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1.Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors 失效
标题翻译: 哌啶基和哌嗪基 - 磺酰基甲基异羟肟酸及其作为蛋白酶抑制剂的用途公开(公告)号:US07119203B2
公开(公告)日:2006-10-10
申请号:US10618288
申请日:2003-04-25
申请人: Thomas E. Barta , Daniel P. Becker , Louis J. Bedell , Terri L. Boehm , David L. Brown , Jeffery N. Carroll , Yiyuan Chen , Yvette M. Fobian , John N. Freskos , Alan F. Gasiecki , Margaret L. Grapperhaus , Robert M. Heintz , Susan L. Hockerman , Darren J. Kassab , Ish K. Khanna , Stephen A. Kolodziej , Mark A. Massa , Joseph J. McDonald , Brent V. Mischke , Deborah A. Mischke , Patrick B. Mullins , Mark A. Nagy , Monica B. Norton , Joseph G. Rico , Michelle A. Schmidt , Nathan W. Stehle , John J. Talley , William F. Vernier , Clara I. Villamil , Lijuan J. Wang , Thomas A. Wynn
发明人: Thomas E. Barta , Daniel P. Becker , Louis J. Bedell , Terri L. Boehm , David L. Brown , Jeffery N. Carroll , Yiyuan Chen , Yvette M. Fobian , John N. Freskos , Alan F. Gasiecki , Margaret L. Grapperhaus , Robert M. Heintz , Susan L. Hockerman , Darren J. Kassab , Ish K. Khanna , Stephen A. Kolodziej , Mark A. Massa , Joseph J. McDonald , Brent V. Mischke , Deborah A. Mischke , Patrick B. Mullins , Mark A. Nagy , Monica B. Norton , Joseph G. Rico , Michelle A. Schmidt , Nathan W. Stehle , John J. Talley , William F. Vernier , Clara I. Villamil , Lijuan J. Wang , Thomas A. Wynn
IPC分类号: C07D405/14 , C07D405/12 , A61K31/496
CPC分类号: C07D213/74 , C07D211/66 , C07D211/96 , C07D309/08 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D411/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要: This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to the following formula: (wherein A1, A2, Y, E1, E2, E3, and Rx are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.
摘要翻译: 本发明一般涉及蛋白酶(也称为“蛋白酶”)抑制剂,尤其涉及哌啶基和哌嗪基 - 磺酰基甲基异羟肟酸,其特别是抑制基质金属蛋白酶(也称为“基质金属蛋白酶”或“MMP “)活性和/或蛋白聚糖蛋白聚糖酶活性。 这样的异羟肟酸通常在结构上对应于下式:(其中A 1,A 2,Y,E 1, 2,E 3和R x如本说明书中所定义),并且还包括这些化合物的盐。 本发明还涉及这种异羟肟酸的组合物,用于合成这种异羟肟酸的中间体,制备这种异羟肟酸的方法,以及用于治疗与MMP活性和/或蛋白聚糖蛋白聚糖酶活性相关的病症(特别是病理状态)的方法。
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公开(公告)号:US06689794B2
公开(公告)日:2004-02-10
申请号:US10142737
申请日:2002-05-10
申请人: John N. Freskos , Yvette M. Fobian , Thomas E. Barta , Daniel P. Becker , Louis J. Bedell , Terri L. Boehm , Jeffery N. Carroll , Gary A. DeCrescenzo , Susan L. Hockerman , Darren J. Kassab , Steve A. Kolodziej , Joseph McDonald , Deborah A. Mischke , Monica B. Norton , Joseph G. Rico , John J. Talley , Clara I. Villamil , Lijuan Jane Wang
发明人: John N. Freskos , Yvette M. Fobian , Thomas E. Barta , Daniel P. Becker , Louis J. Bedell , Terri L. Boehm , Jeffery N. Carroll , Gary A. DeCrescenzo , Susan L. Hockerman , Darren J. Kassab , Steve A. Kolodziej , Joseph McDonald , Deborah A. Mischke , Monica B. Norton , Joseph G. Rico , John J. Talley , Clara I. Villamil , Lijuan Jane Wang
IPC分类号: A61K31445
CPC分类号: C07D401/12 , A61K31/351 , A61K31/41 , A61K31/453 , A61K31/454 , C04B35/632 , C07D211/66 , C07D309/08 , C07D309/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/04 , Y02A50/411
摘要: This invention is directed to aromatic sulfone hydroxamates (also known as “aromatic sulfone hydroxamic acids”) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.
