公开(公告)号：US20110166034A1

公开(公告)日：2011-07-07

申请号：US12901151

申请日：2010-10-08

Applicant: Gabriel A. Kwong ,  Caius G. Radu ,  Owen Witte ,  James R. Heath ,  Antoni Ribas

Inventor： Gabriel A. Kwong ,  Caius G. Radu ,  Owen Witte ,  James R. Heath ,  Antoni Ribas

IPC: C40B30/04

CPC classification number: G01N33/505 ,  C12Q1/6834 ,  G01N33/54306 ,  C12Q2563/131

Abstract: Polynucleotide-encoded capture agents for target detection and in particular modular polynucleotide-capture agents comprising a target binding component, a scaffold component and an encoding component formed by standardized molecular units that can be coupled and decoupled in a controlled fashion, and related compositions methods and systems.

Abstract translation: 用于靶检测的多核苷酸编码捕获剂，特别是模块化多核苷酸捕获剂，其包含靶结合组分，支架组分和通过可以受控制方式偶联和解耦的标准化分子单元形成的编码组分，以及相关组合物方法和 系统。

公开(公告)号：US07906775B2

公开(公告)日：2011-03-15

申请号：US11633043

申请日：2006-12-04

Applicant: James R. Heath ,  Pierre M. Petroff ,  Nicholas A. Melosh

Inventor： James R. Heath ,  Pierre M. Petroff ,  Nicholas A. Melosh

IPC: H01L21/02

CPC classification number: B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  G03F7/0002 ,  H01L21/0337 ,  H01L21/76802 ,  H01L21/76838 ,  Y10S977/755 ,  Y10S977/76 ,  Y10S977/762 ,  Y10S977/847 ,  Y10S977/938

Abstract: Fabrication of metallic or non-metallic wires with nanometer widths and nanometer separation distances without the use of lithography. Wires are created in a two-step process involving forming the wires at the desired dimensions and transferring them to a planar substrate. The dimensions and separation of the wires are determined by the thicknesses of alternating layers of different materials that are in the form of a superlattice. Wires are created by evaporating the desired material onto the superlattice that has been selectively etched to provide height contrast between layers. The wires thus formed upon one set of superlattice layers are then transferred to a substrate.

Abstract translation: 制造具有纳米宽度和纳米分离距离的金属或非金属线，无需光刻。 电线是以两步法制成的，包括以所需尺寸形成电线并将其转移到平面衬底。 导线的尺寸和间距由超晶格形式的不同材料的交替层的厚度决定。 通过将期望的材料蒸发到已经被选择性蚀刻以提供层之间的高度对比度的超晶格上来产生电线。 然后将由此形成在一组超晶格层上的电线转移到基底。

公开(公告)号：US20100009896A1

公开(公告)日：2010-01-14

申请号：US12487333

申请日：2009-06-18

Applicant: Heather AGNEW ,  Rosemary Rohde ,  Steven Millward ,  Arundhati Nag ,  James R. Heath

Inventor： Heather AGNEW ,  Rosemary Rohde ,  Steven Millward ,  Arundhati Nag ,  James R. Heath

IPC: A61K38/00 ,  C07D401/02 ,  C07D209/14 ,  C07K2/00 ,  G01N33/566 ,  A61K31/40 ,  A61K31/445 ,  A61P43/00

CPC classification number: G01N33/54306 ,  A61K38/02 ,  C07D249/04 ,  C07K1/00 ,  C12Q2523/109 ,  C40B30/04 ,  G01N33/531

Abstract: Multi-ligand capture agents comprising two or more ligands are described, and related compositions, methods and systems.

Abstract translation: 描述了包含两个或多个配体的多配位体捕获剂，以及相关组合物，方法和系统。

公开(公告)号：US20090117741A1

公开(公告)日：2009-05-07

申请号：US12125043

申请日：2008-05-21

Applicant: James R. Heath ,  Dunwei Wang ,  Yuri Bunimovich ,  Akram Boukai

Inventor： James R. Heath ,  Dunwei Wang ,  Yuri Bunimovich ,  Akram Boukai

IPC: H01L21/311

CPC classification number: H01L21/3086 ,  B82Y10/00 ,  H01L21/0331 ,  H01L29/0665 ,  H01L29/0673 ,  H01L29/78696

Abstract: A patterning method for the creation of two-dimensional nanowire structures. Nanowire patterning methods are used with lithographical patterning approaches to form patterns in a layer of epoxy and resist material. These patterns are then transferred to an underlying thin film to produce a two-dimensional structure with desired characteristics.

