Methods of producing L-lysine and L-glutamic acid by fermentation
    6.
    发明授权
    Methods of producing L-lysine and L-glutamic acid by fermentation 失效
    通过发酵生产L-赖氨酸和L-谷氨酸的方法

    公开(公告)号:US5846790A

    公开(公告)日:1998-12-08

    申请号:US776597

    申请日:1997-02-18

    摘要: A mutant strain having an ability to produce L-glutamic acid in the absence of any biotin action-suppressing agent in a medium containing an excessive amount of biotin is obtained by giving temperature sensitivity with respect to a biotin action-suppressing agent to a coryneform L-glutamic acid-producing bacterium. This strain is cultivated in a liquid medium to produce and accumulate L-glutamic acid in the medium. A mutant strain having an ability to produce L-lysine and L-glutamic acid in the absence of any biotin action-suppressing agent in a medium containing an excessive amount of biotin is obtained by giving temperature sensitivity with respect to a biotin action-suppressing agent and giving L-lysine productivity to a coryneform L-glutamic acid-producing bacterium. This strain is cultivated in a liquid medium to simultaneously produce and accumulate L-lysine and L-glutamic acid in the medium.

    摘要翻译: PCT No.PCT / JP95 / 01586 Sec。 371日期1997年2月18日 102(e)1997年2月18日PCT PCT 1995年8月9日PCT公布。 出版物WO96 / 06180 日期:1996年2月29日在具有生物素活性抑制剂的情况下,在含有过量生物素的培养基中,不存在生成L-谷氨酸的能力的突变株是通过赋予生物素作用抑制 代谢产L-谷氨酸棒状细菌。 将该菌株在液体培养基中培养以在培养基中产生并积累L-谷氨酸。 通过赋予生物素活性抑制剂的温度敏感度,获得在含有过量生物素的培养基中不存在任何生物素活性抑制剂时能够产生L-赖氨酸和L-谷氨酸的突变株 并向L-谷氨酸棒状杆菌产生细菌提供L-赖氨酸生产力。 该菌株在液体培养基中培养,以在培养基中同时产生和积累L-赖氨酸和L-谷氨酸。

    Process for producing L-amino acids by fermentation
    7.
    发明授权
    Process for producing L-amino acids by fermentation 失效
    通过发酵生产L-氨基酸的方法

    公开(公告)号:US5164307A

    公开(公告)日:1992-11-17

    申请号:US675961

    申请日:1991-03-27

    IPC分类号: C12P19/32

    CPC分类号: C12P19/32

    摘要: A process is provided for producing an L-amino acid, which entails culturing bacteria producing the L-amino acid in a medium containing cane molasses, sucrose or glucose as a main carbon source and containing at least one substance selected from the group consisting of N-methylglycine, N,N-dimethylglycine, N,N,N-trimethylglycine and (2-hydroxyethyl)trimethyl ammonium in an amount effective to enhance the yield of the L-amino acid; and harvesting the L-amino acid, and wherein the L-amino acid is selected from the group consisting of L-glutamic acid, L-lysine, L-glutamine, L-arginine, L-isoleucine, L-valine, L-threonine, L-histidine, L-phenylalanine, L-tryptophan, L-serine, L-ornithine, L-citrulline, L-tyrosine and L-leucine.

    摘要翻译: 提供了一种生产L-氨基酸的方法,其需要在含有甘蔗糖浆,蔗糖或葡萄糖作为主要碳源的培养基中培养产生L-氨基酸的细菌并含有至少一种选自N - 甲基甘氨酸,N,N-二甲基甘氨酸,N,N,N-三甲基甘氨酸和(2-羟乙基)三甲基铵,其量有效提高L-氨基酸的产率; 收集L-氨基酸,其中L-氨基酸选自L-谷氨酸,L-赖氨酸,L-谷氨酰胺,L-精氨酸,L-异亮氨酸,L-缬氨酸,L-苏氨酸 ,L-组氨酸,L-苯丙氨酸,L-色氨酸,L-丝氨酸,L-鸟氨酸,L-瓜氨酸,L-酪氨酸和L-亮氨酸。