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3.Aromatic sulfone hydroxamic acids and their use as protease inhibitors 失效
标题翻译: 芳香砜异羟肟酸及其作为蛋白酶抑制剂的用途公开(公告)号:US06890928B2
公开(公告)日:2005-05-10
申请号:US10657034
申请日:2003-09-05
申请人: John N. Freskos , Yvette M. Fobian , Thomas E. Barta , Daniel P. Becker , Louis J. Bedell , Terri L. Boehm , Jeffrey N. Carroll , Gary A. DeCrescenzo , Susan L. Hockerman , Darren J. Kassab , Steve A. Kolodziej , Joseph McDonald , Deborah A. Mischke , Monica B. Norton , Joseph G. Rico , John J. Talley , Clara I. Villamil , Lijuan Jane Wang
发明人: John N. Freskos , Yvette M. Fobian , Thomas E. Barta , Daniel P. Becker , Louis J. Bedell , Terri L. Boehm , Jeffrey N. Carroll , Gary A. DeCrescenzo , Susan L. Hockerman , Darren J. Kassab , Steve A. Kolodziej , Joseph McDonald , Deborah A. Mischke , Monica B. Norton , Joseph G. Rico , John J. Talley , Clara I. Villamil , Lijuan Jane Wang
IPC分类号: C07D491/048 , A61K31/35 , A61K31/351 , A61K31/357 , A61K31/381 , A61K31/397 , A61K31/4025 , A61K31/404 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/4355 , A61K31/4433 , A61K31/445 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/53 , A61K31/5377 , A61P1/02 , A61P1/04 , A61P1/16 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P25/00 , A61P25/18 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P37/02 , A61P37/06 , A61P39/00 , A61P43/00 , C07D211/66 , C07D309/08 , C07D309/12 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/04 , C07D401/02
CPC分类号: C07D401/12 , A61K31/351 , A61K31/41 , A61K31/453 , A61K31/454 , C04B35/632 , C07D211/66 , C07D309/08 , C07D309/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/04 , Y02A50/411
摘要: This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.
摘要翻译: 本发明涉及特别是抑制基质金属蛋白酶(也称为“基质金属蛋白酶”或“MMP”)活性和/或软骨聚集蛋白聚糖酶活性的芳香族砜异羟肟酸(包括异羟肟酸盐)及其盐。 本发明还涉及一种预防或治疗方法,其包括将有效量的MMP抑制和/或聚集蛋白聚糖蛋白酶抑制剂的这种化合物或盐施用于动物,特别是哺乳动物,所述动物特别是哺乳动物具有(或处置)具有相关的病理状态 具有MMP和/或蛋白聚糖蛋白聚糖酶活性。
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4.Process for preparing prodrugs of benzenesulfonamide-containing COX-2 inhibitors 有权
标题翻译: 制备含苯磺酰胺的COX-2抑制剂前药的方法公开(公告)号:US07420061B2
公开(公告)日:2008-09-02
申请号:US10939852
申请日:2004-09-13
申请人: John J. Talley , James W. Malecha , Stephen Bertenshaw , Matthew J. Graneto , Jeffery S. Carter , Jinglin Li , Srinivasan R. Nagarajan , David L. Brown , Donald J. Rogier, Jr. , Thomas D. Penning , Ish K. Khanna , Xiangdong Xu , Richard M. Weier
发明人: John J. Talley , James W. Malecha , Stephen Bertenshaw , Matthew J. Graneto , Jeffery S. Carter , Jinglin Li , Srinivasan R. Nagarajan , David L. Brown , Donald J. Rogier, Jr. , Thomas D. Penning , Ish K. Khanna , Xiangdong Xu , Richard M. Weier
IPC分类号: C07D263/04
CPC分类号: C07D207/33 , A61K31/18 , A61K31/415 , A61K31/42 , A61K31/635 , C07C311/16 , C07C311/51 , C07C2601/10 , C07D231/12 , C07D233/64 , C07D261/08 , C07D263/32 , C07D307/58 , C07D401/04 , C07D417/04 , C07D495/04
摘要: Prodrugs of COX-2 inhibitors are described as being useful in treating inflammation and inflammation-related disorders.
