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11.发明授权Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof 有权生物可吸收多孔增强组织植入物及其植入物的制备方法公开(公告)号：US08895045B2
公开(公告)日：2014-11-25
申请号：US13466448
申请日：2012-05-08
CPC分类号： A61F2/02 , A61F2/0063 , A61F2/08 , A61F2210/0004 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L2430/34 , C08L67/04
摘要： A biocompatible tissue implant. The tissue implant may be bioabsorbable, consists of a biocompatible polymeric foam. The tissue implant also includes a biocompatible reinforcement member. The polymeric foam and the reinforcement member are soluble in a lyophilizing solvent. The reinforcement may be annealed and/or coated.
摘要翻译： 生物相容性组织植入物。 组织植入物可以是生物可吸收的，由生物相容的聚合物泡沫组成。 组织植入物还包括生物相容性加强构件。 聚合物泡沫和增强构件可溶于冻干溶剂中。 钢筋可以退火和/或涂覆。
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12.发明申请METHOD OF PREPARATION OF BIOABSORBABLE POROUS REINFORCED TISSUE IMPLANTS AND IMPLANTS THEREOF 有权可生物多孔增强组织植入物及其植入物的制备方法公开(公告)号：US20130123937A1
公开(公告)日：2013-05-16
申请号：US13466448
申请日：2012-05-08
IPC分类号： A61F2/02
CPC分类号： A61F2/02 , A61F2/0063 , A61F2/08 , A61F2210/0004 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L2430/34 , C08L67/04
摘要： A biocompatible tissue implant. The tissue implant may be bioabsorbable, consists of a biocompatible polymeric foam. The tissue implant also includes a biocompatible reinforcement member. The polymeric foam and the reinforcement member are soluble in a lyophilizing solvent. The reinforcement may be annealed and/or coated.
摘要翻译： 生物相容性组织植入物。 组织植入物可以是生物可吸收的，由生物相容的聚合物泡沫组成。 组织植入物还包括生物相容性加强构件。 聚合物泡沫和增强构件可溶于冻干溶剂中。 钢筋可以退火和/或涂覆。
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公开(公告)号：US08366787B2
公开(公告)日：2013-02-05
申请号：US10172347
申请日：2002-06-14
申请人： Laura Jean Brown , Iksoo Chun , Sridevi Dhanaraj , Prasanna Malaviya , Mora C. Melican , Alireza Rezania , Li Zhang
发明人： Laura Jean Brown , Iksoo Chun , Sridevi Dhanaraj , Prasanna Malaviya , Mora C. Melican , Alireza Rezania , Li Zhang
IPC分类号： A61F2/02
CPC分类号： A61F2/0063 , A61B2017/0495 , A61F2/08 , A61L27/18 , A61L27/3629 , A61L27/3633 , A61L27/3641 , A61L27/3683 , A61L27/40 , C08L67/04
摘要： A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a three-dimensional synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of small intestine submucosa, and the three-dimensional synthetic portion comprises a foam or a three-dimensional mesh, textile, or felt.
摘要翻译： 提供了用于软组织附着，加强和/或重建的生物假体装置。 该装置包括天然存在的细胞外基质部分和三维合成部分。 在所示实施例中，天然存在的细胞外基质部分包括小肠粘膜下层，并且三维合成部分包括泡沫或三维网，织物或毡。
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公开(公告)号：US20120241496A1
公开(公告)日：2012-09-27
申请号：US13433096
申请日：2012-03-28
申请人： Venkataramanan Mandakolathur Vasudevan , Taylor W. Aronhalt , Jeffrey L. Aldridge , Charles J. Scheib , Chunlin Yang , Christopher J. Schall , Chester O. Baxter, III , Iksoo Chun , Rao S. Bezwada , Sean P. Conlon , Michael S. Cropper , Joshua R. Uth , Richard L. Leimbach , Donna L. Korvick
发明人： Venkataramanan Mandakolathur Vasudevan , Taylor W. Aronhalt , Jeffrey L. Aldridge , Charles J. Scheib , Chunlin Yang , Christopher J. Schall , Chester O. Baxter, III , Iksoo Chun , Rao S. Bezwada , Sean P. Conlon , Michael S. Cropper , Joshua R. Uth , Richard L. Leimbach , Donna L. Korvick
IPC分类号： A61B17/068
CPC分类号： A61B17/0643 , A61B17/00491 , A61B17/0644 , A61B17/0684 , A61B17/072 , A61B17/07207 , A61B17/07292 , A61B17/1155 , A61B17/2909 , A61B2017/00004 , A61B2017/00314 , A61B2017/00327 , A61B2017/00477 , A61B2017/00526 , A61B2017/0053 , A61B2017/00818 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/00898 , A61B2017/00938 , A61B2017/00942 , A61B2017/00951 , A61B2017/07228 , A61B2017/07235 , A61B2017/07242 , A61B2017/07264 , A61B2017/07271 , A61B2017/07278 , A61B2017/07285 , A61B2017/2908 , A61B2017/2919 , A61B2017/2923 , A61B2017/2927 , A61B2017/2933 , A61B2017/2936 , A61B2017/2946 , A61B2017/320052 , A61B2090/037 , A61B2090/0811 , A61L31/042 , A61L31/129 , A61L31/14 , A61L31/148 , A61L31/16 , C08L1/04
摘要： A tissue thickness compensator can comprise a plurality of layers. Various embodiments are disclosed herein for manufacturing a tissue thickness compensator. In certain embodiments, a tissue thickness compensator can comprise at least one medicament tube, capsule, and/or packet contained therein
摘要翻译： 组织厚度补偿器可以包括多个层。 本文公开了用于制造组织厚度补偿器的各种实施例。 在某些实施例中，组织厚度补偿器可以包括其中包含的至少一个药物管，胶囊和/或包装
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15.发明授权Implantable biodegradable devices for musculoskeletal repair or regeneration 有权用于肌肉骨骼修复或再生的植入式可生物降解装置公开(公告)号：US07192604B2
