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    E2F activity-inhibiting compound
    3.
    发明申请
    E2F activity-inhibiting compound 审中-公开
    E2F活性抑制化合物

    公开(公告)号：US20050137138A1

    公开(公告)日：2005-06-23

    申请号：US10752505

    申请日：2004-01-08

    申请人： Kenji Shibata ,  Motoo Yamasaki ,  Tetsuo Yoshida ,  Tamio Mizukami

    发明人： Kenji Shibata ,  Motoo Yamasaki ,  Tetsuo Yoshida ,  Tamio Mizukami

    IPC分类号： A61K38/00 ,  C07K14/47 ,  A61K38/08 ,  C07K7/06

    CPC分类号： C07K14/4705 ,  A61K38/00

    摘要： E2F-inhibiting compounds are represented by the general formula: R1-A-R2 wherein A represents a peptide sequence comprising a partial amino acid sequence having at least 12 continuous residues in the sequence of the dimerization region or DNA binding region of the E2F family), which are useful as a therapeutic agent of diseases such as tumor and arteriosclerosis, for which abnormal cellular growth is responsible.

    摘要翻译： E2F抑制化合物由以下通式表示：其中A表示包含部分氨基酸序列的肽序列，所述部分氨基酸序列具有至少12个连续残基 E2F家族的二聚化区域或DNA结合区域的序列），其可用作肿瘤和动脉硬化疾病的治疗剂，异常细胞生长负责。

    E2F activity inhibitory compounds
    4.
    发明授权
    E2F activity inhibitory compounds 失效
    E2F活性抑制化合物

    公开(公告)号：US06713449B1

    公开(公告)日：2004-03-30

    申请号：US09269576

    申请日：1999-03-30

    申请人： Kenji Shibata ,  Motoo Yamasaki ,  Tetsuo Yoshida ,  Tamio Mizukami

    发明人： Kenji Shibata ,  Motoo Yamasaki ,  Tetsuo Yoshida ,  Tamio Mizukami

    IPC分类号： A61K3817

    CPC分类号： C07K14/4705 ,  A61K38/00

    摘要： E2F-inhibiting compounds are represented by the formula: R1—A—R2 wherein A represents a peptide sequence comprising a partial amino acid sequence having at least 12 continuous residues in the sequence of the dimerization region or DNA binding region of the E2F family, which are useful as a therapeutic agent of diseases such as tumor and arteriosclerosis, for which abnormal cellular growth is implicated.

    摘要翻译： E2F抑制化合物由下式表示：R 1 -AR 2其中A表示包含在二聚化区或DNA结合区的序列中具有至少12个连续残基的部分氨基酸序列的肽序列 E2F家族可用作肿瘤和动脉硬化等疾病的治疗剂，涉及细胞生长异常。

    Reflective polarizing film, and optical member for liquid crystal display device, and liquid crystal display device formed from same
    6.
    发明授权
    Reflective polarizing film, and optical member for liquid crystal display device, and liquid crystal display device formed from same 有权
    反射型偏振片，液晶显示装置用光学构件，以及由其构成的液晶显示装置

    公开(公告)号：US09405048B2

    公开(公告)日：2016-08-02

    申请号：US14122799

    申请日：2012-06-14

    申请人： Taro Oya ,  Mitsumasa Ono ,  Tetsuo Yoshida

    发明人： Taro Oya ,  Mitsumasa Ono ,  Tetsuo Yoshida

    IPC分类号： C09K19/00 ,  G02B5/30 ,  G02F1/1335

    CPC分类号： G02B5/3025 ,  G02B5/305 ,  G02F1/133536 ,  G02F2001/133545 ,  Y10T428/10 ,  Y10T428/1036

    摘要： A multilayered reflective polarizing film is provided that has high polarization performance comparable to that of an absorption-type polarizing plate, and is preferred as a polarizing plate attached to a liquid crystal cell. An optical member for liquid crystal display devices, and a liquid crystal display device formed from such a multilayered reflective polarizing film are also provided. Specifically, the reflective polarizing film includes a uniaxially stretched multilayered film in which a specific aromatic polyester containing (alkylenedioxy)di-2-naphthoic acid as a part of dicarboxylic acid components is used as a first layer, and an optically isotropic polyester having an average refractive index of 1.50 to 1.60 is used as a second layer, and that has a predetermined refractive index difference between the layers. The reflective polarizing film has an angle of orientation of 2 degrees or less.

    摘要翻译： 提供了具有与吸收式偏振片相当的高极化性能的多层反射偏振膜，并且优选作为连接到液晶单元的偏振片。 还提供了一种用于液晶显示装置的光学构件和由这种多层反射偏光膜形成的液晶显示装置。 具体地，反射偏振膜包括单轴拉伸多层膜，其中使用含有作为二羧酸成分的一部分的（亚烷基二氧基）二-2-萘甲酸的特定芳族聚酯作为第一层，和具有平均值的光学各向同性聚酯 折射率为1.50〜1.60用作第二层，并且在层之间具有预定的折射率差。 反射偏振膜的取向角为2度以下。

    COMPOSITION FOR SUPPRESSING EXPRESSION OF TARGET GENE
    7.
    发明申请
    COMPOSITION FOR SUPPRESSING EXPRESSION OF TARGET GENE 审中-公开
    用于抑制目标基因表达的组合物

    公开(公告)号：US20120207818A1

    公开(公告)日：2012-08-16

    申请号：US13348959

    申请日：2012-01-12

    申请人： Fumikazu SHINOHARA ,  Tetsuo Yoshida ,  Hiroko Sugishita ,  Tomoyuki Naoi ,  Toshihiko Ishii ,  Junichi Enokizono