Abstract translation: 用于形成二维纳米线结构的图案化方法。 纳米线图案化方法与光刻图案化方法一起使用以在环氧树脂和抗蚀剂材料层中形成图案。 然后将这些图案转移到下面的薄膜以产生具有期望特性的二维结构。

公开(公告)号：US20080281090A1

公开(公告)日：2008-11-13

申请号：US11792168

申请日：2005-12-05

Applicant: Cheng-Chung Lee ,  Guodong Sui ,  Arkadij Elizarov ,  Hartmuth C. Kolb ,  Jiang Huang ,  James R. Heath ,  Michael E. Phelps ,  Stephen R. Quake ,  Hsian-rong Tseng ,  Paul Wyatt ,  Antoine Daridon

Inventor： Cheng-Chung Lee ,  Guodong Sui ,  Arkadij Elizarov ,  Hartmuth C. Kolb ,  Jiang Huang ,  James R. Heath ,  Michael E. Phelps ,  Stephen R. Quake ,  Hsian-rong Tseng ,  Paul Wyatt ,  Antoine Daridon

IPC: C07H5/02 ,  B01J19/00 ,  B01D15/04 ,  C07C211/43

CPC classification number: B01J19/0093 ,  B01F11/0042 ,  B01F13/0059 ,  B01F2215/0404 ,  B01J2219/00286 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00731 ,  B01J2219/00759 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00907 ,  B01L3/5027 ,  B33Y80/00 ,  C07B59/00

Abstract: New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.

Abstract translation: 提供了用于进行化学反应的新型微流体装置。 该器件适用于片上溶剂交换，需要多次化学反应的化学过程和试剂的快速浓缩。

公开(公告)号：US06979639B2

公开(公告)日：2005-12-27

申请号：US10803119

申请日：2004-03-16

Applicant: James R. Heath ,  Charles P. Collier ,  Yi Luo ,  Erica DeIonno ,  Patricia A. Beck

Inventor： James R. Heath ,  Charles P. Collier ,  Yi Luo ,  Erica DeIonno ,  Patricia A. Beck

IPC: H01L27/28 ,  H01L51/30 ,  H01L21/4763

CPC classification number: H01L27/285 ,  B82Y10/00 ,  H01L51/0052 ,  H01L51/0067 ,  H01L51/0591 ,  H01L51/0595 ,  Y10T428/12542 ,  Y10T428/24917 ,  Y10T428/31663

Abstract: Methods for making electronic devices where a molecular monolayer or multilayer is sandwiched between top and bottom electrodes at electrode intersections. The molecular layer has an electrical characteristic such as bistable switching. A layer of electrically conductive material is used to protect the molecular layer during formation of the top electrode pattern. The electrically conductive material remains sandwiched between the top and bottom electrodes at the electrode intersections in the final electronic device.

Abstract translation: 制造电子器件的方法，其中分子单层或多层被夹在电极交叉处的顶部和底部电极之间。 分子层具有诸如双稳态切换的电特性。 在形成顶部电极图案期间，使用一层导电材料来保护分子层。 导电材料保持夹在最终电子设备中的电极交叉处的顶部和底部电极之间。

公开(公告)号：US09419198B2

公开(公告)日：2016-08-16

申请号：US13278074

申请日：2011-10-20

Applicant: Jen-Kan Yu ,  Slobodan Mitrovic ,  James R. Heath

Inventor： Jen-Kan Yu ,  Slobodan Mitrovic ,  James R. Heath

IPC: H01L35/02 ,  H01L35/26 ,  B82Y30/00 ,  B82Y40/00 ,  B82Y10/00 ,  H01L31/18

CPC classification number: H01L35/26 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  Y10T428/24273 ,  Y10T428/24298

Abstract: A nanomesh phononic structure includes: a sheet including a first material, the sheet having a plurality of phononic-sized features spaced apart at a phononic pitch, the phononic pitch being smaller than or equal to twice a maximum phonon mean free path of the first material and the phononic size being smaller than or equal to the maximum phonon mean free path of the first material.

