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公开(公告)号:US20060251146A1
公开(公告)日:2006-11-09
申请号:US11409936
申请日:2006-04-24
申请人: Benny Pesach , Gabriel Bitton , Allan Entis
发明人: Benny Pesach , Gabriel Bitton , Allan Entis
CPC分类号: G01K13/002 , G01K7/343
摘要: A method for determining concentration of at least one component of the material, the method comprising: measuring at least one of the real and imaginary parts of the permittivity of the material at each of a first plurality of frequencies for which substantially only a second plurality of known components of the material contributes to the dielectric permittivity of the material, wherein for each of the known components the permittivity as a function of temperature is known and the first plurality is greater than the second plurality; determining the concentration of at least one of the known components responsive to a solution of a set of simultaneous equations determined by the first plurality of measurements and the dependence of the permittivities of the known components on temperature.
摘要翻译: 一种用于确定所述材料的至少一种组分的浓度的方法,所述方法包括:测量在第一多个频率中的每一个处的材料的介电常数的至少一个,所述第一多个频率基本上只有第二多个 材料的已知组分有助于材料的介电常数,其中对于每个已知组分,作为温度的函数的介电常数是已知的,并且第一多个大于第二多个; 确定至少一个已知组分的浓度,其响应于由第一多个测量确定的一组联立方程的解,以及已知组分的介电常数对温度的依赖性。
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公开(公告)号:US09220837B2
公开(公告)日:2015-12-29
申请号:US11821230
申请日:2007-06-21
申请人: Benny Pesach , Ron Nagar , Gabriel Bitton , Ram Weiss
发明人: Benny Pesach , Ron Nagar , Gabriel Bitton , Ram Weiss
IPC分类号: A61M5/142 , A61M5/158 , A61M5/168 , A61M5/172 , A61M5/20 , A61B18/14 , A61B18/18 , A61F7/00 , A61M5/14 , A61M39/10 , A61N1/30 , A61N7/00 , A61N5/06 , A61M5/42 , A61B18/08 , A61B18/20
CPC分类号: A61M5/14244 , A61B18/08 , A61B18/14 , A61B18/1477 , A61B18/1492 , A61B18/18 , A61B18/20 , A61B2018/1425 , A61F7/007 , A61M5/1413 , A61M5/158 , A61M5/16831 , A61M5/1723 , A61M5/20 , A61M5/422 , A61M2005/1581 , A61M2005/1726 , A61M2039/1022 , A61M2205/05 , A61M2205/051 , A61M2205/052 , A61M2205/058 , A61M2205/8206 , A61N1/30 , A61N7/00 , A61N2005/0645
摘要: A method and a device for a delivery of a chemical substance to the body of the patient are provided. The device includes an infusion catheter configured to be inserted into a tissue, a catheter securing element configured to be adhered to the skin of the patient and further configured to secure the infusion catheter to the skin, a drug delivery pump configured to infuse a drug into the infusion catheter for delivery to a drug infused region on the body of the patient, and a treatment element configured to apply a treatment to the drug infused region to improve pharmacodynamics of the drug during a period of delivery of the drug to the patient.
摘要翻译: 提供了一种将化学物质输送到患者体内的方法和装置。 该装置包括构造成插入到组织中的输注导管,导管固定元件,其构造成粘附到患者的皮肤上,并进一步构造成将输注导管固定到皮肤上;药物输送泵,被配置为将药物注入 用于输送到患者身体上的药物输注区域的输注导管,以及配置成对药物输注区域施加治疗以改善药物递送到患者期间药物的药效学的治疗元件。
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公开(公告)号:US08409133B2
公开(公告)日:2013-04-02
申请号:US12809425
申请日:2008-12-18
申请人: Benny Pesach , Gabriel Bitton , Ron Nagar , Ram Weiss
发明人: Benny Pesach , Gabriel Bitton , Ron Nagar , Ram Weiss
IPC分类号: A61N1/08
CPC分类号: A61M5/1723 , A61M5/14248 , A61M2005/14296 , A61M2005/1726 , A61M2205/3368 , A61M2205/50 , A61M2205/60 , A61M2230/201 , A61M2230/50 , A61M2230/63
摘要: An apparatus and a system for controlling and/or managing administration of a drug to a body of a patient. The apparatus includes a drug infusion device configured to deliver drug at a predetermined location in the body of the patient, at least one sensor disposed in the drug infusion device and configured to measure a. corresponding property related to the patient and selected from the group consisting of physiological properties, biochemical properties, environmental properties and drug-related properties, a controller disposed in the drug infusion device and configured to receive from the at least one sensor data representative of the measured corresponding property and based on the received data, determine a drug delivery rate. The drug delivery device is configured to deliver the drug to the body of the patient based on the determined drug delivery rate.
