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公开(公告)号：US09745548B2
公开(公告)日：2017-08-29
申请号：US15420073
申请日：2017-01-30
发明人： Bart Lipkens , Rudolf Gilmanshin , Louis Masi , Benjamin Ross-Johnsrud , Erik Miller , Walter M. Presz, Jr. , Thomas J. Kennedy, III
IPC分类号： B01D37/00 , C12M1/00 , B01D21/28 , C12M1/34 , G10K15/04 , G10K9/122 , C12M1/26 , C12N13/00 , C07K1/14
CPC分类号： C12M47/02 , B01D17/04 , B01D17/06 , B01D21/283 , B06B1/0644 , C07K1/14 , C12M29/10 , C12M29/18 , C12M33/08 , C12M35/04 , C12M41/12 , C12M47/10 , C12N13/00 , G10K9/122 , G10K15/00 , G10K15/043
摘要： Methods are disclosed for separating beads and cells from a host fluid. The method includes flowing a mixture containing the host fluid, the beads, and the cells through an acoustophoretic device having an ultrasonic transducer including a piezoelectric material driven by a drive signal to create a multi-dimensional acoustic standing wave. A drive signal is sent to drive the at least one ultrasonic transducer to create the multi-dimensional acoustic standing wave. A recirculating fluid stream having a tangential flow path is located substantially tangential to the standing wave and separated therefrom by an interface region. A portion of the cells pass through the standing wave, and the beads are held back from the standing wave in the recirculating fluid stream at the interface region. Also disclosed is an acoustophoretic device having a coolant inlet adapted to permit the ingress of a cooling fluid into the device for cooling the transducer.
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公开(公告)号：US09744483B2
公开(公告)日：2017-08-29
申请号：US15249129
申请日：2016-08-26
发明人： Bart Lipkens , Walter M. Presz, Jr. , Jeffrey King , Jason Barnes , Dane Mealey , Brian McCarthy , Ben Ross-Johnsrud , Kedar Chitale
CPC分类号： B01D21/283 , B01D21/0042 , B01D21/0045 , B01D21/0087 , B01D21/2422 , B06B1/06 , C02F1/36 , C12M47/02
摘要： Devices for separating a host fluid from a second fluid or particulate are disclosed. The devices include an acoustic chamber, a fluid outlet at a top end of the acoustic chamber, a concentrate outlet at a bottom end of the acoustic chamber, and an inlet on a first side end of the acoustic chamber. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the acoustic chamber that traps and separates particulates (e.g. cells) from a host fluid. The host fluid is collected via the fluid outlet, and the particulates are collected via the concentrate outlet. The device is a large-scale device that is able to process liters/hour, and has a large interior volume.
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公开(公告)号：US09738866B2
公开(公告)日：2017-08-22
申请号：US15139248
申请日：2016-04-26
发明人： Bart Lipkens , Erik Miller , Benjamin Ross-Johnsrud , Walter M. Presz, Jr. , Kedar Chitale , Thomas J. Kennedy, III , Lauren Winiarski
IPC分类号： C12N1/02 , C12M1/00 , C12N13/00 , B01D17/04 , B01D17/06 , B01D21/28 , B06B1/06 , C12M1/26 , C12M1/42 , H01L41/09
CPC分类号： C12M47/02 , B01D17/04 , B01D17/06 , B01D21/283 , B06B1/0644 , C12M29/10 , C12M29/18 , C12M33/08 , C12M35/04 , C12N13/00 , H01L41/0973
摘要： Acoustic perfusion devices for separating biological cells from other material in a fluid mixture are disclosed. The devices include an inlet port, an outlet port, and a collection port that are connected to an acoustic chamber. An ultrasonic transducer creates an acoustic standing wave in the acoustic chamber that permits a continuous flow of fluid to be recovered through the collection port while keeping the biological cells within the acoustic chamber to be returned to the bioreactor from which the fluid mixture is being drawn.
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公开(公告)号：US09718708B2
公开(公告)日：2017-08-01
申请号：US13866943
申请日：2013-04-19
发明人： Nicholas M. LoRicco , Bart Lipkens
CPC分类号： C02F1/36 , B01D21/283 , H04R23/00
摘要： A system for enhancing the separation of particles or fluids from water is disclosed. A settling tank or skim tank is provided with an open submersible acoustophoretic separator. In a skim tank, the separator captures and holds oil droplets or particles, permitting them to coalesce until they are large enough and have sufficient buoyant force to float to the top of the tank. In a settling or sediment tank, separator captures and holds particles until they are large enough that the force of gravity causes them to settle out of the water. The acoustophoretic device thus speeds up separation of the particles or droplets from the water.
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公开(公告)号：US09675902B2
公开(公告)日：2017-06-13
申请号：US15000573
申请日：2016-01-19
发明人： Bart Lipkens , Jason Dionne , Ari Mercado , Brian Dutra , Walter M. Presz, Jr. , Thomas J. Kennedy, III , Louis Masi
CPC分类号： B01D17/04 , B01D43/00 , B06B1/0644 , C12M47/02
摘要： An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.
