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公开(公告)号：US20050136470A1
公开(公告)日：2005-06-23
申请号：US11048918
申请日：2005-02-03
IPC分类号： G01N33/53 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , G01N21/01 , G01N21/03 , G01N27/447 , G01N33/566
CPC分类号： G01N27/44704 , C12Q1/6825 , G01N27/44721 , G01N27/4473 , C12Q2565/607 , C12Q2565/518
摘要： Provided is an apparatus for detecting biopolymers (DNA) capable of total analysis including non-reacted samples without complicated operations such as washing. A DNA probe is fixed to one of electrodes and direct current voltage is placed between the electrodes, so that it becomes possible to separate complementary strand sample DNA and non-complementary strand sample DNA. By analyzing from a ratio in the whole reaction system, it is possible to obtain clearer results. Further, by using electrophoresis by gel together, it is possible to separate reacted samples and non-reacted samples to perform measurements therefor in the same reaction field.
摘要翻译： 提供了一种用于检测能够进行总体分析的生物聚合物（DNA）的装置，包括没有复杂操作如洗涤的未反应样品。 将DNA探针固定在电极之一中，并且将直流电压置于电极之间，使得可以分离互补链样品DNA和非互补链样品DNA。 通过从整个反应系统的比例分析，可以获得更清楚的结果。 此外，通过使用凝胶电泳在一起，可以在相同的反应场中分离反应的样品和未反应的样品以进行测量。
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公开(公告)号：US06875603B2
公开(公告)日：2005-04-05
申请号：US10001012
申请日：2001-11-30
IPC分类号： G01N33/53 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , G01N21/01 , G01N21/03 , G01N27/447 , G01N33/566 , C12M3/00
CPC分类号： G01N27/44704 , C12Q1/6825 , G01N27/44721 , G01N27/4473 , C12Q2565/607 , C12Q2565/518
摘要： Provided is an apparatus for detecting biopolymers (DNA) capable of total analysis including non-reacted samples without complicated operations such as washing.A DNA probe is fixed to one of electrodes and direct current voltage is placed between the electrodes, so that it becomes possible to separate complementary strand sample DNA and non-complementary strand sample DNA. By analyzing from a ratio in the whole reaction system, it is possible to obtain clearer results. Further, by using electrophoresis by gel together, it is possible to separate reacted samples and non-reacted samples to perform measurements therefor in the same reaction field.
摘要翻译： 本发明提供一种用于检测能够进行总体分析的生物聚合物（DNA）的装置，包括未进行复杂操作的洗涤等未反应的样品。将DNA探针固定在电极中的一个上，并将直流电压置于电极之间， 分离互补链样品DNA和非互补链样品DNA。 通过从整个反应系统的比例分析，可以获得更清楚的结果。 此外，通过使用凝胶电泳在一起，可以在相同的反应场中分离反应的样品和未反应的样品以进行测量。
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公开(公告)号：US07135331B2
公开(公告)日：2006-11-14
申请号：US11048918
申请日：2005-02-03
IPC分类号： C12M1/34
CPC分类号： G01N27/44704 , C12Q1/6825 , G01N27/44721 , G01N27/4473 , C12Q2565/607 , C12Q2565/518
摘要： Provided is an apparatus for detecting biopolymers (DNA) capable of total analysis including non-reacted samples without complicated operations such as washing.A DNA probe is fixed to one of electrodes and direct current voltage is placed between the electrodes, so that it becomes possible to separate complementary strand sample DNA and non-complementary strand sample DNA. By analyzing from a ratio in the whole reaction system, it is possible to obtain clearer results. Further, by using electrophoresis by gel together, it is possible to separate reacted samples and non-reacted samples to perform measurements therefor in the same reaction field.
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公开(公告)号：US06582954B2
公开(公告)日：2003-06-24
申请号：US10062132
申请日：2002-01-30
IPC分类号： C12M136
CPC分类号： C12Q1/6825
摘要： Disclosed is a biopolymer (DNA) detector capable of performing overall analysis including an unreacted sample without needing any complex work such as washing or the like. A DNA probe 66 is fixed to an electrode plate 22, and the electrode plate 22 is displaced by applying a DC voltage between electrode plates 22 and 23. Thus, sample DNA 63 to be detected can be separated. It becomes possible to obtain a clearer result by performing analysis based on a ratio of an entire reaction system.
