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    Microdevice arrays formed by magnetic assembly
    2.
    发明授权
    Microdevice arrays formed by magnetic assembly 有权
    由磁性组装形成的微器件阵列

    公开(公告)号：US09152905B2

    公开(公告)日：2015-10-06

    申请号：US12018319

    申请日：2008-01-23

    申请人： Christopher D. Herold ,  David Rothwarf ,  Bao Nguyen

    发明人： Christopher D. Herold ,  David Rothwarf ,  Bao Nguyen

    IPC分类号： G01N35/00 ,  G01N35/04 ,  G06K19/06 ,  B01J19/00 ,  C40B40/00 ,  C40B50/00 ,  G01N33/543

    CPC分类号： B01J19/0046 ,  B01J2219/00497 ,  B01J2219/00549 ,  B01J2219/00563 ,  B01J2219/00585 ,  B01J2219/00655 ,  B01J2219/00709 ,  C40B40/00 ,  C40B50/00 ,  G01N33/54326 ,  G01N33/54366 ,  G06K19/06187

    摘要： Microdevices containing a predetermined preferential axis of magnetization are disposed in an array having discreet regions. Under influence of a magnetic field, the microdevices can have at least twelve discrete orientations, and can advantageously be flipped upside down in place. Microdevices can be coded in a manner that supports a coding space of at least 102, 103, 106 or even 1010 or more choices, and can include one or more chemically reactive sites. The regions can be defined by long and short bars, in which microdevices span gaps between the longer bars, and the shorter bars measure less than 60% of such gaps. Preferred embodiments are also provided to produce microfabricated microdevices for magnetic assembly-based arraying.

    摘要翻译： 包含预定的磁化优选轴的微器件设置在具有谨慎区域的阵列中。 在磁场的影响下，微器件可以具有至少十二个离散取向，并且可以有利地在适当位置上翻翻。 可以以支持至少102,103,106甚至1010或更多选择的编码空间的方式对微器件进行编码，并且可以包括一个或多个化学反应位点。 这些区域可以由长条和短条定义，其中微型设备跨越长条之间的间隙，较短的条测量小于这种间隙的60％。 还提供了优选实施例以产生用于基于磁性组件的排列的微加工微型器件。

    APPARATUS INCLUDING ION TRANSPORT DETECTING STRUCTURES AND METHODS OF USE
    4.
    发明申请
    APPARATUS INCLUDING ION TRANSPORT DETECTING STRUCTURES AND METHODS OF USE 审中-公开
    装置包括离子运输检测结构和使用方法

    公开(公告)号：US20080286750A1

    公开(公告)日：2008-11-20

    申请号：US11841985

    申请日：2007-08-20

    申请人： Jia XU ,  Antonio Guia ,  Xiaobo Wang ,  Lei Wu ,  Junquan Xu ,  Mingxian Huang ,  David Rothwarf

    发明人： Jia XU ,  Antonio Guia ,  Xiaobo Wang ,  Lei Wu ,  Junquan Xu ,  Mingxian Huang ,  David Rothwarf

    IPC分类号： C12Q1/00

    CPC分类号： G01N33/48728

    摘要： The present invention recognizes that the determination of ion transport function or properties using direct detection methods, such as whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and other fluidic components and methods of use that allow for the direct analysis of ion transport function or properties using microfabricated structures that can allow for automated detection of ion transport function or properties. These biochips and fluidic components and methods of use thereof are particularly appropriate for automating the detection of ion transport function or properties, particularly for screening purposes.

    摘要翻译： 本发明认识到，使用诸如全细胞记录或单通道记录之类的直接检测方法的离子转运功能或性质的确定优于使用间接检测方法的方法，例如基于FRET的检测系统。 本发明提供生物芯片和其他流体组分和使用方法，其允许使用可允许自动检测离子迁移功能或性质的微结构的直接分析离子转运功能或性质。 这些生物芯片和流体组分及其使用方法特别适用于自动化离子迁移功能或性质的检测，特别是用于筛选目的。

    Microdevice Arrays Formed by Magnetic Assembly
    5.
    发明申请
    Microdevice Arrays Formed by Magnetic Assembly 有权
    由磁性组装形成的微器件阵列

    公开(公告)号：US20080176762A1

    公开(公告)日：2008-07-24

    申请号：US12018319

    申请日：2008-01-23

    申请人： Christopher D. Herold ,  David Rothwarf ,  Bao Nguyen

    发明人： Christopher D. Herold ,  David Rothwarf ,  Bao Nguyen

    IPC分类号： C40B50/00 ,  C40B60/14 ,  C40B40/00

    CPC分类号： B01J19/0046 ,  B01J2219/00497 ,  B01J2219/00549 ,  B01J2219/00563 ,  B01J2219/00585 ,  B01J2219/00655 ,  B01J2219/00709 ,  C40B40/00 ,  C40B50/00 ,  G01N33/54326 ,  G01N33/54366 ,  G06K19/06187

    摘要： Microdevices containing a predetermined preferential axis of magnetization are disposed in an array having discreet regions. Under influence of a magnetic field, the microdevices can have at least twelve discrete orientations, and can advantageously be flipped upside down in place. Microdevices can be coded in a manner that supports a coding space of at least 102, 103, 106 or even 1010 or more choices, and can include one or more chemically reactive sites. The regions can be defined by long and short bars, in which microdevices span gaps between the longer bars, and the shorter bars measure less than 60% of such gaps. Preferred embodiments are also provided to produce microfabricated microdevices for magnetic assembly-based arraying.

