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    VARIANT CLASSIFICATION THROUGH HIGH-CONFIDENCE MUTATION DETECTION FROM FLUORESCENCE SIGNALS MEASURED WITH A MULTIPLE MUTATION ASSAY
    16.
    发明公开
    VARIANT CLASSIFICATION THROUGH HIGH-CONFIDENCE MUTATION DETECTION FROM FLUORESCENCE SIGNALS MEASURED WITH A MULTIPLE MUTATION ASSAY 审中-公开

    公开(公告)号：US20240076751A1

    公开(公告)日：2024-03-07

    申请号：US18234573

    申请日：2023-08-16

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Steven Okino

    IPC: C12Q1/70 ,  G01N33/58

    CPC classification number: C12Q1/70 ,  G01N33/582 ,  G01N2800/26

    Abstract: A system and method for SARS-CoV-2 variant classification through mutation detection from qPCR fluorescence signals. The system receives fluorescence signals, wherein a first fluorescence signal indicates quantitative presence of a first genomic region as a control for SARS-CoV-2, and a second fluorescence signal indicates quantitative presence of a second genomic region of a first mutation present in a subset of variants of SARS-CoV-2. The system measures a first Cq for the first fluorescence signal and a second Cq for the second fluorescence signal as the signals cross a threshold RFU. The system calculates a delta Cq as a difference between the two. Further, the system identifies a first peak RFU for the first fluorescence signal and a second peak RFU for the second fluorescence signal, and calculates a RFU ratio of the two. The system detects presence of the first mutation based on the delta Cq and/or the RFU ratio.

    Circuit for sharing current between parallel LEDs or parallel strings of LEDs
    17.
    发明授权
    Circuit for sharing current between parallel LEDs or parallel strings of LEDs 有权

    公开(公告)号：US11917737B2

    公开(公告)日：2024-02-27

    申请号：US17877630

    申请日：2022-07-29

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Edward George Marquette

    IPC: H05B45/46

    CPC classification number: H05B45/46

    Abstract: A circuit for sharing current between parallel LEDs or parallel strings of LEDs, and a method of use of the same, are disclosed herein. The circuit for sharing current between parallel LED pathways can include a first LED pathway, a first transistor coupled to the first set of LEDs and that can control a first current through the first set of LEDs, and a first measurement node having a first sensed voltage. The circuit can include a second LED pathway, a second transistor coupled to the second set of LEDs and that can control a second current through the second set of LEDs, and a second measurement node having a second sensed voltage. The circuit includes a first differential amplifier and a second differential amplifier, each of which can compare sensed voltage and can apply a voltage to a gate of one of the first and second transistors.

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