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    Biodegradable particulate vector for transporting molecules having biological activity
    95.
    发明授权
    Biodegradable particulate vector for transporting molecules having biological activity 失效
    用于输送具有生物活性的分子的可生物降解的颗粒载体

    公开(公告)号：US5736371A

    公开(公告)日：1998-04-07

    申请号：US243079

    申请日：1994-05-16

    Applicant: Daniel Samain ,  Ignacio De Miguel ,  Jaouad Meniali ,  Karim Ioualalen ,  Li Ding ,  Monique Cervilla ,  Valerie Rieumajou ,  Pascal Delrieu ,  Laurent Imbertie

    Inventor： Daniel Samain ,  Ignacio De Miguel ,  Jaouad Meniali ,  Karim Ioualalen ,  Li Ding ,  Monique Cervilla ,  Valerie Rieumajou ,  Pascal Delrieu ,  Laurent Imbertie

    IPC: A61K9/127 ,  A61K9/16 ,  A61K9/51 ,  C12N11/12 ,  A61K38/43 ,  C07K17/12 ,  C12N11/10

    CPC classification number: A61K9/5161 ,  A61K9/127 ,  A61K9/167 ,  A61K9/5192 ,  Y10S530/813 ,  Y10S530/814

    Abstract: A biodegradable particulate vector for transporting biologically active molecules is prepared containing a nucleus for containing a biologically active molecule, a first layer of fatty acid compounds covalently bonded to the nucleus and a second layer of phospholipids hydrophobically bonded to the first layer. The nucleus is between 10 nm and 10 .mu.m in size and is formed of a cross-linked polysaccharide or oligosaccharide matrix onto which ionic ligands are uniformly grafted. The cross-linked polysaccharide may be dextran, cellulose or starch cross-linked with epichlorohydrin. The ligand may be an acidic compound selected from succinic acid, phosphoric acid, citric acid, glycine, alanine, glutamic acid and aspartic acid, or a basic compound such as choline, hydroxycholine, 2-(dimethylamino)ethanol or 2-(dimethylamino)ethylamine fastened onto the matrix via the acidic compound. The polysaccharide or oligosaccharide may be co-cross-linked with a protein such as keratin/collagen or elastase. The vector may be prepared by reacting succinic acid monochloride in aqueous solution with a cross-linked polysaccharide or oligosaccharide matrix to graft succinic acid onto the matrix to form the nucleus, grinding the nucleus to a size between 10 nm and 10 .mu.m, drying the ground nucleus, coupling fatty acid compounds to the nucleus to form a first layer and hydrophobically bonding phospholipids to the first layer to form a second layer. The succinic acid monochloride is preferably prepared by reacting succinic acid dichloride with free succinic acid to form pure crystalline succinic acid monochloride.

    Abstract translation: 制备用于输送生物活性分子的可生物降解的颗粒载体，其包含含有生物活性分子的核，与核共价键合的第一层脂肪酸化合物和与第一层疏水结合的第二层磷脂。 核的尺寸在10nm和10μm之间，并且由交联的多糖或寡糖基质形成，其上离子配体被均匀地接枝到其上。 交联多糖可以是与表氯醇交联的葡聚糖，纤维素或淀粉。 配体可以是选自琥珀酸，磷酸，柠檬酸，甘氨酸，丙氨酸，谷氨酸和天冬氨酸的酸性化合物，或碱性化合物如胆碱，羟基胆碱，2-（二甲基氨基）乙醇或2-（二甲基氨基） 乙胺通过酸性化合物固定在基质上。 多糖或寡糖可以与蛋白质如角蛋白/胶原或弹性蛋白酶共交联。 载体可以通过使琥珀酸一氯化物在水溶液中与交联的多糖或寡糖基质反应来将琥珀酸接枝到基质上以形成核，将细胞核研磨至10nm至10μm的大小，干燥 研磨核，将脂肪酸化合物偶联到细胞核上形成第一层，并将磷脂与第一层疏水结合形成第二层。 琥珀酸一氯化物优选通过琥珀酸二氯化物与游离琥珀酸反应形成纯结晶琥珀酸一氯化物来制备。

    Method for modifying the refractive index of an optical material
    97.
    发明授权
    Method for modifying the refractive index of an optical material 有权
    修改光学材料的折射率的方法

    公开(公告)号：US09144491B2

    公开(公告)日：2015-09-29

    申请号：US13238143

    申请日：2011-09-21

    Applicant: Wayne H. Knox ,  Dharmendra Jani ,  Li Ding

    Inventor： Wayne H. Knox ,  Dharmendra Jani ,  Li Ding

    IPC: B29D11/00 ,  A61F2/16 ,  A61F9/008 ,  A61L27/16 ,  A61L27/50 ,  A61L27/52

    CPC classification number: G02B3/0087 ,  A61F2/1618 ,  A61F2/1627 ,  A61F9/00834 ,  A61L27/16 ,  A61L27/50 ,  A61L27/52 ,  A61L2400/18 ,  A61L2430/16 ,  G02B2003/0093 ,  G02C2202/12 ,  G02C2202/14 ,  C08L33/10

    Abstract: A method for modifying the refractive index of an optical polymeric material. The method comprises continuously irradiating predetermined regions of an optical, polymeric material with femtosecond laser pulses to form a gradient index refractive structure within the material. An optical device includes an optical, polymeric lens material having an anterior surface and posterior surface and an optical axis intersecting the surfaces and at least one laser-modified, GRIN layer disposed between the anterior surface and the posterior surface and arranged along a first axis 45° to 90° to the optical axis, and further characterized by a variation in index of refraction across at least one of at least a portion of the adjacent segments and along each segment.

