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    Fiber reinforced hydrogels and methods of making same
    2.
    发明授权
    Fiber reinforced hydrogels and methods of making same 有权

    公开(公告)号：US10286585B2

    公开(公告)日：2019-05-14

    申请号：US15239808

    申请日：2016-08-17

    Applicant: Case Western Reserve University

    Inventor： LaShanda T. J. Korley ,  Gary E. Wnek ,  Alexander M. Jordan

    IPC: B29C47/00 ,  B29C47/02 ,  B29C47/70 ,  B29K71/00 ,  B29K267/00 ,  C08G18/42

    Abstract: Disclosed herein are biomaterials that include a plurality of fibers embedded in a matrix of hydrogel material. The plurality of fibers and hydrogel material are formed during one process step. In one embodiment, the plurality of fibers and hydrogel materials are formed using a multilayer coextrusion process step. Additional process steps can be performed to form a tissue engineering scaffold. Such a scaffold can be used to grow biological matter. In one embodiment, stem cells are applied to the scaffold to grow biological material. Process steps can be controlled to determine certain mechanical properties of the resulting biomaterial. In one embodiment, the process steps are controlled to determine the stiffness of the resulting biomaterial. In such an embodiment, the stiffness of the resulting biological material determines physical properties of the biological material grown on the scaffold.

    PROTEIN BASED MATERIALS
    4.
    发明申请
    PROTEIN BASED MATERIALS 审中-公开
    基于蛋白质的材料

    公开(公告)号：US20160129151A1

    公开(公告)日：2016-05-12

    申请号：US14534869

    申请日：2014-11-06

    Applicant: Case Western Reserve University

    Inventor： Matthew J. Fullana ,  Daniel J. Brannum ,  Gary E. Wnek

    IPC: A61L27/24 ,  A61L24/00 ,  A61L27/56 ,  A61L24/10

    CPC classification number: A61L27/24 ,  A61L24/0036 ,  A61L24/102 ,  A61L27/56 ,  A61L2400/06

    Abstract: Gels and films can be formed from protein dissolved into a benign solvent that comprises alcohol, water, and salt. In one example, the protein can be collagen. In one example, the benign solvent can include a water to alcohol ratio of between ninety-nine-to-one and one-to-ninety-nine by volume, a salt concentration between zero moles per liter and the maximum salt concentration soluble in water, and a protein amount of between near zero percent and about 25 percent by weight as compared to the mixture of water and alcohol. Once the protein is dissolved in the benign solvent, secondary processing steps can be conducted to form protein based bioadhesives, gels, and films with desirable physical properties. Additional process steps can include washings that improve the properties of the protein structures.

    Abstract translation: 凝胶和膜可以由溶解成包含醇，水和盐的良性溶剂的蛋白质形成。 在一个实例中，蛋白质可以是胶原蛋白。 在一个实例中，良溶剂可以包括体积比为九十九比一至九十九的水与醇比，每升零摩尔之间的盐浓度和可溶于水的最大盐浓度 ，并且与水和醇的混合物相比，蛋白质量在接近零％至约25重量％之间。 一旦蛋白质溶解在良性溶剂中，可以进行二次加工步骤以形成具有所需物理性质的蛋白质基生物粘附剂，凝胶和膜。 另外的方法步骤可以包括改善蛋白质结构性质的洗涤液。

    Controlled cross-linking processing of proteins
    6.
    发明授权
    Controlled cross-linking processing of proteins 有权

    公开(公告)号：US09683011B2

    公开(公告)日：2017-06-20

    申请号：US14720331

    申请日：2015-05-22

    Applicant: Case Western Reserve University

    Inventor： Gary E. Wnek ,  Linghui Meng

    IPC: C07K1/107 ,  C07K1/36 ,  A61L27/22 ,  C07K14/78 ,  D01F1/10 ,  D01F4/00

    CPC classification number: C07K1/1075 ,  A61L27/22 ,  C07K1/107 ,  C07K1/36 ,  C07K14/78 ,  D01F1/10 ,  D01F4/00

    Abstract: A method of forming a cross-linked protein structures includes preparing a solution of protein dissolved in a benign solvent and forming an intermediate protein structure from the solution. The intermediate protein structure can be cross-linked by providing for a specific ratio of chemical cross-linking agents to form the cross-linked protein structure. The solution can be prepared by adding a cross-linker of N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) at a ratio of two-to-one of NHS to EDC to alcohol. PBS buffer (20×) can be added to the solution until the volume ratio of PBS buffer (20×) to alcohol is about one-to-one. About 16 percent by weight of protein can be dissolved in the solution. The solution can be electrospun to form an intermediate protein structure. After a period of time, the protein structure can be cross-linked to form the cross-linked protein structure.

