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    Bubble-free and pressure-generating electrodes for electrophoretic and electroosmotic devices
    15.
    发明申请
    Bubble-free and pressure-generating electrodes for electrophoretic and electroosmotic devices 失效

    公开(公告)号：US20050061669A1

    公开(公告)日：2005-03-24

    申请号：US10984239

    申请日：2004-11-09

    Applicant: Timothy Woudenberg ,  Zbigniew Bryning ,  Reid Kowallis

    Inventor： Timothy Woudenberg ,  Zbigniew Bryning ,  Reid Kowallis

    IPC: G01N27/30 ,  C02F1/461 ,  C02F1/469 ,  G01N27/403 ,  G01N27/447 ,  G01N27/26 ,  G01N27/27

    CPC classification number: G01N27/44704 ,  C02F1/46109 ,  C02F1/469

    Abstract: Bubble-free electrodes, electrochemical cells including bubble-free electrodes, analytical devices, and methods for preparing and using them are provided. The analytical devices each include at least one bubble-free electrode. Analytical devices that include an electrochemical cell and a sample containment device are also provided, wherein the electrochemical cell includes an anodic reservoir, a cathodic reservoir, an electrical connection between the anodic reservoir and the cathodic reservoir, and a first bubble-free electrode disposed within one of the anodic reservoir and the cathodic reservoir. A second electrode is disposed within the other reservoir and a power source is provided having a positive terminal that is normally in electrical contact with the first electrode, and a negative terminal that is normally in electrical contact with the second electrode. The analytical device further includes a power source polarity-inverting device for switching the contacts between the terminals of the power source and the first and second electrodes. The sample containment device includes a sample containment chamber having an opening for introducing a sample into the chamber and being positioned with respect to the electrochemical cell such that an electrical field generated by the electrochemical cell can influence a property of a component of a sample disposed in the sample containment chamber. Pressure-generating cells are also provided.

    Pulsed slit nozzle for generation of planar supersonic jets
    16.
    发明授权
    Pulsed slit nozzle for generation of planar supersonic jets 失效
    用于产生平面超音速喷气机的脉冲狭缝喷嘴

    公开(公告)号：US4834288A

    公开(公告)日：1989-05-30

    申请号：US452

    申请日：1987-01-05

    Applicant: Jonathan E. Kenny ,  Timothy Woudenberg

    Inventor： Jonathan E. Kenny ,  Timothy Woudenberg

    IPC: B05B1/00 ,  B05B3/02

    CPC classification number: B05B1/005 ,  B05B1/083 ,  B05B3/02 ,  Y10T137/86405

    Abstract: The present invention relates to generation of pulsed supersonic gas flow through a slit-shaped nozzle, useful in a wide range of applications, including particle separation, wind-tunnel studies, and especially spectroscopic studies of cold, gas-phase molecules. Specifically, the present invention is directed to a pulsed slit nozzle, which has a high length to width ratio, affording high sensitivity in spectroscopic applications.In addition, the present invention provides low dead volume, superior sealing properties, ease of actuation, heatability, uniform flow, ease of construction and maintenance, chemical inertness and long life.

    Abstract translation: 本发明涉及通过狭缝状喷嘴的脉冲超音速气流的产生，其可用于广泛的应用，包括颗粒分离，风洞研究，特别是冷气相分子的光谱研究。 具体地说，本发明涉及一种具有高长宽比的脉冲狭缝喷嘴，在光谱应用中提供高灵敏度。 此外，本发明提供低死体积，优异的密封性能，易于致动，可加热性，均匀的流动性，易于构造和维护，化学惰性和长寿命。

    Methods of detecting target nucleic acids
    17.
    发明授权
    Methods of detecting target nucleic acids 有权
    检测靶核酸的方法

    公开(公告)号：US08637247B2

    公开(公告)日：2014-01-28

    申请号：US13590794

    申请日：2012-08-21

    Applicant: Muhammad Sharaf ,  Timothy Woudenberg ,  Khairuzzaman Bashar Mullah

    Inventor： Muhammad Sharaf ,  Timothy Woudenberg ,  Khairuzzaman Bashar Mullah

    IPC: C12Q1/68

    CPC classification number: C12Q1/6825 ,  C12Q1/6816 ,  C12Q1/6823 ,  C12Q1/6827 ,  C12Q1/6832 ,  C12Q1/6876 ,  G01N27/44726 ,  G01N27/44791 ,  C12Q2565/631

    Abstract: The present disclosure relates to methods of identifying target nucleic acids by using coded molecules and its analysis by translocation through a nanopore. Generally, coded molecules are subject to a target polynucleotide dependent modification. The modified coded molecule is detected by isolating the modified coded molecules from the unmodified coded molecules prior to analysis through the nanopore or by detecting a change in the signal pattern of the coded molecule when analyzed through the nanopore.

