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公开(公告)号：US09601198B2
公开(公告)日：2017-03-21
申请号：US14543487
申请日：2014-11-17
Applicant: Japan Science and Technology Agency
Inventor： Yusuke Shuto , Shuichiro Yamamoto , Satoshi Sugahara
IPC: G11C14/00
CPC classification number: G11C14/0081 , G11C11/1675 , G11C11/1693
Abstract: A memory circuit includes: a bistable circuit (30) that stores data; nonvolatile elements (MTJ1, MTJ2) that store data written in the bistable circuit in a nonvolatile manner, and restore data stored in a nonvolatile manner into the bistable circuit; and a control unit that stores data written in the bistable circuit in a nonvolatile manner and cuts off a power supply to the bistable circuit when the period not to read data from or write data into the bistable circuit is longer than a predetermined time period, and does not store data written in the bistable circuit in a nonvolatile manner and makes the supply voltage for the bistable circuit lower than a voltage during the period to read data from or write data into the bistable circuit when the period not to read or write data is shorter than the predetermined time period.
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公开(公告)号：US20170067020A1
公开(公告)日：2017-03-09
申请号：US15112027
申请日：2015-01-21
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Makoto SUEMATSU , Yasuhito TOKUMOTO , Shinpei TAMAKI
IPC: C12N5/0797 , A61K35/30 , G01N33/50
CPC classification number: C12N5/0623 , A61K35/30 , C12N2500/02 , C12N2500/38 , C12N2501/385 , C12N2501/395 , G01N33/5058
Abstract: The present invention provides a method for producing adult oligodendrocyte progenitor cells from proliferative oligodendrocyte progenitor cells, and a pharmaceutical composition having for an active ingredient thereof adult OPC produced according to that method. The method for producing adult OPC of the present invention is characterized by inducing proliferating OPC to differentiate into adult OPC by culturing in the presence of a ligand of a thyroid hormone receptor or retinoic acid receptor in a low oxygen environment. The present invention further provides adult OPC produced according to the production method of the present invention, and a pharmaceutical composition having these adult OPC as an active ingredient thereof.
Abstract translation: 本发明提供了一种从增殖性少突神经母细胞祖细胞产生成体少突胶质细胞祖细胞的方法，以及具有活性成分的成分根据该方法生产的OPC的药物组合物。 本发明的成人OPC的制造方法的特征在于，通过在低氧环境下在甲状腺激素受体或视黄酸受体的配体的存在下培养，诱导增殖OPC分化成成人OPC。 本发明还提供了根据本发明的制备方法制备的成人OPC和具有这些成人OPC作为其活性成分的药物组合物。
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公开(公告)号：US09548634B2
公开(公告)日：2017-01-17
申请号：US14420516
申请日：2013-07-25
Inventor： Atsufumi Hirohata
CPC classification number: H02K1/27 , H01L29/66984 , H02K1/12 , H02N1/002 , H02N15/00
Abstract: A spin rotary member includes a substrate, a spin injector made of a ferromagnetic material magnetized in a substrate in-plane direction, and provided on the substrate, a spin rotor made of a ferromagnetic material having a magnetic moment rotatable in the substrate in-plane direction, and provided on the substrate, being separated from the spin injector, a channel part made of a non-magnetic material, arranged between the spin injector and the spin rotor, and bonded with the spin injector and the spin rotor directly or through an insulating layer, and a spin rotation control part configured to control a rotation direction of spin of the channel part.
Abstract translation: 旋转旋转构件包括基板，由在基板的面内方向上被磁化的铁磁材料制成的自旋注入器，并且设置在基板上，由铁磁材料制成的自旋转子，所述铁磁材料具有可在基板内平面旋转的磁矩 并且设置在基板上，与旋转喷射器分离，由非磁性材料制成的通道部分，布置在旋转喷射器和旋转转子之间，并直接或通过旋转喷嘴和旋转旋转转子结合 绝缘层，以及配置为控制通道部的旋转的旋转方向的旋转旋转控制部。
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公开(公告)号：US20170002315A1
公开(公告)日：2017-01-05
申请号：US15113153
申请日：2015-01-23
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Tsuneo Urisu , Zhi-hong Wang , Hidetaka Uno , Yasutaka Nagaoka
Abstract: Provided is a device for seeding cells in a plurality of cell arrangement areas in a simple manner and a short period of time. A seeding and culturing device (1) for cells capable of forming a nerve network, the device comprising a cell-culturing substrate (2) having a plurality of cell arrangement areas (8) enclosed by a plurality of projecting parts, and a flow channel substrate (3) arranged on the cell-cultivating substrate (2) and having a plurality of through-holes (14), wherein the through-holes (14) are configured so as to provide flow channels in which the upper surface side of the substrate is an entrance (15) and the lower surface side of the substrate is an exit, and the exit (16) of the flow channels is positioned above any of the cell arrangement areas.
