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公开(公告)号:US6117977A
公开(公告)日:2000-09-12
申请号:US840062
申请日:1997-04-24
申请人: Laurence A. Lasky , Kai Wu
发明人: Laurence A. Lasky , Kai Wu
IPC分类号: C07K14/705 , C07K14/00 , C07H21/04 , C12N15/00 , C12N15/03
CPC分类号: C07K14/7056 , C07K14/70564 , C07K2319/00 , C07K2319/30
摘要: The invention concerns novel members of the endocytic type C lectin family and methods and means for producing them. The native polypeptides of the invention are characterized by containing a signal sequence, a cysteine rich domain, a fibronectin type II domain, 8 type C lectin domains, a transmembrane domain and a cytoplasmic domain. Nucleotide sequences encoding such polypeptides, vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel type C lectins are also within the scope of the invention.
摘要翻译: 本发明涉及内吞型C凝集素家族的新成员及其生产方法和方法。 本发明的天然多肽的特征在于含有信号序列,富含半胱氨酸的结构域,纤连蛋白II型结构域,8型凝集素结构域,跨膜结构域和胞质结构域。 编码这种多肽的核苷酸序列,含有核苷酸序列的载体,用载体转化的重组宿主细胞,以及用于新型C型凝集素重组生产的方法也在本发明的范围内。
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公开(公告)号:US09695472B2
公开(公告)日:2017-07-04
申请号:US12950729
申请日:2010-11-19
IPC分类号: C12Q1/68 , B82Y30/00 , B01L3/00 , G01N27/414
CPC分类号: C12Q1/6874 , B01J2219/00317 , B01J2219/00511 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00641 , B01J2219/00722 , B01L3/5085 , B82Y30/00 , C12Q1/6825 , G01N27/414 , C12Q2565/301 , C12Q2533/101 , C12Q2521/101 , C12Q2565/607 , C12Q2525/125 , C12Q2521/319
摘要: Embodiments of the present invention provide devices methods for sequencing DNA using arrays of reaction regions containing electronic sensors to monitor changes in solutions contained in the reaction regions. Test and fill reaction schemes are disclosed that allow DNA to be sequenced. By sequencing DNA using parallel reactions contained in large arrays, DNA can be rapidly sequenced.
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公开(公告)号:US08795523B2
公开(公告)日:2014-08-05
申请号:US13430171
申请日:2012-03-26
申请人: Xing Su , David J. Liu , Kai Wu , Kenneth B. Swartz , Mineo Yamakawa
发明人: Xing Su , David J. Liu , Kai Wu , Kenneth B. Swartz , Mineo Yamakawa
IPC分类号: H05K13/04 , G01N33/53 , G01N33/553
CPC分类号: G01N1/4044 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2400/0424 , B01L2400/043 , B01L2400/0638 , B01L2400/086 , G01N35/0098 , G01N35/08 , G01N2015/0038 , G01N2015/0092 , H01F7/20 , H01F7/206 , H01F2007/068 , Y10S436/805 , Y10S436/806 , Y10T29/49117 , Y10T29/4913 , Y10T29/49155 , Y10T436/25
摘要: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
摘要翻译: 本发明的一个实施例涉及用于检测样品中的分析物的装置。 该装置包括流体网络和集成电路部件。 流体网络包括样品区,清洁区和检测区。 流体网络包含磁性颗粒和/或信号颗粒。 引入含有分析物的样品,并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。 微线圈阵列或机械可移动永磁体在功能上耦合到流体网络,流体网络可激活以在流体网络的一部分内产生磁场,并将磁性颗粒从样品区域移动到检测区域。 存在检测元件,其检测来自信号颗粒的光学或电信号,从而指示分析物的存在。
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公开(公告)号:US08563240B2
公开(公告)日:2013-10-22
申请号:US12319168
申请日:2008-12-31
申请人: Xing Su , Kai Wu , David J. Liu
发明人: Xing Su , Kai Wu , David J. Liu
CPC分类号: C12Q1/6874 , C12Q1/6837 , C12Q2565/607 , C12Q2565/518 , C12Q2525/117 , C12Q2537/149 , C12Q2525/113 , C12Q2521/319
摘要: Embodiments of the present invention provide devices methods for sequencing DNA using arrays of reaction regions containing sensors to monitor changes in solutions or bound molecules contained in the reaction regions. Additional embodiments provide devices and methods for sequencing DNA using arrays of reaction regions that allow for optical monitoring of solutions in the reaction regions. Chemical amplification schemes that allow DNA to be sequenced in which multiple nucleotide addition reactions are performed to detect the incorporation of a base are disclosed. By sequencing DNA using parallel reactions contained in large arrays, DNA can be rapidly sequenced.
