公开(公告)号：US11793771B2

公开(公告)日：2023-10-24

申请号：US17838400

申请日：2022-06-13

申请人： CHEMOCENTRYX, INC.

发明人： Christopher Lange ,  Viengkham Malathong ,  Darren J. McMurtrie ,  Sreenivas Punna ,  Rajinder Singh ,  Ju Yang ,  Penglie Zhang

IPC分类号： A61K31/085 ,  C07D211/40 ,  A61P35/00 ,  C07C215/12 ,  C07F5/02 ,  C07D401/14 ,  C07D213/30 ,  C07D405/12 ,  C07C229/22 ,  C07D319/18 ,  C07D417/12 ,  A61K45/06 ,  C07C235/42 ,  C07C235/20 ,  C07D239/42 ,  C07C255/54 ,  C07D213/61 ,  C07D413/12 ,  C07D205/04 ,  A61P31/00 ,  C07D237/08 ,  C07D401/12 ,  C07D213/85 ,  C07D239/30 ,  C07D405/14 ,  C07D401/04 ,  C07D409/12 ,  C07D213/80 ,  A61P29/00 ,  C07C317/22 ,  C07F9/58 ,  A61K31/015 ,  A61K31/03 ,  A61K31/277 ,  A61K38/00 ,  C07C43/168 ,  A61K31/36 ,  A61K31/44 ,  A61K31/505 ,  A61K47/34

CPC分类号： A61K31/085 ,  A61K31/015 ,  A61K31/03 ,  A61K31/277 ,  A61K38/00 ,  A61K45/06 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  C07C43/168 ,  C07C215/12 ,  C07C229/22 ,  C07C235/20 ,  C07C235/42 ,  C07C255/54 ,  C07C317/22 ,  C07D205/04 ,  C07D211/40 ,  C07D213/30 ,  C07D213/61 ,  C07D213/80 ,  C07D213/85 ,  C07D237/08 ,  C07D239/30 ,  C07D239/42 ,  C07D319/18 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07F5/025 ,  C07F9/58 ,  A61K31/36 ,  A61K31/44 ,  A61K31/505 ,  A61K47/34 ,  C07C2601/02 ,  C07C2602/08 ,  Y02A50/30

摘要： Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (II):






including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2a, R2b, R2c, R3, R4, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US11702382B2

公开(公告)日：2023-07-18

申请号：US17511119

申请日：2021-10-26

申请人： SABIC Global Technologies B.V.

发明人： Feng Xu ,  Flaiyh Al-Anazi

IPC分类号： C07C213/10 ,  C07C215/12 ,  C01B35/04 ,  C01D1/04

CPC分类号： C07C213/10 ,  C01B35/04 ,  C01D1/04 ,  C07C215/12 ,  C07C213/10 ,  C07C215/12

摘要： A method of reducing color in an alkanolamine, the method comprising: contacting the alkanolamine with an amount of an aqueous solution effective to provide 5 to 1000 parts per million by weight of an alkali metal borohydride, based on parts by weight of the alkanolamine; and 0.5 to 10,000 parts per million by weight of an alkali metal hydroxide, based on parts by weight of the alkanolamine; preferably wherein the color-reduced alkanolamine is not distilled after the contacting.

公开(公告)号：US11426364B2

公开(公告)日：2022-08-30

申请号：US16751019

申请日：2020-01-23

申请人： CHEMOCENTRYX, INC.

发明人： Christopher Lange ,  Viengkham Malathong ,  Darren J. McMurtrie ,  Sreenivas Punna ,  Rajinder Singh ,  Ju Yang ,  Penglie Zhang

IPC分类号： A61P31/00 ,  A61K31/085 ,  C07D211/40 ,  A61P35/00 ,  C07C215/12 ,  C07F5/02 ,  C07D401/14 ,  C07D213/30 ,  C07D405/12 ,  C07C229/22 ,  C07D319/18 ,  C07D417/12 ,  A61K45/06 ,  C07C235/42 ,  C07C235/20 ,  C07D239/42 ,  C07C255/54 ,  C07D213/61 ,  C07D413/12 ,  C07D205/04 ,  C07D237/08 ,  C07D401/12 ,  C07D213/85 ,  C07D239/30 ,  C07D405/14 ,  C07D401/04 ,  C07D409/12 ,  C07D213/80 ,  A61P29/00 ,  C07C317/22 ,  C07F9/58 ,  A61K31/015 ,  A61K31/03 ,  A61K31/277 ,  A61K38/00 ,  C07C43/168 ,  A61K31/36 ,  A61K31/44 ,  A61K31/505 ,  A61K47/34

摘要： Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20190300564A9

公开(公告)日：2019-10-03

申请号：US15645136

申请日：2017-07-10

申请人： Intercept Pharmaceuticals, Inc.

