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    SYSTEMS AND METHODS FOR MANAGING UTILITY CONSUMPTION
    2.
    发明申请
    SYSTEMS AND METHODS FOR MANAGING UTILITY CONSUMPTION 审中-公开
    用于管理实用消费的系统和方法

    公开(公告)号：US20110178610A1

    公开(公告)日：2011-07-21

    申请号：US13120920

    申请日：2009-10-15

    申请人： Stephen D. O'Connor ,  Ronald C. Gamble ,  Richard A. Suchter

    发明人： Stephen D. O'Connor ,  Ronald C. Gamble ,  Richard A. Suchter

    IPC分类号： G05B13/04 ,  G06G7/48

    CPC分类号： G06Q10/06

    摘要： A system and method for monitoring and managing utility consumption includes use of (A) one or more sensors arranged to monitor an operating condition and/or utility consumption of at least one segment or appliance of a first facility; (B) a memory including at least one of (i) stored utility consumption information correlated or normalized to at least one designated parameter affecting utility consumption or (ii) hypothetical utility consumption; (C) a processor to compare the monitored information with the stored information, and (D) an output medium to store and/or display the comparison information. Stored consumption information may relate to the first facility or a second facility. Hypothetical utility consumption information may relate to a segment or appliance of the first facility operated according to optimized conditions, or an upgraded segment or appliance.

    摘要翻译： 一种用于监测和管理公用事业消耗的系统和方法包括使用（A）布置成监测第一设施的至少一个段或设备的运行状况和/或公用事业消耗的一个或多个传感器; （B）存储器，其包括以下至少一个：（i）存储的与至少一个影响公用事业消耗的指定参数相关或归一化的公用消费信息;（ii）假设的公用事业消费; （C）处理器，用于将所监视的信息与存储的信息进行比较，以及（D）存储和/或显示比较信息的输出介质。 存储的消费信息可能与第一设施或第二设施有关。 假设效用消耗信息可以涉及根据优化条件操作的第一设施的段或设备，或升级的段或设备。

    Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
    6.
    发明授权
    Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species 失效
    含有高浓度包埋离子物质的脂质体的制备和应用方法

    公开(公告)号：US4310506A

    公开(公告)日：1982-01-12

    申请号：US123162

    申请日：1980-02-20

    申请人： John D. Baldeschwieler ,  Ronald C. Gamble ,  Marcia R. Mauk

    发明人： John D. Baldeschwieler ,  Ronald C. Gamble ,  Marcia R. Mauk

    IPC分类号： A61K9/127 ,  A61K51/12 ,  A61K49/00 ,  A61K43/00 ,  B01J13/00

    CPC分类号： A61K51/1234 ,  A61K9/1278 ,  A61K2123/00 ,  Y10T428/2984

    摘要： Unilamellar vesicles comprising a lipid bilayer, an ionophore being incorporated in said lipid bilayer, a chelating agent entrapped within the vesicles, and an effective amount of physiologically compatible cation bound to said chelating agent within the vesicles. Unilamellar vesicles are loaded by incubating the vesicles with the cation, terminating the incubation and recovering the loaded vesicles by chromatography. In some applications of the invention, the cation may be a radioactive tracer, in which case the vesicles can be administered to the human host and observed by scintillation techniques to produce a radioimage which is useful for diagnostic purposes.

    摘要翻译： 包含脂质双层的单层囊泡，掺入所述脂质双层中的离子载体，包封在囊泡内的螯合剂，以及与囊泡内的所述螯合剂结合的有效量的生理上相容的阳离子。 通过将囊泡与阳离子孵育来加载单层囊泡，终止孵育并通过色谱法回收加载的囊泡。 在本发明的一些应用中，阳离子可以是放射性示踪剂，在这种情况下，囊泡可以施用于人宿主并通过闪烁技术观察以产生可用于诊断目的的放射性图像。

    SYSTEM AND METHOD FOR FACILITATING REFLECTOMETRIC DETECTION OF PHYSIOLOGIC ACTIVITY
    7.
    发明申请
    SYSTEM AND METHOD FOR FACILITATING REFLECTOMETRIC DETECTION OF PHYSIOLOGIC ACTIVITY 有权
    用于促进生物活性反射检测的系统和方法