摘要翻译: 本发明的实施方案提供了使用包含传感器的反应区域的阵列来测序DNA的装置方法,以监测反应区域中包含的溶液或结合分子的变化。 另外的实施方案提供了使用允许对反应区域中的溶液进行光学监测的反应区域阵列来测序DNA的装置和方法。 公开了允许进行多核苷酸加成反应进行DNA测序以检测碱基掺入的化学扩增方案。 通过使用大阵列中包含的平行反应测序DNA,可以快速测序DNA。
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公开(公告)号:US08158008B2
公开(公告)日:2012-04-17
申请号:US13197918
申请日:2011-08-04
申请人: Xing Su , David J. Liu , Kenneth B. Swartz , Kai Wu , Mineo Yamakawa
发明人: Xing Su , David J. Liu , Kenneth B. Swartz , Kai Wu , Mineo Yamakawa
IPC分类号: G01N1/00 , G01N21/00 , G01N33/48 , G01N33/53 , G01N33/553
CPC分类号: G01N1/4044 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2400/0424 , B01L2400/043 , B01L2400/0638 , B01L2400/086 , G01N35/0098 , G01N35/08 , G01N2015/0038 , G01N2015/0092 , H01F7/20 , H01F7/206 , H01F2007/068 , Y10S436/805 , Y10S436/806 , Y10T29/49117 , Y10T29/4913 , Y10T29/49155 , Y10T436/25
摘要: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
摘要翻译: 本发明的一个实施例涉及用于检测样品中的分析物的装置。 该装置包括流体网络和集成电路部件。 流体网络包括样品区,清洁区和检测区。 流体网络包含磁性颗粒和/或信号颗粒。 引入含有分析物的样品,并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。 微线圈阵列或机械可移动永磁体在功能上耦合到流体网络,流体网络可激活以在流体网络的一部分内产生磁场,并将磁性颗粒从样品区域移动到检测区域。 存在检测元件,其检测来自信号颗粒的光学或电信号,从而指示分析物的存在。
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公开(公告)号:US20120087054A1
公开(公告)日:2012-04-12
申请号:US13268297
申请日:2011-10-07
申请人: Kai Wu
发明人: Kai Wu
IPC分类号: H02H5/04
CPC分类号: H02S40/34
摘要: The primary objective of the present invention is to provide a solar module with a bimetal breaker, which comprises a solar module with terminal ribbons deposited on both sides of the solar module and inter-connecting ribbons extended and connected to the terminal ribbons, and a bimetal breaker being deposited on a joint of the terminal ribbon and the inter-connecting ribbon of the solar module. The bimetal breaker comprises a bimetal unit that is composed of two metal layers, and when the bimetal unit is heated, the bimetal unit will bend because of different thermal expansion coefficients and push the conducting terminals to separate from each other, so as to prevent the solar module from being damaged due to high temperature.
摘要翻译: 本发明的主要目的是提供一种具有双金属断路器的太阳能模块,其包括太阳能模块,其具有沉积在太阳能模块两侧的端子带和延伸并连接到端子带的互连带和双金属片 断路器沉积在太阳能模块的端子带和连接带的接头上。 双金属断路器包括由两个金属层组成的双金属单元,并且当双金属单元被加热时,双金属单元将由于不同的热膨胀系数而弯曲,并且将导电端子彼此分离,以防止 太阳能组件由于高温而被损坏。
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公开(公告)号:US07979459B2
公开(公告)日:2011-07-12
申请号:US11763539
申请日:2007-06-15
申请人: Kai Wu , Daniel Takacs , Tong Yao , Jiyu Zhang , Hua Yang , Ji-Rong Wen , Jonathan R M Hart , Eric Anthony Reel
发明人: Kai Wu , Daniel Takacs , Tong Yao , Jiyu Zhang , Hua Yang , Ji-Rong Wen , Jonathan R M Hart , Eric Anthony Reel
CPC分类号: G06Q30/02 , G06Q10/101 , Y10S707/944
摘要: Aspects of the subject matter described herein relate to matching product information to products. In aspects, a product matching component receives product information. The product matching component normalizes the product information and obtains keywords from the product information. By querying a database of recognized products, the keywords are used to obtain a list of products that potentially match the product information. A confidence level is assigned to each of the potential matches in the list. A match may be returned for the highest matched product or for a selectable number of products whose confidence level(s) exceed a selectable threshold.