摘要翻译: 描述了COX-2抑制剂的前药用于治疗炎症和炎症相关疾病。
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5.α- and β- amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors 有权
标题翻译: α-和β-二羧酸 - 氨基酸羟乙基氨基磺酰胺,可用作逆转录病毒蛋白酶抑制剂公开(公告)号:USRE42889E1
公开(公告)日:2011-11-01
申请号:US11788947
申请日:2007-04-23
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Robert M. Heintz , Deborah E. Bertenshaw
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Robert M. Heintz , Deborah E. Bertenshaw
IPC分类号: A61K31/36 , C07D317/50
CPC分类号: C07C311/05 , A61K38/00 , C07C311/11 , C07C311/13 , C07C311/14 , C07C311/18 , C07C311/20 , C07C311/24 , C07C311/29 , C07C311/32 , C07C311/41 , C07C311/46 , C07C317/04 , C07C317/10 , C07C317/14 , C07C317/28 , C07C317/44 , C07C323/49 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D213/30 , C07D213/42 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/48 , C07D217/26 , C07D233/64 , C07D239/26 , C07D241/18 , C07D241/44 , C07D261/08 , C07D263/34 , C07D263/56 , C07D277/24 , C07D277/62 , C07D277/82 , C07D307/20 , C07D307/42 , C07D307/45 , C07D307/79 , C07D307/85 , C07D317/62 , C07D333/32 , C07D333/34 , C07D333/48 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D493/04 , C07K5/06026 , C07K5/06139
摘要: α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: α-和β-氨基酸羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。
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6.
公开(公告)号:US07115618B2
公开(公告)日:2006-10-03
申请号:US10812343
申请日:2004-03-30
申请人: Michael J. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Robert M. Heintz , Deborah E. Bertenshaw
发明人: Michael J. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Robert M. Heintz , Deborah E. Bertenshaw
IPC分类号: A61K31/36 , C07D317/50
CPC分类号: C07C311/05 , A61K38/00 , C07C311/11 , C07C311/13 , C07C311/14 , C07C311/18 , C07C311/20 , C07C311/24 , C07C311/29 , C07C311/32 , C07C311/41 , C07C311/46 , C07C317/04 , C07C317/10 , C07C317/14 , C07C317/28 , C07C317/44 , C07C323/49 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D213/30 , C07D213/64 , C07D213/73 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/48 , C07D233/64 , C07D239/26 , C07D277/24 , C07D277/82 , C07D307/20 , C07D307/42 , C07D307/79 , C07D317/62 , C07D333/34 , C07D405/12 , C07D417/12 , C07K5/06026 , C07K5/06139
摘要: α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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7.
公开(公告)号:US06248775B1
公开(公告)日:2001-06-19
申请号:US09288080
申请日:1999-04-08
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Deborah E. Bertenshaw , Robert M. Heintz
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Deborah E. Bertenshaw , Robert M. Heintz
IPC分类号: A61K3138
CPC分类号: C07C311/05 , A61K38/00 , C07C311/11 , C07C311/13 , C07C311/14 , C07C311/18 , C07C311/20 , C07C311/24 , C07C311/29 , C07C311/32 , C07C311/41 , C07C311/46 , C07C317/04 , C07C317/10 , C07C317/14 , C07C317/28 , C07C317/44 , C07C323/49 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D213/30 , C07D213/42 , C07D213/64 , C07D213/73 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/48 , C07D217/26 , C07D233/64 , C07D239/26 , C07D241/18 , C07D241/44 , C07D263/34 , C07D277/24 , C07D277/62 , C07D277/82 , C07D307/20 , C07D307/42 , C07D307/79 , C07D307/85 , C07D317/62 , C07D333/32 , C07D333/34 , C07D333/48 , C07D405/12 , C07D417/12 , C07D493/04 , C07K5/06026 , C07K5/06139
摘要: &agr;- and &bgr;-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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8..alpha.- and .beta.-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors 失效
标题翻译: 可用作逆转录病毒蛋白酶抑制剂的α-和β-氨基酸羟乙基氨基磺酰胺公开(公告)号:US06060476A
公开(公告)日:2000-05-09
申请号:US204827
申请日:1994-03-02
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P Getman , Gary A. DeCrescenzo , John N. Freskos , Robert M. Heintz , Deborah E. Bertenshaw
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P Getman , Gary A. DeCrescenzo , John N. Freskos , Robert M. Heintz , Deborah E. Bertenshaw
