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    Method for specimen measurement
    2.
    发明授权
    Method for specimen measurement 失效
    样本测量方法

    公开(公告)号：US5601983A

    公开(公告)日：1997-02-11

    申请号：US395631

    申请日：1995-02-28

    申请人： Hidehito Takayama ,  Matsuomi Nishimura ,  Kazumi Tanaka ,  Toshikazu Ohnishi ,  Takeshi Miyazaki

    发明人： Hidehito Takayama ,  Matsuomi Nishimura ,  Kazumi Tanaka ,  Toshikazu Ohnishi ,  Takeshi Miyazaki

    IPC分类号： G01N33/543 ,  G01N33/58 ,  C12Q1/68

    CPC分类号： G01N33/582 ,  G01N33/585 ,  Y10S435/961 ,  Y10S435/968 ,  Y10S436/80 ,  Y10S436/804 ,  Y10S436/805 ,  Y10S436/823

    摘要： In a method for measuring a specified component in a specimen by reacting the specimen with a first reagent formed by binding a substance active to the specified component, with carrier particles and a second reagent formed by labelling a substance active to the specified component with a first label, and measuring the substances in the complexes obtained in the reaction, there is disclosed a method featured by labelling the carrier particles with a second label different from the first label, and detecting the second label and then the first label utilizing the detection of the second label as a trigger.This method enables a highly precise measurement without the influence of noise components in the detection of specified trace components in the specimen, utilizing an antigen-antibody reaction or a nucleic acid hybridization.

    摘要翻译： 在通过使样本与通过结合对特定成分有活性的物质结合而形成的第一试剂与载体颗粒和通过将具有活性的物质标记在特定成分上而形成的第二试剂的方法中， 标记和测量在反应中获得的络合物中的物质，公开了一种特征在于用不同于第一标记的第二标记标记载体颗粒的方法，并且利用第二标记的检测来检测第二标记 第二个标签作为触发器。 该方法利用抗原抗体反应或核酸杂交，能够在不受噪声成分影响的情况下进行高精度测定。

    Apparatus for measuring a test specimen
    4.
    发明授权
    Apparatus for measuring a test specimen 失效
    用于测量试样的装置

    公开(公告)号：US5380490A

    公开(公告)日：1995-01-10

    申请号：US821049

    申请日：1992-01-16

    申请人： Hiroaki Hoshi ,  Matsuomi Nishimura ,  Kazumi Tanaka ,  Takeshi Miyazaki ,  Toshikazu Ohnishi ,  Hidehito Takayama

    发明人： Hiroaki Hoshi ,  Matsuomi Nishimura ,  Kazumi Tanaka ,  Takeshi Miyazaki ,  Toshikazu Ohnishi ,  Hidehito Takayama

    IPC分类号： G01N21/59 ,  G01N21/82 ,  G01N33/53 ,  G01N33/543

    CPC分类号： G01N33/5438 ,  G01N21/82 ,  G01N33/5304 ,  G01N33/54313 ,  G01N2021/5953 ,  G01N2021/5957

    摘要： An apparatus is so constructed as to measure a specific substance in a test specimen by the degree of the aggregation of carrier particles in a reaction solution in which the test specimen is mixed with the carrier particles which carry a substance specifically binding to the specific substance. The apparatus includes a substrate having comb-shaped electrodes mounting the reaction solution and amplifier and alternating oscillator for displaying a variable voltage to the comb-shaped electrodes. The test specimen measuring apparatus having the structure accelerates the aggregation of the reaction solution by applying an alternating voltate to the comb-shaped electrodes in a state that the reaction solution is being mounted on the substrate, and detects the spatial spectrum of the comb-shaped electrodes on which the reaction solution is mounted, thus performing the qualitative or quantitative detection of the presence of the substance in the test specimen.

    摘要翻译： 一种装置被构造成通过载体颗粒在其中将试样与携带特异性结合物质的物质的载体颗粒混合的反应溶液中聚集的程度来测量试样中的特定物质。 该装置包括具有安装反应溶液的梳形电极的基板和用于向梳状电极显示可变电压的放大器和交替振荡器。 具有这种结构的试样测量装置在将反应溶液安装在基板上的状态下通过向梳状电极施加交流电压来加速反应溶液的聚集，并且检测梳形电极的空间光谱 在其上安装反应溶液的电极，从而进行定性或定量检测试样中物质的存在。

    Labelled complex
    7.
    发明授权
    Labelled complex 失效
    标签复合体

    公开(公告)号：US5846730A

    公开(公告)日：1998-12-08

    申请号：US888098

    申请日：1997-07-03

    申请人： Takeshi Miyazaki ,  Kazumi Tanaka ,  Tsuyoshi Santo ,  Toshikazu Ohnishi ,  Tetsuro Fukui ,  Tadashi Okamoto

    发明人： Takeshi Miyazaki ,  Kazumi Tanaka ,  Tsuyoshi Santo ,  Toshikazu Ohnishi ,  Tetsuro Fukui ,  Tadashi Okamoto

    IPC分类号： C12Q1/68 ,  G01N33/533 ,  G01N33/58

    CPC分类号： G01N33/582 ,  C12Q1/6816 ,  G01N33/533 ,  G01N33/583 ,  Y10T436/21

    摘要： To provide a reagent with excellent stability under storage, which can detect a subject compound to be measured with higher specificity and sensitibity. Complexes of a compound represented by the general formula (I): ##STR1## (wherein R.sub.1 through R.sub.7 independently represent hydrogen atom, halogen atom, alkyl group, aryl group, aralkyl group, sulfonate group, amino group, styryl group, nitro group, hydroxyl group, carboxyl group, cyano group, or aryl azo group; R.sub.1 through R.sub.7 may or may not be bonded to each other to form a substituted or an unsubstituted condensed ring; F.sub.1 represents a divalent organic residue; and X.sub.1.sup..crclbar. represents an anion) and the like with immunoglobulin and the like are formed.

