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33 条记录 (耗时 0.041 秒)

    Conjugated ligands for the stimulation of blood cell proliferation by effecting dimerization of the receptor for stem cell factor
    1.
    发明授权
    Conjugated ligands for the stimulation of blood cell proliferation by effecting dimerization of the receptor for stem cell factor 失效
    通过实现干细胞因子受体的二聚化来刺激血细胞增殖的共轭配体

    公开(公告)号：US06904369B1

    公开(公告)日：2005-06-07

    申请号：US09609027

    申请日：2000-06-29

    申请人： Wayne A. Hendrickson ,  Xuliang Jiang ,  Keith E. Langley ,  Rashid Syed ,  Yueh-Rong Ann Hsu

    发明人： Wayne A. Hendrickson ,  Xuliang Jiang ,  Keith E. Langley ,  Rashid Syed ,  Yueh-Rong Ann Hsu

    IPC分类号： A61K38/00 ,  C07H21/04 ,  C07K14/11 ,  G01N33/48 ,  C07K1/00 ,  G01N33/50

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C07H21/04 ,  C07K1/1077 ,  C12N2760/16022 ,  G06F19/16

    摘要： This invention provides a computer based method for preparing a stem cell factor (SCF) analog comprising the steps of: (a) providing computer expression of the three dimensional structure of an SCF molecule using its crystal structure; (b) selecting from the computer expression of step (a) at least one site on the SCF molecule for alteration; (c) preparing a SCF molecule having an alteration at said at least one selected site; and (d) optionally, testing the SCF molecule for a desired characteristic. This invention also provides SCF analogs and SCF ligand analogs prepared according to the above-described method. Compositions comprising SCF analogs or SCF ligand analogs prepared according to the above-described method effective to treat a subject and a pharmaceutically acceptable carrier are provided, as are methods of treating a subject comprising administration of pharmaceutical compositions comprising the prepared SCF analogs and SCF ligand analogs prepared by the described methods. This invention also provides methods for designing compounds capable of binding to the SCF receptor site and compounds designed by the above-described methods.

    摘要翻译： 本发明提供了一种用于制备干细胞因子（SCF）类似物的基于计算机的方法，包括以下步骤：（a）使用其晶体结构提供SCF分子的三维结构的计算机表达; （b）选自步骤（a）的计算机表达，SCF分子上的至少一个位点用于改变; （c）制备在所述至少一个所选位点具有改变的SCF分子; 和（d）任选地，测试SCF分子的期望特性。 本发明还提供了根据上述方法制备的SCF类似物和SCF配体类似物。 提供了包含根据有效治疗受试者和药学上可接受的载体的上述方法制备的SCF类似物或SCF配体类似物的组合物，治疗受试者的方法包括施用包含制备的SCF类似物和SCF配体类似物的药物组合物 通过描述的方法准备。 本发明还提供了设计能够结合SCF受体位点的化合物和通过上述方法设计的化合物的方法。

    Mutant glycoproteins
    7.
    发明授权
    Mutant glycoproteins 有权
    突变型糖蛋白

    公开(公告)号：US07317095B2

    公开(公告)日：2008-01-08

    申请号：US10493540

    申请日：2002-10-22

    申请人： William H. Brondyk ,  Xuliang Jiang ,  Robert Campbell

    发明人： William H. Brondyk ,  Xuliang Jiang ,  Robert Campbell

    IPC分类号： C07K14/59 ,  C12N15/00 ,  C12N15/63 ,  C12N5/00

    CPC分类号： C07K14/59 ,  A61K38/00

    摘要： The inventors have designed novel FSH mutants with increased glycosylation and longer half-lives for use in inducing folliculogenesis in human patients. The use of a FSH mutant preparation of the invention permits the use of lower cumulative doses of FSH to achieve the same or better clinical result.

