公开(公告)号：US12116701B2

公开(公告)日：2024-10-15

申请号：US16758317

申请日：2018-10-25

申请人： LENZING AG

发明人： Heinrich Firgo ,  Clemens Bisjak

IPC分类号： D01F1/07 ,  B01F25/23 ,  D01F2/08 ,  D06M13/322 ,  B01F101/00 ,  D06M101/06

CPC分类号： D01F1/07 ,  B01F25/23 ,  D01F2/08 ,  D06M13/322 ,  B01F2101/2805 ,  D06M2101/06 ,  D06M2200/30

摘要： A process for the production of an oxidized polymer from a tetrakis hydroxyalkyl phosphonium compound comprising NH3 or at least one nitrogen compound comprising at least one NH2 or at least two NH groups, or NH3, comprising the steps of: (a) reacting at least one tetrakis hydroxyalkyl phosphonium compound with NH3 or at least one nitrogen compound in order to obtain a precondensate, wherein the molar ratio of the tetrakis hydroxyakyl phosphonium compound to the nitrogen compound is in the range of 1: (0.05 to 2.0), preferably in the range of 1: (0.5 to 1.5), particularly preferably in the range of 1: (0,65 to 1.2), (b) crosslinking the precondensate obtained in process step (a) with the aid of ammonia to form a crosslinked polymer, (c) oxidizing the crosslinked polymer obtained in step (b) by adding an oxidizing agent to the oxidized polymer, wherein, in step (b), the precondensate from step (a) and the ammonia are each injected by means of a nozzle into a reactor space enclosed by a reactor housing onto a common collision point.

公开(公告)号：US20230265774A1

公开(公告)日：2023-08-24

申请号：US18112538

申请日：2023-02-22

申请人： Friedrich Boysen GmbH & Co. KG

发明人： Stefan SAUER ,  Igor ROGOWSKI ,  Robert ANSELM ,  Marco FRIESE

IPC分类号： F01N3/20 ,  F01N3/28 ,  B01F23/213 ,  B01F23/20 ,  B01F25/23 ,  B01F35/71 ,  B01D53/94

CPC分类号： F01N3/208 ,  F01N3/2892 ,  B01F23/2132 ,  B01F23/29 ,  B01F25/23 ,  B01F35/714 ,  B01F35/7179 ,  B01D53/9418 ,  F01N2610/02 ,  F01N2610/1453 ,  B01F2025/918

摘要： The present invention relates to an apparatus for mixing an additive with a gas flow, in particular for an exhaust gas system of a vehicle having an internal combustion engine, that comprises a mixing chamber which can be flowed through by at least a portion of the gas flow, said mixing chamber having at least one inlet opening through which a main inlet flow of the gas flow flows into the mixing chamber on operation of the apparatus, having at least one metering opening and having at least one outlet opening. The apparatus further comprises a metering device by means of which an additive flow of the additive can be introduced into the mixing chamber through the metering opening, wherein the inlet opening and the metering opening are arranged and formed such that the main inlet flow and the additive flow in substantially opposite directions into the mixing chamber so that the main inlet flow and the additive flow impact one another.

公开(公告)号：US11420165B2

公开(公告)日：2022-08-23

申请号：US17189054

申请日：2021-03-01

申请人： ZOLL Medical Corporation

发明人： Stephen E. Myrick ,  Jeffrey L. Creech

IPC分类号： B01F23/23 ,  B01F23/45 ,  B01F25/31 ,  B01F33/82 ,  A61M1/32 ,  B01F23/232 ,  B01F23/454 ,  B01F23/234 ,  B01F25/23 ,  B01F25/313 ,  B29C53/08 ,  A61M25/00 ,  A61M1/16

摘要： The present invention provides a system for enriching a flowing liquid with a dissolved gas inside a conduit. The system comprises two or more capillaries, each capillary delivering a stream of a gas-enriched liquid to the flowing liquid. The first ends of the capillaries are positioned to form an intersecting angle with respect to the effluent streams such that these streams of gas-enriched liquid collide with each other upon exit from the first ends of the capillaries, effecting localized convective mixing within the larger liquid conduit before these gas-enriched streams are able to come into close contact with the boundary surfaces of the conduit, whereby the gas-enriched liquid mixes with the flowing liquid to form a gas-enriched flowing liquid. In the preferred embodiment, no observable bubbles are formed in the gas-enriched flowing liquid. Methods of making and using such system are also provided.