    发明人： Fumikazu SHINOHARA ,  Tetsuo Yoshida ,  Hiroko Sugishita ,  Tomoyuki Naoi ,  Toshihiko Ishii ,  Junichi Enokizono

    IPC分类号： A61K9/127 ,  A61P35/00 ,  A61P29/00 ,  A61K31/7088

    CPC分类号： A61K31/713 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/1271 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2320/32 ,  C12N2310/321 ,  C12N2310/3521

    摘要： The present invention provides a composition that comprises a liposome encapsulating a double-stranded nucleic acid molecule, wherein the antisense strand is a polynucleotide of 17 to 30 bases in which a sequence is complementary to the sequence of the 17 contiguous bases of a target gene's mRNA, the sense strand is a polynucleotide of 17 to 30 bases that contains a base sequence complementary to the base sequence of bases 1 to 17 in the 5′-end to 3′-end direction of the antisense strand, and a particular amount of the sugars binding to certain bases of the antisense strand and the sense strand are deoxyribose, or ribose whose hydroxyl group at the 2′ position is substituted by a modifying group, and wherein the liposome contains a lipid bilayer membrane whose constituent component is a lipid conjugate, a fatty acid conjugate or an aliphatic hydrocarbon conjugate of a water-soluble substance.

    摘要翻译： 本发明提供一种包含包封双链核酸分子的脂质体的组合物，其中，所述反义链是17〜30个碱基的多核苷酸，其中序列与靶基因的mRNA的17个连续碱基的序列互补 有义链是17〜30个碱基的多核苷酸，其含有与反义链的5'端至3'-端方向的碱基1至17的碱基序列互补的碱基序列，特定量的 与反义链和有义链的某些碱基结合的糖是脱氧核糖或其2'位的羟基被修饰基团取代的核糖，并且其中所述脂质体含有脂质双层膜，其构成成分是脂质缀合物， 脂肪酸结合物或水溶性物质的脂族烃共轭物。

    Cylinder apparatus
    8.
    发明授权
    Cylinder apparatus 有权
    气缸装置

    公开(公告)号：US08047341B2

    公开(公告)日：2011-11-01

    申请号：US12219425

    申请日：2008-07-22

    申请人： Satsuki Yamamoto ,  Yusuke Maegawa ,  Tetsuo Yoshida

    发明人： Satsuki Yamamoto ,  Yusuke Maegawa ,  Tetsuo Yoshida

    IPC分类号： F16F9/32

    CPC分类号： F16F9/56

    摘要： A hydraulic shock absorber enables its piston rod to be locked near its minimum length position and allows the locked condition to be visually confirmed easily. A cap member is secured to a distal end portion of a piston rod extending from a cylinder part, and a dust cover is secured to the cap member. A lock member is secured to an end of the cylinder part from which the piston rod extends to the outside. The lock member is cut and bent upward to form engaging portions. The cap member is cut and bent downward to form engaging pieces and windows. With the piston rod contracted to near its minimum length position, the cap member is rotated to engage the engaging portions and the engaging pieces with each other, thereby locking the piston rod. The engaged condition of the engaging portions and the engaging pieces can be visually confirmed through the windows.

    摘要翻译： 液压减震器使其活塞杆在其最小长度位置附近锁定，并允许容易地目视确认锁定状态。 帽构件固定到从气缸部分延伸的活塞杆的远端部分，并且防尘盖固定到盖构件。 锁定构件固定到活塞杆从其延伸到外部的气缸部分的端部。 锁定构件被向上切割并弯曲以形成接合部分。 盖构件被切割并向下弯曲以形成接合件和窗。 随着活塞杆收缩到其最小长度位置附近，盖构件被旋转以使接合部分和接合件彼此接合，从而锁定活塞杆。 可以通过窗户目视确认接合部分和接合件的接合状态。

    BIAXIALLY ORIENTED FILM FOR ELECTRIC INSULATION
    9.
    发明申请
    BIAXIALLY ORIENTED FILM FOR ELECTRIC INSULATION 审中-公开
    双向电导率电绝缘膜

    公开(公告)号：US20100209722A1

    公开(公告)日：2010-08-19

    申请号：US12602964

    申请日：2008-05-28

    申请人： Tetsuo Yoshida

    发明人： Tetsuo Yoshida

    IPC分类号： B32B15/09 ,  B32B27/36

    CPC分类号： B32B15/08 ,  B29C55/143 ,  B29K2067/00 ,  B29K2105/0044 ,  B29K2995/0007 ,  C08J5/18 ,  C08J2367/02 ,  H01G4/18 ,  Y10T428/31681 ,  Y10T428/31786

    摘要： A biaxially oriented polyester film which has high dielectric strength at a temperature range from room temperature to a high temperature, maintains high dielectric strength even after it is heated for a long time and is suitable for electric insulation application.The film comprises at least one layer made of a polyester, the polyester of the at least one layer contains a titanium compound as a catalyst and a radical scavenging stabilizer, the content of the radical scavenging stabilizer is 1,000 to 50,000 ppm based on the weight of the polyester, and the amount of the radical scavenging stabilizer chemically bonded to the polyester does not exceed 200 ppm.

    摘要翻译： 在从室温到高温的温度范围内具有高介电强度的双轴取向聚酯膜，即使在长时间加热之后也保持高介电强度，并且适用于电绝缘应用。 该薄膜包括至少一层由聚酯制成的层，该至少一层的聚酯含有钛化合物作为催化剂和自由基清除稳定剂，自由基清除稳定剂的含量以重量计为1000-50,000ppm 聚酯，与聚酯化学键合的自由基清除稳定剂的量不超过200ppm。