    公开(公告)号：US20130245437A1

    公开(公告)日：2013-09-19

    申请号：US13827555

    申请日：2013-03-14

    申请人： Ronald C. Gamble ,  Lawrence Randolph Weill ,  Steve Perry Monacos

    发明人： Ronald C. Gamble ,  Lawrence Randolph Weill ,  Steve Perry Monacos

    IPC分类号： A61B5/05 ,  A61B5/024 ,  A61B5/00

    CPC分类号： A61B5/725 ,  A61B5/0006 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/0507 ,  A61B5/7257 ,  A61B5/7275 ,  A61B5/742 ,  A61B5/746

    摘要： A method for remotely sensing cardiac-related data of an animal subject includes transmitting a RF signal to impinge on tissue of the subject, receiving a reflected portion of the RF signal, generating baseband data, filtering baseband data (e.g., including high pass filtering), performing waveform phase position determination, performing at least one auto-correlation of the waveform phase position determined data, determining periodicity of the auto-correlated data, and (i) computing heart rate using a maximum periodicity of the periodicity, or (ii) identifying abnormalities in cardiac function, such as may be indicated by temporal variations in heart rate and/or signal amplitude corresponding to cardiac activity. Multiple bandpass filtering schemes may be employed.

    摘要翻译： 用于远程感测动物对象的心脏相关数据的方法包括：发送RF信号以撞击对象的组织，接收RF信号的反射部分，产生基带数据，滤波基带数据（例如，包括高通滤波） 执行波形相位位置确定，执行波形相位位置确定数据的至少一个自相关，确定自动相关数据的周期性，以及（i）使用周期的最大周期来计算心率，或者（ii） 识别心脏功能异常，例如可以通过对应于心脏活动的心率和/或信号幅度的时间变化来指示。 可以采用多个带通滤波方案。

    Parallel fluid processing systems and methods
    8.
    发明授权
    Parallel fluid processing systems and methods 有权
    平行流体处理系统和方法

    公开(公告)号：US07178386B1

    公开(公告)日：2007-02-20

    申请号：US10821567

    申请日：2004-04-09

    申请人： Ronald C. Gamble ,  Sergey I. Osechinskiy

    发明人： Ronald C. Gamble ,  Sergey I. Osechinskiy

    IPC分类号： G01N30/02 ,  B01D15/08

    CPC分类号： G01N30/466 ,  G01N30/6095 ,  G01N30/8665 ,  G01N30/8668

    摘要： A parallel fluid processing system including multiple fluid process regions containing solid material in fluid communication with a common first fluid source may be used to conduct analyses and/or synthesis in parallel. A parallel fluid processing data correction method includes supplying and processing a calibrant in each fluid process region, measuring a first physical parameter and deriving at least one correction factor based on the parameter, supplying and processing at least one second fluid in each fluid process region, and then applying the correction factor to yield corrected process data. Retention time correction, peak area correction, and other useful data corrections may be performed. Parallel fluid processing may be performed with microfluidic devices and systems. A system for correcting retention times in parallel liquid chromatography is further provided.

    摘要翻译： 可以使用包括含有与公共第一流体源流体连通的固体材料的多个流体处理区域的平行流体处理系统来并行地进行分析和/或合成。 并行流体处理数据校正方法包括在每个流体处理区域中提供和处理校准物，测量第一物理参数并基于该参数导出至少一个校正因子，在每个流体处理区域中提供和处理至少一个第二流体， 然后应用校正因子来产生校正过程数据。 可以执行保留时间校正，峰值区域校正和其他有用的数据校正。 可以用微流体装置和系统进行并行流体处理。 还提供了用于校正并联液相色谱中保留时间的系统。

    Treatment of systemic fungal infections with phospholipid particles encapsulating polyene antibiotics
    9.
    发明授权
    Treatment of systemic fungal infections with phospholipid particles encapsulating polyene antibiotics 失效
    用包封多烯抗生素的磷脂颗粒治疗全身真菌感染