    Abstract translation: 一种用于改变光学聚合物材料的折射率的方法。 该方法包括用飞秒激光脉冲连续照射光学聚合材料的预定区域，以在材料内形成梯度折射率折射结构。 光学装置包括具有前表面和后表面的光学聚合物透镜材料和与表面相交的光轴以及设置在前表面和后表面之间并且沿着第一轴线45布置的至少一个激光修饰的GRIN层 °至90°，并且进一步的特征在于，相邻段的至少一部分中的至少一个和沿着每个段的折射率的变化。

    Ion trap with parallel bar-electrode arrays
    98.
    发明授权
    Ion trap with parallel bar-electrode arrays 有权
    具有平行棒电极阵列的离子阱

    公开(公告)号：US09111741B2

    公开(公告)日：2015-08-18

    申请号：US12298968

    申请日：2007-04-13

    Applicant: Chuanfan Ding ,  Li Ding

    Inventor： Chuanfan Ding ,  Li Ding

    IPC: H01J49/42 ,  H01J49/06

    CPC classification number: H01J49/4225 ,  H01J49/004 ,  H01J49/065 ,  H01J49/4235

    Abstract: The invention “Ion Trap Array (ITA)” pertains generally to the field of ion storage and analysis technologies, and particularly to the ion storing apparatus and mass spectrometry instruments which separate ions by its character such as mass-to-charge ratio. The aim of this invention is providing an apparatus for ion storage and analysis comprising at least two or more rows of parallel placed electrode array wherein each electrode array includes at least two or more parallel bar-shaped electrodes, by applying different phase of alternating current voltages on different bar electrodes to create alternating electric fields inside the space between two parallel electrodes of different rows of electrode arrays, multiple linear ion trapping fields paralleled constructed in the space between the different rows of electrode arrays which are open to adjacent each other without a real barrier. This invention also provides a method for ion storage and analysis involving with the trapping, cooling and mass-selected analyzing of ions by this apparatus mentioned which constructs multiple conjoint linear ion trapping fields in the space between the different rows of electrode arrays.

    Abstract translation: 本发明“离子阱阵列（ITA）”一般涉及离子存储和分析技术领域，特别涉及离子存储装置和质谱仪器，它们通过诸如质荷比的特性分离离子。 本发明的目的是提供一种用于离子存储和分析的装置，其包括至少两行或多行平行放置的电极阵列，其中每个电极阵列包括至少两个或更多个平行的棒状电极，通过施加不同相位的交流电压 在不同的棒电极上在不同行电极阵列的两个平行电极之间的空间内部产生交替电场，多个线性离子俘获场平行地构造在电极阵列的不同行之间的空间中，这些空间彼此相邻而没有实际 屏障。 本发明还提供了一种离子存储和分析的方法，其涉及通过所述装置进行捕集，冷却和质量选择的离子分析，其在不同行电极阵列之间的空间中构成多个联合线性离子捕获场。

    Video laryngoscope
    99.
    发明授权
    Video laryngoscope 有权
    视频喉镜

    公开(公告)号：US08894570B2

    公开(公告)日：2014-11-25

    申请号：US13138112

    申请日：2009-12-31

    Applicant: Wenqiang Jiang ,  Li Ding

    Inventor： Wenqiang Jiang ,  Li Ding

    IPC: A61B1/267 ,  A61B1/00 ,  A61B1/06

    CPC classification number: A61B1/267 ,  A61B1/00052 ,  A61B1/00073 ,  A61B1/06

    Abstract: A video laryngoscope has a handle and a groove on one side of the handle. The groove is used for guiding a guide wire when the larynogoscope is placed in a patient's mouth. A video camera located near the end of the handle is used to view the area around the glottis. When the guide wire is properly positioned near the glottis, the upper part of the guide wire is disengaged from the groove so as to allow an endotracheal tube to be slipped over the guide wire and to be inserted into part of the trachea through the glottis. When the tube is properly inserted for intubation, the guide wire is removed from the tube. An illuminating light source such as an LED lamp can be installed at the end of the handle to provide illumination for the video camera.

    Abstract translation: 视频喉镜在手柄的一侧具有手柄和凹槽。 当喉镜放置在患者口中时，该凹槽用于引导导丝。 位于手柄末端附近的摄像机用于查看声门周围的区域。 当引导线适当地定位在声门附近时，导丝的上部与凹槽脱离，以允许气管内导管滑过导丝并通过声门插入到气管的一部分中。 当管正确插入插管时，导丝从管中取出。 诸如LED灯的照明光源可以安装在手柄的端部以为摄像机提供照明。

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