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    Hydrofluorocarboximidate and methods of making and using the same
    1.
    发明授权
    Hydrofluorocarboximidate and methods of making and using the same 有权

    公开(公告)号：US11053206B2

    公开(公告)日：2021-07-06

    申请号：US16634707

    申请日：2018-08-23

    申请人： 3M INNOVATIVE PROPERTIES COMPANY

    发明人： Sean M. Smith

    IPC分类号： C07D265/32 ,  C07C231/14 ,  C07D207/24

    摘要： Described herein is an hydrofluorocarboximidate of formula (I) where: RH is a linear or branched alkyl group comprising 1 or 2 carbon atoms and (a) Rf1 and Rf2 are independent-selected from a linear or branched perfluorinated alkyl group comprising 1-8 carbon atoms and optionally comprising at least one catenated atom selected from oxygen, nitrogen, or combinations thereof; or (b) Rf1 and Rf2 are connected to form a ring structure comprising a total of 4-8 carbon atoms and in addition to the nitrogen atom from the carboximidate the ring structure may optionally comprises at least one catenated atom selected from oxygen, nitrogen, or combinations thereof. A method of making the hydrofluorocarboximidate with improved yield is described as well as various uses for the hydrofluorocarboximidate of Formula (I).

    Viloxazine compositions
    6.
    发明授权
    Viloxazine compositions 有权
    维罗他嗪组合物

    公开(公告)号：US09434703B2

    公开(公告)日：2016-09-06

    申请号：US14577380

    申请日：2014-12-19

    申请人： Supernus Pharmaceuticals, Inc.

    发明人： Likan Liang ,  Padmanabh P. Bhatt ,  David Dain ,  Jean-Philippe Taquet ,  Aleksandr Pechenov ,  Alexei Tchesnokov ,  Reynold Mariaux

    IPC分类号： C07C215/08 ,  C07D265/30 ,  C07C217/34 ,  C07D265/32 ,  A61P25/00 ,  A61P25/24 ,  A61K31/535

    CPC分类号： C07D265/30 ,  C07C215/08 ,  C07C217/34 ,  C07D265/32

    摘要： Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.

    摘要翻译： 本文提供了维罗他嗪及其各种盐的制备方法，以及与维甲内酯相关的化合物，例如新的中间体反应产物及其多晶型物。 特别地，该方法提供基本上纯的维罗他嗪HCl的API，同时避免不期望的杂质。 该方法进一步提供了分离，鉴定和表征viloxazine的新型多晶型物。 还提供了用于合成和鉴定和描述维罗他嗪的新型中间体的方法，以及一些重要的代谢产物和维罗他嗪代谢物的前体。

    HEMI-AMINAL ETHERS AND THIOETHERS OF N-ALKENYL CYCLIC COMPOUNDS
    7.
    发明申请
    HEMI-AMINAL ETHERS AND THIOETHERS OF N-ALKENYL CYCLIC COMPOUNDS 有权
    N-烷基环化合物的氨基甲酸酯及其衍生物

    公开(公告)号：US20150344461A1

    公开(公告)日：2015-12-03

    申请号：US14762220

    申请日：2014-01-21

    申请人： ISP INVESTMENTS INC.

    发明人： Yi ZHANG ,  Osama M. MUSA

    IPC分类号： C07D403/12 ,  C07D207/27 ,  C08F26/10 ,  C07D265/32 ,  C08B11/14 ,  C07D223/10 ,  C07D233/34

    CPC分类号： C07D403/12 ,  C07D207/27 ,  C07D223/10 ,  C07D233/34 ,  C07D265/32 ,  C08B11/02 ,  C08B11/08 ,  C08B11/12 ,  C08B11/14 ,  C08B11/193 ,  C08B11/20 ,  C08B31/08 ,  C08B33/04 ,  C08B35/04 ,  C08B37/003 ,  C08B37/0033 ,  C08B37/0039 ,  C08B37/0042 ,  C08B37/0045 ,  C08B37/0084 ,  C08B37/0087 ,  C08B37/009 ,  C08B37/0093 ,  C08B37/0096 ,  C08F26/10

    摘要： Described herein are hemi-aminal ethers and thioethers of N-alkenyl cyclic compounds that may be produced through a reaction comprising: (A) at least one first reactant represented by a structure (I), wherein X is a functionalized or unfunctionalized C1-C5 alkylene group optionally having one or more heteroatoms, and each R1, R2, and R3 is independently selected from the group consisting of hydrogen and functionalized and unfunctionalized alkyl groups optionally having one or more heteroatoms, and (B) at least one second reactant having at least one hydroxyl moiety or thiol moiety. The hemi-aminal ethers and thioethers of N-alkenyl cyclic compounds may comprise a polymerizable moiety, in which case they may be left as-is or used to create homopolymers or non-homopolymers, or they may not comprise a polymerizable moiety. A wide variety of formulations may be created using the hemi-aminal ethers and thioethers of N-alkenyl cyclic compounds, including personal care, oilfield, and construction formulations.

    摘要翻译： 本文描述的是可通过以下反应制备的N-烯基环状化合物的半缩醛醚和硫醚：包括：（A）由结构（I）表示的至少一种第一反应物，其中X是官能化或未官能化的C1-C5 任选具有一个或多个杂原子的亚烷基，并且每个R 1，R 2和R 3独立地选自氢和任选具有一个或多个杂原子的官能化和未官能化的烷基，和（B）至少一种第二反应物，其具有 至少一个羟基部分或硫醇部分。 N-烯基环状化合物的半芳基醚和硫醚可以包含可聚合部分，在这种情况下，它们可以原样保留或用于产生均聚物或非均聚物，或者它们可以不包含可聚合部分。 可以使用N-烯基环状化合物的半缩醛醚和硫醚，包括个人护理，油田和施工制剂，可以产生多种制剂。