公开(公告)日：2007-03-20
申请号：US10020021
申请日：2001-12-07
申请人： Kelly R. Brown , Iksoo Chun , Joseph J. Hammer , Victor F. Janas , Jennifer Mandanas , Mora C Melican , Alireza Rezania , Mark C. Zimmerman
发明人： Kelly R. Brown , Iksoo Chun , Joseph J. Hammer , Victor F. Janas , Jennifer Mandanas , Mora C Melican , Alireza Rezania , Mark C. Zimmerman
摘要： An implantable biodegradable device is disclosed containing a fibrous matrix, the fibrous matrix being constructed from fibers A and fibers B, wherein fibers A biodegrade faster than fibers B, fibers A and fibers B are present in relative amounts and are organized such that the fibrous matrix is provided with properties useful in repair and/or regeneration of mammalian tissue.
摘要翻译： 公开了一种可植入的可生物降解的装置，其包含纤维基质，该纤维基质由纤维A和纤维B构成，其中纤维A比纤维B，纤维A和纤维B生物降解得更快，并以组织使纤维基质 具有可用于哺乳动物组织的修复和/或再生的性质。
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公开(公告)号：US08663541B2
公开(公告)日：2014-03-04
申请号：US11842804
申请日：2007-08-21
CPC分类号： D04H3/07 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2475 , A61F2/915 , A61F2002/825 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2002/91583 , A61F2220/0058 , A61F2230/0054 , A61L27/18 , A61L27/34 , A61L27/54 , A61L2300/00 , D01D5/0084 , D01F6/32 , D01F6/84 , C08L67/04
摘要： The present invention relates to a medical device and method of forming the medical device. In particular, the present invention relates to a medical device having a tubular membrane structure over a radially expandable structural frame, and to a method of forming the tubular membrane on the radially expandable structural frame. In one aspect, a structural frame is placed over a spinning mandrel and a fiber is electro-statically spun over at least a portion of the structural frame forming a membrane. A transfer sheath may be used between the mandrel and structural frame to prevent the electro-statically spun fiber from adhering to the mandrel. In another aspect, a first membrane is spun over the mandrel before the structural frame is placed over the mandrel. In this aspect, at least a portion of the structural frame is sandwiched between the membranes. The membrane or membranes and structural frame form a fiber spun frame assembly. The fiber spun frame assembly may be coated with an elastic polymer. In addition, the membrane or membranes may go through some post processing to achieve desired characteristics or configurations.
摘要翻译： 本发明涉及形成医疗装置的医疗装置及其方法。 特别地，本发明涉及一种在可径向扩张的结构框架上具有管状膜结构的医疗装置以及在径向可扩张的结构框架上形成管状膜的方法。 在一个方面，将结构框架放置在纺丝心轴上，并且将纤维在形成膜的结构框架的至少一部分上静电纺丝。 可以在心轴和结构框架之间使用转移护套，以防止静电纺丝纤维粘附到心轴上。 在另一方面，在结构框架放置在心轴上之前，将第一膜旋转在心轴上。 在这方面，结构框架的至少一部分被夹在膜之间。 膜或膜和结构框架形成纤维纺纱架组件。 纤维纺丝框架组件可以涂覆有弹性聚合物。 此外，膜或膜可以经历一些后处理以实现期望的特性或构型。
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公开(公告)号：US07914808B2
公开(公告)日：2011-03-29
申请号：US10195341
申请日：2002-07-15
IPC分类号： A61F2/00
CPC分类号： A61L27/3691 , A61B17/0401 , A61B17/06166 , A61B17/064 , A61B17/0642 , A61B2017/00004 , A61B2017/0475 , A61B2017/06057 , A61B2017/0646 , A61F2/0063 , A61F2/08 , A61F2/0811 , A61F2/28 , A61F2/30749 , A61F2/30756 , A61F2/3094 , A61F2/30965 , A61F2/3872 , A61F2/442 , A61F2002/2817 , A61F2002/2839 , A61F2002/30032 , A61F2002/30062 , A61F2002/30131 , A61F2002/30153 , A61F2002/30199 , A61F2002/3021 , A61F2002/30217 , A61F2002/30224 , A61F2002/30225 , A61F2002/30233 , A61F2002/30261 , A61F2002/30281 , A61F2002/30293 , A61F2002/30294 , A61F2002/30429 , A61F2002/30611 , A61F2002/30677 , A61F2002/30678 , A61F2002/30751 , A61F2002/30764 , A61F2002/30766 , A61F2002/30785 , A61F2002/30841 , A61F2002/30848 , A61F2002/30878 , A61F2002/30891 , A61F2002/30892 , A61F2002/30914 , A61F2002/30957 , A61F2002/3096 , A61F2002/30971 , A61F2002/30975 , A61F2210/0004 , A61F2220/0025 , A61F2230/0013 , A61F2230/0019 , A61F2230/0063 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2230/0086 , A61F2230/0091 , A61F2240/001 , A61F2240/004 , A61F2250/003 , A61F2250/0063 , A61F2250/0067 , A61F2310/00365 , A61L27/18 , A61L27/3629 , A61L27/3633 , A61L27/3683 , A61L27/56 , A61L31/005 , A61L2430/06 , C08L67/04
摘要： Methods of making a hybrid biologic/synthetic scaffold for repairing damaged or diseased tissue are provided. The methods include the step of suspending pieces of an extracellular matrix material in a liquid to form a slurry, and coating a synthetic mat with the slurry, or mixing or layering the slurry with a synthetic polymer solution. The liquid is subsequently driven off so as to form a foam. Porous implantable scaffolds fabricated by such a method are also disclosed.
