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1466 条记录 (耗时 0.035 秒)

    Guided Tissue Regeneration Membrane
    121.
    发明申请
    Guided Tissue Regeneration Membrane 审中-公开
    引导组织再生膜

    公开(公告)号：US20140080096A1

    公开(公告)日：2014-03-20

    申请号：US14055718

    申请日：2013-10-16

    申请人： Kent Kuohua Chang

    发明人： Chao-Fu Chang ,  Kent Kuohua Chang

    IPC分类号： A61C8/02

    CPC分类号： A61C8/0006 ,  A61L31/088 ,  A61L31/146 ,  A61L2400/12

    摘要： A guided tissue regeneration membrane has a top surface, a bottom surface and the two surfaces are characterized by the plurality of through conical holes. Each of the plurality of through holes has a base opening on the top surface and a tip opening on the bottom surface. The diameter of the base opening is larger than that of the tip opening The guided tissue regeneration membrane is placed between a hard tissue and a soft tissue of gums with the top surface thereof facing the hard tissue so as to hinder the soft tissue from rapidly growing. The tip openings are available for the soft tissue to supply nutrient to the hard tissue therethrough. The hard tissue can grow from the base openings, through the corresponding through holes and to the soft tissue to repair periodontal tissue. In order to achieve a better affinity for cell growth, the guided tissue membrane surface facing the bony surface is coated with a hydrophilic, bioactive and biocompatible nano scaled oxidation layer.

    摘要翻译： 引导组织再生膜具有顶表面，底表面，两个表面的特征在于多个通孔。 多个通孔中的每一个在顶表面上具有基部开口，在底面上具有顶端开口。 基部开口的直径大于尖端开口的直径引导的组织再生膜被放置在硬组织和牙龈的软组织之间，其顶表面面向硬组织，从而阻碍软组织快速生长 。 尖端开口可用于软组织，以通过其中的硬组织提供营养。 硬组织可以从基底开口，通过相应的通孔和软组织生长，以修复牙周组织。 为了实现对细胞生长的更好的亲和力，面向骨表面的引导组织膜表面涂覆有亲水的，生物活性的和生物相容的纳米级氧化层。

    METHODS OF TREATMENT WITH BIODEGRADATION OF A STENT SCAFFOLDING
    124.
    发明申请
    METHODS OF TREATMENT WITH BIODEGRADATION OF A STENT SCAFFOLDING 有权
    使用生物降解治疗的方法

    公开(公告)号：US20140012362A1

    公开(公告)日：2014-01-09

    申请号：US13925750

    申请日：2013-06-24

    申请人： Abbott Cardiovascular Systems Inc.

    发明人： David C. Gale ,  Bin Huang

    IPC分类号： A61F2/82

    CPC分类号： A61L31/14 ,  A61F2/82 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/604

    摘要： Disclosed is a stent comprising a bioabsorbable polymeric scaffolding; and a plurality of depots in at least a portion of the scaffolding, wherein the plurality of depots comprise a bioabsorbable material, wherein the degradation rate of all or substantially all of the bioabsorbable polymer of the scaffolding is faster than the degradation rate of all or substantially all of the bioabsorbable material of the depots.

    摘要翻译： 公开了一种支架，其包括生物可吸收聚合物支架; 以及在所述脚手架的至少一部分中的多个仓库，其中所述多个仓库包含生物可吸收材料，其中所述脚手架的所有或基本上全部所述生物可吸收聚合物的降解速度比全部或基本上 所有生物可吸收材料的仓库。

    Polyporous hollow bone screw
    126.
    发明授权
    Polyporous hollow bone screw 有权
    多孔中空骨螺钉

    公开(公告)号：US08579947B2

    公开(公告)日：2013-11-12

    申请号：US12807785

    申请日：2010-09-14

    申请人： Yangguan Wu

    发明人： Yangguan Wu

    IPC分类号： A61B17/86

    CPC分类号： A61B17/8685 ,  A61B17/74 ,  A61B17/866 ,  A61B2017/561 ,  A61K9/0024 ,  A61K9/19 ,  A61K9/5161 ,  A61K35/28 ,  A61K38/1875 ,  A61L31/129 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/64 ,  A61L2400/12 ,  C08L89/06 ,  C08L5/08 ,  A61K2300/00

