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公开(公告)号：US20070155016A1
公开(公告)日：2007-07-05
申请号：US11466104
申请日：2006-08-21
申请人： Luke Lee , Jeonggi Seo , Cristian Ionescu-Zanetti , Michelle Khine , Adrian Lau
发明人： Luke Lee , Jeonggi Seo , Cristian Ionescu-Zanetti , Michelle Khine , Adrian Lau
CPC分类号： G01N33/48728 , B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2400/0487 , C12M23/16 , C12M35/02 , C12N15/87
摘要： Method and systems provide improved cell handling in microfluidic systems and devices using lateral cell trapping and methods of fabrication of the same that allow for selective low voltage electroporation and electrofusion.
摘要翻译： 方法和系统在使用横向细胞捕获的微流体系统和装置中提供改进的细胞处理以及允许选择性低电压电穿孔和电融合的制造方法。
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公开(公告)号：US08058056B2
公开(公告)日：2011-11-15
申请号：US11466104
申请日：2006-08-21
IPC分类号： C12M3/00
CPC分类号： G01N33/48728 , B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2400/0487 , C12M23/16 , C12M35/02 , C12N15/87
摘要： Method and systems provide improved cell handling in microfluidic systems and devices using lateral cell trapping and methods of fabrication of the same that allow for selective low voltage electroporation and electrofusion.
摘要翻译： 方法和系统在使用横向细胞捕获的微流体系统和装置中提供改进的细胞处理以及允许选择性低电压电穿孔和电融合的制造方法。
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3.发明申请公开(公告)号：US20120135887A1
公开(公告)日：2012-05-31
申请号：US13291018
申请日：2011-11-07
CPC分类号： G01N33/48728 , B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2400/0487 , C12M23/16 , C12M35/02 , C12N15/87
摘要： Method and systems provide improved cell handling in microfluidic systems and devices using lateral cell trapping and methods of fabrication of the same that allow for selective low voltage electroporation and electrofusion.
摘要翻译： 方法和系统在使用横向细胞捕获的微流体系统和装置中提供改进的细胞处理以及允许选择性低电压电穿孔和电融合的制造方法。
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公开(公告)号：US20110045582A1
公开(公告)日：2011-02-24
申请号：US10598830
申请日：2005-03-14
申请人： Luke P. Lee , Jeonggi Seo , Cristian Ionescu-Zanetti , Michelle Khine , Poorya Sabounchi , Robin Shaw
发明人： Luke P. Lee , Jeonggi Seo , Cristian Ionescu-Zanetti , Michelle Khine , Poorya Sabounchi , Robin Shaw
CPC分类号： G01N33/48728 , B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2200/12 , B01L2200/16 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2400/049 , B01L2400/0655 , B29C33/3842 , B29C45/372
摘要： Method and systems that provide improved cell handling and assays in microfluidic systems and devices particularly using lateral cell trapping and methods of fabrication of the same.
摘要翻译： 在微流体系统和装置中提供改进的细胞处理和测定的方法和系统，特别是使用横向细胞捕获及其制备方法。
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5.发明申请Methods and Apparatus for the Manipulation of Particle Suspensions and Testing Thereof 有权用于操作颗粒悬浮液及其测试的方法和装置公开(公告)号：US20070243523A1
公开(公告)日：2007-10-18
申请号：US11690831
申请日：2007-03-25
CPC分类号： G01N15/1404 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L3/565 , B01L2200/025 , B01L2200/027 , B01L2200/0647 , B01L2200/0668 , B01L2200/0689 , B01L2300/041 , B01L2300/046 , B01L2300/0627 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/163 , B01L2400/0487 , B01L2400/086 , C12M21/06 , C12M23/16 , C12M35/04 , C12M41/36 , G01N15/1459 , G01N15/1463 , G01N15/1475 , G01N15/1484 , G01N2015/1006 , G01N2015/1075 , G01N2015/1409 , G01N2015/1495 , G01N2015/1497
摘要： Apparatus and methods are provided for analysis of individual particles in a microfluidic device. The methods involve the immobilization of an array of particles in suspension and the application of experimental compounds. Such methods can also include electrophysiology studies including patch clamp recording, electroporation, or both in the same microfluidic device. The apparatus provided includes a microfluidic device coupled to a multi-well structure and an interface for controlling the flow of media within the microchannel device.
摘要翻译： 提供了用于分析微流体装置中的各个颗粒的装置和方法。 这些方法涉及在悬浮液中固定一系列颗粒并应用实验化合物。 这样的方法还可以包括电生理学研究，包括在同一微流体装置中的膜片钳记录，电穿孔或两者。 提供的装置包括耦合到多孔结构的微流体装置和用于控制微通道装置内的介质流动的界面。
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6.发明授权Methods and apparatus for the manipulation of particle suspensions and testing thereof 有权用于操作颗粒悬浮液的方法和设备及其测试公开(公告)号：US08293524B2
公开(公告)日：2012-10-23
申请号：US11690831
申请日：2007-03-25
CPC分类号： G01N15/1404 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L3/565 , B01L2200/025 , B01L2200/027 , B01L2200/0647 , B01L2200/0668 , B01L2200/0689 , B01L2300/041 , B01L2300/046 , B01L2300/0627 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/163 , B01L2400/0487 , B01L2400/086 , C12M21/06 , C12M23/16 , C12M35/04 , C12M41/36 , G01N15/1459 , G01N15/1463 , G01N15/1475 , G01N15/1484 , G01N2015/1006 , G01N2015/1075 , G01N2015/1409 , G01N2015/1495 , G01N2015/1497
摘要： Apparatus and methods are provided for analysis of individual particles in a microfluidic device. The methods involve the immobilization of an array of particles in suspension and the application of experimental compounds. Such methods can also include electrophysiology studies including patch clamp recording, electroporation, or both in the same microfluidic device. The apparatus provided includes a microfluidic device coupled to a multi-well structure and an interface for controlling the flow of media within the microchannel device.