公开(公告)号：US11772058B2

公开(公告)日：2023-10-03

申请号：US16657016

申请日：2019-10-18

申请人： TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY LIMITED

发明人： Ming Shing Lin ,  Chin Shen Hsieh

IPC分类号： C23C16/40 ,  B01F25/23 ,  C23C16/455 ,  H01L21/67 ,  B01F23/10 ,  B01F35/91 ,  B01F35/10 ,  B01F35/90 ,  B01F101/58

CPC分类号： B01F25/23 ,  B01F23/19 ,  B01F35/1453 ,  B01F35/91 ,  C23C16/45565 ,  H01L21/67017 ,  B01F2035/98 ,  B01F2101/58

摘要： A gas mixing system for semiconductor fabrication includes a mixing block. The mixing block defines a gas mixing chamber, a first gas channel fluidly coupled to the gas mixing chamber at a first exit location, and a second gas channel fluidly coupled to the gas mixing chamber at a second exit location, wherein the first exit location is diametrically opposite the second exit location relative to the gas mixing chamber and the second gas channel has a bend of 90 degrees or less between an entrance of the second gas channel and the second exit location.

公开(公告)号：US20230219044A1

公开(公告)日：2023-07-13

申请号：US18001440

申请日：2021-06-10

申请人： The Johns Hopkins University

发明人： Rajat Mittal ,  Jung Hee Seo ,  Hai-Quan Mao ,  Yue Hao ,  Yizong Hu

IPC分类号： B01F25/23 ,  B01F25/10 ,  B01F25/25

CPC分类号： B01F25/23 ,  B01F25/101 ,  B01F25/25

摘要： A process and a device for continuous micromixing of two fluids is disclosed. The process and the device can be used in particular when micromixing plays an important role, for example, in the yield and characteristics of the products. This is the case for crystallization, precipitation and combustion reactions and for micelle assembly or polyelectrolyte complexation processes.

公开(公告)号：US20230022647A1

公开(公告)日：2023-01-26

申请号：US17860514

申请日：2022-07-08

申请人： ZOLL Medical Corporation

发明人： Stephen E. Myrick ,  Jeffrey L. Creech

IPC分类号： B01F23/232 ,  A61M1/32 ,  B01F23/454 ,  B01F23/234 ,  B01F25/23 ,  B01F25/313 ,  B01F33/82

摘要： The present invention provides a system for enriching a flowing liquid with a dissolved gas inside a conduit. The system comprises two or more capillaries, each capillary delivering a stream of a gas-enriched liquid to the flowing liquid. The first ends of the capillaries are positioned to form an intersecting angle with respect to the effluent streams such that these streams of gas-enriched liquid collide with each other upon exit from the first ends of the capillaries, effecting localized convective mixing within the larger liquid conduit before these gas-enriched streams are able to come into close contact with the boundary surfaces of the conduit, whereby the gas-enriched liquid mixes with the flowing liquid to form a gas-enriched flowing liquid. In the preferred embodiment, no observable bubbles are formed in the gas-enriched flowing liquid. Methods of making and using such system are also provided.

公开(公告)号：US20220097011A1

公开(公告)日：2022-03-31

申请号：US17426922

申请日：2020-02-05

申请人： JAGTECH AS

发明人： Geir Olav Ånesbug

IPC分类号： B01F25/23 ,  B01F25/312 ,  B01F35/21 ,  B01F35/213 ,  B01F35/22 ,  E21B21/06

摘要： Method and device for conditioning of drilling fluid comprising supplying drilling fluid at high pressure to opposite placed inline directed high pressure nozzles arranged in fluid communication with a sealed spacing for shearing the supplied drilling fluid followed by additionally mixing by high velocity streams colliding, and discharging the conditioned drilling fluid through an outlet of the sealed spacing.

公开(公告)号：US12097495B2

公开(公告)日：2024-09-24

申请号：US17750195

申请日：2022-05-20

申请人： Bio-Rad Laboratories, Inc.