    摘要： Present invention depicts a poly-porous (micropore) hollow screws as diffusion chamber filled with core matrix for targeted delivery of growth factors and bone marrow stem cells. The screws comprise at least two parts: the distal part of the screw consists of the tip of the screw made of poly porous material and hollow inside proximally. It has threaded navel attached to the threaded nipple of the distal part of the proximal screw which has the screw head and is made of the solid material of the same kind. The screw head had hexagonal recess targeted for screw driver insertion. Assembly of screw created a chamber in the middle of the screw. The chamber is filled with core matrix consisting of gelatin nano-particles pre-impregnated with BMPs (BMP2/BMP7 for bone or BMP12 for tendon, ligament) and fibrin sealants or Chitosan dispersed with bone marrow stem cells and/or other growth factors. Bioactive protein core material is prepared during the surgery and filled the chamber of the screw by the surgeon. Fibrin sealants or Chitosan will polymerize to form a gel to hold the growth factors and stem cell in place. The screw can be used as the lag screw or other function to provide mechanical fixation in variety of condition. Once the screw implanted in the human body, the fibrin sealant or Chitosin/gelatin nano-particles are gradually degraded and slowly release growth factors and stem cells via micropores of screw to facilitate the bone healing and regeneration. The gelatin nanoparticles and fibril sealant/or Chitosan matrix also serve as the scaffold and platform for bone in-growth to the screw or alternatively, the stem cell inside of screw can regenerate new bone, providing the biological fixation. At the mean time as the bone regenerate and/or in growth, mechanical strength of the screw increased.

    摘要翻译： 本发明描述了作为扩散室的多孔（微孔）中空螺钉，其填充有核心基质，用于靶向递送生长因子和骨髓干细胞。 螺钉包括至少两个部分：螺钉的远端部分由多孔材料制成的螺钉的尖端和近侧的中空部分组成。 其具有螺纹肚脐，其附接到具有螺钉头的近端螺钉的远端部分的螺纹接头，并且由相同种类的固体材料制成。 螺钉头具有用于螺丝刀插入的六角凹槽。 螺丝的组装在螺钉的中间形成了一个腔室。 填充有核心基质，其由预先浸渍有BMP的明胶纳米颗粒（BMP2 / BMP7用于腱或BMP12用于腱，韧带）和纤维蛋白密封剂或分离有骨髓干细胞和/或其他生长因子的壳聚糖。 在手术过程中制备生物活性蛋白芯材料，并由外科医生填充螺钉的腔室。 纤维蛋白密封剂或壳聚糖将聚合形成凝胶以将生长因子和干细胞保持在适当位置。 螺杆可用作拉力螺钉或其他功能，可在各种条件下提供机械固定。 一旦螺钉植入人体，纤维蛋白密封剂或壳聚糖/明胶纳米颗粒逐渐降解，并通过螺杆的微孔缓慢释放生长因子和干细胞，以促进骨愈合和再生。 明胶纳米颗粒和原纤维密封剂/或壳聚糖基质还可用作骨螺旋生长骨架和平台，或者，螺钉内的干细胞可再生新骨，提供生物固定。 同时当骨再生和/或生长时，螺杆的机械强度增加。

    GUIDEWIRE WITH INTEGRAL RADIOPQUE MARKERS
    128.
    发明申请
    GUIDEWIRE WITH INTEGRAL RADIOPQUE MARKERS 有权
    GUIDEWIRE与整体无线电标记

    公开(公告)号：US20130237963A1

    公开(公告)日：2013-09-12

    申请号：US13418092

    申请日：2012-03-12

    申请人： Mark STIGER ,  Richard Thomas

    发明人： Mark STIGER ,  Richard Thomas

    IPC分类号： A61M25/098 ,  B44C1/22

    CPC分类号： A61M25/09 ,  A61L31/022 ,  A61L31/146 ,  A61L31/18 ,  A61M2025/09075 ,  A61M2025/09108 ,  A61M2025/09133 ,  A61M2025/09166 ,  C23F4/00

    摘要： Embodiments hereof relate to a guidewire formed from an elongated shaft, at least a portion of the shaft having an outer layer, a plurality of channels formed through the outer layer, and an inner core. The outer layer is formed from a material non susceptible to erosion by an erosion agent and the inner core is formed from a radiopaque material susceptible to erosion by the erosion agent. When exposed to the erosion agent, core material adjacent to the channels is removed to form a pattern of integral radiopaque segments or markers with a plurality of voids therebetween. By controlling the location of channels and the rate of erosion of the core material, the pattern of integral radiopaque segments and voids allow for in situ measurement when viewed under fluoroscopy.

    摘要翻译： 本发明的实施方案涉及由细长轴形成的导丝，所述轴的至少一部分具有外层，穿过外层形成的多个通道和内芯。 外层由不易受侵蚀剂侵蚀的材料形成，内芯由易受腐蚀剂腐蚀的不透射线材料形成。 当暴露于侵蚀剂时，除去与通道相邻的芯材料以形成其间具有多个空隙的整体不透射线段或标记的图案。 通过控制通道的位置和芯材的侵蚀速率，整体不透射线段和空隙的图案允许在荧光透视下观察时的原位测量。