摘要翻译： 提供了用于分析微流体装置中的各个颗粒的装置和方法。 这些方法涉及在悬浮液中固定一系列颗粒并应用实验化合物。 这样的方法还可以包括电生理学研究，包括在同一微流体装置中的膜片钳记录，电穿孔或两者。 提供的装置包括耦合到多孔结构的微流体装置和用于控制微通道装置内的介质流动的界面。
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7.发明申请METHODS AND APPARATUS FOR THE MANIPULATION OF PARTICLE SUSPENSIONS AND TESTING THEREOF 审中-公开用于操作颗粒悬浮液及其测试的方法和装置公开(公告)号：US20120264134A1
公开(公告)日：2012-10-18
申请号：US13454849
申请日：2012-04-24
CPC分类号： G01N15/1404 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L3/565 , B01L2200/025 , B01L2200/027 , B01L2200/0647 , B01L2200/0668 , B01L2200/0689 , B01L2300/041 , B01L2300/046 , B01L2300/0627 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/163 , B01L2400/0487 , B01L2400/086 , C12M21/06 , C12M23/16 , C12M35/04 , C12M41/36 , G01N15/1459 , G01N15/1463 , G01N15/1475 , G01N15/1484 , G01N2015/1006 , G01N2015/1075 , G01N2015/1409 , G01N2015/1495 , G01N2015/1497
摘要： Apparatus and methods are provided for analysis of individual particles in a microfluidic device. The methods involve the immobilization of an array of particles in suspension and the application of experimental compounds. Such methods can also include electrophysiology studies including patch clamp recording, electroporation, or both in the same microfluidic device. The apparatus provided includes a microfluidic device coupled to a multi-well structure and an interface for controlling the flow of media within the microchannel device.
摘要翻译： 提供了用于分析微流体装置中的各个颗粒的装置和方法。 这些方法涉及在悬浮液中固定一系列颗粒并应用实验化合物。 这样的方法还可以包括电生理学研究，包括在同一微流体装置中的膜片钳记录，电穿孔或两者。 提供的装置包括耦合到多孔结构的微流体装置和用于控制微通道装置内的介质流动的界面。
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公开(公告)号：US20130017538A1
公开(公告)日：2013-01-17
申请号：US13183271
申请日：2011-07-14
申请人： Cristian Ionescu-Zanetti , Joshua Tanner Nevill , Michael Schwartz , Carolyn G. Conant , Roger Rudoff
发明人： Cristian Ionescu-Zanetti , Joshua Tanner Nevill , Michael Schwartz , Carolyn G. Conant , Roger Rudoff
CPC分类号： C12Q1/6806 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0883 , B01L2400/043 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N33/54326 , C12Q2563/143 , C12Q2565/629
摘要： Methods, microfluidic devices, and instruments for magnetic separation of particles from a fluid are described. Examples include microfluidic devices having a removable portion. Examples include microfluidic devices having one or more regions of reduced fluid velocity. Examples further including instruments having pneumatic interfaces. Examples further includes instruments having controllable magnets, imaging components, or combinations thereof.
摘要翻译： 描述了用于从流体中分离颗粒的方法，微流体装置和仪器。 实例包括具有可移除部分的微流体装置。 实例包括具有一个或多个减少流体速度的区域的微流体装置。 示例还包括具有气动接口的仪器。 实例还包括具有可控磁体，成像组件或其组合的仪器。
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9.发明申请公开(公告)号：US20070028683A1
公开(公告)日：2007-02-08
申请号：US11448509
申请日：2006-06-07
CPC分类号： A61B5/021 , A61B2562/0247 , G01L9/0058
摘要： A pressure sensing device and method for sensing pressure utilizes a deformable cavity containing a conductive medium. Pressure changes induce deformations of the cavity, resulting in changes of conductivity, as measured by electrodes. The device may either sense pressure directly or may be used to sense the pressure in a separate cavity that is in close proximity. Since the measurements do not require electrodes in the sensing region, the device is simple to fabricate. The device also has high sensitivity, making it suitable for microfluidic or biomedical applications where a low profile and disposable device is required.
摘要翻译： 用于感测压力的压力感测装置和方法利用包含导电介质的可变形空腔。 压力变化引起空腔的变形，导致电极的变化，如通过电极测量的。 该装置可以直接感测压力或者可以用于感测紧邻的单独空腔中的压力。 由于测量不需要感测区域中的电极，所以该器件制造简单。 该设备还具有高灵敏度，使其适用于需要低剖面和一次性设备的微流体或生物医学应用。
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公开(公告)号：US10240186B2
公开(公告)日：2019-03-26
申请号：US13183271
申请日：2011-07-14
申请人： Cristian Ionescu-Zanetti , Joshua Tanner Nevill , Michael Schwartz , Carolyn G. Conant , Roger Rudoff
发明人： Cristian Ionescu-Zanetti , Joshua Tanner Nevill , Michael Schwartz , Carolyn G. Conant , Roger Rudoff
IPC分类号： G01N33/543 , C12Q1/6806 , B03C1/28 , B01L3/00 , B01L7/00
摘要： Methods, microfluidic devices, and instruments for magnetic separation of particles from a fluid are described. Examples include microfluidic devices having a removable portion. Examples include microfluidic devices having one or more regions of reduced fluid velocity. Examples further including instruments having pneumatic interfaces. Examples further includes instruments having controllable magnets, imaging components, or combinations thereof.
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