MICROFLUIDIC FEEDBACK USING IMPEDANCE DETECTION
    1.
    发明申请
    MICROFLUIDIC FEEDBACK USING IMPEDANCE DETECTION 有权
    使用阻抗检测的微流感应反馈

    公开(公告)号:US20140190830A1

    公开(公告)日:2014-07-10

    申请号:US14116553

    申请日:2012-05-08

    IPC分类号: G01R27/16

    摘要: Methods comprising measuring the impedance of the electrode produced by the excitation signal, wherein the impedance indicates presence of liquid at the electrode are disclosed. Computer readable mediums storing processor executable instructions for performing the method, and systems are also disclosed. The systems comprise a processor, memory and code stored in the memory that when executed cause the processor at least to: receive an output voltage signal, superimpose an excitation signal onto the output voltage signal to produce a superimposed signal, connect the superimposed signal to an electrode in a droplet actuator, suppress the output voltage signal, when detecting an impedance of the electrode, and measure the impedance of the electrode produced by the excitation signal, wherein the impedance indicates presence of liquid at the electrode.

    摘要翻译: 方法包括测量由激发信号产生的电极的阻抗,其中阻抗表示在电极处存在液体。 还公开了存储用于执行该方法的处理器可执行指令的计算机可读介质,以及系统。 系统包括存储在存储器中的处理器,存储器和代码,当执行时,处理器至少要使接收输出电压信号,将激励信号叠加在输出电压信号上,产生叠加信号,将叠加的信号连接到 液滴致动器中的电极,当检测到电极的阻抗时抑制输出电压信号,并测量由激励信号产生的电极的阻抗,其中阻抗表示在电极处存在液体。

    Microfluidic feedback using impedance detection
    2.
    发明授权
    Microfluidic feedback using impedance detection 有权
    微流体反馈采用阻抗检测

    公开(公告)号:US09188615B2

    公开(公告)日:2015-11-17

    申请号:US14116553

    申请日:2012-05-08

    IPC分类号: G01R27/16 B01L3/00

    摘要: Methods comprising measuring the impedance of the electrode produced by the excitation signal, wherein the impedance indicates presence of liquid at the electrode are disclosed. Computer readable mediums storing processor executable instructions for performing the method, and systems are also disclosed. The systems comprise a processor, memory and code stored in the memory that when executed cause the processor at least to: receive an output voltage signal, superimpose an excitation signal onto the output voltage signal to produce a superimposed signal, connect the superimposed signal to an electrode in a droplet actuator, suppress the output voltage signal, when detecting an impedance of the electrode, and measure the impedance of the electrode produced by the excitation signal, wherein the impedance indicates presence of liquid at the electrode.

    摘要翻译: 方法包括测量由激发信号产生的电极的阻抗,其中阻抗表示在电极处存在液体。 还公开了存储用于执行该方法的处理器可执行指令的计算机可读介质,以及系统。 系统包括存储在存储器中的处理器,存储器和代码,当执行时,处理器至少要使接收输出电压信号,将激励信号叠加在输出电压信号上,产生叠加信号,将叠加的信号连接到 液滴致动器中的电极,当检测到电极的阻抗时抑制输出电压信号,并测量由激励信号产生的电极的阻抗,其中阻抗表示在电极处存在液体。

    Method of reducing liquid volume surrounding beads
    3.
    发明授权
    Method of reducing liquid volume surrounding beads 有权
    降低珠粒周围液体的方法

    公开(公告)号:US08927296B2

    公开(公告)日:2015-01-06

    申请号:US12992939

    申请日:2009-05-18

    IPC分类号: G01N1/40 B01L3/00 G01N35/00

    摘要: The invention provides droplet actuators and droplet actuator techniques. Among other things, the droplet actuators and methods are useful for manipulating beads on a droplet actuator, such as conducting droplet operations using bead-containing droplets on a droplet actuator. For example, beads may be manipulated on a droplet actuator in the context of executing a sample preparation protocol and/or an assay protocol. An output of the methods of the invention may be beads prepared for execution of an assay protocol. Another output of the methods of the invention may be results of an assay protocol executed using beads. Among the methods described herein are methods of concentrating beads in droplets, methods of washing beads, methods of suspending beads, methods of separating beads, methods of localizing beads within a droplet, methods of forming emulsions in which droplets include beads, methods of loading beads into a droplet operations gap of a droplet actuator, methods of organizing beads in a monolayer, and methods of capturing, trapping or restraining beads.

    摘要翻译: 本发明提供了液滴致动器和液滴致动器技术。 除其他之外,液滴致动器和方法可用于操纵液滴致动器上的珠,例如使用液滴致动器上的含珠液滴进行液滴操作。 例如,在执行样品制备方案和/或测定方案的上下文中,珠可以在液滴致动器上操作。 本发明方法的输出可以是准备用于执行测定方案的珠粒。 本发明方法的另一个输出可以是使用珠子执行的测定方案的结果。 在本文描述的方法中,将珠粒集中在液滴中的方法,洗涤珠粒的方法,悬浮珠粒的方法,分离珠粒的方法,在液滴内定位珠粒的方法,形成液滴包括珠粒的乳液的方法,加载珠粒的方法 液滴致动器的液滴操作间隙,单层组织珠粒的方法,以及捕获,捕获或抑制珠粒的方法。

    Method of Reducing Liquid Volume Surrounding Beads
    6.
    发明申请
    Method of Reducing Liquid Volume Surrounding Beads 有权
    减少液体体积环绕珠的方法

    公开(公告)号:US20140057363A9

    公开(公告)日:2014-02-27

    申请号:US12992939

    申请日:2009-05-18

    IPC分类号: G01N1/40

    摘要: The invention provides droplet actuators and droplet actuator techniques. Among other things, the droplet actuators and methods are useful for manipulating beads on a droplet actuator, such as conducting droplet operations using bead-containing droplets on a droplet actuator. For example, beads may be manipulated on a droplet actuator in the context of executing a sample preparation protocol and/or an assay protocol. An output of the methods of the invention may be beads prepared for execution of an assay protocol. Another output of the methods of the invention may be results of an assay protocol executed using beads. Among the methods described herein are methods of concentrating beads in droplets, methods of washing beads, methods of suspending beads, methods of separating beads, methods of localizing beads within a droplet, methods of forming emulsions in which droplets include beads, methods of loading beads into a droplet operations gap of a droplet actuator, methods of organizing beads in a monolayer, and methods of capturing, trapping or restraining beads.

    摘要翻译: 本发明提供了液滴致动器和液滴致动器技术。 除其他之外,液滴致动器和方法可用于操纵液滴致动器上的珠,例如使用液滴致动器上的含珠液滴进行液滴操作。 例如,在执行样品制备方案和/或测定方案的上下文中,珠可以在液滴致动器上操作。 本发明方法的输出可以是准备用于执行测定方案的珠粒。 本发明方法的另一个输出可以是使用珠子执行的测定方案的结果。 在本文描述的方法中,将珠粒集中在液滴中的方法,洗涤珠粒的方法,悬浮珠粒的方法,分离珠粒的方法,在液滴内定位珠粒的方法,形成液滴包括珠粒的乳液的方法,加载珠粒的方法 液滴致动器的液滴操作间隙,单层组织珠粒的方法,以及捕获,捕获或抑制珠粒的方法。