摘要翻译: 一种用于控制和/或管理药物对患者体内的药物的装置和系统。 该装置包括药物输注装置,其配置成在患者体内的预定位置输送药物,至少一个传感器设置在药物输注装置中并且被配置为测量a。 与患者相关的并且选自生理特性,生物化学性质,环境特性和药物相关性质的对应性质,设置在药物输注装置中并被配置为从所述至少一个传感器接收表示所测量的数据的数据 相应的财产,并根据收到的数据,确定药物递送率。 药物递送装置被配置为基于确定的药物递送速率将药物递送到患者的身体。
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公开(公告)号:US20120203164A1
公开(公告)日:2012-08-09
申请号:US13499704
申请日:2010-10-04
申请人: Gabriel Bitton , Ron Nagar , Benny Pesach
发明人: Gabriel Bitton , Ron Nagar , Benny Pesach
IPC分类号: A61M37/00
CPC分类号: A61M5/422 , A61M5/3287 , A61M5/425 , A61M5/44 , A61M2205/058
摘要: The present invention relates to a device and method for the controlled delivery of a drug to a targeted layer of the skin in a human or animal subject. In particular, the present invention relates to such a device, system and method for selective drug delivery to the cutaneous or subcutaneous layer of skin to enhances the effectiveness of the drug delivery.
摘要翻译: 本发明涉及用于在人或动物受试者中将药物控制递送至皮肤目标层的装置和方法。 特别地,本发明涉及用于选择性药物递送至皮肤皮下或皮下层的装置,系统和方法,以提高药物递送的有效性。
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公开(公告)号:US20080194929A1
公开(公告)日:2008-08-14
申请号:US10551543
申请日:2004-03-29
申请人: Benny Pesach , Gabriel Bitton , Michal Balberg
发明人: Benny Pesach , Gabriel Bitton , Michal Balberg
IPC分类号: A61B5/1455 , A61B8/00
CPC分类号: A61B5/0066 , A61B5/0059 , A61B5/0095 , A61B5/14532 , A61B5/1455 , G01N21/1702 , G01N2021/1706
摘要: Apparatus (20, 100) for assaying a target analyte in a localized tissue region (22) that may include the target and other analytes comprising: a light source (34, 104) that illuminates the region with light at each of a plurality of wavelengths at which light is absorbed and/or scattered by tissue in the region wherein light at a least one of the wavelengths is absorbed or scattered by the target analyte; a signal generator (40) that generates signals responsive to intensity of the light from the light source (34, 104) at different locations in the localized region (22); and a controller (32, 102) that: receives the generated signals; processes the signals to determine an extinction coefficient for light in the localized region at each wavelength; and determines the concentration of the target analyte responsive to a solution of a set of simultaneous equations having as unknown variables concentrations of a plurality of analytes in the region (22), one of which is the target analyte, wherein each equation in the set expresses a relationship between the extinction coefficient, the absorption coefficient and/or the reduced scattering coefficient for light at a different one of the plurality of wavelengths and at least one of the equations expresses a relationship between the extinction coefficient and the reduced scattering coefficient.
