公开(公告)号：US12005152B2

公开(公告)日：2024-06-11

申请号：US17168780

申请日：2021-02-05

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Sang-Heon Kim ,  Seung Ja Oh ,  Ha Eun Chung

IPC分类号： A61L26/00

CPC分类号： A61L26/0033 ,  A61L26/0023 ,  A61L26/008 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/60 ,  A61L27/26 ,  C08L89/06 ,  A61L27/26 ,  C08L5/08

摘要： The present disclosure relates to a microgel composition comprising collagen and hyaluronic acid and a method of preparing the same. The microgel according to an embodiment is composed of natural biocompatible substances and is non-toxic and has high mechanical stability or long persistence, and thus can be effectively used in a microgel composition, a three-dimensional scaffold composition, and a tissue-engineering scaffold.

公开(公告)号：US11712511B2

公开(公告)日：2023-08-01

申请号：US16709716

申请日：2019-12-10

申请人： AdjuCor GmbH

发明人： Stephen Manuel Wildhirt ,  Andreas Maier ,  Kei Wieland Muller ,  Bjorn Hofmann

IPC分类号： A61M5/14 ,  A61F2/24 ,  A61M5/142 ,  A61L31/14 ,  A61L31/16 ,  A61L31/00 ,  A61M5/172

CPC分类号： A61M5/14 ,  A61F2/2481 ,  A61M5/14276 ,  A61F2002/2484 ,  A61F2230/0067 ,  A61F2240/001 ,  A61F2250/0068 ,  A61L31/005 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/60 ,  A61L2300/64 ,  A61L2430/20 ,  A61M5/1723 ,  A61M2205/04 ,  A61M2205/05 ,  A61M2210/122 ,  A61M2210/125

摘要： A device for administration of substances onto an epicardial surface of a heart includes a frame structure for at least partially encircling a circumference of the heart which is able to assume shaping, positioning, guiding and stabilizing functions. The frame structure may be coupled to a heart-shaped sleeve. A substance carrier for accommodating the substances to be administered may be coupled to the device.

公开(公告)号：US11701448B2

公开(公告)日：2023-07-18

申请号：US17002399

申请日：2020-08-25

申请人： Boston Scientific Scimed, Inc.

发明人： Gerald Fredrickson ,  Amanda L. Smith ,  Andrew Pic ,  Sophia Gervasio ,  Lauren Lydecker

IPC分类号： A61L31/16 ,  A61L26/00 ,  A61K31/722 ,  A61L31/04 ,  A61M25/09

CPC分类号： A61L26/0023 ,  A61K31/722 ,  A61L26/008 ,  A61L26/0066 ,  A61L31/042 ,  A61L31/16 ,  A61L2300/232 ,  A61L2300/418 ,  A61L2300/60 ,  A61L2400/04 ,  A61M25/09 ,  A61M2025/091 ,  A61M2202/064 ,  A61M2210/1042 ,  A61L26/0023 ,  C08L5/08 ,  A61L31/042 ,  C08L5/08

摘要： In various aspects, the present disclosure pertains to methods of treating or preventing bleeding at a tissue site comprising applying a chitosan powder composition to the tissue site. In various aspects, the present disclosure pertains to chitosan powder compositions for application to a tissue site, where the powder compositions comprise a chitosan salt, a crosslinked chitosan, a derivatized chitosan, or a combination thereof. In various aspects, the disclosure pertains to catheter assemblies, which are preloaded with a chitosan powder composition and which are configured to deliver the chitosan powder composition a tissue site.

公开(公告)号：US20230201414A1

公开(公告)日：2023-06-29

申请号：US17927037

申请日：2021-05-28

申请人： UNIVERSITY OF MONTANA

发明人： Monica SERBAN

IPC分类号： A61L26/00

CPC分类号： A61L26/0023 ,  A61L26/0028 ,  A61L2300/20 ,  A61L2300/412 ,  A61L2300/60

摘要： The present disclosure provides biocompatible and bioresorbable devices for tissue repair and regeneration and delivery of an active agent across a biological barrier comprising silk fibroin and hyaluronic acid.