Abstract translation: 提供了一种用于以简单的方式和短时间段在多个单元布置区域中种植单元的装置。 一种用于形成神经网络的细胞的接种和培养装置（1），所述装置包括具有由多个突出部分包围的多个细胞排列区域（8）的细胞培养基板（2），以及流路 配置在细胞培养基板（2）上并具有多个通孔（14）的基板（3），其中，所述通孔（14）构成为提供流路，其中， 衬底是入口（15），衬底的下表面侧是出口，并且流动通道的出口（16）位于任何单元布置区域上方。
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公开(公告)号：US09506892B2
公开(公告)日：2016-11-29
申请号：US14302842
申请日：2014-06-12
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Kazuhiko Matsumoto , Atsuhiko Kojima , Satoru Nagao , Masanori Katou , Yutaka Yamada , Kazuhiro Nagaike , Yasuo Ifuku , Hiroshi Mitani
IPC: G01N27/414 , B82Y10/00 , B82Y30/00 , H01L29/06 , H01L29/423 , H01L29/76
CPC classification number: G01N27/4145 , B82Y10/00 , B82Y30/00 , G01N27/4146 , H01L29/068 , H01L29/42364 , H01L29/7613
Abstract: A sensor capable of detecting detection targets that are necessary to be detected with high sensitivity is provided.It comprises a field-effect transistor 1A having a substrate 2, a source electrode 4 and a drain electrode 5 provided on said substrate 2, and a channel 6 forming a current path between said source electrode 4 and said drain electrode 5; wherein said field-effect transistor 1A comprises: an interaction-sensing gate 9 for immobilizing thereon a specific substance 10 that is capable of selectively interacting with the detection targets; and a gate 7 applied a voltage thereto so as to detect the interaction by the change of the characteristic of said field-effect transistor 1A.
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Patent Agency Ranking
96.发明申请PROTECTIVE AGENT FOR ELECTRON MICROSCOPIC OBSERVATION OF BIOLOGICAL SAMPLE IN WATER-CONTAINING STATE, KIT FOR ELECTRON MICROSCOPIC OBSERVATION, METHODS FOR OBSERVATION, DIAGNOSIS, EVALUATION, AND QUANTIFICATION BY ELECTRON MICROSCOPE, AND SAMPLE STAGE 审中-公开含水状态生物样品的电子微观观察保护剂，电子显微镜观察套件，电子显微镜观察，诊断，评估和定量方法及样品分析公开(公告)号：US20160343539A1
公开(公告)日：2016-11-24
申请号：US15114978
申请日：2015-01-28
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Takahiko HARIYAMA , Yasuharu TAKAKU , Hiroshi SUZUKI , Satoshi HIRAKAWA , Hideaki KAWASAKI , Masatsugu SHIMOMURA , Daisuke ISHII , Isao OHTA , Yoshinori MURANAKA
IPC: H01J37/20 , G01N33/50 , H01J37/22 , G01N33/483
CPC classification number: H01J37/20 , G01N33/4833 , G01N33/5011 , G01N2223/612 , G01N2800/7028 , H01J37/22 , H01J2237/2002 , H01J2237/2007
Abstract: Provided are a protective agent for electron microscopic observation in a vacuum which can protect a biological sample in a water-containing state, such as a mammal, a plant tissue or a cultured cell, and a single cell in the living state without deforming it even in a vacuum, a kit using the same, methods for observation, diagnosis, evaluation, and quantification of a sample by an electron microscope, and a sample stage to be used for the observation. The protective agent for electron microscopic observation of the present invention contains a a component to impart the survival environment, a saccharide, and an electrolyte.
Abstract translation: 提供一种用于真空中电子显微镜观察的保护剂，其可以保护生物状态中的含水状态的生物样品例如哺乳动物，植物组织或培养细胞，以及单一细胞，而不使其变形甚至 在真空中，使用其的试剂盒，通过电子显微镜观察，诊断，评价和定量样品的方法以及用于观察的样品台。 本发明的电子显微镜观察用保护剂含有赋予生存环境的成分，糖类和电解质。
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97.发明授权公开(公告)号：US09490511B2
公开(公告)日：2016-11-08
申请号：US14772239
申请日：2014-02-25
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Tetsuya Ueda , Andrey Porokhnyuk
Abstract: When a phase constant in a first mode of propagation in the forward direction is βp, and a phase constant in a second mode of propagation in the backward direction is βm, respective first and second electrical lengths of stub conductors are set so that a function of nonreciprocal phase shift amount βNR=(βp−βm)/2 with respect to an operating angular frequency comes close to a function βNRZ with respect to an operating angular frequency, when beam squint of such a phenomenon that a radiation direction of electromagnetic waves radiated from a nonreciprocal transmission line apparatus changes in accordance with frequency does not occur in the vicinity of an intersection of a dispersion curve representing a relation between the phase constant βp and the operating angular frequency and a dispersion curve representing a relation between the phase constant βm and the operating angular frequency.