发明人： Roberto Pellicciari

IPC分类号： C07J9/00 ,  C07J43/00 ,  C07J41/00 ,  C07C215/08 ,  C07C215/12 ,  C07C215/10

摘要： The invention relates to compounds of formula (I): wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.

公开(公告)号：US10315993B2

公开(公告)日：2019-06-11

申请号：US15962498

申请日：2018-04-25

申请人： Cadila Healthcare Limited

发明人： Mukul R. Jain ,  Suresh Giri ,  Himanshu M. Kothari ,  Kaushik Banerjee ,  Rashmikant Kachhiya

IPC分类号： C07D207/333 ,  C07C215/40 ,  A61K38/26 ,  C07D295/027 ,  A61K31/4985 ,  C07C215/10 ,  C07C217/60 ,  C07C211/51 ,  C07D233/58 ,  A61K31/4015 ,  C07C211/11 ,  C07C215/12 ,  C07C211/30 ,  C07C229/26 ,  A61K31/40 ,  A61K31/155 ,  C07C211/27 ,  A61K31/64 ,  A61K31/505 ,  C07C211/35 ,  A61K45/06 ,  C07C279/14

摘要： The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (Ia) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of these novel salts and use thereof.

公开(公告)号：US09713788B2

公开(公告)日：2017-07-25

申请号：US14885214

申请日：2015-10-16

申请人： David Charles Calabro ,  Lisa Saunders Baugh ,  Pavel Kortunov ,  Benjamin A. McCool ,  Michael Siskin ,  Dennis George Peiffer ,  Quanchang Li

发明人： David Charles Calabro ,  Lisa Saunders Baugh ,  Pavel Kortunov ,  Benjamin A. McCool ,  Michael Siskin ,  Dennis George Peiffer ,  Quanchang Li

IPC分类号： C07C215/18 ,  C07C215/12 ,  C07C215/14 ,  C07C211/14 ,  B01D53/14 ,  B01D53/62

CPC分类号： B01D53/1493 ,  B01D53/1475 ,  B01D53/62 ,  B01D2252/20415 ,  B01D2252/20421 ,  B01D2252/20426 ,  B01D2252/20431 ,  B01D2252/20478 ,  B01D2252/2056 ,  B01D2252/30 ,  Y02A50/2342 ,  Y02C10/04 ,  Y02C10/06

摘要： A method is described for separating CO2 and/or H2S from a mixed gas stream by contacting the gas stream with a non-aqueous, liquid absorbent medium of a primary and/or secondary aliphatic amine, preferably in a non-aqueous, polar, aprotic solvent under conditions sufficient for sorption of at least some of the CO2. The solution containing the absorbed CO2 can then be treated to desorb the acid gas. The method is usually operated as a continuous cyclic sorption-desorption process, with the sorption being carried out in a sorption zone where a circulating stream of the liquid absorbent contacts the gas stream to form a CO2-rich sorbed solution, which is then cycled to a regeneration zone for desorption of the CO2 (advantageously at 0.5:1 (approaching 1:1) may be achieved.

公开(公告)号：US20160152657A1

公开(公告)日：2016-06-02

申请号：US15016802

申请日：2016-02-05

申请人： Intercept Pharmaceuticals, Inc.

发明人： Roberto Pellicciari

IPC分类号： C07J9/00 ,  C07C215/12 ,  C07C215/08 ,  C07J41/00 ,  C07C215/10

CPC分类号： C07J9/005 ,  C07C215/08 ,  C07C215/10 ,  C07C215/12 ,  C07J9/00 ,  C07J41/0055 ,  C07J43/00 ,  Y10S514/893

摘要： The invention relates to compounds of formula (I): wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.