Abstract translation: 纳米级声子结构包括：包括第一材料的片材，该片材具有以声子间距间隔开的多个声子大小的特征，声子间距小于或等于第一材料的最大声子平均自由程的两倍 并且声子尺寸小于或等于第一材料的最大声子平均自由程。

公开(公告)号：US09239332B2

公开(公告)日：2016-01-19

申请号：US13546575

申请日：2012-07-11

Applicant: James R. Heath ,  Arundhati Nag ,  Samir Das ,  Kaycie M. Deyle ,  Steven Wesley Millward ,  Paul Edward Kearney

Inventor： James R. Heath ,  Arundhati Nag ,  Samir Das ,  Kaycie M. Deyle ,  Steven Wesley Millward ,  Paul Edward Kearney

IPC: G01N33/574 ,  A61K49/00 ,  C12Q1/48 ,  G01N33/573 ,  A61K38/08 ,  C12N15/10 ,  C12Q1/68 ,  C07K14/01 ,  C07K7/02 ,  C07K14/00

CPC classification number: C07K7/02 ,  A61K38/00 ,  A61K38/08 ,  A61K49/0043 ,  A61K49/0056 ,  A61K51/08 ,  C07K14/001 ,  C12N15/1058 ,  C12Q1/485 ,  C12Q1/6804 ,  G01N33/573 ,  G01N33/57449 ,  G01N33/5748 ,  G01N33/57496 ,  G01N2333/91205 ,  G01N2333/91215

Abstract: The present application provides stable peptide-based Akt capture agents and the use thereof as detection, diagnosis, and treatment agents. The application further provides novel methods of developing stable peptide-based capture agents, including Akt capture agents, using iterative on-bead in situ click chemistry.

Abstract translation: 本申请提供稳定的基于肽的Akt捕获剂及其用作检测，诊断和治疗剂。 该应用进一步提供了使用迭代在珠粒原位点击化学开发稳定的基于肽的捕获剂（包括Akt捕获剂）的新方法。

公开(公告)号：US08658112B2

公开(公告)日：2014-02-25

申请号：US13286418

申请日：2011-11-01

Applicant: Arkadij M. Elizarov ,  Hartmuth C. Kolb ,  R. Michael Van Dam ,  James R. Heath

Inventor： Arkadij M. Elizarov ,  Hartmuth C. Kolb ,  R. Michael Van Dam ,  James R. Heath

IPC: G01N33/00

CPC classification number: B01F11/0042 ,  B01F11/0071 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00731 ,  B01J2219/00759 ,  B01J2219/00783 ,  B01J2219/00788 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00858 ,  B01J2219/0086 ,  B01J2219/00862 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00907 ,  B01J2219/00916 ,  B01J2219/00927 ,  B01J2219/00986

Abstract: Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.

Abstract translation: 本文描述的是包括用于进行化学反应的化学反应芯片的自动化集成微流体装置，与芯片集成的微量柱，并且构造成用于从柱流到至少一个流动通道的液体流，并且其中流入塔的流体流是 由片上阀控制; 并且包括用于控制微流体装置中的流体流动的至少两个片上阀。

公开(公告)号：US08641912B2

公开(公告)日：2014-02-04

申请号：US12125043

申请日：2008-05-21

Applicant: James R. Heath ,  Dunwei Wang ,  Yuri Bunimovich ,  Akram Boukai

Inventor： James R. Heath ,  Dunwei Wang ,  Yuri Bunimovich ,  Akram Boukai

IPC: C23F1/00 ,  B44C1/22

CPC classification number: H01L21/3086 ,  B82Y10/00 ,  H01L21/0331 ,  H01L29/0665 ,  H01L29/0673 ,  H01L29/78696

Abstract: A patterning method for the creation of two-dimensional nanowire structures. Nanowire patterning methods are used with lithographical patterning approaches to form patterns in a layer of epoxy and resist material. These patterns are then transferred to an underlying thin film to produce a two-dimensional structure with desired characteristics.

Abstract translation: 用于形成二维纳米线结构的图案化方法。 纳米线图案化方法与光刻图案化方法一起使用以在环氧树脂和抗蚀剂材料层中形成图案。 然后将这些图案转移到下面的薄膜以产生具有期望特性的二维结构。