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1.发明申请公开(公告)号：US20070075010A1
公开(公告)日：2007-04-05
申请号：US11479125
申请日：2006-06-30
申请人： John Gilbert , Manish Deshpande , Jaishree Trikha
发明人： John Gilbert , Manish Deshpande , Jaishree Trikha
CPC分类号： B01D63/087 , B01D63/088 , B01D67/0034 , B01D67/0062 , B01D2313/13 , B01D2313/40 , B01D2325/028 , B01D2325/12 , B01L3/06 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L2200/027 , B01L2200/028 , B01L2200/146 , B01L2300/041 , B01L2300/047 , B01L2300/0681 , B01L2300/0816 , B01L2300/0874 , B01L2400/0421 , B01L2400/0481 , B01L2400/0655 , B01L2400/0666 , C02F2209/36 , C30B7/00 , C30B29/58 , G01N27/44743 , G01N27/44773 , Y10S977/786 , Y10T156/10
摘要： A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system. The microfluidic element may comprise a matrix having an affinity for selected molecules in a sample. The matrix binds, reacts with and/or retains the selected molecules without affecting other molecules in the sample.
摘要翻译： 用于在微流体系统中整合微流体组分的系统和方法使得微流体系统能够执行选定的微流体功能。 封盖模块包括用于执行微流控功能的微流体元件。 封盖模块堆叠在具有微流管道的微流体衬底上，以将微流控功能结合到系统中。 微流体元件可以包含对样品中选定分子具有亲和性的基质。 该基质与所选择的分子结合，反应和/或保留，而不影响样品中的其它分子。
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公开(公告)号：US07153699B2
公开(公告)日：2006-12-26
申请号：US10328932
申请日：2002-12-23
申请人： John Gilbert , Jaishree Trikha
发明人： John Gilbert , Jaishree Trikha
CPC分类号： C40B50/08 , B01L3/0244 , B01L3/0248 , B01L3/0255 , B01L3/06 , B01L3/5088 , B01L2200/142 , B01L2200/143 , B01L2200/147 , B01L2300/1822 , B01L2400/0439 , C40B40/10 , G01N2035/1037 , Y10T436/25 , Y10T436/2575
摘要： A two-pin liquid handling system for crystallizing biomolecules comprises a pair of interacting pins for holding a droplet of liquid therebetween. Each pin includes a tip spaced predetermined distance from the other pin to define a sample acquisition region. The two-pin liquid handling system includes a temperature and humidity control element for controlling the temperature of the sample acquisition region to cause transpiration of water to and from a droplet of biomolecule solution to promote crystallization of the biomolecule.
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公开(公告)号：US20060269446A1
公开(公告)日：2006-11-30
申请号：US11295183
申请日：2005-12-05
申请人： John Gilbert , Hugh Lewis , Derek Beaupre , Jaishree Trikha , Manish Deshpande
发明人： John Gilbert , Hugh Lewis , Derek Beaupre , Jaishree Trikha , Manish Deshpande
IPC分类号： B01L9/00
CPC分类号： G01N33/577 , B01L3/502761 , B01L3/502776 , B01L5/00 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/082 , B01L2200/10 , B01L2300/0809 , B01L2300/0864 , B01L2400/0487 , C12M47/04 , G01N15/1056 , G01N15/1484 , G01N2015/1486 , G01N2015/149 , Y10T436/2575
摘要： A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles.
摘要翻译： 用于在颗粒上进行过程的单个一次性盒，例如颗粒分选，将所有流体接触表面封装在盒中以用于微流体颗粒处理技术。 墨盒与操作系统接口，用于进行颗粒处理。 流体接触表面的封装确保，改善或促进操作者隔离和/或产品隔离。 墨盒可以采用任何合适的处理颗粒的技术。
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公开(公告)号：US20070054408A1
公开(公告)日：2007-03-08
申请号：US11595543
申请日：2006-11-10
申请人： John Gilbert , Jaishree Trikha
发明人： John Gilbert , Jaishree Trikha
IPC分类号： G01N33/00
摘要： A two-pin liquid handling system for crystallizing biomolecules comprises a pair of interacting pins for holding a droplet of liquid therebetween. Each pin includes a tip spaced predetermined distance from the other pin to define a sample acquisition region. The two-pin liquid handling system includes a temperature and humidity control element for controlling the temperature of the sample acquisition region to cause transpiration of water to and from a droplet of biomolecule solution to promote crystallization of the biomolecule.
