利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

108 条记录 (耗时 0.028 秒)

    Stimulating the differentiation of preadipocytic cells and therapies based thereon
    3.
    发明授权
    Stimulating the differentiation of preadipocytic cells and therapies based thereon 有权
    基于此，刺激前脂肪细胞的分化和疗法

    公开(公告)号：US06248791B1

    公开(公告)日：2001-06-19

    申请号：US09127734

    申请日：1998-08-03

    申请人： Gérard Ailhaud ,  Paul Grimaldi ,  Irina Safonova ,  Braham Shroot ,  Uwe Reichert

    发明人： Gérard Ailhaud ,  Paul Grimaldi ,  Irina Safonova ,  Braham Shroot ,  Uwe Reichert

    IPC分类号： A61K3107

    CPC分类号： A61K31/195 ,  A61K31/20 ,  A61K31/19 ,  A61K2300/00

    摘要： The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and atherosclerosis, is stimulated by treating such preadipocytic cells, or a patient in need of such treatment, with an effective amount of (a) at least one ligand displaying affinity for the nuclear receptors for retinoic acid and/or isomers thereof, preferably at least one ligand displaying a specific affinity for the RAR receptors and even more preferably the RAR-&agr; receptor and (b) at least one fatty acid, e.g., a polyunsaturated fatty acid.

    摘要翻译： 前脂肪细胞分化为脂肪细胞，特别是用于校正哺乳动物生物体，特别是人类中的胰岛素抗性疾病状态，例如II型糖尿病和心血管疾病如高血压和动脉粥样硬化，通过治疗这种前脂肪细胞被刺激，或 需要这种治疗的患者，有效量的（a）至少一种对视黄酸和/或其异构体的核受体显示亲和力的配体，优选至少一种对RAR受体显示特异性亲和力的配体，甚至更多 优选RAR-α受体和（b）至少一种脂肪酸，例如多不饱和脂肪酸。

    Bi-aromatic esters, a process for their preparation and their use in human or veterinary medicine and in cosmetic compositions
    6.
    发明授权
    Bi-aromatic esters, a process for their preparation and their use in human or veterinary medicine and in cosmetic compositions 失效
    双芳族酯，其制备方法及其在人或兽医学和化妆品组合物中的应用

    公开(公告)号：US5468897A

    公开(公告)日：1995-11-21

    申请号：US237991

    申请日：1994-05-04

    申请人： Braham Shroot ,  Jean-Michel Bernardon ,  William R. Pilgrim

    发明人： Braham Shroot ,  Jean-Michel Bernardon ,  William R. Pilgrim

    IPC分类号： A61K31/235 ,  A61K8/00 ,  A61K8/30 ,  A61K8/33 ,  A61K8/37 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K8/46 ,  A61K8/49 ,  A61P11/00 ,  A61P17/00 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61Q5/00 ,  A61Q19/00 ,  C07C67/14 ,  C07C69/00 ,  C07C69/76 ,  C07C69/773 ,  C07C69/78 ,  C07C69/88 ,  C07C69/94 ,  C07C309/42 ,  C07C309/58 ,  C07C311/29 ,  C07C317/22 ,  C07C317/44 ,  C07C323/62 ,  C07C321/00

    CPC分类号： C07C323/62 ,  C07C69/94 ,  C07C2103/74

    摘要： Bi-aromatic esters have the formula ##STR1## wherein R.sub.1 represents H, OH, --CH.sub.3, --CH.sub.2 OH, --CH(OH)CH.sub.3, --COOR.sub.9, ##STR2## or SO.sub.2 R.sub.10 ; R.sub.9 represents H, C.sub.1 -C.sub.6 alkyl or mono or polyhydroxyalkyl; R.sub.10 represents OH, C.sub.1 -C.sub.6 alkyl or ##STR3## r' and r" represent H, C.sub.1 -C.sub.6 alkyl, aryl, aralkyl, mono or polyhydroxyalkyl, or r' and r" taken together form a heterocycle; R.sub.2 represents H, C.sub.1 -C.sub.6 alkyl, OR.sub.9, F or --CF.sub.3 ; R.sub.3, R.sub.4 and R.sub.5 represent H, F, OH, --CH.sub.3, --OCH.sub.3, --CF.sub.3, --COOH or --CH.sub.2 OH; R.sub.6 and R.sub.8 represent H, .alpha.-substituted C.sub.3 -C.sub.15 alkyl, .alpha., .alpha.'-disubstituted C.sub.4 -C.sub.12 alkyl, C.sub.3 -C.sub.12 cycloalkyl, C.sub.5 -C.sub.12 mono or polycyclic cycloalkyl whose linking carbon is trisubstituted, --SR.sub.11, --SO.sub.2 R.sub.11 or --SOR.sub.11 ; R.sub.11 represents C.sub.1 -C.sub.6 alkyl or cycloalkyl; R.sub.6 and R.sub.8 cannot simultaneously represent H; R.sub.7 represents H, C.sub.1 -C.sub.6 alkyl, alkenyl, alkenyloxy, OR.sub.12 or SR.sub.13 ; R.sub.12 represents H, C.sub.1 -C.sub.6 alkyl or alkenyl; R.sub.3 represents H, C1-C.sub.6 alkyl or aralkyl; with the proviso that when R.sub.1 represents ##STR4## and R.sub.2 represents H then: (i) either R.sub.3 and R.sub.4 are other than H or --CH.sub.3, (ii) or R.sub.7 is other than OR.sub.12 and R.sub.6 or R.sub.8 is cycloalkyl having more than 7 carbon atoms, (iii) or R.sub.7 is OR.sub.12 but R.sub.6 and R.sub.8 are other than H, (iv) or R.sub.7 is OR.sub.12 but R.sub.5 is other than H.The bi-aromatic esters are employed in human and veterinary medicine and in cosmetic compositions.

    摘要翻译： 双芳族酯具有式（I）其中R 1表示H，OH，-CH 3，-CH 2 OH，-CH（OH）CH 3，-COOR 9，或SO 2 R 10; R9表示H，C1-C6烷基或单或多羟基烷基; R 10表示OH，C 1 -C 6烷基或R 3'，R“表示H，C 1 -C 6烷基，芳基，芳烷基，单或多羟基烷基，或r'和r”一起形成杂环; R 2表示H，C 1 -C 6烷基，OR 9，F或-CF 3; R3，R4和R5表示H，F，OH，-CH3，-OCH3，-CF3，-COOH或-CH2OH; R 6和R 8表示H，α-取代的C 3 -C 15烷基，α，α'-二取代的C 4 -C 12烷基，C 3 -C 12环烷基，连接碳是三取代的C 5 -C 12单环或多环环烷基，-SR 11，-SO 2 R 11或 - SOR11; R11表示C1-C6烷基或环烷基; R6和R8不能同时代表H; R7表示H，C1-C6烷基，烯基，烯氧基，OR12或SR13; R12表示H，C1-C6烷基或烯基; R3表示H，C1-C6烷基或芳烷基; 条件是当R1表示且R2表示H时：（i）R3和R4不是H或-CH3，（ii）或R7不是OR12，R6或R8是大于7的环烷基 碳原子，（iii）或R7是OR12，但R6和R8不是H，（iv）或R7是OR12，但R5不是H.双芳族酯用于人类和兽医学和化妆品组合物中。