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公开(公告)号：US06835352B2
公开(公告)日：2004-12-28
申请号：US10434214
申请日：2003-05-09
申请人： Seiichiro Ito , Mitsuhiro Tachibana
发明人： Seiichiro Ito , Mitsuhiro Tachibana
IPC分类号： B01L302
CPC分类号： B01L3/0244 , B01L3/0248 , B01L3/0262 , B01L2200/0605 , B01L2400/025 , B01L2400/0406 , Y10T436/2575
摘要： A spotting pin 10 capable of spotting equal amounts of a solution in a sequential manner comprises a first member 11 having a solution holding portion 13 formed at the tip thereof for holding a predetermined amount of solution, and a second member 12 having a solution supply portion 14 for holding the solution by a capillary action, the second member adapted to slide along the first member. As the solution supply portion 14 is brought into contact with the solution holding portion 13, the solution enters the solution holding portion 13 from the solution supply portion 14 by a capillary action. As the solution supply portion 14 and the solution holding portion 13 are separated from each other, a predetermined amount of the solution can be carried in the solution holding portion 13. Then, as the solution holding portion 13 is brought into contact with a water-absorbing support 21, a spot 22 of a predetermined amount of the solution can be formed thereon.
摘要翻译： 能够顺序地分配等量溶液的点针10包括：第一构件11，其具有形成在其顶端处的用于保持预定量溶液的溶液保持部分13;以及第二构件12，其具有溶液供应部分 14，用于通过毛细作用保持溶液，第二构件适于沿着第一构件滑动。 当溶液供应部分14与溶液保持部分13接触时，溶液通过毛细作用从溶液供应部分14进入溶液保留部分13。 当溶液供应部分14和溶液保持部分13彼此分离时，可以在溶液保留部分13中承载预定量的溶液。然后，当溶液保持部分13与水溶液保持部分13接触时， 吸收支撑件21，可以在其上形成预定量的溶液的点22。
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公开(公告)号：US06787349B1
公开(公告)日：2004-09-07
申请号：US09889747
申请日：2001-07-19
IPC分类号： C12M100
CPC分类号： G01N33/543 , B01J2219/00536 , Y10T436/13
摘要： The present invention provides a high-sensitive, inexpensive biochip reader for reading a biochip as compared to a fluorescence method. The biochip reader is provided with an X-Y stage (3) for mounting a biochip (6) and scanning the biochip (6) in a two-dimensional manner, a controller (4) for the X-Y stage, a magnetic sensor (1) for reading the magnetic field strength, an ohmmeter (2), and a computer (5) for signal processing. As a result, a high-performance, inexpensive biochip reader can be provided without using an expensive laser or an expensive optical system, by employing a magnetic sensor and a disk driving mechanism generally used in a hard disk drive and the like.
摘要翻译： 与荧光方法相比，本发明提供了一种用于读取生物芯片的高灵敏度，便宜的生物芯片读取器。 生物芯片读取器设置有用于安装生物芯片（6）并以二维方式扫描生物芯片（6）的XY台（3），用于XY台的控制器（4），用于 读取磁场强度，欧姆表（2）和用于信号处理的计算机（5）。 结果，通过采用通常用于硬盘驱动器等中的磁传感器和盘驱动机构，可以提供高性能，廉价的生物芯片读取器，而不需要使用昂贵的激光器或昂贵的光学系统。
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公开(公告)号：US06767748B2
公开(公告)日：2004-07-27
申请号：US10429825
申请日：2003-05-06
IPC分类号： G01N128
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00387 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00689 , B01J2219/00698 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/10 , G01N2035/1037 , Y10T436/2575
摘要： The present invention enables the accurate management of the total number of spotting counts for each spotting pin. An IC chip is installed on the spotting pin to allow the IC chip to accumulate spotting-count information, and during each spotting time the information is loaded up and displayed.