    摘要翻译： 本发明人设计了具有增加的糖基化和更长半衰期的新型FSH突变体用于诱导人类患者的卵泡发生。 使用本发明的FSH突变体制剂允许使用较低累积剂量的FSH来实现相同或更好的临床结果。

    METHODS OF INCERASING PROTEIN EXPESSION LEVELS
    8.
    发明申请
    METHODS OF INCERASING PROTEIN EXPESSION LEVELS 失效
    蛋白质渗透水平的方法

    公开(公告)号：US20050074840A1

    公开(公告)日：2005-04-07

    申请号：US10496218

    申请日：2004-09-13

    申请人： William Brondyk ,  Xuliang Jiang ,  Rene Schweickhardt

    发明人： William Brondyk ,  Xuliang Jiang ,  Rene Schweickhardt

    IPC分类号： C12N15/09 ,  C07K14/47 ,  C07K14/715 ,  C12N15/00 ,  C12P21/02 ,  C07H21/04

    CPC分类号： C12P21/02 ,  C07K14/7151 ,  C12N15/00 ,  Y10S930/144

    摘要： Abstract of the DisclosureThe present invention relates to methods of increasing protein expression levels whereby at least one amino acid in a protein amino acid sequence is substituted for the amino acid, proline. Preferably, the substitution occurs within 15 amino acids, more preferably within 10 amino acids and most preferably within 5 amino acids of a cysteine amino acid residue. The present invention not only includes methods for polypeptides with proline substitutions, but also polynucleotides with codon substitutions for which a codon for any amino acid, except proline, is substituted for a codon encoding for proline.

    摘要翻译： 发明内容本发明涉及增加蛋白质表达水平的方法，其中蛋白质氨基酸序列中的至少一个氨基酸被氨基酸脯氨酸取代。 优选地，取代发生在半胱氨酸氨基酸残基的15个氨基酸内，更优选在10个氨基酸内，最优选在5个氨基酸内。 本发明不仅包括具有脯氨酸取代的多肽的方法，而且还包括具有密码子取代的多核苷酸，除了脯氨酸之外，任何氨基酸的密码子都代替编码脯氨酸的密码子。

    Method for producing of ultra-clean and high-purity aqueous hydrogen peroxide solution
    10.
    发明授权
    Method for producing of ultra-clean and high-purity aqueous hydrogen peroxide solution 有权
    超清洁和高纯度过氧化氢水溶液的生产方法

    公开(公告)号：US08715613B2

    公开(公告)日：2014-05-06

    申请号：US12981541

    申请日：2010-12-30

    申请人： Jiarong Zhan ,  Zhen Song ,  Xuliang Jiang

    发明人： Jiarong Zhan ,  Zhen Song ,  Xuliang Jiang

    IPC分类号： C01B15/01

    CPC分类号： B01J20/28083 ,  B01D61/025 ,  B01D61/04 ,  B01D2311/04 ,  B01D2311/2626 ,  B01J20/103 ,  B01J20/3204 ,  B01J20/3246 ,  B01J20/3248 ,  C01B15/0135

    摘要： The present invention relates to a method for producing of ultra-clean and high-purity aqueous hydrogen peroxide solution. Industrial grade hydrogen peroxide is filtered by SBA-15 molecular sieve with which the chelator is loaded, and then it is further filtered by a hyperfiltration membrane to obtain the ultra-clean and high-purity aqueous hydrogen peroxide solution. The method provided in the present invention overcomes the problems such as complexity of operation, high energy consumption and high content of impurities in the product, and is suitable for continuous production on a large scale because of its simple equipment, simple operation, low energy consumption and stable quality of the product.

    摘要翻译： 本发明涉及一种生产超清洁和高纯度过氧化氢水溶液的方法。 工业级过氧化氢用负载螯合剂的SBA-15分子筛过滤，然后用超滤膜进一步过滤，得到超清洁和高纯度的过氧化氢水溶液。 本发明提供的方法克服了操作复杂性高，能耗高，产品杂质含量高等问题，其设备简单，操作简便，能耗低，适合大规模连续生产 稳定的产品质量。