    摘要翻译： 包含预定的磁化优选轴的微器件设置在具有谨慎区域的阵列中。 在磁场的影响下，微器件可以具有至少十二个离散取向，并且可以有利地在适当位置上翻翻。 可以以支持至少10个，10个，10个，6个，甚至10个以上的编码空间的方式对微器件进行编码。 10个或更多个选择，并且可以包括一个或多个化学反应位点。 这些区域可以由长条和短条定义，其中微型设备跨越长条之间的间隙，较短的条测量小于这种间隙的60％。 还提供了优选实施例以产生用于基于磁性组件的排列的微加工微型器件。

    Apparatus including ion transport detecting structures and methods of use
    6.
    发明申请
    Apparatus including ion transport detecting structures and methods of use 审中-公开
    包括离子传输检测结构和使用方法的装置

    公开(公告)号：US20050009004A1

    公开(公告)日：2005-01-13

    申请号：US10760886

    申请日：2004-01-20

    申请人： Jia Xu ,  Antonio Guia ,  Xiaobo Wang ,  Lei Wu ,  Junquan Xu ,  Mingxian Huang ,  David Rothwarf

    发明人： Jia Xu ,  Antonio Guia ,  Xiaobo Wang ,  Lei Wu ,  Junquan Xu ,  Mingxian Huang ,  David Rothwarf

    IPC分类号： C12M1/34 ,  C12Q1/00 ,  G01N33/487

    CPC分类号： G01N33/48728

    摘要： The present invention recognizes that the determination of ion transport function or properties using direct detection methods, such as whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and other fluidic components and methods of use that allow for the direct analysis of ion transport function or properties using microfabricated structures that can allow for automated detection of ion transport function or properties. These biochips and fluidic components and methods of use thereof are particularly appropriate for automating the detection of ion transport function or properties, particularly for screening purposes.

    摘要翻译： 本发明认识到，使用诸如全细胞记录或单通道记录之类的直接检测方法的离子转运功能或性质的确定优于使用间接检测方法的方法，例如基于FRET的检测系统。 本发明提供生物芯片和其他流体组分和使用方法，其允许使用可允许自动检测离子迁移功能或性质的微结构的直接分析离子转运功能或性质。 这些生物芯片和流体组分及其使用方法特别适用于自动化离子迁移功能或性质的检测，特别是用于筛选目的。

    Sorting Of Microdevices
    8.
    发明申请
    Sorting Of Microdevices 审中-公开
    微型设备排序

    公开(公告)号：US20080176765A1

    公开(公告)日：2008-07-24

    申请号：US12018439

    申请日：2008-01-23

    申请人： David Rothwarf

    发明人： David Rothwarf

    IPC分类号： C40B40/06 ,  C40B50/16 ,  C40B40/00 ,  B07C5/344 ,  C40B40/14 ,  C40B40/10

    CPC分类号： B01J19/0046 ,  B01J2219/00497 ,  B01J2219/00549 ,  B01J2219/00563 ,  B01J2219/00585 ,  B01J2219/00655 ,  B01J2219/00709 ,  C40B40/00 ,  C40B50/00 ,  G01N33/54326 ,  G01N33/54366 ,  G06K19/06187

    摘要： Particles or other microdevices are disposed in an array having discreet regions (e.g. magnetic bars), oriented within a magnetic field, and then sorted through application of a removing force under conditions that remove a proper subset of the microdevices from the array as a function of differing orientations of the microdevices. Methods are also contemplated for using magnetic patterns to sort collections of microdevices by magnetic complementarity. Preferred methods use a capture and release process to sort microdevices (microdevices), and unlike conventional sorters, do not require high particle flow rates. Also contemplated are microdevice libraries in which microdevices have mutually distinct magnetic codes, and a region with a mutually distinct polymeric or other chemical moiety.

    摘要翻译： 颗粒或其他微型设备被布置成具有定向在磁场内的离散区域（例如磁棒）的阵列中，然后在将阵列中的微型设备的适当子集从数组中移除的条件下通过施加去除力进行排序，作为 微器件的不同取向。 也考虑使用磁图案通过磁互补来分类微器件的集合的方法。 优选的方法使用捕获和释放过程来排序微型设备（微型设备），并且与传统的分选机不同，不需要高的颗粒流速。 还考虑了微器件库，其中微器件具有相互不同的磁性代码，以及具有相互不同的聚合物或其它化学部分的区域。

    Gamma subunit of cytokine responsive lkB-alpha kinase complex
    9.
    发明申请
    Gamma subunit of cytokine responsive lkB-alpha kinase complex 审中-公开
    细胞因子反应性lkB-α激酶复合物的γ亚基

    公开(公告)号：US20070166812A1

    公开(公告)日：2007-07-19

    申请号：US11716086

    申请日：2007-03-09

    申请人： Michael Karin ,  David Rothwarf ,  Ebrahim Zandi

    发明人： Michael Karin ,  David Rothwarf ,  Ebrahim Zandi

    IPC分类号： C12N9/12

    CPC分类号： C12N9/1205

    摘要： The present invention provides a novel essential regulatory subunit of the IκB kinase (IKK) complex, IKK-γ. The isolated IKK-γ subunit of the invention has substantially the same amino acid sequence as SEQ ID NO: 2 shown in FIG. 2.

    摘要翻译： 本发明提供IkappaB激酶（IKK）复合物IKK-γ的新型必需调节亚基。 本发明的分离的IKK-γ亚基具有与图1所示的SEQ ID NO：2基本相同的氨基酸序列。 2。