    FIBER REINFORCED HYDROGELS AND METHODS OF MAKING SAME
    7.
    发明申请
    FIBER REINFORCED HYDROGELS AND METHODS OF MAKING SAME 审中-公开
    纤维增强水凝胶及其制备方法

    公开(公告)号：US20170050364A1

    公开(公告)日：2017-02-23

    申请号：US15239808

    申请日：2016-08-17

    Applicant: Case Western Reserve University

    Inventor： LaShanda T.J. Korley ,  Gary E. Wnek ,  Alexander M. Jordan

    IPC: B29C47/00

    CPC classification number: B29C47/0004 ,  B29C47/025 ,  B29C47/707 ,  B29K2071/02 ,  B29K2267/046 ,  B29K2995/006 ,  C08G18/4277

    Abstract: Disclosed herein are biomaterials that include a plurality of fibers embedded in a matrix of hydrogel material. The plurality of fibers and hydrogel material are formed during one process step. In one embodiment, the plurality of fibers and hydrogel materials are formed using a multilayer coextrusion process step. Additional process steps can be performed to form a tissue engineering scaffold. Such a scaffold can be used to grow biological matter. In one embodiment, stem cells are applied to the scaffold to grow biological material. Process steps can be controlled to determine certain mechanical properties of the resulting biomaterial. In one embodiment, the process steps are controlled to determine the stiffness of the resulting biomaterial. In such an embodiment, the stiffness of the resulting biological material determines physical properties of the biological material grown on the scaffold.

    Abstract translation: 本文公开了包括嵌入水凝胶材料基质中的多种纤维的生物材料。 多个纤维和水凝胶材料在一个工艺步骤中形成。 在一个实施方案中，使用多层共挤出工艺步骤形成多个纤维和水凝胶材料。 可以执行附加的工艺步骤以形成组织工程支架。 这种支架可用于生长生物物质。 在一个实施方案中，将干细胞施用于支架以生长生物材料。 可以控制工艺步骤以确定所得生物材料的某些机械性能。 在一个实施例中，控制工艺步骤以确定所得生物材料的刚度。 在这种实施方案中，所得生物材料的刚度决定了在脚手架上生长的生物材料的物理性质。

    Elastomeric and viscoelastic materials formed from poly(acrylic acid) gels
    8.
    发明授权
    Elastomeric and viscoelastic materials formed from poly(acrylic acid) gels 有权

    公开(公告)号：US10604636B2

    公开(公告)日：2020-03-31

    申请号：US15383206

    申请日：2016-12-19

    Applicant: Case Western Reserve University

    Inventor： Gary E. Wnek ,  Anne Walker ,  Maria Vratsanos

    IPC: C08F20/06 ,  C08L33/02 ,  C08K3/16 ,  C08J3/075 ,  C09J133/02 ,  C08F265/06 ,  C08K5/20 ,  C09J4/06

    Abstract: Disclosed herein are novel materials and methods of forming those novel materials. The materials are synthesized from Poly(acrylic acid), a crosslinker; and a salt. The material can be further synthesized from sodium hydroxide. The crosslinker can be a covalent crosslinking agent such as N,N′-methylenebisacrylamide. Examples of applicable salts are calcium chloride, lithium chloride, zinc chloride, sodium chloride, potassium chloride, barium chloride, cesium chloride, magnesium chloride, cobalt chloride, lithium bromide. In example, the Poly(acrylic acid) can be about 3 moles of Poly(acrylic acid), the crosslinker can be about 0.005 moles of N,N′-methylenebisacrylamide, and the salt can be formed by the addition of about 0.003 moles of potassium persulfate.

    Poly (Acrylic Acid) Modified Cellulose Fiber Materials
    10.
    发明申请
    Poly (Acrylic Acid) Modified Cellulose Fiber Materials 审中-公开
    聚（丙烯酸）改性纤维素纤维材料

    公开(公告)号：US20160319414A1

    公开(公告)日：2016-11-03

    申请号：US15141747

    申请日：2016-04-28

    Applicant: Case Western Reserve University

    Inventor： Anne Walker ,  Gary E. Wnek

    IPC: C23C2/00 ,  C09D133/02

    CPC classification number: C23C2/00 ,  C08F222/385 ,  C08L33/02 ,  C09D133/02

    Abstract: In one embodiment, PAA is immobilized on dry, solid, fibrous media, such as cellulose fiber paper (“PAA-CF”) to yield a robust, flexible material with substantial wicking and fluid uptake capabilities. PAA-CF materials demonstrate the ability for use as collection and storage devices for applications such as dried blood spot analysis, protein and DNA preservation and analysis, enzymatic assays, biomarker identification, and other processes used for biological materials. PAA-CF materials can readily take up whole blood, plasma, proteins, and solutions of molecules that can then be easily extracted and analyzed.

    Abstract translation: 在一个实施方案中，将PAA固定在干燥，固体，纤维介质如纤维素纤维纸（“PAA-CF”）上，以产生具有显着芯吸和流体吸收能力的坚固且柔性的材料。 PAA-CF材料显示了用作收集和储存装置的能力，例如干血斑分析，蛋白质和DNA保存和分析，酶测定，生物标志物鉴定和用于生物材料的其他过程。 PAA-CF材料可以容易地吸收全血，血浆，蛋白质和分子溶液，然后可以容易地提取和分析。

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