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公开(公告)号：US09670477B2
公开(公告)日：2017-06-06
申请号：US15143481
申请日：2016-04-29
IPC分类号： C12N13/00 , B01D21/00 , G01N29/00 , B01D21/28 , A61M1/36 , C12M1/00 , G01N15/00 , G01N15/10 , G01N15/14
CPC分类号： C12N13/00 , A61M1/3678 , B01D21/283 , B01L3/502761 , B01L2300/0864 , B01L2300/0867 , B01L2400/0436 , B01L2400/0439 , C12M47/04 , G01N15/1484 , G01N2015/0053 , G01N2015/1006 , G01N2015/149
摘要： Devices for separating materials from a host fluid are disclosed. The devices include a flow chamber, an ultrasonic transducer, and a reflector. The ultrasonic transducer and reflector create an angled acoustic standing wave oriented at an angle relative to the direction of mean flow through the flow chamber. The angled acoustic standing wave results in an acoustic radiation force having an axial force component that deflects the materials, so that the materials and the host fluid can thus be separated. The angled acoustic standing wave can be oriented at an angle of about 20° to about 70° relative to the direction of mean flow through the flow chamber to deflect, collect, differentiate, or fractionate the materials from the fluid flowing through the device at flow rates of about 400 mL/min up to about 700 mL/min.
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公开(公告)号：US20170128857A1
公开(公告)日：2017-05-11
申请号：US15414465
申请日：2017-01-24
CPC分类号： H04L12/40032 , B01D17/00 , B01D17/0202 , B01D21/0084 , B01D21/283 , B01D43/00 , B06B1/0276 , B06B1/0674 , C02F1/32 , C12M47/02 , H04L2012/4026
摘要： A method for separating a second fluid or a particulate from a host fluid is disclosed. The method includes flowing the mixture through an acoustophoretic device comprising an acoustic chamber, an ultrasonic transducer, and a reflector. The transducer includes a piezoelectric material driven by a voltage signal to create a multi-dimensional acoustic standing wave in the acoustic chamber. A voltage signal is sent to drive the ultrasonic transducer in a displacement profile that is a superposition of a combination of different mode shapes that are the same order of magnitude to create the multi-dimensional acoustic standing wave in the acoustic chamber such that the second fluid or particulate is continuously trapped in the standing wave, and then agglomerates, aggregates, clumps, or coalesces together, and subsequently rises or settles out of the host fluid due to buoyancy or gravity forces, and exits the acoustic chamber.
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公开(公告)号：US09567559B2
公开(公告)日：2017-02-14
申请号：US15238624
申请日：2016-08-16
发明人： Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, Jr. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin
CPC分类号： C12M47/10 , B01D17/04 , B01D17/06 , B01D21/283 , B06B1/0644 , C12M23/14 , C12M23/22 , C12M27/00 , C12M27/02 , C12M29/18 , C12M33/08 , C12M33/14 , C12M35/04 , C12M47/02 , C12M47/04 , C12P21/02
摘要： A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
摘要翻译： 灌注生物反应器包括至少一个可声学地产生多维驻波的超声换能器。 驻波可用于将细胞保留在生物反应器中，并且也可用于从生物反应器中生产的废物中脱水或进一步收获产品。
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公开(公告)号：US20160325206A1
公开(公告)日：2016-11-10
申请号：US15149036
申请日：2016-05-06
CPC分类号： B01D21/283 , B01D21/0012 , B06B1/06 , B06B2201/71 , B06B2201/76 , C12M47/04
摘要： Devices and methods for pre-conditioning and/or post-conditioning a host fluid containing a second fluid or particulate are disclosed. The devices include a flow chamber having first opening and a particulate outlet. The devices can also include side openings and alignment, fluid, and particulate screens. An ultrasonic transducer can be driven to create an acoustic standing wave in the flow chamber, or alternatively be driven to excite the wall of the flow chamber in which it is located. This creates a uniformly stratified flow within the flow chamber, with the second fluid or particulate being aligned in planes in the fluid mixture. This permits the host fluid to be separated therefrom using the fluid screen and the particulate screen.
摘要翻译： 公开了用于预处理和/或后处理含有第二流体或颗粒的主体流体的装置和方法。 这些装置包括具有第一开口和颗粒出口的流动室。 该装置还可以包括侧开口和对准，流体和颗粒筛。 可以驱动超声波换能器以在流动室中产生声驻波，或者可选地被驱动以激发其所在的流动室的壁。 这在流动室中产生均匀分层的流动，其中第二流体或颗粒在流体混合物中的平面中对准。 这允许使用流体筛网和颗粒筛网将主体流体与其分离。
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公开(公告)号：US09422328B2
公开(公告)日：2016-08-23
申请号：US14329723
申请日：2014-07-11
CPC分类号： C07K1/145 , B01D17/04 , B01D17/044 , B01D17/06 , B01D21/283 , B01D43/00 , B06B1/0622 , C12M29/04 , C12M35/02 , C12M35/04 , C12M47/10
摘要： A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. Biomolecules produced by the cell culture are collected by the nutrient fluid stream and separated downstream of the cell culture.
摘要翻译： 在生物反应器的生长体积内建立一系列多维声驻波。 声波驻波被用于将细胞培养物保持在适当的位置，因为营养液流流过细胞培养物。 通过营养液流收集由细胞培养产生的生物分子，并在细胞培养物的下游分离。
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