Abstract translation: 当正向传播的第一传播模式的相位常数为βp时，向后方向的第二传播方式的相位常数为βm时，各个第一和第二电长度的短截线导体被设定为使得 相对于操作角频率的非相互相移量βNR=（βp-βm）/ 2相对于操作角频率接近于函数βNRZ，当光束眯眼时，电磁波的辐射方向从 在表示相位常数βp与运算角频率之间的关系的色散曲线的交点附近不发生不可逆传输线路装置的频率变化，表示相位常数βm与 操作角频率。
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公开(公告)号：US20160297764A1
公开(公告)日：2016-10-13
申请号：US15100866
申请日：2014-12-09
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Motomu KANAI , Yohei SOMA , Tadamasa ARAI , Takushi ARAYA
IPC: C07D213/81
CPC classification number: C07D213/81 , C07D239/30
Abstract: Provided is a novel compound which has an excellent Aβ aggregation inhibitory effect and is useful as a pharmaceutical. An amide compound represented by the formula (1) or a salt thereof, wherein Z represents CH or N; A and B are the same or different and each represents —CH2—, —O—, —S—, or —NH—; R1 and R2 are the same or different and each represents a branched alkyl group, a branched alkenyl group, an optionally substituted aromatic hydrocarbon group, an optionally substituted aralkyl group, an optionally substituted cycloalkyl group, or an optionally substituted aromatic heterocyclic group; and R3 represents a branched alkyl group, a branched alkenyl group, an optionally substituted cycloalkyl group, or an optionally substituted aralkyl group.
Abstract translation: 提供具有优异的A 2聚集抑制作用的新型化合物，可用作药物。 由式（1）表示的酰胺化合物或其盐，其中Z表示CH或N; A和B相同或不同，各自表示-CH 2 - ， - O - ， - S-或-NH-。 R 1和R 2相同或不同，各自表示支链烷基，支链烯基，任选取代的芳族烃基，任选取代的芳烷基，任选取代的环烷基或任选取代的芳族杂环基; 并且R 3表示支链烷基，支链烯基，任选取代的环烷基或任选取代的芳烷基。
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99.发明授权Nanodiamond particle and method of manufacturing the same, and fluorescent molecular probe and method of analyzing structure of protein 有权纳米金刚石颗粒及其制造方法，荧光分子探针和分析蛋白质结构的方法公开(公告)号：US09465035B2
公开(公告)日：2016-10-11
申请号：US14434640
申请日：2013-10-10
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Masahiro Shirakawa , Shingo Sotoma , Ryuji Igarashi , Yoshie Harada
CPC classification number: G01N33/6803 , C01B32/25 , C01B32/28 , G01N21/6428 , G01N24/087 , G01N24/10 , G01N33/582 , G01N2021/6439 , G01R33/323 , G01R33/60 , Y10T436/203332 , Y10T436/23 , Y10T436/24
Abstract: A nanodiamond particle including an NV center having ODMR intensity enhanced, of which surface is modified with a functional group containing a heteroatom, is provided. This nanodiamond particle as being chemically modified can serve for a fluorescent molecular probe which can be made use of in a biological system. By tracking a rotational motion of the NV center included in this fluorescent molecular probe, structural change of a protein can be analyzed in real time. The functional group containing a heteroatom can be at least any functional group of a hydroxyl group and a hydroxyalkyl group, or a carboxyl group.
Abstract translation: 提供了包括具有ODMR强度的NV中心的纳米金刚石颗粒，其表面用含杂原子的官能团修饰。 经化学修饰的该纳米金刚石颗粒可用于可在生物系统中使用的荧光分子探针。 通过跟踪该荧光分子探针中包含的NV中心的旋转运动，可以实时分析蛋白质的结构变化。 含有杂原子的官能团可以是羟基和羟基烷基或羧基的至少任何官能团。
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公开(公告)号：US09452417B2
公开(公告)日：2016-09-27
申请号：US14429255
申请日：2013-09-18
Applicant: Japan Science and Technology Agency
Inventor： Hiroshi Kitagawa , Kohei Kusada , Katsutoshi Nagaoka , Katsutoshi Sato , Md. Shahajahan Kutubi
CPC classification number: B01J23/462 , B01D53/9418 , B01D53/945 , B01D2255/1023 , B01D2255/1026 , B01J23/63 , B01J35/0013 , B01J35/002 , B01J37/0009 , B01J37/0036 , B01J37/0063 , B01J37/0211 , B01J37/08 , B01J37/16 , B22F1/0018 , B22F9/24 , B82Y30/00 , C07B37/04 , C07C1/321 , C07C37/16 , C07C45/61 , C07C45/64 , C07C2523/44 , C07C2523/46 , C22C1/0466 , Y02A50/2324 , Y02A50/2325 , Y02T10/22 , C07C15/14
Abstract: The catalyst disclosed is a catalyst including palladium-ruthenium alloy fine particles in which palladium and ruthenium form a solid solution. The palladium-ruthenium alloy fine particles used in this catalyst can be produced by a production method including the step of maintaining a solution containing a protective agent, a reducing agent, a palladium compound or palladium ions, and a ruthenium compound or ruthenium ions at a temperature equal to or higher than a predetermined temperature.
Abstract translation: 所公开的催化剂是包含钯 - 钌合金微粒的催化剂，其中钯和钌形成固溶体。 在该催化剂中使用的钯 - 钌合金微粒可以通过包括以下步骤的制备方法制备：包含保护剂，还原剂，钯化合物或钯离子的溶液，钌化合物或钌离子的溶液 温度等于或高于预定温度。
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