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    Transfection reagents
    5.
    发明授权
    Transfection reagents 有权

    公开(公告)号：US07173154B2

    公开(公告)日：2007-02-06

    申请号：US10629522

    申请日：2003-07-28

    Applicant: Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    Inventor： Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    IPC: C07C215/14 ,  A61K31/13 ,  C12N15/63 ,  C12N15/86 ,  C12N15/87 ,  C12N15/85 ,  C12N15/88

    CPC classification number: A61K47/48046 ,  A61K9/16 ,  A61K31/14 ,  A61K38/28 ,  A61K38/40 ,  A61K47/543 ,  C07C211/21 ,  C07C211/63 ,  C07C211/64 ,  C07C229/26 ,  C07D209/48 ,  C07D241/12 ,  C12N15/88 ,  Y10S435/81

    Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L′-X2-Z or -Z; R1–R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wherein at least one of R1, R3, R4 and R6 is a straight chain or branched, cyclic, alkyl, alkenyl, alkynyl or aryl group; and anyone of R1, R3, R4 and/or R6 may optionally be covalently linked with each other, with Y or with L when L is C or CH to form a cyclic moiety; Z is selected from the group consisting of amine, spermiyl, carboxyspermiyl, guanidyl, spermidinyl, putricinyl, diaminoalkyl, pyridyl, piperidinyl, pyrrolidinyl, polyamine, amino acid, peptide, and protein; X1 and X2, independently of one another, are selected from the group consisting of NH, O, S, alkylene, and arylene; L′ is selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, alkylene ether, and polyether; D is Q or a bond; A1 and A2, independently of one another, are selected from the group consisting of CH2O, CH2S, CH2NH, C(O), C{NH), C(S) and (CH2)t; X is a physiologically acceptable anion; m, n, r, s, u, v, w and y are 0 or 1, with the proviso that when both m and n are 0 at least one of r, s, u and y is other than 0; i, j, k, l, p and are integers from 0 to about 100; q is an integer from 1 to about 1000; and a is the number of positive charge divided by the valence of the anion.

    Luminescent nanoparticles and methods for their preparation
    6.
    发明授权
    Luminescent nanoparticles and methods for their preparation 有权
    发光纳米颗粒及其制备方法

    公开(公告)号：US07172791B2

    公开(公告)日：2007-02-06

    申请号：US10985249

    申请日：2004-11-09

    Applicant: Joseph A. Treadway ,  Donald A. Zehnder ,  Marc D. Schrier

    Inventor： Joseph A. Treadway ,  Donald A. Zehnder ,  Marc D. Schrier

    IPC: B05D7/00 ,  B05D3/02

    CPC classification number: C09K11/883 ,  C09K11/08 ,  C09K11/0805 ,  C09K11/0811 ,  C09K11/54 ,  C09K11/565 ,  Y10T428/2984 ,  Y10T428/2991 ,  Y10T428/2993

    Abstract: Methods for synthesizing luminescent nanoparticles and nanoparticles prepared by such methods are provided. The nanoparticles are prepared by a method in which an additive is included in the reaction mixture. The additive may be a Group 2 element, a Group 12 element, a Group 13 element, a Group 14 element, a Group 15 element, or a Group 16 element. In additions, a luminescent nanoparticle is provided that comprises a semiconductive core surrounded by an inorganic shell, an interfacial region and an additive present in the interfacial region or both the interfacial region and the shell.

    Abstract translation: 提供了通过这些方法制备发光纳米颗粒和纳米颗粒的方法。 通过反应混合物中包含添加剂的方法制备纳米颗粒。 添加剂可以是2族元素，12族元素，13族元素，14族元素，15族元素或16族元素。 另外，提供了一种发光纳米颗粒，其包括由无机壳包围的半导体芯，界面区域和存在于界面区域中的添加剂或界面区域和壳体两者。

    Transfection reagents
    7.
    发明授权
    Transfection reagents 有权

    公开(公告)号：US07145039B2

    公开(公告)日：2006-12-05

    申请号：US11040562

    申请日：2005-01-21

    Applicant: Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    Inventor： Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    IPC: C07C215/18 ,  C12N15/88

    CPC classification number: A61K47/48046 ,  A61K9/16 ,  A61K31/14 ,  A61K38/28 ,  A61K38/40 ,  A61K47/543 ,  C07C211/21 ,  C07C211/63 ,  C07C211/64 ,  C07C229/26 ,  C07D209/48 ,  C07D241/12 ,  C12N15/88 ,  Y10S435/81

    Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1—L′—X2—Z or —Z; R1–R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D—Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wherein at least one of R1, R3, R4 and R6 is a straight chain or branched, cyclic, alkyl, alkenyl, alkynyl or aryl group; and anyone of R1, R3, R4 and/or R6 may optionally be covalently linked with each other, with Y or with L when L is C or CH to form a cyclic moiety; Z is selected from the group consisting of amine, spermiyl, carboxyspermiyl, guanidyl, spermidinyl, putricinyl, diaminoalkyl, pyridyl, piperidinyl, pyrrolidinyl, polyamine, amino acid, peptide, and protein; X1 and X2, independently of one another, are selected from the group consisting of NH, O, S, alkylene, and arylene; L′ is selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, alkylene ether, and polyether; D is Q or a bond; A1 and A2, independently of one another, are selected from the group consisting of CH2O, CH2S, CH2NH, C(O), C{NH), C(S) and (CH2)t; X is a physiologically acceptable anion; m, n, r, s, u, v, w and y are 0 or 1, with the proviso that when both m and n are 0 at least one of r, s, u and y is other than 0; i, j, k, l, p and are integers from 0 to about 100; q is an integer from 1 to about 1000; and a is the number of positive charge divided by the valence of the anion.

    Use of multiple recombination sites with unique specificity in recombinational cloning
    8.
    发明授权
    Use of multiple recombination sites with unique specificity in recombinational cloning 有权
    在重组克隆中使用具有独特特异性的多个重组位点

    公开(公告)号：US07351578B2

    公开(公告)日：2008-04-01

    申请号：US10640422

    申请日：2003-08-14

    Applicant: David Cheo ,  Michael A. Brasch ,  Gary F. Temple ,  James L. Hartley ,  Devon R. N. Byrd

    Inventor： David Cheo ,  Michael A. Brasch ,  Gary F. Temple ,  James L. Hartley ,  Devon R. N. Byrd

    IPC: C12Q1/68

    CPC classification number: C12N15/1086 ,  C07K14/47 ,  C12N9/00 ,  C12N15/10 ,  C12N15/102 ,  C12N15/1093 ,  C12N15/64 ,  C12N15/66 ,  C12P21/00

    Abstract: The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites with unique specificity. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different. Such molecules and/or compounds or combinations of such molecules and/or compounds can also be bound through recombination to various structures or supports according to the invention.

    Abstract translation: 本发明提供了用于重组克隆的组合物和方法。 组合物包括具有独特特异性的多个重组位点的载体。 该方法允许同时克隆两种或更多种不同的核酸分子。 在一些实施方案中，分子融合在一起，而在其它实施方案中，分子被插入载体中的不同位点。 本发明还通常提供通过重组连接或连接许多可以相同或不同的分子和/或化合物（例如，化合物，药物，蛋白质或肽，脂质，核酸，碳水化合物等）。 这样的分子和/或化合物或这些分子和/或化合物的组合也可以通过重组与根据本发明的各种结构或支持物结合。

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