摘要翻译: 用于测定局部组织区域(22)中可能包括目标物和其它分析物的靶分析物的装置(20,100),包括:光源(34,104),其以多个波长中的每一个的光照射该区域 在该区域中的组织被光吸收和/或散射,其中至少一个波长的光被靶分析物吸收或散射; 信号发生器(40),其在所述局部区域(22)中的不同位置处产生响应于来自所述光源(34,104)的光的强度的信号; 以及控制器(32,102),其接收所生成的信号; 处理信号以确定每个波长处的局部区域中的光的消光系数; 并且确定目标分析物的浓度,其响应于在区域(22)中具有多个分析物浓度的未知变量的一组联立方程(其中一个是目标分析物)的溶液的溶液,其中集合中的每个方程表示 在多个波长中的不同一个波长处的光的消光系数,吸收系数和/或减小的散射系数之间的关系以及至少一个等式表示消光系数和降低的散射系数之间的关系。
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公开(公告)号:US20070052965A1
公开(公告)日:2007-03-08
申请号:US11355434
申请日:2006-02-16
申请人: Benny Pesach , Gabriel Bitton , Ron Nagar
发明人: Benny Pesach , Gabriel Bitton , Ron Nagar
IPC分类号: G01N21/00
CPC分类号: G01N21/1702 , G01N21/314 , G01N21/64 , G01N2021/6491
摘要: A method of determining an optical parameter or function thereof for a liquid, the method comprising: flowing the liquid through a flow cell; transmitting a pulse of light into the liquid in the flow cell; generating a signal responsive to energy that the material emits responsive to a portion of the light from the light pulse that is absorbed by the liquid; and using the signal to determine the optical parameter or function thereof.
摘要翻译: 一种确定液体的光学参数或其功能的方法,所述方法包括:使液体流过流动池; 将光脉冲传输到流动池中的液体中; 产生响应于材料发射的能量的信号,所述能量响应于来自由液体吸收的光脉冲的光的一部分; 并使用该信号来确定其光学参数或功能。
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公开(公告)号:US08622991B2
公开(公告)日:2014-01-07
申请号:US12450246
申请日:2008-03-19
申请人: Benny Pesach , Gabriel Bitton , Ram Weiss , Ron Nagar
发明人: Benny Pesach , Gabriel Bitton , Ram Weiss , Ron Nagar
CPC分类号: A61M5/1723 , A61B18/14 , A61B18/1492 , A61B18/18 , A61F7/007 , A61F7/10 , A61H9/0057 , A61H23/00 , A61M5/14244 , A61M5/158 , A61M5/16831 , A61M37/0092 , A61M2005/1581 , A61M2005/1726 , A61M2205/05 , A61M2205/051 , A61M2205/052 , A61M2205/058 , A61N1/30 , A61N1/406 , A61N2/002 , A61N5/062 , A61N7/00 , A61N2005/0645 , G06F19/00
摘要: Systems, devices and methods for delivery of a chemical substance to the body of the patient are provided. Such embodiments may include an infusion catheter configured to be inserted into tissue, a catheter securing element configured to be adhered to the skin of the patient and further configured to secure the infusion catheter to the skin, a drug delivery pump configured to infuse a drug into the infusion catheter for delivery to a drug infused region on the body of the patient, and a treatment element configured to apply a treatment to the drug infused region to improve pharmacodynamics of the drug during a period of delivery of the drug to the patient.
摘要翻译: 提供了将化学物质递送到患者体内的系统,装置和方法。 这样的实施例可以包括构造成插入组织中的输注导管,导管固定元件,其构造成粘附到患者的皮肤上,并进一步被配置成将输注导管固定到皮肤上;药物输送泵,被配置为将药物注入 用于输送到患者身体上的药物输注区域的输注导管,以及配置成对药物输注区域施加治疗以改善药物递送到患者期间药物的药效学的治疗元件。
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公开(公告)号:US20110288527A1
公开(公告)日:2011-11-24
申请号:US13127823
申请日:2009-11-06
申请人: Benny Pesach , Gabriel Bitton , Ron Nagar , Ram Weiss
发明人: Benny Pesach , Gabriel Bitton , Ron Nagar , Ram Weiss
IPC分类号: A61M37/00
CPC分类号: A61M5/44 , A61B2018/00005 , A61B2090/0803 , A61F7/007 , A61F7/02 , A61F2007/0093 , A61F2007/0096 , A61F2007/0226 , A61M5/003 , A61M5/20 , A61M5/427 , A61M2205/273 , A61M2205/3368 , A61M2205/3653 , A61M2209/00
摘要: A therapeutic treatment device, system and method for improving administration of a temperature sensitive drug into a tissue on the body of a patient at a drug injection site are disclosed. The device includes a treatment element with a controllable heating element in temperature communicative contact with the tissue adjacent to the drug injection site. The controllable heating element is configured to heat the tissue adjacent to the drug injection site to a controllable temperature but does not heat the injected drug above a predetermined limiting temperature, above which degradation of the injected drug may occur.