    摘要翻译： 提供在储存下具有优异稳定性的试剂，其可以以更高的特异性和敏感性检测待测化合物。 由通式（I）表示的化合物的络合物：其中，R 1〜R 7分别独立地表示氢原子，卤素原子，烷基，芳基，芳烷基，磺酸酯基，氨基，苯乙烯基， 硝基，羟基，羧基，氰基或芳基偶氮基; R 1〜R 7可以彼此键合或不相互结合形成取代或未取代的稠环; F1表示二价有机残基; X1（ - ）代表阴离子）等形成免疫球蛋白等。

    Labeled complex
    8.
    发明授权
    Labeled complex 失效
    标签复合体

    公开(公告)号：US5512446A

    公开(公告)日：1996-04-30

    申请号：US900302

    申请日：1992-06-18

    申请人： Takeshi Miyazaki ,  Kazumi Tanaka ,  Tsuyoshi Santo ,  Toshikazu Ohnishi ,  Tetsuro Fukui ,  Tadashi Okamoto

    发明人： Takeshi Miyazaki ,  Kazumi Tanaka ,  Tsuyoshi Santo ,  Toshikazu Ohnishi ,  Tetsuro Fukui ,  Tadashi Okamoto

    IPC分类号： C12Q1/68 ,  G01N33/533 ,  G01N33/58

    CPC分类号： G01N33/582 ,  C12Q1/6816 ,  G01N33/533 ,  G01N33/583 ,  Y10T436/21

    摘要： To provide a reagent with excellent stability under storage, which can detect a subject compound to be measured with higher specificity and sensitibity.Complexes of a compound represented by the general formula (I): ##STR1## (wherein R.sub.1 through R.sub.7 independently represent hydrogen atom, halogen atom, alkyl group, aryl group, aralkyl group, sulfonate group, amino group, styryl group, nitro group, hydroxyl group, carboxyl group, cyano group, or aryl azo group; R.sub.1 through R.sub.7 may or may not be bonded to each other to form a substituted or an unsubstituted condensed ring; R represents a divalent organic residue; and X.sub.1.sup..crclbar. represents an anion) and the like with immunoglobulin and the like are formed.

    摘要翻译： 提供在储存下具有优异稳定性的试剂，其可以以更高的特异性和敏感性检测待测化合物。 由通式（I）表示的化合物的络合物：其中，R 1〜R 7分别独立地表示氢原子，卤素原子，烷基，芳基，芳烷基，磺酸酯基，氨基，苯乙烯基， 硝基，羟基，羧基，氰基或芳基偶氮基; R 1〜R 7可以相互键合，也可以不相互键合，形成取代或未取代的稠环; R表示二价有机残基; X1（ - ）代表阴离子）等形成免疫球蛋白等。

    Polymeric liquid crystal composition and liquid crystal device
    9.
    发明授权
    Polymeric liquid crystal composition and liquid crystal device 失效
    聚合物液晶组合物和液晶装置

    公开(公告)号：US5384069A

    公开(公告)日：1995-01-24

    申请号：US938596

    申请日：1992-09-03

    申请人： Kazuo Yoshinaga ,  Yutaka Kurabayashi ,  Toshikazu Ohnishi ,  Yukiko Futami ,  Takeshi Miyazaki

    发明人： Kazuo Yoshinaga ,  Yutaka Kurabayashi ,  Toshikazu Ohnishi ,  Yukiko Futami ,  Takeshi Miyazaki

    IPC分类号： C09K19/38 ,  G02F1/1333 ,  G02F1/141 ,  C09K19/00 ,  G02F1/13

    CPC分类号： G02F1/133365 ,  C09K19/3809 ,  C09K19/3833 ,  G02F1/141 ,  Y10T428/1095

    摘要： A polymeric liquid crystal composition includes a polymer mesomorphic compound having an asymmetric carbon atom and a low-molecular weight mesomorphic compound. The composition can be easily formed into a film of a large area, exhibits a response speed which is not substantially different from that of the low-molecular weight mesomorphic compound alone and stably retains alignment resistant to pressure or heat impact. Such a good alignment is especially obtained when the polymeric liquid crystal composition is incorporated in a liquid crystal device by being disposed between a pair of substrates preferably having an alignment face provided with an orientation characteristic for aligning the molecular axis of the liquid crystal composition in one direction. It is suitable that the polymer mesomorphic compound is optically active and has a helical rotation direction opposite to that of the low-molecular weight mesomorphic compound.

    摘要翻译： 聚合物液晶组合物包括具有不对称碳原子的聚合物介晶化合物和低分子量介晶化合物。 组合物可以容易地形成大面积的膜，显示出与单独的低分子量介晶化合物基本上不同的响应速度，并且稳定地保持耐压力或热冲击的取向。 当聚合物液晶组合物通过配置在优选具有将液晶组合物的分子轴在一个对准方向上具有取向特性的对准面的一对基板配置在液晶装置中时，特别优选对准 方向。 聚合物介晶化合物是光学活性的并且具有与低分子量介晶化合物相反的螺旋旋转方向是合适的。