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公开(公告)号：US09927425B2
公开(公告)日：2018-03-27
申请号：US14758291
申请日：2013-12-27
Inventor： Se Hyun Shin , Chae Seung Lim , Jeong Hoon Nam , Hyun Jung Lim
CPC classification number: G01N33/5029 , B01F13/0059 , B01F13/0818 , B01F15/0233 , B01L3/502746 , B01L2300/0803 , B01L2300/087 , B01L2300/0883 , B01L2400/0409 , B01L2400/0677 , G01N33/491 , G01N33/5044 , G01N35/00069 , G01N2035/00237
Abstract: The present invention relates to an apparatus and method for testing a multi-function and a drug response of platelet based on a centrifugal microfluidics. The testing apparatus according to the present invention may include: a rotatable disk; a sample chamber arranged at the center of the disk such that a blood sample is accommodated therein; stirring chambers respectively connected to the sample chamber in multiple radial directions so as to introduce a shear flow in the blood sample; microchannels connected to the stirring chambers such that adhesion and cohesion of platelets occur during the movement of the blood sample; and a waste sample chamber in which the blood sample is accommodated after passing through the microchannels. According to the present invention, multiple drug tests can be performed on a single blood sample at one time in multiple channels such that multiple tests is possible with respect to complex platelet functions, and thus testing time is reduced and testing costs can be saved.
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公开(公告)号：US10082455B2
公开(公告)日：2018-09-25
申请号：US14758249
申请日：2013-12-27
Inventor： Se Hyun Shin , Jeong Hoon Nam
CPC classification number: G01N15/1056 , B01D15/34 , B01D15/3866 , B01D15/3885 , B01L3/50273 , B01L2200/0652 , B01L2300/0816 , B01L2300/0867 , B01L2400/0436 , G01N15/02 , G01N30/6095 , G01N30/76 , G01N2015/1081 , G01N2030/027
Abstract: The present invention related to an apparatus for separating micro-nano scale particles based on microfluidic chromatography using surface acoustic waves, comprising: a piezoelectric substrate; a pair of transducers, which are patterned on the piezoelectric substrate and generate surface acoustic waves when electric energy is applied to the piezoelectric substrate; a microfluidic chip, which is mounted on the piezoelectric substrate and include a microfluidic channel disposed between the pair of transducers, wherein a fluid including micro-nano scale particles flows in the microfluidic channel; and a detection unit, which detects micro-nano scale particles separated by the surface acoustic waves while the micro-nano scale particles pass through the microfluidic channel, wherein forces of the surface acoustic waves generated by the pair of transducers are formed in a direction opposite to a fluid flow to generate flow resistance to the micro-nano scale particles which flows in the microfluidic channel.
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3.发明授权公开(公告)号：US09983220B2
公开(公告)日：2018-05-29
申请号：US14655437
申请日：2013-12-26
Inventor： Se Hyun Shin , Chae Seung Lim
CPC classification number: G01N33/86 , B01L3/502715 , B01L3/50273 , B01L2200/10 , B01L2300/0627 , B01L2300/0645 , B01L2300/0654 , B01L2300/0663 , B01L2400/0406 , B01L2400/0478 , B01L2400/06 , G01N15/0612 , G01N15/1463 , G01N15/1484 , G01N33/49 , G01N2015/0092
Abstract: The present invention relates to an apparatus and a method for testing a function and a drug response of a platelet based on a microfluidic chip. The apparatus for test comprises a measuring device containing a blood sample and measuring aggregation and adhesion of a platelet generated by flow of the blood sample; and a fluid driving device which is connected to the measuring device and generates a oscillating shear flow of the blood sample. Therefore, activation of factors such as a platelet and von Willebrand factor (vWF) etc. can be activated uniformly and completely, and a repeatability of the platelet aggregation can be increased.
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