , B01L3/0241 , G01F15/075 , G01F22/00 , G01N1/312 , G01N15/1459 , G01N35/00663 , G01N35/00722 , G01N35/1002 , B01L2200/061 , B01L2200/14 , B01L2200/143 , G01N2015/1075 , G01N2015/1493 , G01N2035/00673 , G01N2035/009
摘要： A system and method for dispense characterization is disclosed. According to particular embodiments of the dispense characterization system and method, volumes of dispensed liquids can be determined. In more particular embodiments, additional characteristics and combinations of characteristics of a liquid dispensing event can be determined. Examples of additional characteristics that can be determined include the shape of the dispensing event, the velocity of the dispensing event, and the trajectory of the dispensing event. The dispense characterization system and method can be employed in automated biological sample analysis systems, and are particularly suited for monitoring liquid reagent dispensing events that deliver liquid reagents to a surface of a microscope slide holding a biological sample.
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公开(公告)号：US11959840B2
公开(公告)日：2024-04-16
申请号：US16721054
申请日：2019-12-19
CPC分类号： G01N1/30 , G01N29/07 , G01N29/4418 , G01N1/31 , G01N2291/02475 , G01N2291/02491
摘要： A tissue sample that has been removed from a subject can be evaluated. A change in speed of the energy traveling through the sample is evaluated to monitor changes in the biological sample during processing. The monitoring can detect movement of fluid with the sample and cross-linking. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy.
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