IPC分类号: C07D295/12 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4433 , A61K31/505 , A61K31/535 , A61K31/5375 , A61K38/00 , A61P31/12 , C07C311/05 , C07C311/11 , C07C311/13 , C07C311/14 , C07C311/18 , C07C311/20 , C07C311/24 , C07C311/29 , C07C311/32 , C07C311/41 , C07C311/46 , C07C313/06 , C07C317/04 , C07C317/10 , C07C317/14 , C07C317/28 , C07C317/44 , C07C323/49 , C07C323/57 , C07C323/67 , C07C327/38 , C07D209/08 , C07D211/78 , C07D213/30 , C07D213/53 , C07D213/56 , C07D213/64 , C07D213/73 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/48 , C07D233/54 , C07D239/02 , C07D239/26 , C07D277/24 , C07D277/30 , C07D277/82 , C07D307/20 , C07D307/42 , C07D307/79 , C07D317/62 , C07D333/34 , C07D405/12 , C07D409/12 , C07D417/12 , C07K5/06 , C07K5/078
CPC分类号: C07C311/05 , C07C311/11 , C07C311/13 , C07C311/14 , C07C311/18 , C07C311/20 , C07C311/24 , C07C311/29 , C07C311/32 , C07C311/41 , C07C311/46 , C07C317/04 , C07C317/10 , C07C317/14 , C07C317/28 , C07C317/44 , C07C323/49 , C07C323/67 , C07D209/08 , C07D213/30 , C07D213/64 , C07D213/73 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/48 , C07D233/64 , C07D239/26 , C07D277/24 , C07D277/82 , C07D307/20 , C07D307/42 , C07D307/79 , C07D317/62 , C07D333/34 , C07D405/12 , C07D417/12 , C07K5/06026 , C07K5/06139 , A61K38/00 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2101/18 , C07C2102/10
摘要: .alpha.- and .beta.-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: α-和β-氨基酸羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。
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公开(公告)号:US5610190A
公开(公告)日:1997-03-11
申请号:US476009
申请日:1995-06-07
申请人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Ko-Chung Lin , Michael L. Vazquez , Richard A. Mueller , Kathryn L. Reed , Robert M. Heintz , Michael Clare , John N. Freskos , Eric T. Sun
发明人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Ko-Chung Lin , Michael L. Vazquez , Richard A. Mueller , Kathryn L. Reed , Robert M. Heintz , Michael Clare , John N. Freskos , Eric T. Sun
IPC分类号: A61K31/17 , A61K31/195 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K38/00 , C07C213/00 , C07C213/02 , C07C213/08 , C07C215/28 , C07C269/06 , C07C271/16 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D303/36 , C07D307/85 , C07D401/12 , C07K5/02 , C07K5/06 , C07K5/078
CPC分类号: C07K5/06191 , A61K31/17 , A61K31/195 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , C04B35/632 , C07C213/00 , C07C213/02 , C07C213/08 , C07C269/06 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D303/36 , C07D307/85 , C07D401/12 , C07K5/0207 , C07K5/021 , C07K5/06026 , C07K5/06139 , A61K38/00 , C07B2200/07 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要: Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV Protease.
摘要翻译: 含尿素的羟胺化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。
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公开(公告)号:US5475013A
公开(公告)日:1995-12-12
申请号:US886531
申请日:1992-05-20
申请人: John J. Talley , Daniel P. Getman , John N. Freskos , Ko-Chung Lin , Robert M. Heintz , Donald J. Rogier, Jr. , Deborah E. Bertenshaw
发明人: John J. Talley , Daniel P. Getman , John N. Freskos , Ko-Chung Lin , Robert M. Heintz , Donald J. Rogier, Jr. , Deborah E. Bertenshaw
IPC分类号: A61K31/17 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K38/00 , C07C213/02 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D307/85 , C07D401/12 , C07K5/02 , C07K5/06 , C07K5/078
CPC分类号: C07K5/06191 , A61K31/17 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , C07C213/02 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D307/85 , C07D401/12 , C07K5/0207 , C07K5/021 , C07K5/06026 , C07K5/06139 , A61K38/00 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要: Urea-containing hydroxyethylamine peptide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: 含尿素的羟胺胺化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。
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