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    Contactless power solution for low power sensors in bioprocess environments
    92.
    发明授权
    Contactless power solution for low power sensors in bioprocess environments 有权

    公开(公告)号：US08501119B2

    公开(公告)日：2013-08-06

    申请号：US12079396

    申请日：2008-03-26

    Applicant: Aaron Burke ,  Jiwan Adhikari

    Inventor： Aaron Burke ,  Jiwan Adhikari

    IPC: B01D35/00

    CPC classification number: H01Q19/10 ,  G06K7/10178 ,  H01Q1/22 ,  H01Q1/40 ,  H01Q7/00

    Abstract: A method and apparatus for providing more reliable wireless communication and power to sensors in electrically challenging bioprocess environments is disclosed. An unconnected antenna is located within the bioprocess environment, preferably in the same plane as the primary powered antenna. This unconnected antenna, also referred to as reflective antenna, enhances and confines the electromagnetic field created by the powered antenna. This reflective antenna is incorporated in or proximate to the devices containing a sensor or communication device. In one embodiment, the reflective antenna is incorporated into the filter housing. In another embodiment, it is incorporated into the filtering element itself. In another embodiment, it is incorporated into or affixed on the disposable bioprocess components, such as bags and tubes.

    Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
    93.
    发明授权
    Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same 有权
    用于基于聚合伯胺的膜离子交换色谱的介质，含有该介质的吸附装置和使用其的色谱方案和纯化方法

    公开(公告)号：US08435406B2

    公开(公告)日：2013-05-07

    申请号：US13363397

    申请日：2012-02-01

    Applicant: Mikhail Kozlov ,  Wilson Moya ,  Michael W. Phillips ,  Senthilkumar Ramaswamy ,  Brian Gagnon

    Inventor： Mikhail Kozlov ,  Wilson Moya ,  Michael W. Phillips ,  Senthilkumar Ramaswamy ,  Brian Gagnon

    IPC: B01D15/08

    CPC classification number: B01J20/28033 ,  B01D15/1871 ,  B01D15/362 ,  B01D15/363 ,  B01D15/3804 ,  B01J20/3282 ,  B01J47/12 ,  Y10T428/249987

    Abstract: Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities even at high conductivities and pH.

    Abstract translation: 介质和装置，例如包括这种介质的阴离子交换剂，其中介质是具有涂覆聚合物如聚烯丙基胺的表面的膜。 与基于季铵盐（包括三甲基铵配体）的常规配体相比，所得到的膜提供了更强的蛋白质杂质结合和优于宿主细胞蛋白质从生物样品中的去除。 还描述了用于纯化单克隆抗体的色谱方法和方法，其中阴离子交换吸附剂置于亲和柱（例如蛋白A或蛋白G亲和柱）的下游，以及任选的一种或多种抛光装置如阳离子交换柱。 阳离子交换池（或不使用阳离子交换剂的亲和柱交换池）的稀释很少或不需要，以降低样品的电导率。 即使在高电导率和pH下，吸附剂也能很好地结合宿主细胞蛋白质和其他杂质。

    Adsorbent Filter Media For Removal Of Biological Contaminants In Process Liquids
    96.
    发明申请
    Adsorbent Filter Media For Removal Of Biological Contaminants In Process Liquids 有权
    用于去除工艺液体中生物污染物的吸附剂过滤介质

    公开(公告)号：US20130062280A1

    公开(公告)日：2013-03-14

    申请号：US13669494

    申请日：2012-11-06

    Applicant: EMD MILLIPORE CORPORATION

    Inventor： David P. Yavorsky

    IPC: B01D39/14

    CPC classification number: B01D39/2079 ,  B01D2239/0407 ,  B01D2239/08 ,  B01J20/10 ,  B01J20/103 ,  B01J20/14 ,  B01J20/165 ,  B01J20/18 ,  B01J20/20 ,  B01J20/28026 ,  B01J20/2803

    Abstract: Adsorbent filter media particularly suited for removal of biological contaminants in process liquids. A porous fixed bed of adsorbent material is formed, using only a granular adsorbent and a water-insoluble thermoplastic binder. The resulting composite filter allows for a higher amount of adsorbent with smaller adsorbent particles than conventional depth filters. Elimination of cellulose fiber, as well as the elimination of the thermoset binder, results in reduced contamination of the process liquid.