    公开(公告)号：US5874104A

    公开(公告)日：1999-02-23

    申请号：US467864

    申请日：1995-06-06

    申请人： Jill Adler-Moore ,  Ronald C. Gamble ,  Richard T. Proffitt

    发明人： Jill Adler-Moore ,  Ronald C. Gamble ,  Richard T. Proffitt

    IPC分类号： A61K9/10 ,  A61K9/127 ,  A61K9/133 ,  A61K31/70

    CPC分类号： A61K9/1271 ,  A61K31/7048 ,  B82Y5/00

    摘要： Formulations consisting of phospholipid small unilamellar particles encapsulating polyene antifungal antibiotics and methods for using such compositions to treat systemic fungal infections are described. In a preferred embodiment, the particles are in the form of vesicles which comprise a polyene antifungal antibiotic, preferably amphotericin B and/or nystatin, egg phosphatidylcholine and cholesterol, preferably in the molar ratio of about 0.2 (AMB):2(PL):1(CHOL). These vesicles may also have an amine modified surface. The vesicles are suspended in a low isonic strength saccharide/tris solution at a pH of from about 6.0 to about 8.0 and may be administered to deliver the antifungal antibiotic to treat systemic fungal infections.

    摘要翻译： 描述由包含多烯抗真菌抗生素的磷脂小单层颗粒组成的制剂以及使用这些组合物治疗全身性真菌感染的方法。 在优选的实施方案中，颗粒是囊泡形式，其包含多烯抗真菌抗生素，优选两性霉素B和/或制霉菌素，卵磷脂酰胆碱和胆固醇，优选摩尔比为约0.2（AMB）：2（PL）： 1（CHOL）。 这些囊泡也可以具有胺改性的表面。 将囊泡悬浮在pH为约6.0至约8.0的低等强度糖/ tris溶液中，并且可以施用以输送抗真菌抗生素以治疗全身性真菌感染。

    Preparation small unilamellar vesicles including polyene antifungal antibiotics
    10.
    发明授权
    Preparation small unilamellar vesicles including polyene antifungal antibiotics 失效
    制备小单层囊泡，包括多烯抗真菌抗生素

    公开(公告)号：US5043107A

    公开(公告)日：1991-08-27

    申请号：US427732

    申请日：1989-10-27

    申请人： Jill Adler-Moore ,  Ronald C. Gamble ,  Richard T. Proffitt

    发明人： Jill Adler-Moore ,  Ronald C. Gamble ,  Richard T. Proffitt

    IPC分类号： A61K9/127 ,  A61K9/133

    CPC分类号： A61K9/1271 ,  A61K31/7048 ,  Y10S436/829 ,  Y10S514/885 ,  Y10T428/2984

    摘要： Formulations consisting of phospholipid small unilamellar particles encapsulating polyene antifungal antibiotics and methods for using such compositions to treat systemic fungal infections are described. In a preferred embodiment, the particles are in the form of vesicles which comprise a polyene antifungal antibiotic, preferably amphotericin B and/or nystatin, egg phosphatidylcholine and cholesterol, preferably in the molar ratio of about 0.2 (AMB):2(PL):1(CHOL). These vesicles may also have an amine modified surface. The vesicles are suspended in a low ionic strength saccharide/tris solution at a pH of from about 6.0 to about 8.0 and may be administered to deliver the anti-fungal antibiotic to treat systemic fungal infections.

    摘要翻译： 描述由包含多烯抗真菌抗生素的磷脂小单层颗粒组成的制剂以及使用这些组合物治疗全身性真菌感染的方法。 在优选的实施方案中，颗粒是囊泡形式，其包含多烯抗真菌抗生素，优选两性霉素B和/或制霉菌素，卵磷脂酰胆碱和胆固醇，优选摩尔比为约0.2（AMB）：2（PL）： 1（CHOL）。 这些囊泡也可以具有胺改性的表面。 将囊泡悬浮在约6.0至约8.0的pH下的低离子强度的糖/三溶液中，并且可以施用以递送抗真菌抗生素以治疗全身性真菌感染。