发明人： Benjamin J. Hindson ,  Serge Saxonov ,  Phillip Belgrader ,  Kevin D. Ness ,  Michael Y. Lucero ,  Billy W. Colston, Jr. ,  Shawn Paul Hodges ,  Nicholas J. Heredia ,  Jeffrey Clark Mellen ,  Camille Bodley Troup ,  Paul Wyatt

IPC分类号： B01L3/00 ,  B01F23/41 ,  B01F33/3011 ,  B01F33/81 ,  B01L9/00 ,  C12Q1/686 ,  B01F25/00 ,  B01F25/23 ,  B01F33/302 ,  G01N35/08

CPC分类号： B01L3/50273 ,  B01F23/41 ,  B01F33/3011 ,  B01F33/813 ,  B01L3/502 ,  B01L3/502784 ,  B01L3/52 ,  B01L9/527 ,  C12Q1/686 ,  B01F25/14 ,  B01F25/23 ,  B01F33/3021 ,  B01L3/502761 ,  B01L2200/025 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/0609 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0861 ,  B01L2400/049 ,  G01N35/08

摘要： The present disclosure provides methods and compositions for detecting polynucleotides in a sample and for quantifying polynucleotide load in a sample. The polynucleotides can be associated with a disease, disorder, or condition. In some applications, methylated DNA is quantified, e.g., in order to determine the load of polynucleotides in a sample. The present disclosure also provides methods and compositions for determining the load of fetal polynucleotides in a biological sample, e.g., the load of fetal polynucleotides (e.g., DNA, RNA) in maternal plasma. The present disclosure provides methods and compositions for detecting cellular processes such as cellular viability, growth rates, and infection rates. This disclosure also provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some embodiments, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g., blood, plasma). The methods and materials described apply techniques for allowing detection of small, but statistically significant, differences in polynucleotide copy number.

公开(公告)号：US20230405540A1

公开(公告)日：2023-12-21

申请号：US18030707

申请日：2021-10-05

申请人： AVL LIST GMBH

发明人： Wolfgang Rath ,  Vedran Burazer

IPC分类号： B01F35/221 ,  B01F23/45 ,  B01F25/23 ,  B01F25/432 ,  B01F25/452 ,  B01F33/81 ,  B01F33/82 ,  G01M15/02 ,  G01M17/00 ,  G01M99/00 ,  G05D23/13

CPC分类号： B01F35/2215 ,  B01F23/453 ,  B01F25/23 ,  B01F25/432 ,  B01F25/4523 ,  B01F33/811 ,  B01F33/821 ,  G01M15/02 ,  G01M17/00 ,  G01M99/002 ,  G05D23/1393

摘要： To condition an operating medium in a test object circuit (PK) of a test object (P) on a test bench to a desired temperature as quickly as possible, the invention proposes providing a mixing unit (3), there being provided, in the mixing unit (3), a mixing region (28) in which operating medium of the test object circuit (PK) can be mixed with preconditioned operating medium from a conditioning circuit (KK) in order to condition the operating medium in the test object circuit (PK) to the predefined setpoint temperature (T_SOLL), there being provided, on the mixing unit (3), for the fluidic integration of the mixing unit (3) in the test object circuit (PK), at least one test object circuit supply connection (26a) and at least one test object circuit outlet connection (26b) which are fluidically connected to one another via the mixing region (28) in order to form a part of the test object circuit (PK), there being provided, on the mixing unit (3), for connection of the mixing unit (3) to a conditioning unit (2) of the conditioning system (1), at least one conditioning unit supply connection (27a) and at least one conditioning unit return connection (27b) which are fluidically connected to one another via the mixing region (28) in order to form a part of the conditioning circuit (KK) for the operating medium.

公开(公告)号：US11744805B2

公开(公告)日：2023-09-05

申请号：US17962635

申请日：2022-10-10

申请人： leon-nanodrugs GmbH

发明人： Pascale Clement ,  Beatriz López-Sánchez

IPC分类号： A61K9/51 ,  B01F25/23 ,  B82Y40/00 ,  A61K45/06 ,  B82Y5/00

CPC分类号： A61K9/5192 ,  A61K9/5146 ,  A61K9/5161 ,  A61K45/06 ,  B01F25/23 ,  B82Y40/00 ,  B82Y5/00

摘要： The invention provides a method for validating the functioning of an apparatus with a static mixing device for mixing two liquid streams for producing nanoparticles. The static mixing device may be a jet impingement reactor. The method is based on the use of PLA, PLG or PLGA for producing polymeric nanoparticles with highly reproducible particle sizes. The invention further provides kits and liquid compositions for carrying out the method.