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46 条记录 (耗时 0.043 秒)

    Transition state analogs
    2.
    发明授权
    Transition state analogs 失效
    过渡状态类比

    公开(公告)号：US5952462A

    公开(公告)日：1999-09-14

    申请号：US333237

    申请日：1994-11-02

    申请人： Michael J. Powell ,  Richard C. Titmas ,  Richard J. Massey

    发明人： Michael J. Powell ,  Richard C. Titmas ,  Richard J. Massey

    IPC分类号： C07C237/22 ,  C07K16/10 ,  C12N9/00 ,  C12Q1/25 ,  C07K5/12 ,  A61K38/12

    CPC分类号： B82Y5/00 ,  C07C237/22 ,  C07K16/1063 ,  C12N9/0002 ,  C12Q1/25 ,  G01N2333/16 ,  G01N2333/96472

    摘要： Antigens capable of eliciting antibodies which can catalyze chemical reactions, in particular, the cleavage or formation of a peptide linkage, comprising a hapten or a hapten and a suitable carrier molecule are disclosed. Haptens include, among others, silicon and boron containing compounds. Antibodies which are catalytically active for chemical reactions, in particular, the cleavage or formation of a selected peptide linkage or an ester bond, and which are elicited by such antigens are disclosed as well as methods for producing the antibodies and methods for catalyzing the cleavage or formation of a peptide linkage or in ester bond in a molecule.

    摘要翻译： 公开了能够引发抗体的抗原，其可以催化化学反应，特别是包含半抗原或半抗原和合适的载体分子的肽键的切割或形成。 除了其他之外，半抗原包括含有硅和硼的化合物。 公开了对于化学反应具有催化活性的抗体，特别是选择的肽键或酯键的切割或形成，并且由这些抗原引发的抗体以及用于产生抗体的方法和用于催化切割的方法 在分子中形成肽键或酯键。

    Method of catalyzing stereochemical reactions
    4.
    发明授权
    Method of catalyzing stereochemical reactions 失效
    催化立体化学反应的方法

    公开(公告)号：US6057121A

    公开(公告)日：2000-05-02

    申请号：US478954

    申请日：1995-06-07

    申请人： Richard J. Massey ,  Michael J. Powell ,  Richard C. Titmas

    发明人： Richard J. Massey ,  Michael J. Powell ,  Richard C. Titmas

    IPC分类号： C07K16/10 ,  C12N9/00 ,  C12P1/00 ,  C12P13/22 ,  C12P17/10 ,  C12P19/34 ,  C12P21/08 ,  C12P41/00 ,  C12Q1/25

    CPC分类号： B82Y5/00 ,  C07K16/1063 ,  C12N9/0002 ,  C12P1/00 ,  C12P13/227 ,  C12P17/10 ,  C12P19/34 ,  C12P41/004 ,  C12Q1/25 ,  G01N2333/16 ,  G01N2333/96472

    摘要： A method for increasing the rate of a chemical reaction involving conversion of at least one reactant to at least one product which comprises contacting the reactant with at least one appropriate monoclonal antibody to the reactant under suitable conditions permitting formation of a complex between the monoclonal antibody and the reactant, conversion of the reactant to the product and release of the product from the complex, the monoclonal antibody being characterized by a K>1, where K=k.sub.r /k.sub.p, k.sub.r is the affinity constant of the monoclonal antibody for the reactant and k.sub.p is the affinity constant of the monoclonal antibody for the product, by an r.sub.1 >r.sub.0, where r.sub.1 is the rate of formation of the complex between the antibody and the reactant and where r.sub.0 is the rate of the chemical reaction in the absence of monclonal antibody, by an r.sub.2 >r.sub.0, where r.sub.2 is the rate of the conversion of the complexed reactant to the complexed product and by an r.sub.3 >r.sub.0, where r.sub.3 is the rate of release of the product from the complex.

    摘要翻译： 一种用于增加涉及将至少一种反应物转化为至少一种产物的化学反应速率的方法，该方法包括使反应物与至少一种合适的单克隆抗体在合适的条件下接触，从而允许单克隆抗体和 反应物，反应物向产物的转化和产物从复合物的释放，单克隆抗体的特征在于K> 1，其中K = kr / kp，kr是单克隆抗体对于反应物的亲和常数， kp是单克隆抗体对产物的亲和常数，通过r1> r0，其中r1是抗体和反应物之间复合物的形成速率，其中r0是在没有单克隆的情况下化学反应的速率 抗体，r2> r0，其中r2是复合反应物转化为络合产物的速率和r3> r0，其中r3是产物释放速率 从复杂。