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    Sequential Method
    3.
    发明申请
    Sequential Method 审中-公开
    顺序方法

    公开(公告)号：US20090215196A1

    公开(公告)日：2009-08-27

    申请号：US11572316

    申请日：2005-07-15

    申请人： Bo Ek ,  Mats Holmquist ,  Karolina Osterlund ,  Mats Inganas

    发明人： Bo Ek ,  Mats Holmquist ,  Karolina Osterlund ,  Mats Inganas

    IPC分类号： G01N33/566

    CPC分类号： G01N33/54306 ,  B01L3/5027 ,  G01N33/54366

    摘要： A method for determination of an analyte in an original liquid sample by performing an inhibition affinity assay in a microchannel structure of a microfluidic device. The main characteristic feature is the steps of: (i) providing the microfluidic device in a form where the microchannel structure comprises a reaction microcavity which a) an inlet end, and b) contains a solid phase with binding sites (BS) for an analyte or an analyte-related entity, (ii) providing a liquid sample (1) containing the analyte or the analyte-related entity within the microchannel structure at the inlet end of the reaction microcavity, and flowing sample (1) through the reaction microcavity under conditions such that the analyte or the analyte-related entity is captured by BS leaving a portion of BS unoccupied (free BS), (iii) providing a liquid sample (2) which contains an analytically detectable analogue of the analyte or of the analyte-related entity, and flowing sample (2) through said reaction microcavity to capture the analogue by free BS, and (iv) measuring the amount of analyte analogue captured in step (iii) and relating this amount to the amount of analyte in an original sample.

    摘要翻译： 一种通过在微流体装置的微通道结构中进行抑制亲和力测定来测定原始液体样品中的分析物的方法。 主要特征是以下步骤：（i）以微通道结构包含反应微腔的形式提供微流体装置，其中a）入口端和b）包含具有用于分析物的结合位点（BS）的固相 或分析物相关实体，（ii）在反应微腔的入口端处提供在微通道结构内含有分析物或分析物相关实体的液体样品（1），并将样品（1）流过反应微腔下 条件，使得分析物或分析物相关实体被BS捕获，留下一部分BS未占用（自由BS），（iii）提供含有分析物或分析物 - 分析物的可分析检测的类似物的液体样品（2） 相关实体和流动样品（2）通过所述反应微腔以通过游离BS捕获类似物，和（iv）测量步骤（iii）中捕获的分析物类似物的量，并将该量与在 原始样本

    Structural units that define fluidic functions
    5.
    发明授权
    Structural units that define fluidic functions 失效
    定义流体功能的结构单元

    公开(公告)号：US07429354B2

    公开(公告)日：2008-09-30

    申请号：US10472255

    申请日：2002-03-19

    申请人： Per Andersson ,  Gunnar Ekstrand ,  Ulrike Selditz ,  Sussanne Wallenborg ,  Helene Derand ,  Gunnar Thorsen ,  Ebru Togan-Tekin

    发明人： Per Andersson ,  Gunnar Ekstrand ,  Ulrike Selditz ,  Sussanne Wallenborg ,  Helene Derand ,  Gunnar Thorsen ,  Ebru Togan-Tekin

    IPC分类号： G01N21/00

    CPC分类号： G01N33/54366 ,  B01J19/0093 ,  B01L3/5025 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2200/0678 ,  B01L2200/0684 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688 ,  B01L2400/086 ,  G01N35/00069

    摘要： A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and therebetween a substructure comprising a fluidic function. The device has an axis of symmetry around which the microchannel structures are arranged as two or more concentric annular zones. for an inlet port and an outlet port of the same microchannel structure the inlet port is typically closer to the axis of symmetry than the outlet port. Each microchannel structure comprises a substructure that can retain liquid while the disc is spun around the axis and/or the inlet ports are positioned separate from the paths waste liquid leaving open waste outlet ports will follow across the surface of the disc when it is spun. For the microchannel structures of an annular zones the corresponding substructures are at essentially at the same radial distance while corresponding substructures in microchannel structures of different annular zones are at different radial distances. The invention also refers to several other substructures. The substructure are primarily adapted for transporting liquid aliquots that have a surface tnsion >5 mN/m with centrifugal force.