摘要翻译: 公开了一种治疗装置,系统和方法,用于在药物注射部位改善对患者体内的组织中的感温药物的给药。 该装置包括具有可控加热元件的处理元件,其与邻近药物注射部位的组织温度交互接触。 可控制加热元件被配置为将邻近药物注射部位的组织加热到可控温度,但是不将注射的药物加热到预定的极限温度以上,在该极限温度以上可能发生注射药物的降解。
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公开(公告)号:US20110184342A1
公开(公告)日:2011-07-28
申请号:US12809425
申请日:2008-12-18
申请人: Benny Pesach , Gabriel Bitton , Ron Nagar , Ram Weiss
发明人: Benny Pesach , Gabriel Bitton , Ron Nagar , Ram Weiss
IPC分类号: A61M5/00
CPC分类号: A61M5/1723 , A61M5/14248 , A61M2005/14296 , A61M2005/1726 , A61M2205/3368 , A61M2205/50 , A61M2205/60 , A61M2230/201 , A61M2230/50 , A61M2230/63
摘要: An apparatus and a system for controlling and/or managing administration of a drug to a body of a patient. The apparatus includes a drug infusion device configured to deliver drug at a predetermined location in the body of the patient, at least one sensor disposed in the drug infusion device and configured to measure a. corresponding property related to the patient and selected from the group consisting of physiological properties, biochemical properties, environmental properties and drug-related properties, a controller disposed in the drug infusion device and configured to receive from the at least one sensor data representative of the measured corresponding property and based on the received data, determine a drug delivery rate. The drug delivery device is configured to deliver the drug to the body of the patient based on the determined drug delivery rate.
摘要翻译: 一种用于控制和/或管理药物对患者体内的药物的装置和系统。 该装置包括药物输注装置,其配置成在患者体内的预定位置输送药物,至少一个传感器设置在药物输注装置中并且被配置为测量a。 与患者相关的并且选自生理特性,生物化学性质,环境特性和药物相关性质的对应性质,设置在药物输注装置中并被配置为从所述至少一个传感器接收表示所测量的数据的数据 相应的财产,并根据收到的数据,确定药物递送率。 药物递送装置被配置为基于确定的药物递送速率将药物递送到患者的身体。
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公开(公告)号:US20100292557A1
公开(公告)日:2010-11-18
申请号:US12450250
申请日:2008-03-19
申请人: Benny Pesach , Gabriel Bitton , Ram Weiss , Ron Nagar
发明人: Benny Pesach , Gabriel Bitton , Ram Weiss , Ron Nagar
IPC分类号: A61B5/00
CPC分类号: A61B5/1495 , A61B5/14532 , A61B5/14865 , A61B5/1491
摘要: Embodiments of the present disclosure present systems, devices and methods for ISF glucose monitoring that more accurately reflects the blood glucose levels by introducing a treatment element allowing stable and accurate prediction of blood glucose levels based measured glucose levels from interstitial fluid.
摘要翻译: 本公开的实施例提供了用于ISF葡萄糖监测的系统,装置和方法,其通过引入治疗元件更准确地反映血糖水平,所述治疗元件允许基于来自间质液的测量的葡萄糖水平来稳定和准确地预测血糖水平。
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