Compounds for modulating integrin CD11b/CD18
    4.
    发明授权
    Compounds for modulating integrin CD11b/CD18 有权
    用于调节整合蛋白CD11b / CD18的化合物

    公开(公告)号:US08846667B2

    公开(公告)日:2014-09-30

    申请号:US13614046

    申请日:2012-09-13

    摘要: The application describes an assay for the identification of small molecule modulators of integrin CD11b/CD18 and small molecules capable of modulating activity of this receptor. Such compounds may be used in certain embodiments for treating a disease or condition selected from inflammation, immune-related disorders, cancer, ischemia-reperfusion injury, stroke, neointimal thickening associated with vascular injury, bullous pemphigoid, neonatal obstructive nephropathy, and cardiovascular disease, or in other embodiments for the treatment of a disease or condition selected from immune deficiency, acquired immune deficiency syndrome (AIDS), myeloperoxidase deficiency, Wiskott-Aldrich syndrome, chronic granulomatous disease, hyper-IgM syndromes, leukocyte adhesion deficiency, Chediak-Higashi syndrome, and severe combined immunodeficiency.

    摘要翻译: 该应用描述了用于鉴定整合素CD11b / CD18的小分子调节剂和能够调节该受体活性的小分子的测定法。 这些化合物可用于某些实施方案中用于治疗选自炎症,免疫相关疾病,癌症,缺血再灌注损伤,中风,与血管损伤相关的新内膜增厚,大疱性类天疱疮,新生儿梗阻性肾病和心血管疾病的疾病或病症, 或在其它实施方案中用于治疗选自免疫缺陷,获得性免疫缺陷综合征(AIDS),髓过氧化物酶缺乏症,威斯科特 - 奥德里奇综合征,慢性肉芽肿病,超IgM综合征,白细胞粘附缺陷,Chediak-Higashi综合征 ,和严重的联合免疫缺陷。

    System and method for wide area wireless connectivity to the internet
    8.
    发明授权
    System and method for wide area wireless connectivity to the internet 有权
    用于广域无线连接到互联网的系统和方法

    公开(公告)号:US08571222B1

    公开(公告)日:2013-10-29

    申请号:US10845281

    申请日:2004-05-13

    IPC分类号: H04L29/06

    CPC分类号: H04W12/06

    摘要: A system and method for managing access to a Wi-Fi system include redirecting an access request, comprising a user credential, from a wireless user device to an authentication server, obtaining, from a first database, a list of a plurality of authentication databases from which users may be authenticated, the list including a protocol required for communication with each of the authentication databases, transmitting a request to each of the listed authentication databases using the identified protocol, and permitting the user access to the Internet through the Wi-Fi system if the user is authenticated by at least one of the listed authentication databases.

    摘要翻译: 用于管理对Wi-Fi系统的访问的系统和方法包括将包括用户凭证的访问请求从无线用户设备重定向到认证服务器,从第一数据库获取多个认证数据库的列表, 哪些用户可以被认证,该列表包括与每个认证数据库通信所需的协议,使用所识别的协议向每个列出的认证数据库发送请求,并允许用户通过Wi-Fi系统访问因特网 如果用户被至少一个列出的认证数据库认证。