    摘要翻译： 一种微流体装置，其包括几个微通道结构，其中存在入口端口，出口以及其间具有流体功能的子结构。 该装置具有对称轴，微通道结构围绕该轴布置为两个或更多个同心的环形区域。 对于相同微通道结构的入口和出口，入口通常比出口更接近对称轴。 每个微通道结构包括一个子结构，其可以在圆盘围绕轴线旋转时保持液体，和/或入口端口与路径分离，离开开放废料出口的废液在旋转时将跟随盘的表面。 对于环形区域的微通道结构，相应的子结构基本上处于相同的径向距离，而不同环形区域的微通道结构中的相应子结构处于不同的径向距离。 本发明还涉及几个其他子结构。 子结构主要适用于输送具有离心力的表面尺寸> 5mN / m的液体等分试样。

    Microfluidic affinity assays with improved performance
    8.
    发明申请
    Microfluidic affinity assays with improved performance 审中-公开
    具有改善性能的微流控亲和测定

    公开(公告)号：US20060246526A1

    公开(公告)日：2006-11-02

    申请号：US11292996

    申请日：2005-12-02

    申请人： Mats Inganas ,  Magnus Ljungstrom

    发明人： Mats Inganas ,  Magnus Ljungstrom

    IPC分类号： G01N33/53

    CPC分类号： G01N33/54366 ,  G01N33/581

    摘要： Method for measuring the signal from a label in a labeled measuring reagent that has been specifically adsorbed to its affinity counterpart in a zone of a porous nanolitre (nl) bed that is present in a microchannel structure of a microfluidic device. The measuring is part of an assay for determining an analyte of a sample by performing one, two or more heterogeneous specific affinity reactions which comprises that said labeled measuring reagent becomes affinity bound to said zone.

    摘要翻译： 用于测量来自在微流体装置的微通道结构中存在的多孔纳尼特（nl）床的区域中已特异性吸附到其亲和对应物的标记测量试剂中的标记的信号的方法。 测量是通过进行一种，两种或更多种非均相特异性亲和反应来测定样品分析物的测定的一部分，其包括所述标记的测量试剂变得亲和结合到所述区域。

    Polymer valves
    9.
    发明授权
    Polymer valves 有权
    聚合物阀门

    公开(公告)号：US07104517B1

    公开(公告)日：2006-09-12

    申请号：US10030297

    申请日：2000-06-30

    申请人： Helene Derand ,  Per Andersson ,  Anders Larsson

    发明人： Helene Derand ,  Per Andersson ,  Anders Larsson

    IPC分类号： F16K31/00

    CPC分类号： F16K99/0001 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00891 ,  B01L3/502738 ,  B01L2200/12 ,  B01L2300/0806 ,  B01L2300/1861 ,  B01L2400/0661 ,  F15C5/00 ,  F16K13/10 ,  F16K99/0019 ,  F16K99/0034 ,  F16K99/0036

    摘要： The invention relates to a method of controlling flow of liquids in a micro channel structure. It comprises providing in said micro channel structure plugs (34) of polymer material in said structure, said polymer material in a first state blocking said channel from liquid flow, and in a second state providing a free path-way (32) for liquid flow. Energy is selectively applied so as to cause said polymer to enter a desired one of said first or second states. It also relates to a micro channel valve system, comprising a plurality of such plugs (34). Additionally it comprises a chemical reactor, comprising a plurality of micro chambers interconnected by micro channels, having a valve system according to the invention.

    摘要翻译： 本发明涉及一种控制微通道结构中液体流动的方法。 它包括在所述微通道结构中提供在所述结构中的聚合物材料的塞子（34），所述聚合物材料处于第一状态，从而阻止所述通道从液体流动，并且在第二状态下提供用于液体流动的自由通路（32） 。 选择性地施加能量以使所述聚合物进入所述第一或第二状态中的期望的一种。 它还涉及一种微通道阀系统，其包括多个这样的塞子（34）。 另外，它包括化学反应器，包括通过微通道互连的多个微室，具有根据本发明的阀系统。

    Method and kit for analyte determination at acidic conditions
    10.
    发明授权
    Method and kit for analyte determination at acidic conditions 有权

    公开(公告)号：US10036745B2

    公开(公告)日：2018-07-31

    申请号：US14433276

    申请日：2013-10-03

    申请人： GYROS Patent AB

    发明人： Mats Inganäs ,  Pirjo Lehtonen

    IPC分类号： G01N33/537 ,  G01N33/543 ,  G01N33/53

    CPC分类号： G01N33/54393 ,  G01N33/5306 ,  G01N33/5375 ,  G01N2333/195

    摘要： A method of quantitatively determining an analyte in a fluid sample by an immunoassay comprises binding of the analyte to a ligand capable of specifically binding to the analyte, wherein at least part of the analyte is present as an analyte complex is disclosed. The method comprises the steps of: a) subjecting the sample to a first acidic pH to at least substantially dissociate any analyte complex present and provide substantially all analyte in free form, b) raising the first acidic pH to a second acidic pH where re-formation of complexes is prevented but where binding of analyte to the ligand is permitted, and c) determining the binding of analyte to the ligand to quantitatively determine the analyte in the sample.