    Abstract translation: 本公开内容涉及通过使用编码分子鉴定靶核酸的方法及其通过纳米孔易位的分析。 通常，经编码的分子经受目标多核苷酸依赖性修饰。 通过在通过纳米孔分析之前将经修饰的编码分子与未修饰的编码分子分离，或者当通过纳米孔分析时，通过检测编码分子的信号图谱的变化来检测修饰的编码分子。

    MICROFLUIDIC DEVICES AND METHODS
    18.
    发明申请
    MICROFLUIDIC DEVICES AND METHODS 有权
    微流体装置和方法

    公开(公告)号：US20120261007A1

    公开(公告)日：2012-10-18

    申请号：US13295028

    申请日：2011-11-11

    Applicant: Martin Pieprzyk ,  Geoff Facer ,  Timothy Woudenberg ,  Brian Fowler

    Inventor： Martin Pieprzyk ,  Geoff Facer ,  Timothy Woudenberg ,  Brian Fowler

    IPC: F16K31/12

    CPC classification number: G01N1/28 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/16 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0655 ,  B33Y80/00 ,  C12Q1/686 ,  G01N21/05 ,  G01N21/6452 ,  G01N2021/0346 ,  Y10T137/7793 ,  Y10T436/2575

    Abstract: Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device. Methods and systems are provided for improved fluorescent imaging of microfluidic devices.

    Abstract translation: 本发明的实施例提供了改进的微流体装置和相关装置，系统和方法。 提供了减少使用微流体装置期间的混合时间的方法。 微流控装置和相关的制造方法具有提高的制造成品率。 提供改进的装置和相关系统用于向微流体装置提供受控的压力。 提供了方法和相关的微流体装置，用于在使用过程中减少微流体装置的脱水。 微流控装置和相关方法提供了改进的样品与试剂混合比控制。 微流体装置和系统具有改进的抗压缩夹具压力引起的故障的阻力。 提供了使用微流体装置进行温度控制反应的方法和系统，其减少微流体装置内的冷凝水平。 提供了用于改进微流体装置的荧光成像的方法和系统。

    Method and System for Multiplex Genetic Analysis
    19.
    发明申请
    Method and System for Multiplex Genetic Analysis 有权
    多重遗传分析方法与系统

    公开(公告)号：US20100261158A1

    公开(公告)日：2010-10-14

    申请号：US11423403

    申请日：2006-06-09

    Applicant: Eric S. Nordman ,  Mark F. Oldham ,  Timothy Woudenberg

    Inventor： Eric S. Nordman ,  Mark F. Oldham ,  Timothy Woudenberg

    IPC: C12Q1/68 ,  C12M1/34 ,  C40B60/14 ,  C40B60/00 ,  C02F1/461

    CPC classification number: C12Q1/6874 ,  C12Q1/6869 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/648 ,  G01N21/6486 ,  G01N2021/6441 ,  C12Q2563/107

    Abstract: The present disclosure provides apparatus, systems and method for detecting separately and substantially simultaneously light emissions from a plurality of localized light-emitting analytes. A system according to exemplary embodiments of the present disclosure comprises a sample holder having structures formed thereon for spatially separating and constraining a plurality of light-emitting analytes each having a single nucleic acid molecule or a single nucleic acid polymerizing enzyme, a light source configured to illuminate the sample holder, an optical assembly configured to collect and detect separately and substantially simultaneously light emissions associated with the plurality of light emitting analytes. The system may further include a computer system configured to analyze the light emissions to determine the structures or properties of a target nucleic acid molecule associated with each analyte.

    Abstract translation: 本公开提供了用于单独和基本同时地检测来自多个局部发光分析物的光发射的装置，系统和方法。 根据本公开的示例性实施例的系统包括具有形成在其上的结构的样本保持器，用于空间分离和约束各自具有单个核酸分子或单个核酸聚合酶的多个发光分析物，光源被配置为 照亮样品架，光学组件被配置成分别收集和检测与多个发光分析物相关联的基本上同时的发光。 该系统还可以包括被配置为分析光发射以确定与每个分析物相关联的靶核酸分子的结构或性质的计算机系统。

    MICROFLUIDIC DEVICES AND METHODS
    20.
    发明申请
    MICROFLUIDIC DEVICES AND METHODS 有权
    微流体装置和方法

    公开(公告)号：US20100230613A1

    公开(公告)日：2010-09-16

    申请号：US12688462

    申请日：2010-01-15

    Applicant: Martin Pieprzyk ,  Geoff Facer ,  Timothy Woudenberg ,  Brian Fowler

    Inventor： Martin Pieprzyk ,  Geoff Facer ,  Timothy Woudenberg ,  Brian Fowler

    IPC: G01J1/58

    CPC classification number: G01N1/28 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/16 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0655 ,  B33Y80/00 ,  C12Q1/686 ,  G01N21/05 ,  G01N21/6452 ,  G01N2021/0346 ,  Y10T137/7793 ,  Y10T436/2575

    Abstract: Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device. Methods and systems are provided for improved fluorescent imaging of microfluidic devices.

    Abstract translation: 本发明的实施例提供了改进的微流体装置和相关装置，系统和方法。 提供了减少使用微流体装置期间的混合时间的方法。 微流控装置和相关的制造方法具有提高的制造产率。 提供改进的装置和相关系统用于向微流体装置提供受控的压力。 提供了方法和相关的微流体装置，用于在使用过程中减少微流体装置的脱水。 微流控装置和相关方法提供了改进的样品与试剂混合比控制。 微流体装置和系统具有改进的抗压缩夹具压力引起的故障的阻力。 提供了使用微流体装置进行温度控制反应的方法和系统，其减少微流体装置内的冷凝水平。 提供了用于改进微流体装置的荧光成像的方法和系统。

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