公开(公告)号：US5384069A

公开(公告)日：1995-01-24

申请号：US938596

申请日：1992-09-03

申请人： Kazuo Yoshinaga ,  Yutaka Kurabayashi ,  Toshikazu Ohnishi ,  Yukiko Futami ,  Takeshi Miyazaki

发明人： Kazuo Yoshinaga ,  Yutaka Kurabayashi ,  Toshikazu Ohnishi ,  Yukiko Futami ,  Takeshi Miyazaki

IPC分类号： C09K19/38 ,  G02F1/1333 ,  G02F1/141 ,  C09K19/00 ,  G02F1/13

CPC分类号： G02F1/133365 ,  C09K19/3809 ,  C09K19/3833 ,  G02F1/141 ,  Y10T428/1095

摘要： A polymeric liquid crystal composition includes a polymer mesomorphic compound having an asymmetric carbon atom and a low-molecular weight mesomorphic compound. The composition can be easily formed into a film of a large area, exhibits a response speed which is not substantially different from that of the low-molecular weight mesomorphic compound alone and stably retains alignment resistant to pressure or heat impact. Such a good alignment is especially obtained when the polymeric liquid crystal composition is incorporated in a liquid crystal device by being disposed between a pair of substrates preferably having an alignment face provided with an orientation characteristic for aligning the molecular axis of the liquid crystal composition in one direction. It is suitable that the polymer mesomorphic compound is optically active and has a helical rotation direction opposite to that of the low-molecular weight mesomorphic compound.

摘要翻译： 聚合物液晶组合物包括具有不对称碳原子的聚合物介晶化合物和低分子量介晶化合物。 组合物可以容易地形成大面积的膜，显示出与单独的低分子量介晶化合物基本上不同的响应速度，并且稳定地保持耐压力或热冲击的取向。 当聚合物液晶组合物通过配置在优选具有将液晶组合物的分子轴在一个对准方向上具有取向特性的对准面的一对基板配置在液晶装置中时，特别优选对准 方向。 聚合物介晶化合物是光学活性的并且具有与低分子量介晶化合物相反的螺旋旋转方向是合适的。

公开(公告)号：US5039208A

公开(公告)日：1991-08-13

申请号：US609067

申请日：1990-11-01

申请人： Toshikazu Ohnishi ,  Kazuo Yoshinaga ,  Takeshi Miyazaki ,  Yutaka Kurabayashi

发明人： Toshikazu Ohnishi ,  Kazuo Yoshinaga ,  Takeshi Miyazaki ,  Yutaka Kurabayashi

IPC分类号： G02F1/13 ,  C09K19/38 ,  C09K19/40 ,  G02F1/1333 ,  G02F1/1337 ,  G02F1/137 ,  G02F1/141

CPC分类号： C09K19/3857 ,  C09K19/38 ,  C09K19/3804 ,  C09K19/3852 ,  G02F1/133365

摘要： A crosslinked polymer liquid crystal is stretched to provide a polymer liquid crystal layer with a higher degree of uniform alignment than a non-crosslinked polymer liquid crystal. Such a stretched layer of crosslinked polymer liquid crystal is disposed between a pair of substrates to form a liquid crystal device showing a better contrast as a recording medium or display device. The improvement in alignment obtained by stretching of a crosslinked polymer liquid crystal is also effective in increasing the responsive characteristics in response to an electric field or magnetic field and also the pyro-electric effect of the resultant polymer liquid crystal layer where the polymer liquid crystal is a ferro-electric one.

公开(公告)号：US4995705A

公开(公告)日：1991-02-26

申请号：US133797

申请日：1987-12-16

申请人： Kazuo Yoshinaga ,  Takeshi Miyazaki ,  Toshikazu Ohnishi ,  Yutaka Kurabayashi ,  Yoshio Takasu ,  Tadashi Kobayashi

发明人： Kazuo Yoshinaga ,  Takeshi Miyazaki ,  Toshikazu Ohnishi ,  Yutaka Kurabayashi ,  Yoshio Takasu ,  Tadashi Kobayashi

IPC分类号： C09K19/38 ,  G02F1/1333 ,  G02F1/141 ,  G11B7/0055 ,  G11B7/24 ,  G11B7/25 ,  G11B9/02

CPC分类号： G11B7/00557 ,  C09K19/38 ,  C09K19/3852 ,  C09K19/3857 ,  G02F1/133365 ,  G02F1/141 ,  G11B7/24 ,  G11B7/25 ,  G11B9/02

摘要： An optical modulation method comprises writing in a ferroelectric having a glass transition point at or above the glass transition point, and holding the resultant written state below the glass transition point. Preferably, the ferroelectric is formed in an optical modulation layer set to have an optical thickness capable of providing a multiple reflection state. The multiple reflection state of the optical modulation layer is locally changed at or above the glass transition point by irradiating the optical modulation layer under an electric field with a laser beam to write in the optical modulation layer.