摘要翻译: 本文描述的主题的方面涉及将产品信息与产品相匹配。 在方面,产品匹配组件接收产品信息。 产品匹配组件对产品信息进行规范化,并从产品信息中获取关键字。 通过查询已识别产品的数据库,关键字用于获取可能与产品信息相匹配的产品列表。 信任级别分配给列表中的每个潜在匹配项。 可以为最高匹配产品或可信度等级超过可选阈值的产品的可选数量返回匹配。
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公开(公告)号:US20080313165A1
公开(公告)日:2008-12-18
申请号:US11763539
申请日:2007-06-15
申请人: Kai Wu , Daniel Takacs , Tong Yao , Jiyu Zhang , Hua Yang , Ji-Rong Wen , Jonathan R.M. Hart , Eric Anthony Reel
发明人: Kai Wu , Daniel Takacs , Tong Yao , Jiyu Zhang , Hua Yang , Ji-Rong Wen , Jonathan R.M. Hart , Eric Anthony Reel
CPC分类号: G06Q30/02 , G06Q10/101 , Y10S707/944
摘要: Aspects of the subject matter described herein relate to matching product information to products. In aspects, a product matching component receives product information. The product matching component normalizes the product information and obtains keywords from the product information. By querying a database of recognized products, the keywords are used to obtain a list of products that potentially match the product information. A confidence level is assigned to each of the potential matches in the list. A match may be returned for the highest matched product or for a selectable number of products whose confidence level(s) exceed a selectable threshold.
摘要翻译: 本文描述的主题的方面涉及将产品信息与产品相匹配。 在方面,产品匹配组件接收产品信息。 产品匹配组件对产品信息进行规范化,并从产品信息中获取关键字。 通过查询已识别产品的数据库,关键字用于获取可能与产品信息相匹配的产品列表。 信任级别分配给列表中的每个潜在匹配项。 可以为最高匹配产品或可信度等级超过可选阈值的产品的可选数量返回匹配。
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公开(公告)号:US20080241828A1
公开(公告)日:2008-10-02
申请号:US11694427
申请日:2007-03-30
申请人: Kai Wu , Xing Su , Mineo Yamakawa
发明人: Kai Wu , Xing Su , Mineo Yamakawa
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6827 , C12Q2523/125 , C12Q2565/628
摘要: Epigenetic events such as DNA methylation play important roles in the regulation of gene expression. DNA methylation patterns have been found to differ between healthy and diseased tissue, such as healthy and cancerous tissue, thereby allowing DNA methylation to serve as a biomarker for disease states. Embodiments of the invention provide methods for detecting methylation patterns in DNA polymers. Methylation patterns are detected, in part, through the use of surface enhanced Raman spectroscopy (SERS). SERS provides a sensitive structure-based technique for chemical analysis.
摘要翻译: 表观遗传事件如DNA甲基化在调控基因表达中起重要作用。 已经发现DNA甲基化模式在健康和患病组织如健康和癌组织之间不同,从而允许DNA甲基化作为疾病状态的生物标志物。 本发明的实施方案提供了检测DNA聚合物中甲基化模式的方法。 甲基化模式部分地通过使用表面增强拉曼光谱(SERS)来检测。 SERS提供了一种敏感的基于结构的化学分析技术。
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公开(公告)号:US20060277328A1
公开(公告)日:2006-12-07
申请号:US11145763
申请日:2005-06-06
申请人: Jacob Cherian , Kai Wu
发明人: Jacob Cherian , Kai Wu
IPC分类号: G06F3/00
CPC分类号: G06F3/0659 , G06F3/0607 , G06F3/0632 , G06F3/0689
摘要: A system and method is disclosed for managing access command transmitted to a storage controller during the period that a device coupled to the storage controller is undergoing a firmware update. The storage controller manages access commands directed to the storage controller so that the access command may be managed in a manner that does not disrupt the firmware update processor or the completion of the access command itself. The storage controller enters a guard mode in which the firmware of the storage controller intercepts commands directed to the device undergoing a firmware update. Depending on the characteristics of the access command, the data of the command may be generated from other drives in a redundant drive array or the command may be saved to a cache or journal for later processing.
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