摘要翻译： 用于结晶生物分子的双针液体处理系统包括一对用于在其间保持液滴的相互作用的销。 每个引脚包括与另一个引脚间隔预定距离的尖端以限定采样区域。 双针液体处理系统包括温度和湿度控制元件，用于控制样品采集区域的温度，以使水与生物分子溶液液滴一起蒸发以促进生物分子的结晶。
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公开(公告)号：US06849459B2
公开(公告)日：2005-02-01
申请号：US10328931
申请日：2002-12-23
申请人： John Gilbert , Jaishree Trikha
发明人： John Gilbert , Jaishree Trikha
CPC分类号： C30B7/00 , B01L3/0248 , B01L3/06 , B01L3/502715 , B01L3/502723 , B01L3/502753 , B01L2200/0678 , B01L2300/0681 , B01L2300/087 , B01L2300/1827 , B01L2400/0487 , C30B29/58 , Y10T436/25 , Y10T436/2525 , Y10T436/255
摘要： A system for crystallizing a protein and other biomolecules comprises a flow channel for conveying a solution containing the biomolecule to be crystallized and one or more substations related to the crystallization process formed along the flow channel. The system operates by flowing a biomolecule solution through a the flow channel, then performing dialysis on a micro-scale to set crystallization conditions. After dialysis, the concentration of the biomolecule solution is changed by removing water or solvent from the biomolecule solution to promote formation of crystals in a segment of the flow channel. Formed crystals may be observed and harvested from the flow channel.
摘要翻译： 用于结晶蛋白质和其他生物分子的系统包括用于输送含有待结晶的生物分子的溶液的流动通道和与沿流动通道形成的结晶过程相关的一个或多个变电站。 该系统通过使生物分子溶液流过流动通道，然后在微量级上进行透析以设定结晶条件来操作。 透析后，通过从生物分子溶液中除去水或溶剂来改变生物分子溶液的浓度，以促进在流动通道的段中形成晶体。 可以从流动通道观察并收获形成的晶体。
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公开(公告)号：US20050112774A1
公开(公告)日：2005-05-26
申请号：US10973138
申请日：2004-10-25
申请人： John Gilbert , Jaishree Trikha
发明人： John Gilbert , Jaishree Trikha
CPC分类号： C30B7/00 , B01L3/0248 , B01L3/06 , B01L3/502715 , B01L3/502723 , B01L3/502753 , B01L2200/0678 , B01L2300/0681 , B01L2300/087 , B01L2300/1827 , B01L2400/0487 , C30B29/58 , Y10T436/25 , Y10T436/2525 , Y10T436/255
摘要： A system for crystallizing a protein and other biomolecules comprises a flow channel for conveying a solution containing the biomolecule to be crystallized and one or more substations related to the crystallization process formed along the flow channel. The system operates by flowing a biomolecule solution through a the flow channel, then performing dialysis on a micro-scale to set crystallization conditions. After dialysis, the concentration of the biomolecule solution is changed by removing water or solvent from the biomolecule solution to promote formation of crystals in a segment of the flow channel. Formed crystals may be observed and harvested from the flow channel.
摘要翻译： 用于结晶蛋白质和其他生物分子的系统包括用于输送含有待结晶的生物分子的溶液的流动通道和与沿流动通道形成的结晶过程相关的一个或多个变电站。 该系统通过使生物分子溶液流过流动通道，然后在微量级上进行透析以设定结晶条件来操作。 透析后，通过从生物分子溶液中除去水或溶剂来改变生物分子溶液的浓度，以促进在流动通道的段中形成晶体。 可以从流动通道观察并收获形成的晶体。
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公开(公告)号：US20120009619A1
公开(公告)日：2012-01-12
申请号：US13240521
申请日：2011-09-22
CPC分类号： G01N33/577 , B01L3/502761 , B01L3/502776 , B01L5/00 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/082 , B01L2200/10 , B01L2300/0809 , B01L2300/0864 , B01L2400/0487 , C12M47/04 , G01N15/1056 , G01N15/1484 , G01N2015/1486 , G01N2015/149 , Y10T436/2575
摘要： A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles.