公开(公告)号：US5599502A

公开(公告)日：1997-02-04

申请号：US280132

申请日：1994-07-25

申请人： Takeshi Miyazaki ,  Matsuomi Nishimura ,  Kazuo Isaka ,  Kazumi Tanaka ,  Toshikazu Ohnishi ,  Yoshito Yoneyama ,  Hidehito Takayama

发明人： Takeshi Miyazaki ,  Matsuomi Nishimura ,  Kazuo Isaka ,  Kazumi Tanaka ,  Toshikazu Ohnishi ,  Yoshito Yoneyama ,  Hidehito Takayama

IPC分类号： F04F99/00 ,  B01L3/00 ,  B41J2/005 ,  F04B19/00 ,  F04B19/24 ,  G01N15/14 ,  G01N37/00 ,  G01N27/00 ,  G01N21/00 ,  G01N21/85

CPC分类号： B41J2/005 ,  B01L3/502715 ,  B01L3/50273 ,  F04B19/006 ,  F04B19/24 ,  B01L2300/0645 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2300/1816 ,  B01L2300/1827 ,  B01L2300/1833 ,  B01L2300/1861 ,  B01L2400/0466

摘要： A minute flow path is filled with liquid so that the liquid may be supplied from an accumulating portion. Energy is imparted to the liquid exposed outwardly of an opening in the flow path by a heat generating element or by energy application to thereby heat and gasify the liquid. Thereupon, the liquid is supplied by an amount corresponding to the gasified liquid by capillary phenomenon through the flow path, and gasification is continuously effected, whereby a flow free of pulsating flow can be formed in the flow path.

摘要翻译： 一个微小的流路充满液体，从而可以从一个积聚部分提供液体。 通过发热元件或通过能量施加向流动路径中的开口向外暴露的液体赋予能量，从而加热和气化液体。 因此，通过流路通过毛细管现象向气化液体供给液体，连续进行气化，能够在流路中形成不产生脉动流的流动。

公开(公告)号：US5601983A

公开(公告)日：1997-02-11

申请号：US395631

申请日：1995-02-28

申请人： Hidehito Takayama ,  Matsuomi Nishimura ,  Kazumi Tanaka ,  Toshikazu Ohnishi ,  Takeshi Miyazaki

发明人： Hidehito Takayama ,  Matsuomi Nishimura ,  Kazumi Tanaka ,  Toshikazu Ohnishi ,  Takeshi Miyazaki

IPC分类号： G01N33/543 ,  G01N33/58 ,  C12Q1/68

CPC分类号： G01N33/582 ,  G01N33/585 ,  Y10S435/961 ,  Y10S435/968 ,  Y10S436/80 ,  Y10S436/804 ,  Y10S436/805 ,  Y10S436/823

摘要： In a method for measuring a specified component in a specimen by reacting the specimen with a first reagent formed by binding a substance active to the specified component, with carrier particles and a second reagent formed by labelling a substance active to the specified component with a first label, and measuring the substances in the complexes obtained in the reaction, there is disclosed a method featured by labelling the carrier particles with a second label different from the first label, and detecting the second label and then the first label utilizing the detection of the second label as a trigger.This method enables a highly precise measurement without the influence of noise components in the detection of specified trace components in the specimen, utilizing an antigen-antibody reaction or a nucleic acid hybridization.

摘要翻译： 在通过使样本与通过结合对特定成分有活性的物质结合而形成的第一试剂与载体颗粒和通过将具有活性的物质标记在特定成分上而形成的第二试剂的方法中， 标记和测量在反应中获得的络合物中的物质，公开了一种特征在于用不同于第一标记的第二标记标记载体颗粒的方法，并且利用第二标记的检测来检测第二标记 第二个标签作为触发器。 该方法利用抗原抗体反应或核酸杂交，能够在不受噪声成分影响的情况下进行高精度测定。

公开(公告)号：US5427959A

公开(公告)日：1995-06-27

申请号：US769366

申请日：1991-10-01

申请人： Matsuomi Nishimura ,  Kazumi Tanaka ,  Takeshi Miyazaki ,  Hidehito Takayama ,  Toshikazu Ohnishi

发明人： Matsuomi Nishimura ,  Kazumi Tanaka ,  Takeshi Miyazaki ,  Hidehito Takayama ,  Toshikazu Ohnishi

IPC分类号： G01N15/00 ,  G01N15/02 ,  G01N15/04 ,  G01N21/03 ,  G01N33/53 ,  G01N33/543 ,  G01N33/546

CPC分类号： G01N33/54366 ,  B01L3/5027 ,  G01N21/03 ,  G01N33/5304 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N15/0255 ,  G01N2015/0053 ,  G01N2015/0065 ,  G01N2015/0092 ,  G01N2015/045 ,  G01N2021/0346 ,  Y10S436/805 ,  Y10S436/807 ,  Y10S436/808 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/824 ,  Y10S436/908