公开(公告)号：US09328220B2

公开(公告)日：2016-05-03

申请号：US14191750

申请日：2014-02-27

申请人： INNOVIA FILMS LIMITED

发明人： Adam John Walker

IPC分类号： B01F1/00 ,  C08K5/3415 ,  B01J31/00 ,  B01J31/02 ,  C07C215/08 ,  C07C215/12 ,  C07C217/30 ,  C08K5/19

CPC分类号： C08K5/3415 ,  B01J31/003 ,  B01J31/0278 ,  C07C215/08 ,  C07C215/12 ,  C07C215/40 ,  C07C217/30 ,  C08K5/19 ,  C10N2220/04 ,  Y02P20/542

摘要： The present invention relates to an ionic liquid comprising an anion and a cation, wherein the cation is a primary, secondary or tertiary ammonium ion containing a protonated nitrogen atom.

公开(公告)号：US09260376B2

公开(公告)日：2016-02-16

申请号：US14124956

申请日：2012-07-20

申请人： Neil Frankish ,  Helen Sheridan

发明人： Neil Frankish ,  Helen Sheridan

IPC分类号： C07C69/78 ,  C07C65/17 ,  C07C215/12 ,  C07C235/42 ,  C07C229/38 ,  C07C65/19 ,  C07C69/76 ,  C07C215/10 ,  C07C229/08

CPC分类号： C07C69/78 ,  C07B2200/07 ,  C07C65/17 ,  C07C65/19 ,  C07C69/76 ,  C07C215/10 ,  C07C215/12 ,  C07C229/08 ,  C07C229/38 ,  C07C235/42 ,  C07C2602/08

摘要： Compounds particularly for use in an autoimmune inflammatory disease and especially the treatment of inflammatory bowel disease have the formula: wherein R is selected from one or more of the same or different of hydrogen, hydroxyl, optionally substituted alkyl, optionally substituted aryl, alkoxy, aryloxy, thiol, and optionally substituted amino, and wherein R1 is selected from one or more of the same or different of hydrogen, acetyl, optionally substituted alkyl, optionally substituted aryl, and an amino acid selected from leucine, valine, isoleucine, and glycine.

摘要翻译： 特别是用于自身免疫性炎性疾病，特别是治疗炎症性肠病的化合物具有下式：其中R选自氢，羟基，任选取代的烷基，任选取代的芳基，烷氧基，芳氧基中的一个或多个 ，硫醇和任选取代的氨基，其中R 1选自氢，乙酰基，任选取代的烷基，任选取代的芳基和选自亮氨酸，缬氨酸，异亮氨酸和甘氨酸的氨基酸中的一种或多种。

公开(公告)号：US20150005487A1

公开(公告)日：2015-01-01

申请号：US14344718

申请日：2012-09-17

申请人： INSTRACTION GMBH

发明人： Markus Arendt ,  Björn Degel ,  Thomas Schwarz ,  Gerhard Stumm ,  Martin Welter

IPC分类号： B01J20/286 ,  A61K31/47 ,  C07C215/12 ,  A61K31/573 ,  C07C225/06 ,  A61K31/337 ,  A61K31/724 ,  A61K31/365 ,  C07C211/09 ,  C07D295/185

CPC分类号： B01J20/286 ,  A61K31/337 ,  A61K31/365 ,  A61K31/47 ,  A61K31/573 ,  A61K31/724 ,  B01D15/3804 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3253 ,  B01J20/3255 ,  B01J20/328 ,  B01J20/3285 ,  B01J2220/80 ,  C07B63/00 ,  C07C37/82 ,  C07C211/09 ,  C07C215/12 ,  C07C225/06 ,  C07D215/18 ,  C07D295/185 ,  C07D305/14 ,  C07D313/00 ,  C07D493/22 ,  C07H3/02 ,  C07H17/08 ,  C07C39/30

摘要： The present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent single bond to a functional group on the surface of either the bulk solid support material itself or of a polymer film on the surface of the solid support material. Furthermore, the present invention relates to the use of the sorbent according to the invention for the purification of organic molecules, in particular pharmaceutically active compounds, preferably in chromatographic application.

摘要翻译： 本发明涉及包含固体支持材料的吸附剂，其表面包含通式（I）的残基，其中所述残基通过共价单键连接到本体固体的表面上的官能团 支撑材料本身或固体支撑材料表面上的聚合物膜。 此外，本发明涉及根据本发明的吸着剂用于纯化有机分子，特别是药学活性化合物，优选在色谱应用中的用途。