    Abstract translation: 吸附剂过滤介质特别适用于去除工艺液体中的生物污染物。 仅使用粒状吸附剂和水不溶性热塑性粘合剂形成吸附剂材料的多孔固定床。 所得到的复合过滤器允许比常规深度过滤器更大量的具有较小吸附剂颗粒的吸附剂。 消除纤维素纤维以及消除热固性粘合剂导致工艺液体的污染减少。

    Gamma hardened pharmaceutical devices
    97.
    发明授权
    Gamma hardened pharmaceutical devices 有权
    Gamma硬化药物装置

    公开(公告)号：US08383037B2

    公开(公告)日：2013-02-26

    申请号：US13414884

    申请日：2012-03-08

    Applicant: Aaron Burke

    Inventor： Aaron Burke

    IPC: A61L2/00

    CPC classification number: A61L2/081 ,  A61L2/087 ,  A61L2202/24

    Abstract: A system and method for implementing embedded electronics in environments where radiation or extreme temperatures are used is disclosed. Embedded electronics are affixed to various components of a pharmaceutical system, thereby enabling the customer to download pertinent information about the component, such as lot number, date of manufacturer, test parameters, etc. Additionally, these electronics allow an array of functions and features to be implemented, such as integrity tests and diagnostics. The electronics in the pharmaceutical components utilize a technology that is not as susceptible to radiation and extreme temperatures as traditional electronics.

    Abstract translation: 公开了一种在使用辐射或极端温度的环境中实现嵌入式电子设备的系统和方法。 嵌入式电子设备固定在药物系统的各种组件上，从而使客户能够下载有关组件的相关信息，例如批号，制造商日期，测试参数等。此外，这些电子装置允许一系列功能和特征 实施，如​​完整性测试和诊断。 药物部件中的电子元件利用了不像传统电子产品那样易受辐射和极端温度影响的技术。

    Biomaterial Freezing
    98.
    发明申请
    Biomaterial Freezing 有权
    生物材料冻结

    公开(公告)号：US20130039382A1

    公开(公告)日：2013-02-14

    申请号：US13654595

    申请日：2012-10-18

    Applicant: EMD Millipore Corporation

    Inventor： Aaron Burke ,  Michael Felo ,  Brian Pereira ,  Elias Noukas ,  Dennis Wong

    IPC: G01N25/00

    CPC classification number: F25D29/00 ,  A01N1/0263 ,  F25D2331/802 ,  F25D2400/28 ,  F25D2400/30 ,  F25D2600/06 ,  F25D2700/12 ,  Y10T29/53

    Abstract: The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.

    Abstract translation: 本发明的生物容器提供了在生物药物材料的运输，冷冻和解冻期间遇到的许多问题的低成本，简单的解决方案。 本发明使得用户能够在低温过程期间监测每个生物药物容器的温度曲线，以便通过使用预先安装和预灭菌的温度传感器来确保每个生物容器内的材料的完整性。 在一些实施例中，传感器组件包括无线发射器，并且能够发送关于测量读数的信息。 在其他实施例中，传感器组件包括处理单元，其确定温度分布是否可接受。 在另一实施例中，包括指示器，使得处理单元可以指示生物药物材料是否已被适当地冷冻。 在其他实施例中，传感器组件还包括存储元件，其能够在冷冻过程期间存储各种参数。

    Biomaterial Freezing
    99.
    发明申请
    Biomaterial Freezing 有权

    公开(公告)号：US20130038469A1

    公开(公告)日：2013-02-14

    申请号：US13654593

    申请日：2012-10-18

    Applicant: EMD Millipore Corporation

    Inventor： Aaron Burke ,  Michael Felo ,  Brian Pereira ,  Elias Noukas ,  Dennis Wong

    IPC: G08C19/00

    CPC classification number: F25D29/00 ,  A01N1/0263 ,  F25D2331/802 ,  F25D2400/28 ,  F25D2400/30 ,  F25D2600/06 ,  F25D2700/12 ,  Y10T29/53

    Abstract: The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.

    Centrifugal Filter
    100.
    发明申请
    Centrifugal Filter 有权
    离心过滤器

    公开(公告)号：US20130032539A1

    公开(公告)日：2013-02-07

    申请号：US13649365

    申请日：2012-10-11

    Applicant: EMP Millipore Corporation

    Inventor： Louis Bonhomme ,  John Doyle ,  Kurt Greenizen ,  George Gagne ,  Sean Devin ,  Gerard Lombard ,  Vincent Smith

    IPC: B01D63/16 ,  B01D61/00

    CPC classification number: B01D63/16 ,  B01D61/145 ,  B01D61/18 ,  B01D63/08 ,  B01D2313/08 ,  B01L3/502 ,  B01L3/5021 ,  B01L3/5635 ,  B01L2300/0681

    Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.

    Abstract translation: 适用于浓缩液体样品，特别是生物分子的过滤装置，以及浓缩，脱盐，纯化和/或分馏液体样品的方法。 在某些实施方案中，该装置包括具有样品储存器的壳体和设置在壳体中的两个基本垂直定向和间隔开的膜。 与每个膜相关联的下划线，使得通过每个膜的流体通过相应的下划线流入滤液收集室。 不通过膜的流体被收集在滞留物收集室中，并且可以通过反转纺步骤回收，实现大于约90％的回收率。 膜的基本垂直取向将可用的膜面积增加了传统过滤装置中可用面积的至少2.7倍。 两面板配置在过滤的最后阶段比在单面板配置中还维持使用更多的可用膜面积。

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