公开(公告)号：US20180250432A1

公开(公告)日：2018-09-06

申请号：US15873381

申请日：2018-01-17

申请人： Howmedica Osteonics Corp

发明人： Venkat R. Garigapati ,  Brian J. Hess ,  Cassandra L. Kimsey ,  Matthew E. Murphy

IPC分类号： A61L24/00 ,  A61L27/42 ,  A61L24/02 ,  A61L24/04 ,  A61L24/06

CPC分类号： A61L24/0084 ,  A61L24/0068 ,  A61L24/02 ,  A61L24/043 ,  A61L24/046 ,  A61L24/06 ,  A61L27/425 ,  A61L2300/112 ,  A61L2300/60 ,  A61L2430/02 ,  A61L2430/12 ,  A61L2430/24

摘要： Certain small molecule amino acid phosphate compounds such as phosphoserine and certain multivalent metal compounds such as calcium phosphate containing cements have been found to have improved properties and form an interpenetrating network in the presence of a polymer that contains either an electronegative carbonyl oxygen atom of the ester group or an electronegative nitrogen atom of the amine group as the bonding sites of the polymer surfaces to the available multivalent metal ions.

公开(公告)号：US20170252460A1

公开(公告)日：2017-09-07

申请号：US15598505

申请日：2017-05-18

申请人： Nicolai Bovin ,  Stephen HENRY ,  Iain HOSIE ,  Stephen PARKER

发明人： Nicolai Bovin ,  Stephen HENRY ,  Iain HOSIE ,  Stephen PARKER

IPC分类号： A61K31/7028 ,  A61L27/18 ,  D01F1/10 ,  C07F9/655 ,  C07F9/6558 ,  C07F9/6561 ,  A61L27/16 ,  A61K49/00 ,  A61L27/20 ,  A61L27/54 ,  A61L15/26 ,  A61L15/28 ,  A61L15/44 ,  D01D5/00 ,  C08L1/12 ,  C08L29/14 ,  C08G69/42

CPC分类号： A61K47/6953 ,  A61K31/7028 ,  A61K47/543 ,  A61K47/544 ,  A61K47/551 ,  A61K47/59 ,  A61K47/595 ,  A61K47/61 ,  A61K47/6435 ,  A61K49/0043 ,  A61K49/0054 ,  A61K49/0093 ,  A61L15/26 ,  A61L15/28 ,  A61L15/44 ,  A61L27/16 ,  A61L27/18 ,  A61L27/20 ,  A61L27/54 ,  A61L2300/22 ,  A61L2300/60 ,  A61L2400/14 ,  A61L2430/00 ,  C07F9/65522 ,  C07F9/65586 ,  C07F9/6561 ,  D01D5/003 ,  D01D5/0069 ,  D01F1/10 ,  C08L1/12 ,  C08L29/14

摘要： Methods for functionalizing the surface of nanofiber substrates, including electrospun fibres and non-woven or woven mats of fibres are described. Functionalised nanofiber substrates presenting biologically active moieties such as biotin and saccharides are described.

公开(公告)号：US09440008B2

公开(公告)日：2016-09-13

申请号：US14694466

申请日：2015-04-23

申请人： Children's Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61F13/00 ,  A61L31/06 ,  A61K9/00 ,  A61F2/02 ,  A61L31/14 ,  A61L27/26 ,  A61L27/58 ,  A61L31/16 ,  A61F2/44 ,  A61L31/00 ,  A61L31/04

CPC分类号： A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

公开(公告)号：US09265800B2

公开(公告)日：2016-02-23

申请号：US14619987

申请日：2015-02-11

申请人： MiMedx Group, Inc.