摘要翻译： 提供了用于修复损伤或患病组织的混合生物/合成支架的方法。 所述方法包括将细胞外基质材料块悬浮在液体中以形成浆料，并用浆料涂覆合成垫，或者用合成聚合物溶液混合或分层浆料的步骤。 随后将液体排出以形成泡沫。 还公开了通过这种方法制造的多孔可植入支架。
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公开(公告)号：US07674408B2
公开(公告)日：2010-03-09
申请号：US11230220
申请日：2005-09-19
申请人： Kelly R. Brown , Mora C. Melican , Iksoo Chun
发明人： Kelly R. Brown , Mora C. Melican , Iksoo Chun
IPC分类号： C08J9/26
CPC分类号： A61L31/146 , A61F2/0077 , A61F2/28 , A61F2/30756 , A61F2/30767 , A61F2002/0086 , A61F2002/2817 , A61F2002/30062 , A61F2002/30199 , A61F2002/30677 , A61F2002/30762 , A61F2002/30766 , A61F2002/30785 , A61F2002/30787 , A61F2002/3093 , A61F2002/4648 , A61F2210/0004 , A61F2230/0063 , A61F2250/0067 , A61L27/18 , A61L27/56 , A61L31/06 , C08L67/04
摘要： The present invention provides a biomedical, biocompatible, polymeric foam scaffold suitable for use in the repair and regeneration of tissue and which contains located therein a network of, branched channels that are effective to encourage and facilitate vascularization and tissue growth within the scaffold and to methods for making such biomedical scaffolds.
摘要翻译： 本发明提供了适用于组织修复和再生的生物医学，生物相容的聚合物泡沫支架，其包含有效促进和促进支架内的血管形成和组织生长以及方法的分支通道网络 用于制造这样的生物医学支架。
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公开(公告)号：US20070239205A1
公开(公告)日：2007-10-11
申请号：US11395474
申请日：2006-03-31
申请人： Chunlin Yang , Yufu Li , Hiep Do , Matthew Gounis , Iksoo Chun , Richard Davis , Darren Sherman
发明人： Chunlin Yang , Yufu Li , Hiep Do , Matthew Gounis , Iksoo Chun , Richard Davis , Darren Sherman
CPC分类号： A61L31/14 , A61L31/10 , A61L31/146 , A61L2400/18 , A61L2430/36 , Y10T428/1355 , Y10T428/1376 , C08L27/20
摘要： Vaso-occlusive devices are provided that have a polymer foam disposed about them. The polymer is treated with a plasma to facilitate thrombogenicity. A method for making and using such devices also is provided. The preferred polymer is a copolymer of a halogenated vinylidene and a halogenated alkene.
摘要翻译： 提供具有围绕它们设置聚合物泡沫的血管闭塞装置。 用等离子体处理聚合物以促进血栓形成。 还提供了制造和使用这种装置的方法。 优选的聚合物是卤代亚乙烯基和卤代烯烃的共聚物。
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公开(公告)号：US07112417B2
公开(公告)日：2006-09-26
申请号：US09938364
申请日：2001-08-24
申请人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Iksoo Chun , Mora C. Melican , Clairene A. Bazilio , Mark B. Roller , David V. Gorky
发明人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Iksoo Chun , Mora C. Melican , Clairene A. Bazilio , Mark B. Roller , David V. Gorky
CPC分类号： A61L27/3852 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/3817 , A61L27/3843 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10T428/24132 , Y10T428/24149 , Y10T428/24165 , Y10T428/24322 , Y10T428/24793 , Y10T428/249953 , Y10T428/249955 , Y10T428/249958 , Y10T428/249986 , Y10T428/268 , Y10T428/31786 , C08L67/04
摘要： The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
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