摘要翻译： 用于在颗粒上进行过程的单个一次性盒，例如颗粒分选，将所有流体接触表面封装在盒中以用于微流体颗粒处理技术。 墨盒与操作系统接口，用于进行颗粒处理。 流体接触表面的封装确保，改善或促进操作者隔离和/或产品隔离。 墨盒可以采用任何合适的处理颗粒的技术。
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公开(公告)号：US08679422B2
公开(公告)日：2014-03-25
申请号：US13240521
申请日：2011-09-22
IPC分类号： B01L3/00
CPC分类号： G01N33/577 , B01L3/502761 , B01L3/502776 , B01L5/00 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/082 , B01L2200/10 , B01L2300/0809 , B01L2300/0864 , B01L2400/0487 , C12M47/04 , G01N15/1056 , G01N15/1484 , G01N2015/1486 , G01N2015/149 , Y10T436/2575
摘要： A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles.
摘要翻译： 用于在颗粒上进行过程的单个一次性盒，例如颗粒分选，将所有流体接触表面封装在盒中以用于微流体颗粒处理技术。 墨盒与操作系统接口，用于进行颗粒处理。 流体接触表面的封装确保，改善或促进操作者隔离和/或产品隔离。 墨盒可以采用任何合适的处理颗粒的技术。
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9.发明授权公开(公告)号：US07514000B2
公开(公告)日：2009-04-07
申请号：US11479125
申请日：2006-06-30
CPC分类号： B01D63/087 , B01D63/088 , B01D67/0034 , B01D67/0062 , B01D2313/13 , B01D2313/40 , B01D2325/028 , B01D2325/12 , B01L3/06 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L2200/027 , B01L2200/028 , B01L2200/146 , B01L2300/041 , B01L2300/047 , B01L2300/0681 , B01L2300/0816 , B01L2300/0874 , B01L2400/0421 , B01L2400/0481 , B01L2400/0655 , B01L2400/0666 , C02F2209/36 , C30B7/00 , C30B29/58 , G01N27/44743 , G01N27/44773 , Y10S977/786 , Y10T156/10
摘要： A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system. The microfluidic element may comprise a matrix having an affinity for selected molecules in a sample. The matrix binds, reacts with and/or retains the selected molecules without affecting other molecules in the sample.
摘要翻译： 用于在微流体系统中整合微流体组分的系统和方法使得微流体系统能够执行选定的微流体功能。 封盖模块包括用于执行微流控功能的微流体元件。 封盖模块堆叠在具有微流管道的微流体衬底上，以将微流控功能结合到系统中。 微流体元件可以包含对样品中选定分子具有亲和性的基质。 该基质与所选择的分子结合，反应和/或保留，而不影响样品中的其它分子。
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公开(公告)号：US08277764B2
公开(公告)日：2012-10-02
申请号：US11295183
申请日：2005-12-05
IPC分类号： A61J1/06
CPC分类号： G01N33/577 , B01L3/502761 , B01L3/502776 , B01L5/00 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/082 , B01L2200/10 , B01L2300/0809 , B01L2300/0864 , B01L2400/0487 , C12M47/04 , G01N15/1056 , G01N15/1484 , G01N2015/1486 , G01N2015/149 , Y10T436/2575
摘要： A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles.
摘要翻译： 用于在颗粒上进行过程的单个一次性盒，例如颗粒分选，将所有流体接触表面封装在盒中以用于微流体颗粒处理技术。 墨盒与操作系统接口，用于进行颗粒处理。 流体接触表面的封装确保，改善或促进操作者隔离和/或产品隔离。 墨盒可以采用任何合适的处理颗粒的技术。
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