摘要:
Compounds formula (I): ##STR1## in which: R.sup.1 represents a hydrogen atom, an alkyl group, a substituted alkyl group, a C.sub.2 -C.sub.6 alkenyl group, an aryl group, a substituted aryl group or an alkoxycarbonyl group wherein the alkoxy part has from 1 to 6 carbon atoms; R.sup.2 represenets a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or a C.sub.3 or C.sub.4 alkenyl group; R.sup.3 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group; R.sup.4 represents a hydroxy group, a C.sub.1 -C.sub.21 aliphatic acyloxy group or a carbocyclic aryl carboxylic aryloxy group; R.sup.5 represents a C.sub.1 -C.sub.12 alkyl group, a C.sub.1 -C.sub.6 alkoxy group, a hydroxy group, a C.sub.1 -C.sub.7 aliphatic acyloxy group or a carbocyclic aryl carboxylic acyloxy group; R.sup.6 represents a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or a C.sub.1 -C.sub.6 alkoxy group; and n is 0, 1, or 2;and pharmaceutically acceptable salts thereof are valuable in the treatment of circulatory disorders and allergies.
摘要:
Compounds formula (I): ##STR1## in which: R.sup.1 represents a hydrogen atom, an alkyl group, a substituted alkyl group, a C.sub.2 -C.sub.6 alkenyl group, an aryl group, a substituted aryl group or an alkoxycarbonyl group wherein the alkoxy part has from 1 to 6 carbon atoms; R.sup.2 represents a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or a C.sub.3 or C.sub.4 alkenyl group; R.sup.3 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group; R.sup.4 represents a hydroxy group, a C.sub.1 -C.sub.21 aliphatic acyloxy group or a carbocyclic aryl carboxylic acyloxy group; R.sup.5 represents a C.sub.1 -C.sub.12 alkyl group, a C.sub.1 -C.sub.6 alkoxy group, a hydroxy group, a C.sub.1 -C.sub.7 aliphatic acyloxy group or a carbocyclic aryl carboxylic acyloxy group; R.sup.6 represents a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or a C.sub.1 -C.sub.6 alkoxy group; and n is 0, 1, or 2; and pharmaceutically acceptable salts thereof are valuable in the treatment of circulatory disorders and allergies.
摘要:
Compounds of formula (I): ##STR1## (in which R.sup.1 -R.sup.7 are hydrogen or various organic groups, n is 1-10, Ar is an aromatic group, U is CH.sub.2 or a carbon atom doubly bonded to either one of its adjacent carbons, and W is >CH.sub.2, >C.dbd.O, >CHOH, >C.dbd.NOH or various derivatives thereof) have the ability to lower the levels of blood lipid peroxides and blood sugars and to inhibit the activity of aldose reductase; they may be used therapeutically for these purposes.
摘要翻译:式(I)化合物:其中R 1 -R 7为氢或各种有机基团,n为1-10,Ar为芳族基团,U为CH 2或与两者双键结合的碳原子 的相邻碳,W是> CH2,> C = O,> CHOH,> C = NOH或其各种衍生物)具有降低血脂过氧化物和血糖水平并抑制醛糖还原酶活性的能力 ; 它们可以用于治疗这些目的。
摘要:
Compounds of formula (I): ##STR1## wherein R.sup.1 represents a group of formula (II) or (III): ##STR2## R.sup.2 is alkyl, alkenyl or alkynyl; R.sup.3 and R.sup.4 are each hydrogen, alkyl, alkenyl or alkynyl; R.sup.5 is hydrogen or a carboxy-protecting group; R.sup.a is a group of formula --OR.sup.6 ; R.sup.6 is hydrogen; R.sup.6a and R.sup.6b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulfonyl, halogenated alkanesulfonyl or arysulfonyl, and their salts and esters. Such compounds inhibit the synthesis of cholesterol, and can be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.
摘要:
Compounds of formula (I) are provided: ##STR1## wherein: R.sup.1 represents an alkyl group; or a group of formula (II), (III), (IV) or (V): ##STR2## and wherein the groups R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are hydrogen or various organic groups; and pharmaceutically acceptable salts thereof; as well as methods for the preparation of such compounds and their use in the treatment and prophylaxis of hypercholesteremia and arteriosclerosis.