摘要： On a slab-like board formed of a transparent material is closely attached a wedge-shaped transparent cover member provided with a recess in a central inner portion, thereby to form a clearance. The height of the clearance between the recess and the board is configured to decrease continuously or in steps. When an immunological active substance such as a monoclonal antibody is caused to sensitize carrier particles F, and a reagent having the carrier particles F dispersed into a liquid medium mainly composed of the water is mixed with a specimen, the reaction will occur in which the flocculate is formed from plural carrier particles. When this reaction liquid is poured into the clearance through the opening, the reaction liquid penetrates in the direction having a narrower vertical spacing due to surface tension. A single carrier particle unflocculated can move deep within the recess because it is small in diameter, but the flocculate G is trapped on its way and can not move because of its size.

摘要翻译： 在由透明材料形成的板状板上紧密地连接有在中心内部设置有凹部的楔形透明盖构件，从而形成间隙。 凹槽和板之间的间隙的高度被配置为连续或逐步减小。 当使诸如单克隆抗体的免疫活性物质使载体颗粒F致敏时，将分散在主要由水组成的液体介质中的载体颗粒F的试剂与样品混合时，将发生絮凝反应 由多个载体颗粒形成。 当该反应液通过开口倒入间隙中时，由于表面张力，反应液体沿着垂直间隔较窄的方向渗透。 未絮凝的单载体颗粒由于其直径小而在凹槽内深深移动，而是絮凝的G被捕获，因为其尺寸不能移动。

公开(公告)号：US5380490A

公开(公告)日：1995-01-10

申请号：US821049

申请日：1992-01-16

申请人： Hiroaki Hoshi ,  Matsuomi Nishimura ,  Kazumi Tanaka ,  Takeshi Miyazaki ,  Toshikazu Ohnishi ,  Hidehito Takayama

发明人： Hiroaki Hoshi ,  Matsuomi Nishimura ,  Kazumi Tanaka ,  Takeshi Miyazaki ,  Toshikazu Ohnishi ,  Hidehito Takayama

IPC分类号： G01N21/59 ,  G01N21/82 ,  G01N33/53 ,  G01N33/543

CPC分类号： G01N33/5438 ,  G01N21/82 ,  G01N33/5304 ,  G01N33/54313 ,  G01N2021/5953 ,  G01N2021/5957

摘要： An apparatus is so constructed as to measure a specific substance in a test specimen by the degree of the aggregation of carrier particles in a reaction solution in which the test specimen is mixed with the carrier particles which carry a substance specifically binding to the specific substance. The apparatus includes a substrate having comb-shaped electrodes mounting the reaction solution and amplifier and alternating oscillator for displaying a variable voltage to the comb-shaped electrodes. The test specimen measuring apparatus having the structure accelerates the aggregation of the reaction solution by applying an alternating voltate to the comb-shaped electrodes in a state that the reaction solution is being mounted on the substrate, and detects the spatial spectrum of the comb-shaped electrodes on which the reaction solution is mounted, thus performing the qualitative or quantitative detection of the presence of the substance in the test specimen.

摘要翻译： 一种装置被构造成通过载体颗粒在其中将试样与携带特异性结合物质的物质的载体颗粒混合的反应溶液中聚集的程度来测量试样中的特定物质。 该装置包括具有安装反应溶液的梳形电极的基板和用于向梳状电极显示可变电压的放大器和交替振荡器。 具有这种结构的试样测量装置在将反应溶液安装在基板上的状态下通过向梳状电极施加交流电压来加速反应溶液的聚集，并且检测梳形电极的空间光谱 在其上安装反应溶液的电极，从而进行定性或定量检测试样中物质的存在。

公开(公告)号：US5370842A

公开(公告)日：1994-12-06

申请号：US979811

申请日：1992-11-20

申请人： Takeshi Miyazaki ,  Matsuomi Nishimura ,  Takayuki Yagi ,  Kazumi Tanaka ,  Toshikazu Ohnishi ,  Masanori Sakuranaga ,  Yoshito Yoneyama ,  Hidehito Takayama ,  Kazuo Isaka

发明人： Takeshi Miyazaki ,  Matsuomi Nishimura ,  Takayuki Yagi ,  Kazumi Tanaka ,  Toshikazu Ohnishi ,  Masanori Sakuranaga ,  Yoshito Yoneyama ,  Hidehito Takayama ,  Kazuo Isaka

IPC分类号： B01L3/00 ,  B01L3/02 ,  G01N15/14 ,  G01N21/03 ,  G01N33/543 ,  G01N35/00 ,  G01N35/08 ,  G01N35/10 ,  G01N21/00 ,  G01N21/85 ,  B01L21/85