发明人： John Daniel

IPC分类号： A61L27/36 ,  A61K35/50 ,  A61L27/40 ,  A61J1/00 ,  A61L27/54 ,  A61L27/58 ,  A61F2/02 ,  A61L27/50 ,  B65D25/20 ,  B65D81/18 ,  B65D85/00

CPC分类号： A61K35/50 ,  A61F2/02 ,  A61J1/00 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/40 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/412 ,  A61L2300/60 ,  A61L2300/64 ,  A61L2430/40 ,  B65D25/205 ,  B65D81/18 ,  B65D85/70

摘要： A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion.

公开(公告)号：US20160022861A1

公开(公告)日：2016-01-28

申请号：US14776721

申请日：2014-03-15

申请人： Martin MACPHEE ,  Dawson BEALL ,  Jennifer BRICHETTI ,  Belinda WILMER ,  STB, LTD.

发明人： Martin MACPHEE ,  Dawson BEALL ,  Jennifer BRICHETTI ,  Belinda WILMER

IPC分类号： A61L15/44 ,  A61L15/32 ,  A61F13/26

CPC分类号： A61F13/15 ,  A61F13/00034 ,  A61F13/2002 ,  A61F13/26 ,  A61F13/266 ,  A61F2013/00357 ,  A61F2013/00472 ,  A61F2013/15008 ,  A61F2013/15284 ,  A61F2013/2014 ,  A61L15/32 ,  A61L15/44 ,  A61L24/0015 ,  A61L24/0036 ,  A61L24/0042 ,  A61L24/0073 ,  A61L24/106 ,  A61L2300/00 ,  A61L2300/418 ,  A61L2300/60 ,  A61L2400/04

摘要： Disclosed are solid and frozen haemostatic materials utilizing an absorbable scaffolding material and consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings, particularly for the treatment of injured tissue via endoscopic or minimally-invasive surgical techniques.

摘要翻译： 公开了使用可吸收脚手架材料并基本上由纤维蛋白原组分和纤维蛋白原激活剂组成的固体和冷冻止血材料。 还公开了通过应用一种或多种这些止血材料和敷料来治疗哺乳动物的内部受伤组织的方法，特别是通过内窥镜或微创手术技术治疗损伤的组织。

公开(公告)号：US09226990B2

公开(公告)日：2016-01-05

申请号：US14330753

申请日：2014-07-14

申请人： Industrial Technology Research Institute ,  National Taiwan University Hospital

发明人： Chun-Jen Liao ,  Sheng-Hong Tseng ,  Huang-Chien Liang ,  Yi-Chun Su ,  Pei-Chi Hsu

IPC分类号： A61K9/12 ,  A61K38/01 ,  A61K38/39 ,  A61K8/65 ,  A61L26/00 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26 ,  A61L27/56 ,  B65D83/14

CPC分类号： A61L26/0085 ,  A61K8/65 ,  A61K9/12 ,  A61K38/014 ,  A61K38/39 ,  A61L26/0023 ,  A61L26/0033 ,  A61L26/0052 ,  A61L26/0066 ,  A61L26/0076 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26 ,  A61L27/56 ,  A61L2300/412 ,  A61L2300/60 ,  B65D83/752 ,  C08L5/08 ,  C08L89/06

摘要： A foamed biocompatible material for use in tissue repair and a kit for producing same. The kit includes a container having a valve and an inlet, and a tissue-repair composition containing a biocompatible material and a liquid carrier, in which the composition is placed in the inlet of the container and the inside of container has a pressure lower than that of the outside so that, upon opening the valve, the composition is forced into the container by the pressure difference to form a foam inside the container. Also disclosed is a method of preparing a foamed biocompatible material for tissue repair.

摘要翻译： 用于组织修复的发泡生物相容性材料和用于制造其的试剂盒。 该试剂盒包括具有阀和入口的容器，以及含有生物相容性材料和液体载体的组织修复组合物，其中组合物被放置在容器的入口中，并且容器内部的压力低于容器内部的压力 使得在打开阀时，通过压力差将组合物压入容器中，以在容器内形成泡沫。 还公开了一种制备用于组织修复的泡沫生物相容性材料的方法。