摘要:
There are provided a trouble diagnosis device and a trouble diagnosis method for an exhaust gas purification system in which the presence or absence of a trouble of the exhaust gas purification system such as abnormality of a control system for the exhaust gas purification system, catalyst deterioration or the like can be determined with high precision, and the reliability of the exhaust gas purification system can be enhanced.The device includes upstream-side NOx flow rate calculating means, downstream-side NOx flow rate calculating means, reduction condition determining means for determining whether at least one condition for performing normal reduction of NOx is satisfied, upstream-side NOx flow amount calculating means for integrating the upstream-side NOx flow amount to calculate the amount of NOx passing through the upstream side of the catalyst within a predetermined time when the condition concerned is determined to be satisfied, downstream-side NOx amount calculating means for integrating the downstream-side NOx flow amount to calculate the amount of NOx passing through the downstream side of the catalyst within a predetermined time when the condition concerned is determined to be satisfied, and trouble determining means for comparing the upstream-side NOx amount and the downstream-side NOx amount to determine whether the exhaust gas purification system operates normally.
摘要:
Compounds of formula (I): ##STR1## wherein: R.sup.1 is alkyl; R.sup.2a, R.sup.2b, R.sup.2c and R.sup.2d are the same or different and each is hydrogen, optionally substituted alkyl or various other organic groups; R.sup.3 is alkyl; R.sup.4 is a group of formula (II), (III), (IV), (V), (VI), (VII), (VIII) or (IX): ##STR2## wherein: A.sup.1 is a single bond, alkylene or alkenylene; A.sup.2 is or alkenylene; A.sup.3 is a single bond, alkyleneor alkenylene; R.sup.5a and R.sup.5b are the same or different and each is hydrogen, alkyl or various other groups; R.sup.6 is alkyl or phenyl; R.sup.7 is hydrogen or alkyl; R.sup.8 is alkyl or various other groups; and n is 0 and pharmaceutically acceptable salts thereof have valuable inhibitory activity against acyl-CoA: cholesterol acyl transferase.
摘要:
A trouble diagnosis device and method for an NOx sensor for determining abnormality of an NOx sensor used in an exhaust gas purification system. The device can perform a trouble diagnosis without forcedly creating a diagnosis mode during operation of an internal combustion engine and without deterioration of drivability or fuel consumption. The device detects the time-lapse variation of the exhaust NOx flow rate suitable for diagnosis in a normal operation mode and determines whether the NOx sensor responds with following this variation.
摘要:
There are provided a clogging determining device for a reducing agent passage and a clogging determining method for a reducing agent passage, which can accurately detect clogging and estimate a clogged place when clogging occurs in any place of a supply line or a return line.The device includes pump driving control element for subjecting the pump to DUTY control so that a pressure value is kept to a predetermined value, driving DUTY determining element for determining whether the driving DUTY of the pump is less than a predetermined threshold value corresponding to the opening degree of the reducing agent injection valve, or not; pressure reduction amount calculating element for calculating a pressure reduction amount by which the pressure value detected by the pressure sensor is reduced within a predetermined time after the pump is stopped and the reducing agent injection valve is fully opened when it is determined that the driving DUTY of the pump is less than the threshold value, and clogging determining element for determining on the basis of the pressure reduction amount calculated by the pressure reduction amount: calculating element whether clogging occurs in the first reducing agent passage or the second reducing agent passage.
摘要:
Compounds of formula (I): ##STR1## wherein: R.sup.1 is alkyl; R.sup.2a, R.sup.2b, R.sup.2c and R.sup.2d are the same or different and each is hydrogen, optionally substituted alkyl, --(C.dbd.O)--B.sup.1 (wherein B.sup.1 is hydrogen or alkyl), nitro, --NR.sup.c R.sup.d (wherein R.sup.c is hydrogen or alkyl and Rd is alkyl), hydroxy, protected hydroxy group, alkoxy, cyano, alkylthio, alkylsulfinyl, alkylsulfonyl or halogen;R.sup.3 is alkyl; R.sup.4 is a group of the formula (II) ##STR2## wherein A.sup.1 is a single bond, alkylene or alkenylene; R.sup.5a and R.sup.5b are the same or different and each is hydrogen, alkyl or --A.sup.4 R.sup.5.sub.c wherein A is a single bond, alkylene or alkenylene and R.sup.5.sub.c is alkoxy; and n is 0, and pharmaceutically acceptable salts thereof. Such compounds have valuable inhibitory activity against acyl-CoA (cholesterol acyl transferase).