CPC分类号： G01N15/1459 ,  B01L3/0268 ,  B01L3/502715 ,  G01N15/1484 ,  G01N21/0303 ,  G01N33/54366 ,  G01N35/08 ,  B01L2200/027 ,  B01L2200/0636 ,  B01L2300/0654 ,  B01L2300/0825 ,  B01L2400/0442 ,  B01L2400/0466 ,  G01N2035/00237 ,  G01N2035/1039 ,  G01N2035/1041

摘要： An injection port for injecting a sample, an accumulation portion for accumulating the injected sample having a reagent carrier enclosed, a flow passage portion, having a light receiving element at a measuring position located halfway thereof, for passing a reaction fluid having reacted with the reagent in the accumulation portion therethrough, a micro-pump having a feed action of the sample fluid within the flow passage portion and which is a heat generating element provided near a nozzle downstream of the measuring position of the flow passage portion are formed integrally and intensively as a cartridge by a producing method including a semiconductor fabrication process.

摘要翻译： 用于注射样品的注入口，用于积聚注入了试剂载体的注射样品的积聚部分，在位于其中途的测量位置处具有光接收元件的流路部分，用于使与反应物反应的反应流体 在其中的积聚部分中，具有在流动通道部分内具有样品流体的进给动作并且设置在流路部分的测量位置下游的喷嘴附近的发热元件的微型泵一体地集中地形成为 一种通过包括半导体制造工艺的制造方法的盒。

公开(公告)号：US5700647A

公开(公告)日：1997-12-23

申请号：US568680

申请日：1995-12-07

申请人： Takeshi Miyazaki ,  Kazumi Tanaka ,  Tsuyoshi Santo ,  Toshikazu Ohnishi ,  Tetsuro Fukui ,  Tadashi Okamoto

发明人： Takeshi Miyazaki ,  Kazumi Tanaka ,  Tsuyoshi Santo ,  Toshikazu Ohnishi ,  Tetsuro Fukui ,  Tadashi Okamoto

IPC分类号： C12Q1/68 ,  G01N33/533 ,  G01N33/58

CPC分类号： G01N33/582 ,  C12Q1/6816 ,  G01N33/533 ,  G01N33/583 ,  Y10T436/21

摘要： To provide a reagent with excellent stability under storage, which can detect a subject compound to be measured with higher specificity and sensitibity. Complexes of a compound represented by the general formula (IV): ##STR1##

摘要翻译： 提供在储存下具有优异稳定性的试剂，其可以以更高的特异性和敏感性检测待测化合物。 由通式（IV）表示的化合物的配合物：（IV）

公开(公告)号：US06224732B1

公开(公告)日：2001-05-01

申请号：US08734971

申请日：1996-11-19

申请人： Totaro Imasaka ,  Kazuo Isaka ,  Toshikazu Ohnishi ,  Takeshi Miyazaki

发明人： Totaro Imasaka ,  Kazuo Isaka ,  Toshikazu Ohnishi ,  Takeshi Miyazaki

IPC分类号： C25B900

CPC分类号： G01N30/6078 ,  G01N30/00 ,  G01N30/02 ,  G01N30/6026 ,  G01N30/6052 ,  G01N30/6082 ,  G01N30/6095 ,  G01N2030/285 ,  H05H3/04 ,  B01D2015/3895

摘要： A dispersing medium containing plural types of particles is let to flow in a flow path formed in a flow cell. The flow cell is irradiated with interfering light to form interference fringes of a pattern of stripes. In another arrangement, light is two-dimensionally scanned at high speed so as to cross a flow in the flow path. The moving particles receive a braking force by the light gradient force whenever they pass through each irradiation light stripe. In that case, greater braking forces act on particles having larger sizes (or larger refractive indices) than on particles having smaller sizes (or smaller refractive indices). Accordingly, the particles receiving smaller braking forces pass through the irradiated position more rapidly, so that particles can be separated to flow in the order from the particles receiving smaller braking forces to the particles receiving greater braking forces.

摘要翻译： 使含有多种粒子的分散介质在形成于流通池中的流路中流动。 用干涉光照射流动池，以形成条纹图案的干涉条纹。 在另一种布置中，光以高速二维地扫描，以便穿过流动路径中的流动。 每当它们通过每个照射光条纹时，移动的颗粒通过光梯度力接收制动力。 在这种情况下，与具有较小尺寸（或较小折射率）的颗粒相比，较大的制动力作用于具有较大尺寸（或更大折射率）的颗粒。 因此，接收较小制动力的颗粒更快地穿过照射位置，使得颗粒可以分离成从接收较小制动力的颗粒到接收更大制动力的颗粒的顺序流动。