摘要翻译： 本发明能够精确地管理每个点针的总点数计数。 IC芯片安装在点焊针上，允许IC芯片累积点样数信息，并在每个发光时间内加载和显示信息。
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公开(公告)号：US06737666B1
公开(公告)日：2004-05-18
申请号：US09721703
申请日：2000-11-27
申请人： Natsuko Ito , Tsuyoshi Moriya , Fumihiko Uesugi , Yoshinori Kato , Masaru Aomori , Shuji Moriya , Mitsuhiro Tachibana
发明人： Natsuko Ito , Tsuyoshi Moriya , Fumihiko Uesugi , Yoshinori Kato , Masaru Aomori , Shuji Moriya , Mitsuhiro Tachibana
IPC分类号： G01N2149
CPC分类号： H01J37/32935 , C23C16/4405 , C23C16/52 , G01N21/49 , H01J37/32963 , Y10S438/905
摘要： A cleaning end point detecting apparatus detects an end point of a cleaning process in which contamination attached to an inner wall of a reaction chamber is removed by introducing a cleaning gas into the chamber to produce a cluster cloud and detached particles. An irradiating unit irradiates a laser beam onto the cluster cloud and the detached particles within the reaction chamber to produce a scattered laser beam. A monitoring unit monitors the scattered laser beam as a two-dimensional image information. A judging unit judges the end point of the cleaning process on the basis of the two-dimensional image information. Preferably, the judging unit judges, as the end point of the cleaning process, a time instant when neither the detached particles nor the cluster cloud are detected on the basis of the two-dimensional image information.
摘要翻译： 清洗终点检测装置检测清洁过程的终点，其中通过将清洁气体引入室中来除去附着在反应室内壁上的污染物，以产生簇云和分离的颗粒。 照射单元将激光束照射到聚簇云和反应室内的分离的颗粒以产生散射的激光束。 监视单元将散射的激光束监视为二维图像信息。 判断单元基于二维图像信息判断清洁处理的结束点。 优选地，判断单元基于二维图像信息来判断清除处理的结束点是否没有检测到分离的颗粒和簇云的时刻。
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公开(公告)号：US06646271B2
公开(公告)日：2003-11-11
申请号：US09998527
申请日：2001-11-28
IPC分类号： G01N2164
CPC分类号： G01N21/6408 , G01N21/6458
摘要： The present invention aims at minimizing the influence of residual fluorescence emitted from adjacent spots, upon reading time-resolved fluorescence. The path of laser beam scan is set to be intermittent such that residual fluorescence from adjacent spots gives no effect. In other words, the spots are read in a skipping manner.
摘要翻译： 本发明的目的是在读取时间分辨荧光的同时最小化从相邻光点发射的残留荧光的影响。激光束扫描的路径被设置为间歇的，使得来自相邻斑点的残留荧光不起作用。 换句话说，以跳过的方式读取斑点。
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公开(公告)号：US6036782A
公开(公告)日：2000-03-14
申请号：US166577
申请日：1998-10-06
IPC分类号： H01L21/285 , C23C16/44 , C23C16/455 , H01L21/205 , H01L21/3065 , H01L21/31 , H01L21/687 , C23C16/00
CPC分类号： C23C16/45565 , C23C16/455 , H01L21/687
摘要： A showerhead for use in a process chamber for performing a predetermined process on an object, designed to apply a prescribed gas in the process chamber. The showerhead comprises a main body, a cover, and a support. The main body has a an internal space into which the gas to be supplied into the process chamber is introduced and an opening which opens to the process chamber. The cover closes the opening of the main body and has a plurality of gas-applying holes for applying the gas from the main body. The support supports the cover to the main body and provides a predetermined clearance between the cover and the main body.
摘要翻译： 一种在处理室中使用的用于对物体进行预定处理的喷头，其被设计成在处理室中施加规定的气体。 喷头包括主体，盖和支撑件。 主体具有内部空间，供给到处理室中的气体被引入到该内部空间中，并且开口通向处理室。 盖封闭主体的开口，并具有多个用于从主体施加气体的气体施加孔。 支撑件支撑主体的盖，并且在盖和主体之间提供预定的间隙。
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